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21. 发明授权

US07070566B2 Artifact rejection using pulse quality values 有权
标题翻译：使用脉搏质量值的人工制品排斥
公开(公告)号：US07070566B2
公开(公告)日：2006-07-04
申请号：US10387631
申请日：2003-03-13
申请人： Richard Medero , Lawrence T. Hersh , Sai Kolluri , Bruce A. Friedman
发明人： Richard Medero , Lawrence T. Hersh , Sai Kolluri , Bruce A. Friedman
IPC分类号： A61B5/00
CPC分类号： A61B5/02225
摘要： A method and system for making pulse rate and blood pressure determinations is disclosed. The method and system comprise collecting oscillometric blood pressure data from pulses, determining individual quality values for feature measurements of the pulses, obtaining an overall quality assessment based on the individual quality values, repeating the collecting step until overall quality level is satisfied, and determining blood pressure and pulse rate using the individual quality values.
摘要翻译：公开了一种用于产生脉率和血压测定的方法和系统。该方法和系统包括从脉冲收集示波血压数据，确定脉冲特征测量的个体质量值，基于各个质量值获得总体质量评估，重复收集步骤直到满足整个质量水平，以及确定血液压力和脉搏率使用各个质量值。

22. 发明申请

US20050261597A1 Method and apparatus for determining extreme blood pressure values 失效
标题翻译：用于确定极端血压值的方法和装置
公开(公告)号：US20050261597A1
公开(公告)日：2005-11-24
申请号：US10847934
申请日：2004-05-18
申请人： Sai Kolluri , Lawrence Hersh , Bruce Friedman , Richard Medero
发明人： Sai Kolluri , Lawrence Hersh , Bruce Friedman , Richard Medero
IPC分类号： A61B5/02 , A61B5/0225 , A61B5/04 , A61B5/0456
CPC分类号： A61B5/02225 , A61B5/0225 , A61B5/0456
摘要： In a method and apparatus for measuring extreme blood pressure values during a single non-invasive blood measurement, the time intervals between sequential heartbeats are measured for a series of heartbeats in an oscillometric blood pressure measurement time period. Oscillometric blood pressure measurement data for the heartbeats of the series is obtained and associated with the heartbeat time intervals. An average time interval between heartbeats is also determined. A first data bin may be defined for blood pressure data associated with time intervals that are longer as compared to the average time interval. A second data bin is defined for blood pressure data with time intervals that are shorter as compared to the average time interval. The measured oscillometric blood pressure data is sorted into the data bins in accordance with the associated time intervals. The data in the first data bin is used to derive a high systolic blood pressure value and a low diastolic blood pressure value. The data in the second bin is used to derive a low systolic blood pressure value and a high diastolic blood pressure value. A typical blood pressure value may also be determined.
摘要翻译：在用于在单次非侵入性血液测量期间测量极端血压值的方法和装置中，测量在示波血压测量时间段内的一系列心跳的连续心跳之间的时间间隔。获得该系列心跳的示波血压测量数据，并与心跳时间间隔相关联。心跳之间的平均时间间隔也被确定。可以为与与平均时间间隔相比较长的时间间隔相关联的血压数据定义第一数据箱。第二个数据仓被定义为与平均时间间隔相比时间间隔更短的血压数据。测量的示波血压数据根据相关联的时间间隔被分类到数据箱中。第一数据箱中的数据用于导出高收缩压值和低舒张压值。第二个仓中的数据用于导出低收缩压值和高舒张压值。也可以确定典型的血压值。

23. 发明申请

US20070123784A1 METHOD OF CONTROLLING BLOOD PRESSURE CUFF DEFLATION 有权
标题翻译：控制血压压力缺陷的方法
公开(公告)号：US20070123784A1
公开(公告)日：2007-05-31
申请号：US11290272
申请日：2005-11-30
申请人： Lawrence Hersh , Sai Kolluri , Bruce Friedman , Richard Medero
发明人： Lawrence Hersh , Sai Kolluri , Bruce Friedman , Richard Medero
IPC分类号： A61B5/02
CPC分类号： A61B5/0225 , A61B5/02141 , A61B5/02225
摘要： A method of operating a non-invasive blood pressure (NIBP) monitor that includes a blood pressure cuff and a pressure transducer. The method initially inflates the blood pressure cuff to a level above systolic pressure and begins to deflate the pressure cuff using a continuous or linear deflation technique. During the linear deflation of the pressure cuff, the oscillation pulses from the pressure transducer are obtained and compared to predicted pulse estimates. If the obtained oscillation pulses vary from the predicted pulse estimates, the linear deflation technique is interrupted and the pressure cuff is then deflated in a sequence of distinct pressure steps. During each pressure step, the oscillation pulses are obtained and the pressure cuff is not deflated to the next pressure step until the oscillation pulses correspond to each other.
摘要翻译：一种操作包括血压袖带和压力换能器的非侵入性血压（NIBP）监测器的方法。该方法首先将血压袖带膨胀至高于收缩压的水平，并使用连续或线性放气技术开始压缩压力袖带。在压力袖带的线性放气期间，获得来自压力传感器的振荡脉冲并与预测的脉冲估计值进行比较。如果获得的振荡脉冲从预测的脉冲估计变化，则线性放气技术被中断，并且压力袖带然后以不同压力步骤的顺序放气。在每个压力步骤期间，获得振荡脉冲，并且压力袖带不会放气到下一个压力步骤，直到振荡脉冲彼此对应。

24. 发明申请

US20070118036A1 Computation of blood pressure using different signal processing channels 有权
标题翻译：使用不同的信号处理通道计算血压
公开(公告)号：US20070118036A1
公开(公告)日：2007-05-24
申请号：US11284206
申请日：2005-11-21
申请人： Lawrence Hersh , Sai Kolluri , Bruce Friedman , Richard Medero
发明人： Lawrence Hersh , Sai Kolluri , Bruce Friedman , Richard Medero
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02225 , A61B5/7207
摘要： A blood pressure measurement system that utilizes a non-invasive blood pressure (NIBP) monitor having a blood pressure cuff and pressure transducer. The measurement system provides a plurality of separate processing techniques that each receive a plurality of oscillometric data values from the pressure transducer. Each of the processing techniques separately constructs an oscillometric envelope based upon the oscillometric data values. Based upon the plurality of separate oscillometric envelopes, the system compares the envelopes and develops a calculated blood pressure from the plurality of envelopes. The calculated blood pressure is then displayed by the NIBP system. The plurality of oscillometric envelopes can be compared and combined in different manners to calculate the patient's blood pressure from the plurality of different processing techniques.
摘要翻译：一种血压测量系统，其利用具有血压袖带和压力换能器的非侵入性血压（NIBP）监测器。测量系统提供多个单独的处理技术，每个处理技术从压力传感器接收多个示波数据值。每个处理技术基于示波数据值分别构建示波包络。基于多个单独的示波包络，系统比较信封并从多个信封形成计算出的血压。然后计算的血压由NIBP系统显示。多个示波包络可以以不同的方式进行比较和组合，以从多种不同的处理技术计算出患者的血压。

25. 发明申请

US20050004477A1 Method and apparatus for measuring blood pressure using relaxed matching criteria 有权
标题翻译：使用放松的匹配标准测量血压的方法和装置
公开(公告)号：US20050004477A1
公开(公告)日：2005-01-06
申请号：US10613333
申请日：2003-07-03
申请人： Bruce Friedman , Richard Medero , Lawrence Hersh , Sai Kolluri
发明人： Bruce Friedman , Richard Medero , Lawrence Hersh , Sai Kolluri
IPC分类号： A61B5/021 , A61B5/0452 , A61B5/02
CPC分类号： A61B5/02405 , A61B5/021 , A61B5/02141 , A61B5/02225 , A61B5/0452
摘要： A technique for comparing pressure oscillations obtained during a blood pressure determination wherein two or more sets of matching criteria may be employed. The set of matching criteria to be employed is determined based on the heart rate variability or the presence of heart beat irregularities or arrhythmias as determined by an independent heart monitor, such as an ECG. The selected set of matching criteria may then be employed in determining the acceptability of the time interval between two oscillations and the equivalence of the two oscillations based upon one or more oscillation characteristics, such as peak amplitude. In this manner, non-consecutive oscillations may be matched and used in determining blood pressure.
摘要翻译：用于比较在血压测定期间获得的压力振荡的技术，其中可以采用两组或更多组匹配标准。基于通过独立心脏监测器（例如ECG）确定的心率变异性或心跳不规则性或心律失常的存在来确定要使用的匹配标准的集合。然后可以使用所选择的一组匹配标准来确定两个振荡之间的时间间隔的可接受性和基于一个或多个振荡特性（诸如峰值振幅）的两个振荡的等效性。以这种方式，非连续振荡可以匹配并用于确定血压。

26. 发明申请

US20070129638A1 METHOD AND SYSTEM FOR CUFF PRESSURE REVERSIONS 有权
标题翻译：压力反应的方法和系统
公开(公告)号：US20070129638A1
公开(公告)日：2007-06-07
申请号：US11626170
申请日：2007-01-23
申请人： Lawrence Hersh , Richard Medero , Bruce Friedman , Sai Kolluri
发明人： Lawrence Hersh , Richard Medero , Bruce Friedman , Sai Kolluri
IPC分类号： A61B5/02
CPC分类号： A61B5/02225 , A61B5/0225 , A61B5/7207 , G06F19/00
摘要： A method and system for determining when to make a reversion to smaller cuff pressure steps during an oscillometric blood pressure measurement is disclosed. The method and system comprise comparing conformance of oscillometric envelope blood pressure data with previous blood pressure data, including measuring a shift between the oscillometric envelope blood pressure data and an oscillometric envelope derived from the previous blood pressure data. In addition, the method and system include making a reversion decision based on whether the shift exceeds an allowable threshold. Once a reversion decision is made a subsequent decision may be made as to the need for increasing the cuff pressure level.
摘要翻译：公开了一种用于在示波器血压测量期间确定何时进行更小的袖带压力步骤的方法和系统。所述方法和系统包括比较示波包络血压数据与先前血压数据的一致性，包括测量示波包络血压数据与从先前血压数据得出的示波包络之间的偏移。此外，所述方法和系统包括基于所述偏移是否超过允许阈值来进行回归决定。一旦进行回归决定，可以随后作出关于增加袖带压力水平的需要的决定。

27. 发明申请

US20100249616A1 NIBP TARGET INFLATION PRESSURE AUTOMATION USING DERIVED SPO2 SIGNALS 有权
标题翻译： NIBP目标充气压力自动化使用衍生的SPO2信号
公开(公告)号：US20100249616A1
公开(公告)日：2010-09-30
申请号：US12412057
申请日：2009-03-26
申请人： Robert F. Donehoo , Lawrence T. Hersh , Sai Kolluri
发明人： Robert F. Donehoo , Lawrence T. Hersh , Sai Kolluri
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02225 , A61B5/7239
摘要： A method and system for operating a non-invasive blood pressure monitor that utilizes an SpO2 plethysmograph waveform to determine the initial inflation pressure for the NIBP monitor. A pulse sensor is placed on the patient's limb distal to the blood pressure cuff and provides a pulse waveform to the NIBP monitor. The NIBP monitor calculates a second derivative of the pulse waveform, which includes a series of acceleration peaks corresponding to pulse signals within the pulse waveform. When the blood pressure cuff reaches systolic pressure, the acceleration peaks contained within the acceleration waveform are eliminated, thus providing an indication that the cuff pressure has reached systolic pressure for the patient. Use of the SPO2 plethysmograph signal to determine the initial inflation pressure reduces both the over-inflation of the blood pressure cuff and the under-inflation of the blood pressure cuff, which increases the rate at which the blood pressure measurement can be made while increasing patient comfort.
摘要翻译：一种用于操作非侵入性血压监测器的方法和系统，其利用SpO2体积描记器波形来确定NIBP监测器的初始充气压力。将脉搏传感器放置在远离血压袖带的患者肢体上，并向NIBP监护仪提供脉搏波形。 NIBP监视器计算脉搏波形的二阶导数，其包括与脉冲波形内的脉冲信号相对应的一系列加速度峰值。当血压袖带达到收缩压时，加速波形中包含的加速度峰值被消除，从而提供袖带压力已达到患者收缩压的指示。使用SPO2体积描记器信号来确定初始充气压力会降低血压袖带的过度充气和血压袖带的欠充气，从而增加患者血压测量的速度，同时增加患者安慰。

28. 发明申请

US20090209874A1 EXTRAPOLATING ICA KNOWLEDGE FROM ONE EPOCH TO ANOTHER FOR IMPROVED FETAL ECG SEPARATION 有权
标题翻译：将一个EPOCH的ICA知识扩展到另一个改进的FET心电图分离
公开(公告)号：US20090209874A1
公开(公告)日：2009-08-20
申请号：US12034129
申请日：2008-02-20
申请人： Sai Kolluri , Bruce A. Friedman , Lawrence T. Hersh , Rush Winslow Hood, JR.
发明人： Sai Kolluri , Bruce A. Friedman , Lawrence T. Hersh , Rush Winslow Hood, JR.
IPC分类号： A61B5/0448
CPC分类号： A61B5/0444 , A61B5/4362
摘要： A method of utilizing a maternal-fetal monitoring system to monitor the physiological properties of both a maternal patient and a fetus. A series of ECG electrodes are placed across the maternal patient's abdomen and receives ECG input waveforms across sixteen separate channels. The sixteen channels of information are processed using an ICA algorithm to generate a series of ICA output waveforms and a transfer matrix. Following the current epoch, the transfer matrix is applied to the input waveforms on a continuous basis. The conditioned input waveforms are displayed immediately following the first epoch and prior to the expiration of a subsequent epoch. The transfer matrix for the second epoch is combined with the transfer matrix for the first epoch to generate an updated transfer matrix. Various filtering operations on the transfer matrix coefficients may be used to find the updated transfer matrix before the end of the current epoch.
摘要翻译：一种利用母胎监测系统来监测母亲患者和胎儿的生理特性的方法。一系列ECG电极放置在母亲患者的腹部，并接收跨16个独立通道的ECG输入波形。使用ICA算法处理16个信道的信道，以生成一系列ICA输出波形和传送矩阵。在当前时代之后，传输矩阵连续地应用于输入波形。条件输入波形显示在第一纪元之后，并在随后的时期到期之前。将第二纪元的传递矩阵与第一纪元的传输矩阵组合以生成更新的传送矩阵。可以使用传递矩阵系数上的各种滤波操作来在当前时期结束之前找到更新的传输矩阵。

29. 发明授权

US08556821B2 Adaptive frequency domain filtering for improved non-invasive blood pressure estimation 有权
标题翻译：自适应频域滤波改善非侵入性血压估计
公开(公告)号：US08556821B2
公开(公告)日：2013-10-15
申请号：US12034143
申请日：2008-02-20
申请人： Lawrence T. Hersh , Sai Kolluri , Robert F. Donehoo
发明人： Lawrence T. Hersh , Sai Kolluri , Robert F. Donehoo
IPC分类号： A61B5/22
CPC分类号： A61B5/0225 , A61B5/02225 , A61B5/024 , A61B5/7257
摘要： A system for processing oscillometric data from a plurality of pressure steps to determine the blood pressure of a patient as disclosed herein. A heart rate monitor connected to the patient acquires the patient's heart rate. A time to frequency domain converter receives oscillometric data and converts the oscillometric data into the frequency domain. A harmonic frequency calculator is connected to the heart rate monitor and derives at least the heart rate fundamental frequency. A filter connected to the time to frequency domain converter and the harmonic frequency calculator that produces a filter frequency domain oscillometric signal. A reconstruction calculator receives the filtered frequency domain oscillometric signal and reconstructs a time domain oscillometric signal. A method of computing an oscillometric envelope for use in determining the blood pressure of a patient is also disclosed herein.
摘要翻译：一种用于从多个压力步骤处理示波数据以确定如本文所公开的患者的血压的系统。连接到患者的心率监测器获取患者的心率。一段时间到频域转换器接收示波数据并将示波数据转换成频域。谐波频率计算器连接到心率监测器，并至少得出心率基频。连接到时域转换器的滤波器和产生滤波器频域示波信号的谐波频率计算器。重建计算器接收滤波后的频域示波信号并重构时域示波信号。本文还公开了计算用于确定患者的血压的示波包络的方法。

30. 发明授权

US08211030B2 NIBP target inflation pressure automation using derived SPO2 signals 有权
标题翻译： NIBP目标通气压力自动化使用衍生的SPO2信号
公开(公告)号：US08211030B2
公开(公告)日：2012-07-03
申请号：US12412057
申请日：2009-03-26
申请人： Robert F. Donehoo , Lawrence T. Hersh , Sai Kolluri
发明人： Robert F. Donehoo , Lawrence T. Hersh , Sai Kolluri
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02225 , A61B5/7239
摘要： A method and system for operating a non-invasive blood pressure monitor that utilizes an SpO2 plethysmograph waveform to determine the initial inflation pressure for the NIBP monitor. A pulse sensor is placed on the patient's limb distal to the blood pressure cuff and provides a pulse waveform to the NIBP monitor. The NIBP monitor calculates a second derivative of the pulse waveform, which includes a series of acceleration peaks corresponding to pulse signals within the pulse waveform. When the blood pressure cuff reaches systolic pressure, the acceleration peaks contained within the acceleration waveform are eliminated, thus providing an indication that the cuff pressure has reached systolic pressure for the patient. Use of the SPO2 plethysmograph signal to determine the initial inflation pressure reduces both the over-inflation of the blood pressure cuff and the under-inflation of the blood pressure cuff, which increases the rate at which the blood pressure measurement can be made while increasing patient comfort.
摘要翻译：一种用于操作非侵入性血压监测器的方法和系统，其利用SpO2体积描记器波形来确定NIBP监测器的初始充气压力。将脉搏传感器放置在远离血压袖带的患者肢体上，并向NIBP监护仪提供脉搏波形。 NIBP监视器计算脉搏波形的二阶导数，其包括与脉冲波形内的脉冲信号相对应的一系列加速度峰值。当血压袖带达到收缩压时，加速波形中包含的加速度峰值被消除，从而提供袖带压力已达到患者收缩压的指示。使用SPO2体积描记器信号来确定初始充气压力会降低血压袖带的过度充气和血压袖带的欠充气，从而增加患者血压测量的速度，同时增加患者安慰。

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