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21. 发明申请

US20080019869A1 Multilayer Analysis Element 审中-公开
标题翻译：多层分析单元
公开(公告)号：US20080019869A1
公开(公告)日：2008-01-24
申请号：US10589556
申请日：2005-02-18
申请人： Kentaro Nakamura , Kazuya Kawasaki , Yoshiki Sakaino , Toshihisa Ito , Osamu Seshimoto
发明人： Kentaro Nakamura , Kazuya Kawasaki , Yoshiki Sakaino , Toshihisa Ito , Osamu Seshimoto
IPC分类号： B01L11/00
CPC分类号： G01N33/525
摘要： It is an object of the invention to provide a multilayer analysis element with small intra-lot and lot-to-lot differences that has high measurement accuracy and which is small in size. The present invention provides a multilayer analysis element for liquid sample analysis wherein at least one functional layer and at least one porous liquid sample spreading layer of non-fibrous porous film are integrally laminated in this order on one side of a water-impermeable planar support, and the non-fibrous porous film has a bending rupture strength of 20 gram-weight or more and a tensile percentage of 2% or less when the film is stretched with a tensile force of 50 gram-weight.
摘要翻译：本发明的目的是提供一种具有很小的批量间和批间差异的多层分析元件，其具有高的测量精度并且尺寸小。本发明提供了一种用于液体样品分析的多层分析元件，其中至少一个功能层和非纤维多孔膜的至少一个多孔液体样品扩散层在不透水平面支撑体的一侧上依次一体地层叠，并且当以50克重的拉伸力拉伸膜时，非纤维状多孔膜的弯曲断裂强度为20克重以上，拉伸率为2％以下。

22. 发明授权

US06869512B2 Device for measuring ionic activities 失效
标题翻译：用于测量离子活性的装置
公开(公告)号：US06869512B2
公开(公告)日：2005-03-22
申请号：US10006169
申请日：2001-12-06
申请人： Masaaki Terashima , Osamu Seshimoto
发明人： Masaaki Terashima , Osamu Seshimoto
IPC分类号： G01N27/333 , G01N27/30 , G01N27/416
CPC分类号： G01N27/307
摘要： A device for measuring ionic activity is composed of: a block of insulating material having a hollow space therein, a solution-receiving surface area in which a pair of openings for receiving a sample solution and a reference solution separately are provided, a plurality of solution-supplying surface areas in each of which a pair of openings for supplying outside the sample solution and the reference solution separately are provided; a bridge member fixed on the solution-receiving surface area; a guide member placed in the hollow space which assists to transmit separately the sample solution and the reference member in the hollow space; and two or more ion selective electrodes each of which is placed on each solution-supplying surface area.
摘要翻译：用于测量离子活性的装置包括：其中具有中空空间的绝缘材料块，设置有用于分别接收样品溶液的一对开口和参考溶液的溶液接收表面区域，多个溶液提供各自的表面区域，其中分别提供用于在样品溶液和参考溶液外部供应的一对开口;固定在溶液接收表面区域上的桥接构件;设置在中空空间中的辅助传输的引导构件分别在中空空间中的样品溶液和参考构件; 和两个或更多个离子选择性电极，每个离子选择性电极被放置在每个溶液供应表面区域上。

23. 发明授权

US06767578B2 Ion selective monoelectrode complex 有权
标题翻译：离子选择性单电极复合物
公开(公告)号：US06767578B2
公开(公告)日：2004-07-27
申请号：US09981528
申请日：2001-10-17
申请人： Masaaki Terashima , Osamu Seshimoto
发明人： Masaaki Terashima , Osamu Seshimoto
IPC分类号： B05D512
CPC分类号： G01N27/307 , Y10T29/49002
摘要： An ion selective monoelectrode complex which is favorably employable to manufacture an ion activity measuring apparatus, has on a common non-electroconductive support sheet, plural ion selective monoelectrodes each of which is composed of an electrode composite consisting of, in order, a silver metal layer, a silver halide layer, an electrolytic material layer, and an ion selective membrane, and an electroconductive terminal which is electrically connected to the silver metal layer and which has an exposed surface, under the condition that the ion selective monoelectrodes are aligned, without electric contact with each other, along an imaginary line bridging the electrode composite and the electroconductive terminal.
摘要翻译：有利地用于制造离子活性测量装置的离子选择性单电极配合物在普通的非导电性支持片上具有多个离子选择性单电极，每个离子选择性单电极由依次由银金属层，卤化银层，电解质层和离子选择性膜，以及在离子选择性单电极排列的情况下，电连接到银金属层并且具有暴露表面的导电端子，没有电沿着桥接电极复合体和导电端子的假想线彼此接触。

24. 发明授权

US06638404B2 Ion selective electrode 有权
公开(公告)号：US06638404B2
公开(公告)日：2003-10-28
申请号：US09911290
申请日：2001-07-23
申请人： Masaaki Terashima , Osamu Seshimoto
发明人： Masaaki Terashima , Osamu Seshimoto
IPC分类号： G01N27333
CPC分类号： G01N27/333 , G01N27/307
摘要： In the manufacture of an ion selective electrode composed of a non-electroconductive support, a pair of electrodes each of which has a silver metal layer and a silver halide layer, an electrolytic material layer, an ion selective membrane, and a non-electroconductive sheet having a pair of openings for receiving a sample solution and a reference solution, respectively, and having thereon a bridge member for electrically connecting the sample solution received in one opening and the reference solution received in another opening, the ion selective membrane is advantageously divided into two separate portions, one of which is placed in a position above one electrode and another of which is placed in a position above another electrode.

25. 发明授权

US06217540B1 Blood filter cartridge 失效
标题翻译：血液滤芯
公开(公告)号：US06217540B1
公开(公告)日：2001-04-17
申请号：US09349173
申请日：1999-07-09
申请人： Kenichiro Yazawa , Keiichi Ishizaki , Takeshi Igarashi , Masao Kitajima , Shigeru Tezuka , Takaki Arai , Toshihisa Ito , Osamu Seshimoto
发明人： Kenichiro Yazawa , Keiichi Ishizaki , Takeshi Igarashi , Masao Kitajima , Shigeru Tezuka , Takaki Arai , Toshihisa Ito , Osamu Seshimoto
IPC分类号： A61M3700
CPC分类号： G01N33/491
摘要： The invention provides a blood filter cartridge which is made so that the filtrate discharged from the filtrate outlet is not drawn back to the inside of the filtering chamber. The blood filter cartridge includes a blood filtering material, a holder containing the blood filtering material and having a blood inlet and a filtrate outlet, and a filtrate receiver which receives the filtrate discharged from the filtrate outlet. The blood filter catridge is provided with a means for preventing the filtrate in the filtrate receiver from returning to inside of the holder upon finishing filtration. Such means include the following: removing opposite faces around the filtrate outlet, making length of lower end of the filtrate outlet 0.8 mm or more, smoothing surface around the filtrate outlet, and forming surface around the filtrate outlet by a material having a small surface energy.
摘要翻译：本发明提供了一种血液过滤器滤芯，其被制成使得从滤液出口排出的滤液不会被抽回到过滤室的内部。血液过滤器滤芯包括血液过滤材料，含有血液过滤材料并具有血液入口和滤液出口的保持器和接收从滤液出口排出的滤液的滤液接收器。血液过滤器夹具设置有用于防止滤液接收器中的滤液在完成过滤时返回到保持器内部的装置。这样的方法包括以下步骤：除去滤液出口周围的相对面，使滤液出口的下端长度为0.8mm以上，使滤液出口周围的表面光滑，并且通过具有小表面能的材料在滤液出口周围形成表面。

26. 发明授权

US5639665A Method of spotting sample liquid on dry chemical analysis film 失效
标题翻译：在干化学分析膜上检测样品液的方法
公开(公告)号：US5639665A
公开(公告)日：1997-06-17
申请号：US568475
申请日：1995-12-07
申请人： Takaki Arai , Osamu Seshimoto
发明人： Takaki Arai , Osamu Seshimoto
IPC分类号： G01N1/00 , G01N1/28 , G01N21/78 , G01N33/52 , G01N35/00 , G01N35/02 , G01N35/10
CPC分类号： G01N35/00029 , G01N35/10 , G01N2035/00277 , G01N2035/1034 , Y10T436/112499 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： When spotting a sample liquid onto a plurality of frameless chemical analysis films, a predetermined amount of the sample liquid is sucked into a spotting tip, the lower end of the spotting tip is brought into contact with the surface of each chemical analysis film and the pressure in the spotting tip is increased to discharge the sample liquid therein onto the surface of the chemical analysis film while lifting the spotting tip away from the surface of the film. When a first chemical analysis film includes a component which can deteriorate the accuracy of measurement of the analyte for the second frameless chemical analysis film, the sample liquid is spotted, before the second chemical analysis film after the first chemical analysis film, on a third frameless chemical analysis film which does not include a component which can deteriorate the accuracy of measurement of the analyte of the second chemical analysis film and the analyte of which is not such that the accuracy of its measurement is substantially affected by a component of the first chemical analysis film which can be transferred to the third chemical analysis film.
摘要翻译：当将样品液体检测到多个无框架化学分析膜上时，将预定量的样品液体吸入点样尖端，使点样尖端的下端与每个化学分析膜的表面接触，并且压力在点样尖端被增加以将其中的样品液体排出到化学分析膜的表面上，同时将点样尖端远离膜的表面提升。当第一化学分析膜包含可劣化第二无框化学分析膜的分析物的测量精度的成分时，在第一化学分析膜之后的第二化学分析膜之前，将样品液体点样，化学分析膜不包含可能劣化第二化学分析膜的分析物的测定精度的成分，其分析物不能使其测定精度受到第一化学分析的成分的显着影响可以转移到第三个化学分析膜的薄膜。

27. 发明授权

US5629206A Method of controlling insertion sequence of films in bio-chemical analysis 失效
标题翻译：控制膜生物化学分析插入序列的方法
公开(公告)号：US5629206A
公开(公告)日：1997-05-13
申请号：US582046
申请日：1996-01-02
申请人： Takaki Arai , Osamu Seshimoto
发明人： Takaki Arai , Osamu Seshimoto
IPC分类号： G01N21/78 , G01N33/52 , G01N33/62 , G01N35/00 , G01N35/04
CPC分类号： G01N35/00029 , G01N2035/00277 , Y10T436/112499 , Y10T436/114165 , Y10T436/115831 , Y10T436/12
摘要： A dry chemical analysis film deposited with a sample liquid is inserted into an incubator to be incubated at a predetermined temperature, a coloring reaction of the chemical analysis film is measured after the incubation and then the chemical analysis film is discharged from the incubator. A plurality of chemical analysis films are subjected to these steps one by one after the preceding chemical analysis film is discharged from the incubator. When a first chemical analysis film is for an analyte which generates an interfering gas or the like which can adversely affects the accuracy of measurement of other chemical analysis films and a second chemical analysis film the accuracy of measurement on which can be adversely affected by the interfering gas or the like is to be inserted into the incubator after the first chemical analysis film is discharged, an adsorptive film which adsorbs the interfering gas or the like generated from the first chemical analysis film is inserted into the incubator after discharge of the first chemical analysis film prior to insertion of the second chemical analysis film.
摘要翻译：将沉积有样品液体的干化学分析膜插入培养箱中以在预定温度下孵育，孵育后测量化学分析膜的着色反应，然后化学分析膜从培养箱中排出。在先前的化学分析膜从培养箱中排出之后，多个化学分析膜经过这些步骤。当第一化学分析膜用于产生可能不利地影响其他化学分析膜和第二化学分析膜的测量精度的干扰气体等的分析物时，测量的精度可能受到干扰的不利影响在排出第一化学分析膜后，将气体等插入培养箱中，将第一化学分析膜产生的吸附了干扰气体等的吸附膜插入培养箱中，第一化学分析在插入第二化学分析膜之前的膜。

28. 发明授权

US5538688A Cartridge for storing dry analytical film chips 失效
标题翻译：用于存储干燥分析膜芯片的墨盒
公开(公告)号：US5538688A
公开(公告)日：1996-07-23
申请号：US51037
申请日：1993-04-20
申请人： Shigeru Tezuka , Yasushi Fujisaki , Hikaru Tsuruta , Osamu Seshimoto , Yoshihiko Abe
发明人： Shigeru Tezuka , Yasushi Fujisaki , Hikaru Tsuruta , Osamu Seshimoto , Yoshihiko Abe
IPC分类号： G01N21/78 , G01N31/22 , G01N35/00 , G01N35/04 , G01N21/00 , G01N31/00
CPC分类号： G01N35/00029 , G01N35/00732 , G01N2035/00089 , G01N2035/00108 , G01N2035/00752 , G01N2035/00762
摘要： A cartridge for storing a plurality of stacked chips having an exit for taking out the end dry analytical film chip one by one which are pushed toward the exit, and a flexible engager for inhibiting the discharge of the end chip. The exit and the engager are provided at an end portion of a side wall of the casing, the opening being provided at an end of the casing, and the flexible engager has a strength capable of releasing the end chip from the conveyor but is also capable of holding the second end, wherein the exit and the engager are provided at an end portion of a side wall of the casing, the opening being provided at an end of the casing. The engager is capable of holding the second end chip, or wherein the exit and the engager are provided at an end portion of the casing, and the engager is a non-flexible engager for releasing the end chip by its deformation occurring by the pull of the conveyor through the second end through the release of the lowermost end chip, and the exit also functions as the opening. The cartridge has a compact size and ejects only one chip while preventing the simultaneous ejection of two chips.
摘要翻译：用于存储多个堆叠的芯片，其具有用于取出端部干燥分析膜芯片的出口，所述出口一个接一个地被推向出口，以及柔性接合器，用于抑制端部芯片的放电。出口和接合体设置在壳体的侧壁的端部处，开口设置在壳体的端部，并且柔性接合器具有能够从输送机释放端部芯片的强度，但是也能够其中所述出口和所述接合器设置在所述壳体的侧壁的端部处，所述开口设置在所述壳体的端部。该接合器能够保持第二端芯片，或者其中出口和接头设置在壳体的端部，并且接合器是非柔性接合器，用于通过其拉伸产生的变形来释放端部芯片输送机通过第二端通过最下端的芯片的释放，并且出口也用作开口。墨盒具有紧凑的尺寸，并且仅喷射一个芯片，同时防止两个芯片的同时弹出。

29. 发明授权

US4783251A Ionic activity measuring device 失效
标题翻译：离子活度测量装置
公开(公告)号：US4783251A
公开(公告)日：1988-11-08
申请号：US945644
申请日：1986-12-23
申请人： Osamu Seshimoto , Akira Yamaguchi , Yoshio Saito
发明人： Osamu Seshimoto , Akira Yamaguchi , Yoshio Saito
IPC分类号： G01N27/30 , G01N27/26
CPC分类号： G01N27/307
摘要： An ionic activity measuring device comprises ion selective electrodes, porous liquid distributing members for distributing a reference solution and a sample solution to the ion selective electrodes, a frame for housing the ion selective electrodes and the porous liquid distributing members and provided with a pair of liquid feed holes for feeding the reference solution and the sample solution to the porous liquid distributing members, and a porous bridge for achieving electrical conduction between the reference solution and the sample solution fed in drops to the liquid feed holes. The porous bridge is disposed in a recess formed in the surface of the frame so that the depth of the recess is not smaller than the height of the porous bridge. End portions of the porous liquid distributing members are protruded to regions under the liquid feed holes so that the fed solutions may enter from side faces of the end portions. The porous bridge may extend at positions deviated from centers of the liquid feed holes. The frame may be provided with holes for insertion of potential measuring probes, and air discharging holes.
摘要翻译：一种离子活性测量装置，包括离子选择性电极，用于将参考溶液分散的多孔液体分配部件和样品溶液到离子选择性电极，用于容纳离子选择性电极和多孔液体分配部件的框架，并具有一对液体用于将参考溶液和样品溶液供给到多孔液体分配构件的进料孔，以及用于实现将参比溶液和样品溶液滴入液体进料孔之间导电的多孔桥。多孔桥设置在形成在框架的表面中的凹部中，使得凹部的深度不小于多孔桥的高度。多孔液体分配构件的端部突出到液体供给孔下方的区域，使得供给的溶液可以从端部的侧面进入。多孔桥可以在从液体供给孔的中心偏离的位置延伸。框架可以设置有用于插入潜在测量探针的孔和排气孔。

30. 发明授权

US4732849A Multilayered chemical analysis material for analysis of aqueous liquids 失效
标题翻译：用于水性液体分析的多层化学分析材料
公开(公告)号：US4732849A
公开(公告)日：1988-03-22
申请号：US828562
申请日：1986-02-10
申请人： Osamu Seshimoto , Masao Kitajima
发明人： Osamu Seshimoto , Masao Kitajima
IPC分类号： G01N31/22 , C12Q1/58 , G01N33/52 , G01N33/62
CPC分类号： G01N33/525 , C12Q1/58 , Y10S435/805
摘要： A multi-layered, chemical analysis material for analysis of an aqueous liquid, which comprises in one embodiment(a) a light-transmitting, water-impermeable support having provided thereon in sequence(b) a reagent layer and(c) a porous, sample-spreading layer, with(i) the reagent layer (b) containing a lake dye precursor dispersed in a hydrophilic binder,(ii) urease incorporated in the reagent layer (b) or in a layer adjacent the reagent layer (b), and(iii) a lake forming metal salt or lake forming metal oxide, which does not substantially inhibit the activity of urease, incorporated in the reagent layer (b) or in a layer adjacent the reagent layer (b) or a lake forming metal salt or oxide incorporated in a layer adjacent the reagent layer (b); and in a second embodiment the chemical analysis material includes(d) a radiation-blocking layer interposed between said reagent layer (b) and said porous, sample-spreading layer (c).
摘要翻译：一种用于分析水性液体的多层化学分析材料，其包括在一个实施方案中（a）在序列（b）中提供试剂层的透光性不透水性载体，（c）多孔，样品扩散层，（i）包含分散在亲水性粘合剂中的色淀前体的试剂层（b），（ii）引入试剂层（b）中的脲酶或与试剂层（b）相邻的层中的脲酶，并且（iii）形成金属盐或形成湖的金属氧化物的湖，其基本上不抑制尿素酶的活性，掺入试剂层（b）或试剂层（b）附近的层或形成湖的金属盐或掺入与试剂层（b）相邻的层中的氧化物; 在第二实施方案中，化学分析材料包括（d）插入在所述试剂层（b）和所述多孔样品扩散层（c）之间的辐射阻挡层。

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