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21. 发明授权

US08112347B2 Controlling implied markets during a stop loss trigger 有权
标题翻译：在止损触发期间控制隐含市场
公开(公告)号：US08112347B2
公开(公告)日：2012-02-07
申请号：US11900756
申请日：2007-09-13
申请人： James Farrell , James Krause
发明人： James Farrell , James Krause
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04 , G06Q40/06
摘要： A system mitigates the effects of a market spike caused by the triggering and the election of a conditional order in an automated matching system. Conditional orders submitted to a trading engine are evaluated to compare a price of an order to a predetermined price range. Matching of the orders may be delayed when the price of the orders lies outside of the predetermined price range. An opening price to be used by the trading engine is derived and a time interval is used to delay a matching of the orders until the opening price is within a predetermined price range up to a maximum delay time set by a control center. Implied spreads are also removed until other instruments within a trading unit are verified open.
摘要翻译：系统减轻了自动匹配系统中触发和选择条件订单引起的市场飙升的影响。评估提交给交易引擎的条件订单，以将订单的价格与预定的价格范围进行比较。当订单的价格在预定价格范围之外时，订单的匹配可能会延迟。导出交易引擎使用的开价，并且使用时间间隔来延迟订单的匹配，直到开价在直到由控制中心设置的最大延迟时间之前的预定价格范围内。隐含利差也被移除，直到交易单位内的其他工具被证实开放。

22. 发明申请

US20060188960A1 Chimeric histamine H3 receptor 审中-公开
标题翻译：嵌合组胺H3受体
公开(公告)号：US20060188960A1
公开(公告)日：2006-08-24
申请号：US11355711
申请日：2006-02-16
申请人： Stephen Waters , James Krause
发明人： Stephen Waters , James Krause
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/723
摘要： Chimeric H3 receptor polypeptides are provided, as are polynucleotides encoding such polypeptides, and vectors and cells for recombinant expression of such polypeptides. Chimeric H3 receptor polynucleotides and polypeptides may be used, for example, to identify agents that specifically interact with H3 receptor. Such agents find use within therapies for humans and animals afflicted with conditions responsive to histamine H3 receptor modulation.
摘要翻译：提供嵌合H3受体多肽，以及编码这种多肽的多核苷酸以及用于重组表达这种多肽的载体和细胞。嵌合H3受体多核苷酸和多肽可用于例如鉴定与H3受体特异性相互作用的试剂。这些药物可用于对患有对组胺H3受体调节作用的病症的人和动物的治疗。

23. 发明申请

US20050221428A1 Chimeric neuropeptide Y receptors 审中-公开
标题翻译：嵌合神经肽Y受体
公开(公告)号：US20050221428A1
公开(公告)日：2005-10-06
申请号：US11029242
申请日：2005-01-04
申请人： Michele Kinrade , Robbin Brodbeck , James Krause
发明人： Michele Kinrade , Robbin Brodbeck , James Krause
IPC分类号： C12N15/09 , A61K45/00 , A61P9/00 , A61P25/00 , A61P25/22 , C07K14/705 , C07K19/00 , C12N5/10 , C12Q1/02 , C12R1/91 , C07H21/04
CPC分类号： C07K14/70571
摘要： Novel chimeric G-protein coupled receptors are provided as isolated polypeptides, membrane preparations containing such chimeric receptors, nucleic acids encoding such chimeric receptors, and cells expressing such receptors. The chimeric receptors are NPY5 receptors with most or all of either one or both of the third cytoplasmic loop domain or the C-terminal intracellular domain of NPY5 replaced with the corresponding region(s) of another NPY receptor, preferably an NPY1 receptor.
摘要翻译：提供了新的嵌合G蛋白偶联受体作为分离的多肽，含有这种嵌合受体的膜制剂，编码这种嵌合受体的核酸和表达这种受体的细胞。嵌合受体是NPY5受体，其中NPY5的第三细胞质环结构域或C末端胞内结构域中的大多数或全部都被另一个NPY受体，优选NPY1受体的相应区域取代。

24. 发明申请

US20050203826A1 Implied spread trading system 审中-公开
标题翻译：隐含传播交易系统
公开(公告)号：US20050203826A1
公开(公告)日：2005-09-15
申请号：US10986967
申请日：2004-11-12
申请人： James Farrell , James Krause
发明人： James Farrell , James Krause
IPC分类号： G06F17/60
CPC分类号： G06Q40/06 , G06Q40/04
摘要： Systems and methods are provided for creating and processing implied spread products that include one or more legs having nonstandard tick levels. One or more multiple financial instrument legs consist of underlying financial instruments that have standard tick levels and result in the leg(s) having a nonstandard tick level. The use of underlying financial instruments that have standard tick levels facilitates the linking of spread product markets to markets for the underlying financial instruments.
摘要翻译：提供了系统和方法，用于创建和处理包含一个或多个具有非标准蜱水平的腿的隐含传播产品。一个或多个多个金融工具支柱由具有标准滴答程度的相关金融工具组成，并导致支线具有非标准滴答位。使用具有标准滴答式的基础金融工具有助于将分散的产品市场与相关金融工具的市场联系起来。

25. 发明授权

US08489488B2 Controlling markets during a stop loss trigger 有权
标题翻译：在止损触发期间控制市场
公开(公告)号：US08489488B2
公开(公告)日：2013-07-16
申请号：US13324490
申请日：2011-12-13
申请人： James Farrell , James Krause
发明人： James Farrell , James Krause
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04
摘要： A system mitigates market spike effects caused by conditional ordering triggering and election in an automated matching system. The system monitors trading as a result of cascading triggering of conditional orders. When an order is executed beyond a predetermined price threshold, an instrument may be flagged, allowing matching to occur only at or within the predetermined price threshold. Orders within the price threshold are matched at the price threshold against orders beyond it, dampening any instantaneous damaging effects of the price spike. The system may adjust the price threshold when market appropriate, allowing the order flow to bring the market back to whatever is the true price level. The system mitigates purely conditional order cascade driven price fluctuations, but allows the market to continuously trade in controlled price and time intervals ensuring that true market moves can still occur without price control mechanisms hindering trade matching and true price discovery.
摘要翻译：系统减轻了在自动匹配系统中条件排序触发和选举引起的市场尖峰效应。由于级联触发条件订单，系统监控交易。当订单执行超过预定价格阈值时，可以标记仪器，允许仅在或在预定价格阈值内进行匹配。在价格门槛内的订单与价格门槛相匹配，超过它的订单，抑制价格上涨的任何瞬时的破坏性影响。该系统可以在市场适当时调整价格门槛，允许订单流量将市场恢复到真正的价格水平。该系统减轻了纯粹的有条件订单级联驱动的价格波动，但允许市场以可控的价格和时间间隔持续交易，确保如果没有价格控制机制阻碍贸易匹配和真正的价格发现，真正的市场动向仍然可以发生。

26. 发明授权

US08103576B2 Controlling markets during a stop loss trigger 有权
标题翻译：在止损触发期间控制市场
公开(公告)号：US08103576B2
公开(公告)日：2012-01-24
申请号：US11900810
申请日：2007-09-13
申请人： James Farrell , James Krause
发明人： James Farrell , James Krause
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04
摘要： A system mitigates the effects of a market spike caused by the triggering and election of conditional orders in an automated matching system. The system monitors trading that takes place as a result of the cascading triggering of conditional orders. When an order is executed beyond a predetermined price threshold, an instrument may be flagged, allowing matching to take place only at or within the predetermined price threshold. Orders within the price threshold are matched at the price threshold against orders beyond the price threshold, in order to dampen any instantaneous damaging effects of the price spike. The system may adjust the price threshold when market appropriate, allowing the order flow to bring the market back to whatever is the true price level. The system mitigates price fluctuations that are purely conditional order cascade driven, but allows the market to continuously trade in controlled price and time intervals to ensure that a true market move can still occur and not have price control mechanisms hinder trade matching and true price discovery.
摘要翻译：系统减轻了在自动匹配系统中触发和选择条件订单引起的市场飙升的影响。系统监视由于级联触发有条件订单而产生的交易。当执行订单超过预定价格阈值时，可以标记工具，允许仅在或在预定价格阈值内进行匹配。价格门槛内的订单在价格门槛上匹配超过价格门槛的订单，以抑制价格上涨的任何即时损害影响。该系统可以在市场适当时调整价格门槛，允许订单流量将市场恢复到真正的价格水平。该系统减轻了纯粹是有条件的级联驱动的价格波动，但允许市场以可控的价格和时间间隔持续交易，以确保真正的市场动向仍然可以发生，没有价格控制机制阻碍贸易匹配和真正的价格发现。

27. 发明申请

US20110119173A1 System and Method for Providing Intelligent Market Data Snapshots 有权
标题翻译：提供智能市场数据快照的系统和方法
公开(公告)号：US20110119173A1
公开(公告)日：2011-05-19
申请号：US13010527
申请日：2011-01-20
申请人： Ari Studnitzer , Seshadri Sundaram , Kevin Kometer , Sana Fathallah-Shaykh , James Krause
发明人： Ari Studnitzer , Seshadri Sundaram , Kevin Kometer , Sana Fathallah-Shaykh , James Krause
IPC分类号： G06Q40/00
CPC分类号： G06Q40/06 , G06Q20/102 , G06Q40/04
摘要： Systems and methods are provided for processing and distributing market data. Critical data, such as data showing that a market price has changed is distributed without further delay. When the market data does not result in a change in a market price or does not meet another critical criteria, the market data is aggregated with market data for similar events and distributed when the aggregated market data passes a quantity threshold.
摘要翻译：提供系统和方法来处理和分发市场数据。关键数据，如显示市场价格发生变化的数据，不再拖延地分配。当市场数据不会导致市场价格变化或不符合另一个关键标准时，市场数据与类似事件的市场数据相结合，并在汇总的市场数据通过数量阈值时分配。

28. 发明申请

US20080046356A1 Controlling markets during a stop loss trigger 有权
标题翻译：在止损触发期间控制市场
公开(公告)号：US20080046356A1
公开(公告)日：2008-02-21
申请号：US11900810
申请日：2007-09-13
申请人： James Farrell , James Krause
发明人： James Farrell , James Krause
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04
摘要： A system mitigates the effects of a market spike caused by the triggering and election of conditional orders in an automated matching system. The system monitors trading that takes place as a result of the cascading triggering of conditional orders. When an order is executed beyond a predetermined price threshold, an instrument may be flagged, allowing matching to take place only at or within the predetermined price threshold. Orders within the price threshold are matched at the price threshold against orders beyond the price threshold, in order to dampen any instantaneous damaging effects of the price spike. The system may adjust the price threshold when market appropriate, allowing the order flow to bring the market back to whatever is the true price level. The system mitigates price fluctuations that are purely conditional order cascade driven, but allows the market to continuously trade in controlled price and time intervals to ensure that a true market move can still occur and not have price control mechanisms hinder trade matching and true price discovery.
摘要翻译：系统减轻了在自动匹配系统中触发和选择条件订单引起的市场飙升的影响。系统监视由于级联触发有条件订单而产生的交易。当执行订单超过预定价格阈值时，可以标记工具，允许仅在或在预定价格阈值内进行匹配。价格门槛内的订单在价格门槛上匹配超过价格门槛的订单，以抑制价格上涨的任何即时损害影响。该系统可以在市场适当时调整价格门槛，允许订单流量将市场恢复到真正的价格水平。该系统减轻了纯粹是有条件的级联驱动的价格波动，但允许市场以可控的价格和时间间隔持续交易，以确保真正的市场动向仍然可以发生，而且没有价格控制机制阻碍贸易匹配和真正的价格发现。

29. 发明申请

US20080015183A1 SUBSTITUTED QUINAZOLIN-4-YLAMINE ANALOGUES 审中-公开
标题翻译：取代的喹唑啉-4-亚胺类似物
公开(公告)号：US20080015183A1
公开(公告)日：2008-01-17
申请号：US11864987
申请日：2007-09-29
申请人： Rajagopal Bakthavatchalam , Charles Blum , Harry Brielmann , Timothy Caldwell , Stephane De Lombaert , Kevin Hodgetts , Xiaozhang Zheng , James Krause , Uri Herzberg , Taeyoung Yoon
发明人： Rajagopal Bakthavatchalam , Charles Blum , Harry Brielmann , Timothy Caldwell , Stephane De Lombaert , Kevin Hodgetts , Xiaozhang Zheng , James Krause , Uri Herzberg , Taeyoung Yoon
IPC分类号： A61K31/517 , A61K31/47 , A61K31/519 , A61K31/541 , A61P11/14 , A61P17/02 , C07D215/58 , C07D237/30 , C07D279/12 , C07D471/04 , C07D417/12 , C07D413/14 , C07D413/10 , C07D401/14 , C07D401/10 , C07D239/84 , C07D223/04 , A61P25/04 , A61P11/16 , A61K31/55 , A61K31/5377 , A61K31/502
CPC分类号： C07D401/04 , C07D215/42 , C07D215/44 , C07D237/34 , C07D239/94 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D471/04
摘要： Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译：提供了取代的喹唑啉-4-基胺类似物。这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

30. 发明授权

US06884815B1 High affinity small molecule C5a receptor modulators 失效
标题翻译：高亲和力小分子C5a受体调节剂
公开(公告)号：US06884815B1
公开(公告)日：2005-04-26
申请号：US10461311
申请日：2003-06-12
申请人： Andrew Thurkauf , Xiao-shu He , He Zhao , John Peterson , Xiaoyan Zhang , Robbin Brodbeck , James Krause , George Maynard , Alan Hutchison
发明人： Andrew Thurkauf , Xiao-shu He , He Zhao , John Peterson , Xiaoyan Zhang , Robbin Brodbeck , James Krause , George Maynard , Alan Hutchison
IPC分类号： C07C233/11 , C07C233/22 , C07C233/65 , C07C233/66 , C07C233/73 , C07C233/78 , C07C235/46 , C07C235/48 , C07C235/54 , C07C235/60 , C07C235/62 , C07C235/66 , C07C237/20 , C07C323/62 , C07D207/32 , C07D207/327 , C07D213/38 , C07D213/82 , C07D215/12 , C07D217/04 , C07D217/06 , C07D217/14 , C07D217/16 , C07D231/12 , C07D233/54 , C07D233/68 , C07D235/02 , C07D235/10 , C07D235/14 , C07D235/18 , C07D317/58 , C07D333/24 , C07D333/28 , C07D333/54 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , A61K31/415 , A61K31/44 , C07D233/02 , C07D401/04 , C07D403/02
CPC分类号： C07D207/327 , C07C233/11 , C07C233/22 , C07C233/65 , C07C233/66 , C07C233/73 , C07C233/78 , C07C235/46 , C07C235/48 , C07C235/54 , C07C235/60 , C07C235/62 , C07C235/66 , C07C237/20 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/18 , C07D213/38 , C07D213/82 , C07D215/12 , C07D217/04 , C07D217/06 , C07D217/14 , C07D217/16 , C07D231/12 , C07D233/64 , C07D233/68 , C07D235/02 , C07D235/14 , C07D235/18 , C07D317/58 , C07D333/24 , C07D333/28 , C07D333/54 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04
摘要： This invention relates to low molecular weight, non-peptidic, non-peptidomimetic, organic molecules that act as modulators of mammalian complement C5a receptors, preferably ones that act as high affinity C5a receptor ligands and also to such ligands that act as antagonists or inverse agonists of complement C5a receptors. Preferred compounds of the invention possess some or all of the following properties in that they are: 1) multi-aryl in structure, 2) heteroaryl in structure, 3) a pharmaceutically acceptable oral dose can provide a detectable in vitro effect, 4) comprise fewer than four or preferably no amide bonds, and 5) capable of inhibiting leukocyte chemotaxis at nanomolar or sub-nanomolar concentrations.This invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds in treating a variety of inflammatory and immune system disorders. Additionally, this invention relates to the use such compounds as probes for the localization of C5a receptors.
摘要翻译：本发明涉及作为哺乳动物补体C5a受体调节剂的低分子量，非肽，非拟肽，有机分子，优选用作高亲和力C5a受体配体的调节剂，还涉及作为拮抗剂或反向激动剂的这些配体的补体C5a受体。本发明优选的化合物具有一些或全部以下性质，因为它们是：1）结构中的多芳基，2）结构中的杂芳基，3）药学上可接受的口服剂量可提供可检测的体外效应，4）包含少于四个或优选不存在酰胺键，以及5）能够以纳摩尔或亚纳摩尔浓度抑制白细胞趋化性。本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗各种炎性和免疫系统疾病中的用途。此外，本发明涉及使用这些化合物作为C5a受体定位的探针。

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