专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US5795790A Method for controlling proliferation and differentiation of cells encapsulated within bioartificial organs 失效
标题翻译：用于控制包埋在生物人造器官内的细胞增殖和分化的方法
公开(公告)号：US5795790A
公开(公告)日：1998-08-18
申请号：US448201
申请日：1995-05-23
申请人： Malcolm Schinstine , Molly S. Shoichet , Frank T. Gentile , Joseph P. Hammang , Laura M. Holland , Brian M. Cain , Edward J. Doherty , Shelley R. Winn , Patrick Aebischer
发明人： Malcolm Schinstine , Molly S. Shoichet , Frank T. Gentile , Joseph P. Hammang , Laura M. Holland , Brian M. Cain , Edward J. Doherty , Shelley R. Winn , Patrick Aebischer
IPC分类号： A01K67/027 , A61K48/00 , A61L27/00 , A61L27/18 , A61L27/22 , A61L27/38 , C07K14/82 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/12 , A61K35/12 , C12N11/02 , C12N11/04
CPC分类号： C12N5/0068 , A61L27/18 , A61L27/227 , A61L27/383 , A61L27/3834 , A61L27/3839 , A61L27/3895 , C07K14/82 , A61K48/00 , C12N2510/00 , C12N2510/04 , C12N2533/30 , C12N2533/54 , C12N2533/74
摘要： Methods and compositions are provided for controlling cell distribution within a bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes cell differentiation, or affects cell attachment to a growth surface within the bioartificial organ. Such treatments include (1) genetically manipulating cells, (2) exposing the cells to a proliferation-inhibiting compound or a differentiation-inducing compound or removing the cells from exposure to a proliferation-stimulating compound or a differentiation-inhibiting compound; exposing the cells to irradiation, and (3) modifying a growth surface of the bioartificial organ with extracellular matrix molecules, molecules affecting cell proliferation or adhesion, or an inert scaffold, or a combination thereof. These treatments may be used in combination. In a preferred treatment, cells are exposed to and then removed from exposure to a proliferation-stimulating and differentiation inhibiting compound prior to encapsulation of the cells in a semipermeable biocompatible jacket to form a bioartificial organ. Upon in vivo implantation of the bioartificial organ in a host, cellular proliferation is inhibited and cellular differentiation is promoted.
摘要翻译：提供了用于通过将细胞暴露于抑制细胞增殖，促进细胞分化或影响细胞附着于生物人造器官内的生长表面的处理来控制生物人造器官内的细胞分布的方法和组合物。这样的处理包括（1）遗传操纵细胞，（2）将细胞暴露于增殖抑制化合物或分化诱导化合物，或除去细胞暴露于增殖刺激化合物或分化抑制化合物; 将细胞暴露于照射下，和（3）用细胞外基质分子，影响细胞增殖或粘附的分子，或惰性支架或其组合修饰生物人造器官的生长表面。这些处理可以组合使用。在优选的治疗中，将细胞暴露于暴露于增殖刺激和分化抑制化合物之前，然后将细胞包封在半透性生物相容性护套中以形成生物人造器官。在宿主体内植入生物人造器官后，抑制细胞增殖并促进细胞分化。

22. 发明申请

US20070172454A1 USE OF IL-6/IL-6 CHIMERA IN HUNTINGTON'S DISEASE 审中-公开
标题翻译：在亨廷顿病中使用IL-6 / IL-6 CHIMERA
公开(公告)号：US20070172454A1
公开(公告)日：2007-07-26
申请号：US11622284
申请日：2007-01-11
申请人： Nicole Deglon , Patrick Aebischer , Jean-Charles Bensadoun
发明人： Nicole Deglon , Patrick Aebischer , Jean-Charles Bensadoun
IPC分类号： A61K48/00 , A61K38/20 , C12N15/867
CPC分类号： A61K38/204 , A61K48/00
摘要： The invention relates to the use of an IL-6R/IL-6 chimera, a mutein, isoform, fused protein, functional derivative, active fraction or circularly permutated derivative or a salt thereof, for the manufacture of a medicament for the treatment and/or prevention of Huntington's disease.
摘要翻译：本发明涉及IL-6R / IL-6嵌合体，突变蛋白，同种型，融合蛋白，功能衍生物，活性级分或环状置换衍生物或其盐在制备用于治疗和/ 或预防亨廷顿氏病。

23. 发明授权

US06800281B2 Lentiviral-mediated growth factor gene therapy for neurodegenerative diseases 失效
标题翻译：慢病毒介导的神经变性疾病生长因子基因治疗
公开(公告)号：US06800281B2
公开(公告)日：2004-10-05
申请号：US10008610
申请日：2001-11-08
申请人： Patrick Aebischer , Susan Mary Kingsman , Stuart Naylor , Nicholas Mazarakis
发明人： Patrick Aebischer , Susan Mary Kingsman , Stuart Naylor , Nicholas Mazarakis
IPC分类号： A61K4800
CPC分类号： C12N15/86 , A61K48/00 , C07K14/4756 , C12N2740/15043
摘要： Disclosed and claimed are methods for treating or preventing neurodegenerative diseases, conditions or maladies or symptoms or physiology associated therewith, such as treating or preventing Parkinson's disease or symptoms or physiology associated therewith such as motor deficits or nigrostriatal degeneration; or, for inducing nigrostriatal regeneration. Advantageously, the methods involve administering a lentiviral vector that expresses GDNF, such as human GDNF, or a variant, homolog, analog or derivative thereof.
摘要翻译：公开并要求保护的是用于治疗或预防神经变性疾病，病症或疾病或症状或与之相关的生理学的方法，例如治疗或预防帕金森病或与之相关的症状或生理学，例如运动缺陷或黑质纹状体变性; 或用于诱导黑质纹状体再生。有利地，所述方法包括施用表达GDNF的慢病毒载体，例如人GDNF，或其变体，同系物，类似物或衍生物。

24. 发明授权

US5554148A Renewable neural implant device and method 失效
标题翻译：可再生神经植入装置及方法
公开(公告)号：US5554148A
公开(公告)日：1996-09-10
申请号：US453571
申请日：1995-05-26
申请人： Patrick Aebischer , Paul C. DiCesare , Moses Goddard , Paul J. Mulhauser
发明人： Patrick Aebischer , Paul C. DiCesare , Moses Goddard , Paul J. Mulhauser
IPC分类号： A61F2/02 , A61K9/00 , A61K9/22 , A61K35/12 , A61K35/30 , A61M31/00 , B01J13/02 , C12N5/00 , C12N5/071 , C12N5/0793 , C12N11/04
CPC分类号： A61K9/0092 , A61F2/022 , A61K35/12 , A61K35/30 , A61K38/1825 , A61K9/0024 , A61K9/0085 , A61M31/002 , B01J13/02 , C12N11/04 , C12N5/0012 , C12N5/0614 , C12N5/0619 , C12N5/0676 , A61K2035/126 , A61M2210/0687 , A61M2210/0693 , C12N2533/30
摘要： Refillable immunoisolatory neurological therapy devices for local and controlled delivery of a biologically active factor to the brain of a patient. The devices include a cell chamber adapted for infusion with nsecretory cells and having at least one semipermeable or permselective surface across which biologically active factors secreted by the cells can be delivered to the brain. The devices also include means for introducing secretory cells into the cell chamber, and means for renewing the cells or cell medium.
摘要翻译：用于局部和控制地将生物活性因子递送到患者脑部的可补充的免疫隔离神经治疗装置。所述装置包括适于与分泌细胞一起输注并具有至少一个半透性或选择性选择性表面的细胞室，细胞分泌的生物活性因子可以被输送到脑。所述装置还包括用于将分泌细胞引入细胞室的装置和用于更新细胞或细胞培养基的装置。

25. 发明授权

US5389535A Method of encapsulating cells in a tubular extrudate 失效
标题翻译：将细胞包封在管状挤出物中的方法
公开(公告)号：US5389535A
公开(公告)日：1995-02-14
申请号：US169169
申请日：1993-12-17
申请人： Patrick Aebischer , Lars Wahlberg
发明人： Patrick Aebischer , Lars Wahlberg
IPC分类号： A61F2/02 , A61K9/00 , A61K9/48 , A61K35/12 , A61M31/00 , B01J13/02 , B01J13/04 , C12N5/00 , C12N5/071 , C12N5/0793 , C12N11/04 , C12N11/08 , C12M1/40
CPC分类号： A61K9/0092 , A61F2/022 , A61K35/12 , A61K9/0024 , A61K9/0085 , A61K9/4816 , A61K9/4833 , A61M31/002 , B01J13/02 , B01J13/04 , C12N11/04 , C12N11/08 , C12N5/0012 , C12N5/0614 , C12N5/0619 , A61K2035/126 , A61K2035/128 , A61M2210/0687 , A61M2210/0693 , C12N2533/30
摘要： Methods and systems are disclosed for encapsulating viable cells which produce biologically-active factors. The cells are encapsulated within a semipermeable, polymeric membrane by co-extruding an aqueous cell suspension and a polymeric solution through a common port to form a tubular extrudate having a polymeric outer coating which encapsulates the cell suspension. For example, the cell suspension and the polymeric solution can be extruded through a common extrusion port having at least two concentric bores, such that the cell suspension is extruded through the inner bore and the polymeric solution is extruded through the outer bore. The polymeric solution coagulates to form an outer coating. As the outer coating is formed, the ends of the tubular extrudate can be sealed to form a cell capsule. In one embodiment, the tubular extrudate is sealed at intervals to define separate cell compartments connected by polymeric links.
摘要翻译：公开了用于包封产生生物活性因子的活细胞的方法和系统。通过将水性细胞悬浮液和聚合物溶液共挤出通过共同的口以形成具有封装细胞悬浮液的聚合物外涂层的管状挤出物，将细胞包封在半透膜聚合物膜内。例如，细胞悬浮液和聚合物溶液可以通过具有至少两个同心孔的共同挤出口挤出，使得细胞悬浮液通过内孔挤出并且聚合物溶液通过外孔挤出。聚合物溶液凝结形成外涂层。当形成外涂层时，管状挤出物的端部可被密封以形成电池盒。在一个实施方案中，管状挤出物间隔密封以限定通过聚合物连接物连接的分离的细胞室。

26. 发明授权

US5158881A Method and system for encapsulating cells in a tubular extrudate in separate cell compartments 失效
标题翻译：将细胞封装在分开的细胞室中的管状挤出物中的方法和系统
公开(公告)号：US5158881A
公开(公告)日：1992-10-27
申请号：US461999
申请日：1990-01-08
申请人： Patrick Aebischer , Lars Wahlberg
发明人： Patrick Aebischer , Lars Wahlberg
IPC分类号： A61J3/07 , A61F2/02 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/13 , A61M31/00 , B01J13/02 , B01J13/04 , C12N5/00 , C12N5/071 , C12N5/0793 , C12N11/04 , C12N11/08
CPC分类号： A61K9/0024 , A61F2/022 , A61K35/13 , A61K9/0085 , A61K9/0092 , A61K9/4816 , A61K9/4833 , A61M31/002 , B01J13/02 , B01J13/04 , C12N11/04 , C12N11/08 , C12N5/0012 , C12N5/0614 , C12N5/0619 , A61M2210/0687 , A61M2210/0693 , C12N2533/30
摘要： Methods and systems are disclosed for encapsulating viable cells which produce biologically-active factors. The cells are encapsulated within a semipermeable, polymeric membrane by co-extruding an aqueous cell suspension and a polymeric solution through a common port to form a tubular extrudate having a polymeric outer coating which encapsulates the cell suspension. For example, the cell suspension and the polymeric solution can be extruded through a common extrusion port having at least two concentric bores, such that the cell suspension is extruded through the inner bore and the polymeric solution is extruded through the outer bore. The polymeric solution coagulates to form an outer coating. As the outer coating is formed, the ends of the tubular extrudate can be sealed to form a cell capsule. In one embodiment, the tubular extrudate is sealed at intervals to define separate cell compartments connected by polymeric links.
摘要翻译：公开了用于包封产生生物活性因子的活细胞的方法和系统。通过将水性细胞悬浮液和聚合物溶液共挤出通过共同的口以形成具有封装细胞悬浮液的聚合物外涂层的管状挤出物，将细胞包封在半透膜聚合物膜内。例如，细胞悬浮液和聚合物溶液可以通过具有至少两个同心孔的共同挤出口挤出，使得细胞悬浮液通过内孔挤出并且聚合物溶液通过外孔挤出。聚合物溶液凝结形成外涂层。当形成外涂层时，管状挤出物的端部可被密封以形成电池盒。在一个实施方案中，管状挤出物间隔密封以限定通过聚合物连接物连接的分离的细胞室。

27. 发明授权

US4878913A Devices for neural signal transmission 失效
标题翻译：神经信号传输装置
公开(公告)号：US4878913A
公开(公告)日：1989-11-07
申请号：US93371
申请日：1987-09-04
申请人： Patrick Aebischer , Robert F. Valentini , Pierre M. Galletti
发明人： Patrick Aebischer , Robert F. Valentini , Pierre M. Galletti
IPC分类号： A61F2/72
CPC分类号： A61F2/72
摘要： Devices and methods for transmitting neural signals from a proximal stump of a transected nerve to a prosthetic apparatus are disclosed employing microelectrodes, preferably conductive fiber networks, capable of sensing electrical signals from a nerve and transmitting such signals to a prosthetic apparatus; and a semipermeable guidance channel disposed about the microelectrodes. The channels include an opening adapted to receive the proximal stump of a transected nerve, such that the channel promotes the growth of the stump and the formation of an electrical connection between the transected nerve and the microelectrode.

28. 发明授权

US6140089A Chitosan core matrix containing cells encapsulated in a thermoplastic semipermeable membrane 失效
标题翻译：壳聚糖核心基质含有包封在热塑性半透膜中的细胞
公开(公告)号：US6140089A
公开(公告)日：2000-10-31
申请号：US251004
申请日：1999-02-16
申请人： Patrick Aebischer , Beth A. Zielinski
发明人： Patrick Aebischer , Beth A. Zielinski
IPC分类号： A61K35/12 , A61L27/20 , A61L27/38 , C12N5/077 , C12N5/0793 , C12N11/10 , C12N11/04 , C12N5/00
CPC分类号： C12N5/0012 , A61L27/20 , A61L27/38 , A61L27/3804 , C12N5/0618 , C12N5/0619 , A61K2035/128 , A61K35/12
摘要： Encapsulated viable cells for implanting are prepared having cells dispersed in a particulate, essentially non cross-linked chitosan core matrix that is enclosed within a semipermeable membrane. The cells are entrapped between chitosan particles of the core matrix and there is essentially no interfacial cross-linking between the core matrix and the membrane. The core matrix provides a physical support for the cells such that the cells are evenly dispersed throughout the core matrix so as to allow their maintenance, growth, proliferation and differentiation. The encapsulated cells may be prepared by mixing viable cells with a solution of chitosan, encapsulating the resultant mixture in a thermoplastic semipermeable membrane, and causing the chitosan to precipitate such as by changing the pH to form the core matrix. Alternatively, the chitosan in solution is precipitated to form the core matrix containing cells, and the core matrix is encapsulated in a semipermeable membrane. Cells encapsulated include neurosecretory cell lines, .beta.-cell-derived cells lines, fibroblasts, myocytes and glial cells.
摘要翻译：制备用于植入的包封的活细胞，其具有分散在颗粒状基本上非交联壳聚糖核心基质中的细胞，其被包封在半透膜内。细胞被截留在核心基质的壳聚糖颗粒之间，并且核心基质和膜之间基本上没有界面交联。核心基质为细胞提供物理支持，使得细胞均匀地分散在整个核心基质中，以便使其维持，生长，增殖和分化。包封的细胞可以通过将活细胞与壳聚糖溶液混合，将所得混合物包封在热塑性半透膜中并使壳聚糖沉淀，例如通过改变pH以形成核心基质来制备。或者，将溶液中的壳聚糖沉淀以形成含核心基质的细胞，并将核心基质包封在半透膜中。包封的细胞包括神经分泌细胞系，β-细胞来源的细胞系，成纤维细胞，肌细胞和神经胶质细胞。

29. 发明授权

US6080412A Pharmaceutical microencapsulation 失效
标题翻译：药物微胶囊化
公开(公告)号：US6080412A
公开(公告)日：2000-06-27
申请号：US162590
申请日：1998-09-29
申请人： Olivier Jordan , Patrick Aebischer , Jean-Francois Clemence
发明人： Olivier Jordan , Patrick Aebischer , Jean-Francois Clemence
IPC分类号： A61K9/50 , A61K35/12 , A61L27/00 , A61L27/38 , C12N5/071 , C12N11/04 , C07K1/00
CPC分类号： A61L27/3804 , A61K9/5026 , A61K9/5089 , C12N11/04 , C12N5/0677 , A61K2035/128
摘要： A method of producing a microencapsulated pharmaceutical formulation is disclosed comprising causing a dye to be attached to the surface of pharmaceutical particles or particle clusters and applying a source of radiant energy to the dye in the presence of a liquid polymeric or polymerisable material so as to cause the material to cross-link, producing a conformal layer of cross-linked polymer on the particulate surfaces. Preferably, the polymer provides an immuno-protective layer around the particles, while allowing therapeutic components to exit the microcapsules. Microencapsulated pharmaceutical formulations and their medical use are also disclosed, especially for the treatment of diabetes by encapsulating insulin secreting cells.
摘要翻译：公开了一种生产微胶囊化药物制剂的方法，其包括使染料附着在药物颗粒或颗粒簇的表面上，并在液体聚合或可聚合材料的存在下将辐射能源施加到染料上，从而引起交联的材料，在颗粒表面上产生交联聚合物的共形层。优选地，聚合物在颗粒周围提供免疫保护层，同时允许治疗成分离开微胶囊。还公开了微囊化药物制剂及其医疗用途，特别是用于通过包封胰岛素分泌细胞治疗糖尿病。

30. 发明授权

US5871985A Particulate non cross-linked chitosan core matrices for encapsulated cells 失效
标题翻译：用于封装细胞的颗粒非交联壳聚糖核心基质
公开(公告)号：US5871985A
公开(公告)日：1999-02-16
申请号：US294149
申请日：1994-08-22
申请人： Patrick Aebischer , Beth A. Zielinski
发明人： Patrick Aebischer , Beth A. Zielinski
IPC分类号： A61K35/12 , A61L27/20 , A61L27/38 , C12N5/077 , C12N5/0793 , C12N11/10 , C12N11/04 , C12N5/00
CPC分类号： C12N5/0012 , A61L27/20 , A61L27/38 , A61L27/3804 , C12N5/0618 , C12N5/0619 , A61K2035/128 , A61K35/12
摘要： Vehicles containing cells for implanting in the tissue of an individual are prepared having cells dispersed in a particulate, essentially non cross-linked chitosan core matrix that is enclosed within a semipermeable membrane. The cells are entrapped between chitosan particles of the core matrix and there is essentially no interfacial cross-linking between the core matrix and the membrane. The core matrix provides a physical support for viable cells within the vehicle such that the cells are evenly dispersed throughout the core matrix so as to allow their maintenance, growth, proliferation and differentiation. The vehicle can be prepared by mixing viable cells with a solution of chitosan, encapsulating the resultant mixture in a semipermeable membrane and causing the chitosan to precipitate such as by changing the pH to form the core matrix. Alternatively, the chitosan is precipitated to form the core matrix containing cells and then the core matrix is encapsulated in a semipermeable membrane. Cells within the core matrix may be neurosecretory cell lines, .beta.-cell-derived cells lines, fibroblasts, myocytes and glial cells.
摘要翻译：制备含有用于植入个体组织的细胞的载体，其具有分散在颗粒状基本上非交联壳聚糖核心基质中的细胞，所述壳聚糖核心基质被包封在半透膜内。细胞被截留在核心基质的壳聚糖颗粒之间，并且核心基质和膜之间基本上没有界面交联。核心基质为载体内的活细胞提供物理支持，使得细胞均匀分散在整个核心基质中，以使其维持，生长，增殖和分化。载体可以通过将活细胞与壳聚糖溶液混合来制备，将所得混合物包封在半透膜中并使壳聚糖沉淀，例如通过改变pH以形成核心基质。或者，将壳聚糖沉淀形成含核心基质的细胞，然后将核心基质包封在半透膜中。核心基质内的细胞可以是神经分泌细胞系，β-细胞来源的细胞系，成纤维细胞，肌细胞和神经胶质细胞。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式