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    • 21. 发明授权
    • Method for purifying 2,3,3,3-tetrafluoropropene
    • 2,3,3,3-四氟丙烯的纯化方法
    • US08975456B2
    • 2015-03-10
    • US13505520
    • 2010-11-09
    • Takehiro ChakiKazuhiro TakahashiYoshinori TanakaHitoshi Yoshimi
    • Takehiro ChakiKazuhiro TakahashiYoshinori TanakaHitoshi Yoshimi
    • C07C17/25C07C17/383
    • C07C17/383C07C21/18
    • The present invention provides a method for purifying HFO-1234yf, comprising the steps of (1) cooling a liquid mixture containing HFO-1234yf and HF to separate the mixture into a upper liquid phase having a high concentration of HF and a lower liquid phase having a high concentration of 2,3,3,3-tetrafluoropropene; and (2) subjecting the lower liquid phase obtained in step (1) to a distillation operation to withdraw a mixture containing HFO-1234yf and HF from a top of a distillation column, thereby obtaining substantially HF-free HFO-1234yf from a bottom of the distillation column. According to the present invention, HF and HFO-1234yf contained in a mixture containing HF and HFO-1234yf can be separated under simple and economically advantageous conditions.
    • 本发明提供了一种净化HFO-1234yf的方法,包括以下步骤:(1)冷却含有HFO-1234yf和HF的液体混合物,以将混合物分离成具有高浓度HF和较低液相的上液相, 高浓度的2,3,3,3-四氟丙烯; 和(2)将在步骤(1)中获得的下部液相进行蒸馏操作从蒸馏塔的顶部排出含有HFO-1234yf和HF的混合物,从而从底部获得基本上无HF的HFO-1234yf 蒸馏塔。 根据本发明,包含在含有HF和HFO-1234yf的混合物中的HF和HFO-1234yf可以在简单和经济上有利的条件下分离。
    • 26. 发明申请
    • PURIFICATION METHOD OF 2,3,3,3-TETRAFLUOROPROPENE
    • 2,3,3,3-四氯丙烯的纯化方法
    • US20130105296A1
    • 2013-05-02
    • US13808358
    • 2011-07-21
    • Takehiro ChakiKazuhiro Takahashi
    • Takehiro ChakiKazuhiro Takahashi
    • C07C17/386
    • C07C17/386C01B7/196C07C17/38C07C17/383Y02P20/582C07C21/18
    • This invention provides a method for purifying HFO-1234yf by removing HF from a mixture of HFO-1234yf and HF under simple and economically advantageous conditions. According to the present invention, this is a purification method for 2,3,3,3-tetrafluoropropene, (1) the purification method comprising the step of subjecting a mixture comprising 2,3,3,3-tetrafluoropropene and hydrogen fluoride to extractive distillation in a distillation column A using an extractant, thereby obtaining a fraction I that contains 2,3,3,3-tetrafluoropropene and has a lower ratio of hydrogen fluoride to 2,3,3,3-tetrafluoropropene than that of the mixture, while obtaining a fraction II that contains hydrogen fluoride and has a lower ratio of 2,3,3,3-tetrafluoropropene to hydrogen fluoride than that of the mixture; (2) the extractant comprising at least one member selected from the group consisting of: (i) alcohols represented by ROH, wherein R is a C1-5 alkyl group, (ii) ethers represented by ROR′, wherein R and R′ are the same or different, and each is a C1-4 alkyl group, (iii) fluorinated alcohols represented by RfOH, wherein Rf is a C1-3 fluoroalkyl group, (iv) ketones represented by RCOR′, wherein R and R′ are the same or different, and each is a C1-4 alkyl group, (v) esters represented by RCOOR′, wherein R and R′ are the same or different, and each is a C1-4 alkyl group, (vi) polyols represented by R(OH)n, wherein R is a C1-4 alkyl group, and n is an integer of 2 to 3, and (vii) ethylene glycols represented by R1O(CH2CH2O)nR2, wherein R1 and R2 are the same or different, and each is hydrogen or a C1-4 alkyl group, and n is an integer of 1 to 3.
    • 本发明提供了一种通过在简单且经济有利的条件下从HFO-1234yf和HF的混合物中除去HF来净化HFO-1234yf的方法。 根据本发明,这是2,3,3,3-四氟丙烯的纯化方法,(1)纯化方法,其包括将包含2,3,3,3-四氟丙烯和氟化氢的混合物进行萃取 在使用萃取剂的蒸馏塔A中进行蒸馏,从而获得含有2,3,3,3-四氟丙烯的馏分I,并且氟化氢与2,3,3,3-四氟丙烯的比例低于混合物, 同时获得含有氟化氢并且比2,3混合物具有较低的2,3,3,3-四氟丙烯与氟化氢的比例II; (2)萃取剂,其包含选自以下的至少一种:(i)由ROH表示的醇,其中R为C 1-5烷基,(ii)由ROR'表示的醚,其中R和R'为 相同或不同,各自为C1-4烷基,(iii)由RfOH表示的氟化醇,其中Rf为C1-3氟代烷基,(iv)由RCOR'表示的酮,其中R和R'为 相同或不同,并且各自为C 1-4烷基,(v)由RCOOR'表示的酯,其中R和R'相同或不同,并且各自为C 1-4烷基,(vi)由 R(OH)n,其中R是C 1-4烷基,n是2至3的整数,和(vii)由R 10(CH 2 CH 2 O)n R 2表示的乙二醇,其中R 1和R 2相同或不同, 各自为氢或C 1-4烷基,n为1〜3的整数。
    • 27. 发明授权
    • Cell culture carrier comprising poly(meth)acrylic (salt) particle and artificial polypeptide
    • 包含聚(甲基)丙烯酸(盐)颗粒和人造多肽的细胞培养载体
    • US08148111B2
    • 2012-04-03
    • US12293147
    • 2007-03-13
    • Masato KurokawaKazuhiro Takahashi
    • Masato KurokawaKazuhiro Takahashi
    • C12P21/00C12N11/08C12N5/00C12N5/07
    • C12N5/0075C12N2533/30C12N2533/50
    • A carrier for cell culture is provided which improves the cell proliferativity in serum-free culture and which is free from risk from infection factor contamination. The gist of the features of the present invention is to be formed of a crosslinked poly(meth)acrylic acid (salt) particle (A) and an artificial polypeptide (P) having at least one cell-adhesive minimal amino acid sequence (X) in one molecule and to have a water retention value of from 2 to 50 g/g. The (A) is preferably a particle produced by reversed phase suspension polymerization of an aqueous monomer solution containing (meth)acrylic acid and/or an alkali metal salt of (meth)acrylic acid. The (P) preferably has at least one auxiliary amino acid sequence (Y) in one molecule of the (P). The (X) is preferably an Arg Gly Asp sequence.
    • 提供用于细胞培养的载体,其改善了无血清培养物中的细胞增殖性,并且没有感染因子污染的风险。 本发明特征的要点由具有至少一个细胞粘附性最小氨基酸序列(X)的交联聚(甲基)丙烯酸(盐)颗粒(A)和人造多肽(P))形成, 在一个分子中并具有2-50g / g的保水值。 (A)优选为含有(甲基)丙烯酸和/或(甲基)丙烯酸的碱金属盐的单体水溶液的反相悬浮聚合制造的颗粒。 (P)优选在(P)的一个分子中具有至少一个辅助氨基酸序列(Y)。 (X)优选为Arg Gly Asp序列。