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    • 24. 发明授权
    • Fabrication process of a semiconductor device having a capacitor
    • 具有电容器的半导体器件的制造工艺
    • US07592216B2
    • 2009-09-22
    • US12127067
    • 2008-05-27
    • Jun LinHiroyuki OgawaHideyuki Kojima
    • Jun LinHiroyuki OgawaHideyuki Kojima
    • H01L21/8234
    • H01L27/0629H01L27/0802H01L27/0805H01L28/40
    • A method of manufacturing a semiconductor device includes forming a first trench in a capacitor device region of a semiconductor substrate, forming a capacitor insulation film over a sidewall surface of the first trench, forming a semiconductor film to cover the first trench, a resistor device region of the semiconductor substrate and a logic device region of the semiconductor substrate, introducing a first impurity element into the semiconductor film formed over the first trench, patterning the semiconductor film to form a top electrode in the capacitor device region, a resistor in the resistor device region and a gate electrode in the logic device region, annealing the semiconductor substrate, and introducing a second impurity element in the resistor.
    • 一种制造半导体器件的方法包括在半导体衬底的电容器器件区域中形成第一沟槽,在第一沟槽的侧壁表面上形成电容器绝缘膜,形成覆盖第一沟槽的半导体膜,电阻器器件区域 的半导体衬底和半导体衬底的逻辑器件区域,在第一沟槽上形成的半导体膜中引入第一杂质元素,对半导体膜进行构图以在电容器器件区域中形成顶电极,电阻器件中的电阻器 区域和逻辑器件区域中的栅电极,退火半导体衬底,并在电阻器中引入第二杂质元素。
    • 27. 发明申请
    • Underwater trap structure
    • 水下陷阱结构
    • US20050198892A1
    • 2005-09-15
    • US10796087
    • 2004-03-10
    • Jun Lin
    • Jun Lin
    • A01K69/06A01M23/08
    • A01K69/06
    • An improved underwater trap structure is disclosed. The trap structure is easily assembled and conveniently disassembling, and facilitates the trapping of fishes and crabs. The trap structure can sink down to the bottom of waters without being hooked. The trap structure has a trapping cylinder having a handle positioned at the center of the cylinder, and an entrance at the front portion of the trapping cylinder. The entrance is positioned with a rubber funnel having a front grip which is fastened using a front mount. The rear section of the trapping cylinder is mounted with a securing hole and a bait cylinder for holding bait is placed which is secured by a rear cover.
    • 公开了一种改进的水下陷阱结构。 捕捉结构易于组装,方便拆卸,便于钓鱼和捕蟹。 陷阱结构可以下沉到水底而不被钩住。 捕集器结构具有捕捉缸,其具有位于气缸中心的手柄,以及在捕集筒前部的入口。 入口设置有具有前把手的橡胶漏斗,该前把手使用前支架紧固。 捕集筒的后部安装有固定孔,并且放置用于保持诱饵的诱饵筒,其由后盖固定。
    • 28. 发明申请
    • Stem cell-specific promoters and their use
    • 干细胞特异性启动子及其用途
    • US20050125849A1
    • 2005-06-09
    • US10974265
    • 2004-10-27
    • Sergey ShmelkovShahin RafiiJun Lin
    • Sergey ShmelkovShahin RafiiJun Lin
    • C12N15/85A01K67/027C07H21/04C12N5/08C12N9/10C12Q1/68
    • C12N15/85A01K2217/05C12N2830/008C12N2830/46
    • The present invention relates to a method of isolating stem cells from a mixed population of different cell types. This method involves selecting a promoter which functions only in said stem cells and not in the other cell types. The promoter can have a nucleotide sequence selected from the group consisting of SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8. A nucleic acid molecule encoding a marker protein under control of said promoter is introduced into all cell types of said mixed population and only the stem cells, but not the other cell types, within said mixed population are allowed to express said marker protein. The cells of said mixed population of cell types that are expressing the marker protein, which are restricted to the stem cells are identified and separated from the mixed population, where the separated cells are restricted to the stem cells. The promoter, nucleic acid constructs comprising it, and the resulting stem cells are also disclosed. The nucleic constructs can be incorporated in transgenic animals in order to monitor stem cell movement. A disorder mediated by stem cell proliferation can be carried out by administering both (1) a nucleic acid construct comprising the promoter of the present application and an enzyme capable of converting a prodrug to a cytotoxic drug and (2) the prodrug.
    • 本发明涉及从不同细胞类型的混合群体中分离干细胞的方法。 该方法包括选择仅在所述干细胞中起作用但不在其它细胞类型中起作用的启动子。 启动子可以具有选自SEQ ID NO:4,SEQ ID NO:5,SEQ ID NO:6,SEQ ID NO:7和SEQ ID NO:8的核苷酸序列。 将所述启动子控制下的标记蛋白引入所述混合群体的所有细胞类型中,并且仅允许所述混合群体内的干细胞,而不是其他细胞类型表达所述标记蛋白。 将所述混合的表达限制于干细胞的标记蛋白的细胞类型的细胞群从混合群体中鉴定和分离,其中分离的细胞限于干细胞。 还公开了启动子,包含其的核酸构建体和所得干细胞。 核酸构建体可以并入转基因动物中以监测干细胞运动。 通过施用(1)包含本申请的启动子的核酸构建体和能够将前药转化为细胞毒性药物的酶和(2)前药,可以进行由干细胞增殖介导的病症。
    • 29. 发明申请
    • USE OF FITC-DEXTRAN AS DYE FOR FUNDUS ANGIOGRAPHY AND METHODS THEREOF
    • FITC-DEXTRAN作为染色体用于基因印度的方法及其应用
    • US20130165771A1
    • 2013-06-27
    • US13716780
    • 2012-12-17
    • Ming NiKun XuJun Lin
    • Ming NiKun XuJun Lin
    • A61B3/12
    • A61B3/1241A61K49/0043A61K49/0054
    • A novel fundus angiographic application and method using fluorescein isothiocyanate dextrans (FITC-dextran) as fluorescence angiographic dye for diagnosis and evaluation of eye diseases on humans is disclosed. The method involves the process of constitution of FITC-dextran solution and intravenous injection of the said solution, followed by observation and photography of ocular fundus circulation using a fluorescence fundus camera with an image system. The invention offers improved fundus angiograms over the traditional Na-fluorescein fundus angiography (Na-fluorescein) and indocyanine green fundus angiography (ICG) with the advantages of higher clarity and higher resolution; capable of visualizing both the retinal and the choroidal circulations systems simultaneously; providing longer fundus image duration so that it can be used as a directly mapping guidance in retinal surgery or to complete the angiograms for both eyes by a single process; providing more information about the pathological changes occurred among retinal, sub-retinal and choroidal circulation systems.
    • 公开了一种使用荧光素异硫氰酸酯葡聚糖(FITC-葡聚糖)作为荧光血管造影染色来诊断和评估人类眼部疾病的新型眼底血管造影应用和方法。 该方法涉及FITC-葡聚糖溶液的构成和静脉注射所述溶液的过程,然后使用具有图像系统的荧光眼底照相机观察和摄影眼底循环。 本发明提供了比传统的钠 - 荧光素眼底血管造影术(Na-荧光素)和吲哚菁绿眼底血管造影(ICG)更好的眼底血管造影,具有更高的清晰度和更高分辨率的优点; 能够同时观察视网膜和脉络膜循环系统; 提供更长的眼底图像持续时间,使其可以用作视网膜手术中的直接映射指导或通过单个过程完成双眼的血管造影检查; 提供更多关于视网膜,子视网膜和脉络膜循环系统发生病理变化的信息。