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    • 23. 发明授权
    • Broad spectrum optically addressed sensor
    • 广谱光学传感器
    • US07390461B2
    • 2008-06-24
    • US10428785
    • 2003-05-05
    • David G. GrierLewis Gruber
    • David G. GrierLewis Gruber
    • G01N21/00G01N33/545B32B5/16A61B17/20B01J19/08G02B5/02
    • G01N33/54313G01N21/4788G01N21/7703G01N21/7743G01N33/5436G03H2001/0044G03H2001/0077Y10T428/2991
    • The present invention relates to a sensor for detecting chemical, biological, biochemical or other environmental stimuli, and includes a plurality of colloidal particles having chemical receptors bound to each particle's surface, wherein when a target stimulus is directed to the bound chemical receptor, the gelled matrix contracts or expands, which changes the lattice constant, thereby changing the pattern of diffracted light in a measurable manner so that the target stimulus' presence can be detected by a spectrometer. The plurality of colloidal particles are composed of a material having a first dielectric constant, and the gel and surrounding medium have a second dielectric constant. The colloidal particles can be assembled using holographic optical tweezers and polymerized to create an integrated sensor array, which diffracts light in a detectable characteristic manner.
    • 本发明涉及一种用于检测化学,生物,生物化学或其他环境刺激的传感器,并且包括具有结合到每个颗粒表面的化学受体的多个胶体颗粒,其中当靶刺激指向结合的化学受体时,胶凝 矩阵收缩或扩展,其改变晶格常数,从而以可测量的方式改变衍射光的图案,使得目标刺激的存在可以由光谱仪检测。 多个胶体颗粒由具有第一介电常数的材料构成,凝胶和周围介质具有第二介电常数。 可以使用全息光学镊子组装胶体颗粒并进行聚合以产生集成的传感器阵列,其以可检测的特征方式衍射光。