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21. 发明授权

US08812071B2 Transdermal analyte monitoring systems and methods for analyte detection 有权
标题翻译：透皮分析物监测系统和分析物检测方法
公开(公告)号：US08812071B2
公开(公告)日：2014-08-19
申请号：US12043469
申请日：2008-03-06
申请人： Han Chuang , James P. Hurley , Joseph Kost
发明人： Han Chuang , James P. Hurley , Joseph Kost
IPC分类号： A61B5/05 , A61B5/00 , A61B5/145 , A61B5/1486
CPC分类号： A61B5/0002 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/6833
摘要： Transdermal analyte monitoring systems (TAMS) having increased longevity and improved analyte detection are described herein. Kits for use with the TAMS and methods of using the TAMS and kits are also described. In a preferred embodiment, the TAMS includes a protective, semi-permeable membrane covering the surface of the hydrogel. The protective, semi-permeable membrane contacts with the skin of a user and prevents contamination or fouling of the hydrogel. Optionally, the hydrogel comprises one or more humectants and/or an immobilized enzyme. In another preferred embodiment, the TAMS contains at least one channel or pocket for increasing the amount of oxygen provided to the hydrogel. In one embodiment, a method for improving analyte detection by the TAMS is provided. For example, after the skin porosity is increased by an appropriate pretreatment, a skin preparation wipe is applied to the treated skin area and then the TAMS is applied to the treated area.
摘要翻译：本文描述了具有增加的寿命和改进的分析物检测的透皮分析物监测系统（TAMS）。还描述了与TAMS一起使用的试剂盒和使用TAMS和试剂盒的方法。在优选实施方案中，TAMS包括覆盖水凝胶表面的保护性半透膜。保护性半透膜与使用者的皮肤接触并防止水凝胶的污染或结垢。任选地，水凝胶包含一种或多种湿润剂和/或固定化酶。在另一个优选的实施方案中，TAMS含有至少一个通道或口袋，用于增加提供给水凝胶的氧气的量。在一个实施方案中，提供了一种通过TAMS改进分析物检测的方法。例如，在通过适当的预处理增加皮肤孔隙率之后，将皮肤制剂擦拭物施加到经处理的皮肤区域，然后将TAMS施加到处理区域。

22. 发明申请

US20100168648A1 System and method for transfetal (amnion-chorion) membranes transport 有权
标题翻译：用于转运（羊膜绒毛膜）运输的系统和方法
公开(公告)号：US20100168648A1
公开(公告)日：2010-07-01
申请号：US12308244
申请日：2007-06-13
申请人： Joseph Kost , Israel Patla , AVraham Schroeder , Lior Wolloch , Mordechi Hallak
发明人： Joseph Kost , Israel Patla , AVraham Schroeder , Lior Wolloch , Mordechi Hallak
IPC分类号： A61M37/00
CPC分类号： A61B10/0045 , A61B10/0048 , A61B2017/00026 , A61M37/0092
摘要： The invention provides a system and method for trans-fetal membranes transport. A source of ultrasound sonication is used to deliver ultrasound sonication to fetal membranes to enhance the permeability of the fetal membranes of a gestational sac. In one embodiment, a device is used to collect substances transported from the interior of the gestational sac to the exterior of the gestational sac, such as amniotic or coelomic fluid. In another embodiment a device is used to deliver one or more substances, such as a drug, to an external surface of the fetal membranes.
摘要翻译：本发明提供了一种用于跨胎膜转运的系统和方法。使用超声波超声波的来源将超声波超声波提供给胎膜，以增强妊娠囊胎膜的通透性。在一个实施方案中，装置用于收集从妊娠囊内部运送到妊娠囊外部的物质，例如羊水或肠系膜液。在另一个实施方案中，装置用于将一种或多种物质例如药物递送至胎膜的外表面。

23. 发明申请

US20110319790A1 PHARMACEUTICAL COMPOSITION AND SYSTEM FOR PERMEABILIZING FETAL MEMBRANES 审中-公开
标题翻译：药物组合物和用于渗透膜膜的系统
公开(公告)号：US20110319790A1
公开(公告)日：2011-12-29
申请号：US13130916
申请日：2009-11-25
申请人： Joseph Kost , Mordechai Halak , Drora Shmilovitch , Tamar Triatel , Rivka Goldbart , Aharon Azaguri , Lior Wollach
发明人： Joseph Kost , Mordechai Halak , Drora Shmilovitch , Tamar Triatel , Rivka Goldbart , Aharon Azaguri , Lior Wollach
IPC分类号： A61M37/00 , A61K31/185 , A61K31/201 , A61K31/20 , A61B5/00 , A61K31/047 , A61K31/14 , A61K31/4015 , A61K31/015 , A61P43/00 , A61K31/445 , A61K31/167
CPC分类号： A61K41/0047 , A61B10/0048 , A61K9/00 , A61K9/0009 , A61K9/0034 , A61K9/06 , A61K31/167 , A61K31/445 , A61K47/10 , A61K47/12 , A61K47/186 , A61K47/20 , A61K47/22 , A61K47/44
摘要： Provided is a pharmaceutical composition for permeabilizing fetal membranes including an active ingredient having a log K in the range of 2 to 4, where K is the octanol/water partition coefficient. The active ingredient may be, for example, bupivacaine, sodium lauryl sulfate or oleic acid. Further provided is a system for transfetal membrane transport. The system includes a probe unit adapted for insertion into a female reproductive tract and releasing a substance onto fetal membranes that permeabilizes the membranes. The system is also configured to apply ultrasound radiation to the fetal membranes to further increase the membrane permeability.
摘要翻译：本发明提供一种用于透过胎膜的药物组合物，其包含log K在2〜4范围内的活性成分，其中K是辛醇/水分配系数。活性成分可以是例如布比卡因，月桂基硫酸钠或油酸。进一步提供了一种用于转运膜运输的系统。该系统包括适于插入雌性生殖道并将物质释放到渗透膜的胎膜上的探针单元。该系统还被配置为对胎膜施加超声辐射以进一步增加膜渗透性。

24. 发明授权

US08343134B2 System and method for transfetal (amnion-chorion) membranes transport 有权
标题翻译：用于转运（羊膜绒毛膜）运输的系统和方法
公开(公告)号：US08343134B2
公开(公告)日：2013-01-01
申请号：US12308244
申请日：2007-06-13
申请人： Joseph Kost , Israel Patla , Avraham Schroeder , Lior Wolloch , Mordechi Hallak
发明人： Joseph Kost , Israel Patla , Avraham Schroeder , Lior Wolloch , Mordechi Hallak
IPC分类号： A61M31/00
CPC分类号： A61B10/0045 , A61B10/0048 , A61B2017/00026 , A61M37/0092
摘要： The invention provides a system and method for trans-fetal membranes transport. A source of ultrasound sonication is used to deliver ultrasound sonication to fetal membranes to enhance the permeability of the fetal membranes of a gestational sac. In one embodiment, a device is used to collect substances transported from the interior of the gestational sac to the exterior of the gestational sac, such as amniotic or coelomic fluid. In another embodiment a device is used to deliver one or more substances, such as a drug, to an external surface of the fetal membranes.
摘要翻译：本发明提供了一种用于跨胎膜转运的系统和方法。使用超声波超声波的来源将超声波超声波提供给胎膜，以增强妊娠囊胎膜的通透性。在一个实施方案中，装置用于收集从妊娠囊内部运送到妊娠囊外部的物质，例如羊水或肠系膜液。在另一个实施方案中，装置用于将一种或多种物质例如药物递送至胎膜的外表面。

25. 发明申请

US20080281178A1 TRANSDERMAL ANALYTE MONITORING SYSTEMS AND METHODS FOR ANALYTE DETECTION 有权
标题翻译：传感器分析监测系统和分析仪检测方法
公开(公告)号：US20080281178A1
公开(公告)日：2008-11-13
申请号：US12043469
申请日：2008-03-06
申请人： Han Chuang , James P. Hurley , Joseph Kost
发明人： Han Chuang , James P. Hurley , Joseph Kost
IPC分类号： A61B5/1486
CPC分类号： A61B5/0002 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/6833
摘要： Transdermal analyte monitoring systems (TAMS) having increased longevity and improved analyte detection are described herein. Kits for use with the TAMS and methods of using the TAMS and kits are also described. In a preferred embodiment, the TAMS includes a protective, semi-permeable membrane covering the surface of the hydrogel. The protective, semi-permeable membrane contacts with the skin of a user and prevents contamination or fouling of the hydrogel. Optionally, the hydrogel comprises one or more humectants and/or an immobilized enzyme. In another preferred embodiment, the TAMS contains at least one channel or pocket for increasing the amount of oxygen provided to the hydrogel. In one embodiment, a method for improving analyte detection by the TAMS is provided. For example, after the skin porosity is increased by an appropriate pretreatment, a skin preparation wipe is applied to the treated skin area and then the TAMS is applied to the treated area.
摘要翻译：本文描述了具有增加的寿命和改进的分析物检测的透皮分析物监测系统（TAMS）。还描述了与TAMS一起使用的试剂盒和使用TAMS和试剂盒的方法。在优选实施方案中，TAMS包括覆盖水凝胶表面的保护性半透膜。保护性半透膜与使用者的皮肤接触并防止水凝胶的污染或结垢。任选地，水凝胶包含一种或多种湿润剂和/或固定化酶。在另一个优选的实施方案中，TAMS含有至少一个通道或口袋，用于增加提供给水凝胶的氧气的量。在一个实施方案中，提供了一种通过TAMS改进分析物检测的方法。例如，在通过适当的预处理增加皮肤孔隙率之后，将皮肤制剂擦拭物施加到经处理的皮肤区域，然后将TAMS施加到处理区域。

26. 发明申请

US20060015058A1 Agents and methods for enhancement of transdermal transport 审中-公开
标题翻译：用于增强透皮运输的药剂和方法
公开(公告)号：US20060015058A1
公开(公告)日：2006-01-19
申请号：US11065278
申请日：2005-02-25
申请人： Scott Kellogg , Shikha Barman , Lauren Roode , Hannah Farnham , Sean Moran , Samir Mitragotri , Joseph Kost , Nicholas Warner
发明人： Scott Kellogg , Shikha Barman , Lauren Roode , Hannah Farnham , Sean Moran , Samir Mitragotri , Joseph Kost , Nicholas Warner
IPC分类号： A61B17/20 , A61B5/00
CPC分类号： A61B5/681 , A61B5/14514 , A61B5/14532 , A61B5/1486 , A61B5/411 , A61B5/415 , A61B5/418 , A61B5/6843 , A61B17/20 , A61K9/0009 , A61K47/10 , A61M37/0092 , A61N1/30
摘要： The invention according to an exemplary embodiment relates to a method for transporting a substance across a biological membrane comprising the steps of applying a delipidation agent to a portion of the biological membrane, applying a hydration agent to the portion of the biological membrane, sonicating the portion of the biological membrane, and transporting the substance across the biological membrane. The step of applying the delipidation agent may be carried out prior to or simultaneously with the step of applying the hydration agent. The hydration agent may be applied before, during, or after the sonication step. The methods according to exemplary embodiments of the invention can provide improved transdermal transport in applications such as continuous analyte extraction and analysis and transdermal delivery of drugs and vaccines.
摘要翻译：根据示例性实施方案的本发明涉及一种用于在物质膜上输送物质的方法，包括以下步骤：将一种脱脂剂施用于该生物膜的一部分，将该水合剂施用于生物膜的该部分，的生物膜，并将物质运送到生物膜上。施用脱脂剂的步骤可以在施用水化剂的步骤之前或同时进行。水合剂可以在超声处理步骤之前，期间或之后施用。根据本发明的示例性实施方案的方法可以在诸如连续分析物提取和分析以及药物和疫苗的透皮递送等应用中提供改进的透皮转运。

27. 发明申请

US20050049474A1 Preparation for transmission and reception of electrical signals 审中-公开
公开(公告)号：US20050049474A1
公开(公告)日：2005-03-03
申请号：US10950807
申请日：2004-09-28
申请人： Scott Kellogg , Tuan Elstrom , Joseph Kost , Samir Mitragotri , Nicolas Warner , Steve Dimatteo
发明人： Scott Kellogg , Tuan Elstrom , Joseph Kost , Samir Mitragotri , Nicolas Warner , Steve Dimatteo
IPC分类号： A61B5/05 , A61B5/04 , A61B5/0408 , A61B5/053 , A61B8/00 , A61N1/08 , A61N7/00
CPC分类号： A61B8/4281 , A61B5/0048 , A61B5/04 , A61B5/0531 , A61B8/4236 , A61B8/4455 , A61N1/08 , A61N7/00
摘要： The invention provides a convenient and non-invasive means to prepare cells, tissues, and organs for electrical transmission and reception. In an embodiment of the invention, a control method comprises the use of at least one skin electrode, as a reference electrode, and an electrical sensor to measure periodically or continuously the skin's electrical conductance at the site of preparation. The dynamic change in the conductance through the skin is measured while the ultrasound is applied. Signal processing is performed on the measurement and the level of skin impedance change is controlled by performing a mathematical analysis and using the results of such analysis to control the application of ultrasonic energy. A desired level of skin impedance can be set at a predetermined value or based on a chosen level of skin integrity, subject's sensation of discomfort, or duration of the ultrasound application.

28. 发明授权

US06206920B1 Composition and method for forming biodegradable implants in situ and uses of these implants 有权
标题翻译：用于在原位形成生物可降解植入物的组合物和方法以及这些植入物的用途
公开(公告)号：US06206920B1
公开(公告)日：2001-03-27
申请号：US09180500
申请日：1998-12-23
申请人： Rom Eliaz , Joseph Kost
发明人： Rom Eliaz , Joseph Kost
IPC分类号： A61F228
CPC分类号： A61K9/0024 , A61K9/204 , A61L27/18 , C08L67/04
摘要： The invention discloses a composition having a mixture of a pharmaceutically, medically or veterinarily acceptable polymer, preferable a poly (lactic-co-glycolic acid) copolymer (PLGA) containing between about 10 and 100 wt. % lactic acid (LA) units, preferably between about 50 and 90 wt. % LA units, and &agr;-(tetrahydrofuranyl)-&ohgr;-hydroxypoly(oxy-1,2-ethandiyl) (glycofurol). Methods of forming solid implants in situ in an animal body, said implants optionally comprising a drug or other biologically active agent, as well as the use of the compositions of the invention in the treatment of animal bodies, are also disclosed.
摘要翻译：本发明公开了一种具有药物，医学上或兽医学上可接受的聚合物的混合物的组合物，优选含有约10-100重量％的聚（乳酸 - 共 - 乙醇酸）共聚物（PLGA）％乳酸（LA）单位，优选约50至90重量％％LA单元和α-（四氢呋喃基） - 高 - 羟基聚（氧-1,2-乙二基）（glycofurol）。还公开了在动物体内原位形成固体植入物的方法，所述植入物任选地包含药物或其它生物活性剂，以及本发明组合物在动物体的治疗中的用途。

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