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21. 发明授权

US5530126A Process for the preparation of substituted 6-(pyrazol-3yl)-1,4-benzoxazin-3-ones 失效
标题翻译：制备取代的6-（吡唑-3-基）-1,4-苯并恶嗪-3-酮的方法
公开(公告)号：US5530126A
公开(公告)日：1996-06-25
申请号：US189337
申请日：1994-01-31
申请人： Scott S. Woodard , Bruce C. Hamper , Kurt Moedritzer , Michael D. Rogers , Deborah A. Mischke , Gerard A. Dutra
发明人： Scott S. Woodard , Bruce C. Hamper , Kurt Moedritzer , Michael D. Rogers , Deborah A. Mischke , Gerard A. Dutra
IPC分类号： A01N43/56 , A01N43/78 , A01P7/04 , C07C45/29 , C07C45/45 , C07C49/80 , C07C49/835 , C07D231/12 , C07D231/16 , C07D231/18 , C07D231/22 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04 , C07D409/10 , C07D409/12 , C07D411/04 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D498/04 , C07D521/00 , C07D417/10
CPC分类号： C07D231/12 , C07C45/292 , C07C45/455 , C07C49/80 , C07C49/835 , C07D231/16 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04 , C07D409/12 , C07D411/04 , C07D413/10 , C07D413/12 , C07D417/04
摘要： The disclosure herein relates to a process for the preparation of compounds according to Formula N ##STR1## which comprises using a compound of Formula M ##STR2## as starting material for alkylation to said compounds of Formula N in an inert solvent at temperatures within the range of 0.degree.-200.degree. C. whereinR.sub.1 is C.sub.1-5 alkyl;R.sub.2 is C.sub.1-5 haloalkyl;R.sub.3 is halogen;R.sub.5 is hydrogen or halogen;q is 0-2;R.sub.28 and R.sub.30 are independently an alkyl, alkenyl or alkynyl radical having up to 5 carbon atoms or said radicals substituted with a ##STR3## radical; X is O, S(O).sub.m, NR.sub.19 or CR.sub.20 R.sub.21 ;Y is O, S(O).sub.m or NR.sub.22 ;m is 0-2 andR.sub.13 and R.sub.19 -R.sub.22 are hydrogen or an R.sub.28 member.The above compounds are useful as herbicides.
摘要翻译：本文的公开内容涉及制备根据式N的式M化合物的方法，其为在惰性溶剂中在0℃-200℃范围内的烷基化作用的式N化合物的起始原料。其中R1是C1-5烷基; R2是C1-5卤代烷基; R3是卤素; R5是氢或卤素; q为0-2; R 28和R 30独立地为具有至多5个碳原子的烷基，烯基或炔基或所述基团被一个或多个基团取代; X为O，S（O）m，NR 19或CR 20 R 21; Y是O，S（O）m或NR 22; m为0-2，R 13和R 19 -R 22为氢或R 28成员。上述化合物可用作除草剂。

22. 发明申请

US20080207651A1 Heterocyclic compounds useful in treating diseases and conditions 失效
标题翻译：用于治疗疾病和病症的杂环化合物
公开(公告)号：US20080207651A1
公开(公告)日：2008-08-28
申请号：US12032723
申请日：2008-02-18
申请人： Tanisha D. Blake , Bruce C. Hamper , Wei Huang , James R. Kiefer , Joseph B. Moon , Bradley E. Neal , Kirk L. Olson , Matthew J. Pelc , Barbara A. Schweitzer , Atli Thorarensen , John I. Trujillo , Steven R. Turner
发明人： Tanisha D. Blake , Bruce C. Hamper , Wei Huang , James R. Kiefer , Joseph B. Moon , Bradley E. Neal , Kirk L. Olson , Matthew J. Pelc , Barbara A. Schweitzer , Atli Thorarensen , John I. Trujillo , Steven R. Turner
IPC分类号： A61K31/506 , C07D471/04 , C07D401/02 , A61K31/505 , A61K31/519
CPC分类号： C07D401/12 , C07D401/02 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment of various diseases and conditions such as asthma.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中取代基如本文所定义，含有这些化合物的组合物以及这些化合物用于治疗各种疾病和病症例如哮喘的用途。

23. 发明授权

US5883263A Preparation of substituted 3-aryl-5-haloalkyl-pyrazoles having herbicidal activity 失效
标题翻译：具有除草活性的取代的3-芳基-5-卤代烷基 - 吡唑的制备
公开(公告)号：US5883263A
公开(公告)日：1999-03-16
申请号：US943786
申请日：1997-10-03
申请人： Bruce C. Hamper , Michael K. Mao , Wendell Gary Phillips
发明人： Bruce C. Hamper , Michael K. Mao , Wendell Gary Phillips
IPC分类号： C07C45/45 , C07C67/14 , C07C69/738 , C07D231/12 , C07D231/16 , C07D231/10 , C07C49/78 , C07C65/32
CPC分类号： C07D231/12 , C07C45/455 , C07C67/14 , C07C69/738 , C07D231/16
摘要： Processes for preparing substituted 3-aryl-5-haloalkyl-pyrazoles and, specifically, for preparing C.sub.1-5 alkyl esters of 5-�1-(C.sub.1-5 alkyl)-4-halo-5-(C.sub.1-3 haloalkyl)-1H-pyrazole-3-yl!-2,4-dihalo-benzoic acids such as isopropyl 5-�4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl!-2-chloro-4-fluorobenzoate, are presented. The described processes include novel approaches for forming phenyldiketones, forming and alkylating pyrazoles, brominating heterocyclic compounds, oxidizing alkyl-substituted benzene compounds, and esterifying carboxylic acids. These processes may be combined to prepare 3-aryl-5-haloalkyl pyrazoles, or alternatively, used in subcombinations or individually to prepare intermediates or other useful compounds.
摘要翻译：制备取代的3-芳基-5-卤代烷基 - 吡唑的方法，特别是用于制备5- [1-（C 1-5烷基）-4-卤代-5-（C 1-3卤代烷基） - 吡咯烷基的C1-5烷基酯的方法， -1H-吡唑-3-基] -2,4-二卤代苯甲酸如5- [4-溴-1-甲基-5-（三氟甲基）-1H-吡唑-3-基] -2-氯 - 4-氟苯甲酸酯。所描述的方法包括形成苯基二酮的新方法，形成和烷基化吡唑，溴化杂环化合物，氧化烷基取代的苯化合物和酯化羧酸。这些方法可以组合以制备3-芳基-5-卤代烷基吡唑，或者用于亚组合或单独用于制备中间体或其它有用的化合物。

24. 发明授权

US5792430A Solid phase organic synthesis device with pressure-regulated manifold 失效
标题翻译：具有压力调节歧管的固相有机合成装置
公开(公告)号：US5792430A
公开(公告)日：1998-08-11
申请号：US900120
申请日：1997-07-25
申请人： Bruce C. Hamper
发明人： Bruce C. Hamper
IPC分类号： B01J19/00 , C40B50/14 , C40B60/14 , C08F251/00
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/0031 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01J2219/00454 , B01J2219/00493 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , C40B50/14 , C40B60/14
摘要： A solid phase organic synthesis device comprising a manifold and an optional heating block mounted to an upper surface of the manifold. The manifold includes an internal cavity and a first array of holes coupled to the internal cavity. The heating block includes a second array of holes vertically aligned with the corresponding holes of the first array. The first and second arrays of holes are adapted to accommodate flow-through reaction vessels. Each reaction vessel is secured in one of the holes of the first array and a vertically-aligned one of the holes of the second array. The interiors of the reaction vessels are in communication with the internal cavity of the manifold. The flow-through reaction vessels, which contain solid phase resins for solid phase organic synthesis, are controlled by regulating the pressure within the manifold. The manifold includes a pressure port coupled to both an inert gas source and a pressure control device, and a vacuum port coupled to a vacuum control device and a vacuum source. The pressure control device and the vacuum control device are easily operated to create a vacuum and varying degrees of positive pressure within the manifold, as required when carrying out an organic synthesis. A second manifold is mounted on the first manifold in the absence of the reaction vessels for supplying inert gas used to concentrate organic synthesis products.
摘要翻译：一种固相有机合成装置，包括一个歧管和一个安装在歧管的上表面上的任选的加热块。歧管包括内腔和连接到内腔的第一阵列孔。加热块包括与第一阵列的相应孔垂直对准的第二孔阵列。孔的第一和第二阵列适于适应流通的反应容器。每个反应容器固定在第一阵列的一个孔和第二阵列的垂直对齐的一个孔中。反应容器的内部与歧管的内腔连通。含有用于固相有机合成的固相树脂的流通反应容器通过调节歧管内的压力来控制。歧管包括联接到惰性气体源和压力控制装置的压力端口以及耦合到真空控制装置和真空源的真空端口。压力控制装置和真空控制装置易于操作，以在进行有机合成时根据需要产生真空和歧管内的不同程度的正压。在没有用于供应用于浓缩有机合成产物的惰性气体的反应容器的情况下，第二歧管安装在第一歧管上。

25. 发明授权

US5698708A Preparation of substituted 3-aryl-5-haloalkyl-pyrazoles having herbicidal activity 失效
标题翻译：具有除草活性的取代的3-芳基-5-卤代烷基 - 吡唑的制备
公开(公告)号：US5698708A
公开(公告)日：1997-12-16
申请号：US667103
申请日：1996-06-20
申请人： Bruce C. Hamper , Michael K. Mao , Wendell Gary Phillips
发明人： Bruce C. Hamper , Michael K. Mao , Wendell Gary Phillips
IPC分类号： C07C45/45 , C07C67/14 , C07C69/738 , C07D231/12 , C07D231/16 , C07D231/10
CPC分类号： C07D231/12 , C07C45/455 , C07C67/14 , C07C69/738 , C07D231/16
摘要： Processes for preparing substituted 3-aryl-5-haloalkyl-pyrazoles and, specifically, for preparing C.sub.1-5 alkyl esters of 5-�1-(C.sub.1-5 alkyl)-4-halo-5-(C.sub.1-3 haloalkyl)-1H-pyrazole-3-yl!-2,4-dihalo-benzoic acids such as isopropyl 5-�4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl!-2-chloro-4-fluorobenzoate, are presented. The described processes include novel approaches for forming phenyldiketones, forming and alkylating pyrazoles, brominating heterocyclic compounds, oxidizing alkyl-substituted benzene compounds, and esterifying carboxylic acids. These processes may be combined to prepare 3-aryl-5-haloalkyl pyrazoles, or alternatively, used in subcombinations or individually to prepare intermediates or other useful compounds.
摘要翻译：制备取代的3-芳基-5-卤代烷基 - 吡唑的方法，特别是用于制备5- [1-（C 1-5烷基）-4-卤代-5-（C 1-3卤代烷基） - 吡咯烷基的C1-5烷基酯的方法， -1H-吡唑-3-基] -2,4-二卤代苯甲酸如5- [4-溴-1-甲基-5-（三氟甲基）-1H-吡唑-3-基] -2-氯 - 4-氟苯甲酸酯。所描述的方法包括形成苯基二酮的新方法，形成和烷基化吡唑，溴化杂环化合物，氧化烷基取代的苯化合物和酯化羧酸。这些方法可以组合以制备3-芳基-5-卤代烷基吡唑，或者用于亚组合或单独用于制备中间体或其它有用的化合物。

26. 发明授权

US5675017A Herbicidal substituted 3-aryl-pyrazoles 失效
标题翻译：除草取代的3-芳基 - 吡唑
公开(公告)号：US5675017A
公开(公告)日：1997-10-07
申请号：US476794
申请日：1995-06-07
申请人： Bruce C. Hamper , Lisa L. McDermott
发明人： Bruce C. Hamper , Lisa L. McDermott
IPC分类号： A01N43/56 , A01N43/84 , C07D231/12 , C07D231/18 , C07D405/10 , C07D405/12 , C07D413/12 , C07D417/10
CPC分类号： C07D231/12 , A01N43/56 , A01N43/84 , C07D231/18 , C07D405/12 , C07D413/12
摘要： The invention herein relates to certain substituted-arylpyrazole compounds, herbicidal compositions containing same, herbicidal methods of use and processes for preparing said compounds.
摘要翻译：本文的发明涉及某些取代的芳基吡唑化合物，含有其的除草组合物，除草方法和制备所述化合物的方法。

27. 发明授权

US5668088A Herbicidal substituted 3-aryl-pyrazoles 失效
公开(公告)号：US5668088A
公开(公告)日：1997-09-16
申请号：US476518
申请日：1995-06-07
申请人： Bruce C. Hamper , Lisa L. Mc Dermott
发明人： Bruce C. Hamper , Lisa L. Mc Dermott
IPC分类号： A01N43/56 , C07D231/12
CPC分类号： C07D231/12 , A01N43/56
摘要： The invention herein relates to certain substituted-arylpyrazole compounds, herbicidal compositions containing same, herbicidal methods of use and processes for preparing said compounds.

28. 发明授权

US5600008A Benzoyl derivatives and synthesis thereof 失效
公开(公告)号：US5600008A
公开(公告)日：1997-02-04
申请号：US403037
申请日：1995-03-13
申请人： Bruce C. Hamper , Kindrick L. Leschinsky
发明人： Bruce C. Hamper , Kindrick L. Leschinsky
IPC分类号： C07C45/29 , C07C45/45 , C07C45/51
CPC分类号： C07C45/292 , C07C45/455 , C07C45/513
摘要： The present invention relates to novel 4-halo-2-fluoro-5-alkoxybenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for an active class of arylhaloalkylpyrazole and aryl alkylsulfonylpyrazole herbicides.

29. 发明授权

US5536700A Herbicidal compositions comprising aryl-5-haloalkylpyrazoles and glyphosate, it's salts, diquat or paraquat 失效
标题翻译：包含芳基-5-卤代烷基吡唑和草甘膦的除草组合物，它的盐，百草枯或百草枯
公开(公告)号：US5536700A
公开(公告)日：1996-07-16
申请号：US169285
申请日：1993-12-20
申请人： Scott S. Woodard , Bruce C. Hamper , Kurt Moedritzer , Michael D. Rogers , Deborah A. Mischke , Gerard A. Dutra
发明人： Scott S. Woodard , Bruce C. Hamper , Kurt Moedritzer , Michael D. Rogers , Deborah A. Mischke , Gerard A. Dutra
IPC分类号： A01N43/56 , A01N43/78 , A01P7/04 , C07C45/29 , C07C45/45 , C07C49/80 , C07C49/835 , C07D231/12 , C07D231/16 , C07D231/18 , C07D231/22 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04 , C07D409/10 , C07D409/12 , C07D411/04 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D498/04 , C07D521/00 , A01N43/90 , A01N57/20
CPC分类号： C07D231/12 , C07C45/292 , C07C45/455 , C07C49/80 , C07C49/835 , C07D231/16 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04 , C07D409/12 , C07D411/04 , C07D413/10 , C07D413/12 , C07D417/04
摘要： Herbicidal compositions of glyphosate, its salts, diquat, or paraquat in combination with a compound of the following formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and n are as defined. Preferred are combinations of glyphosate, its salts, diquat, or paraquat with 2-chloro-5-(4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 1-methylethyl ester.
摘要翻译：草甘膦，其盐，百草枯或百草枯与下列化学式的化合物（IMAGE）的除草组合物，其中R 1，R 2，R 3，R 4和n如上所定义。优选的是草甘膦，其盐，百草枯或百草枯与2-氯-5-（4-溴-1-甲基-5-（三氟甲基）-1H-吡唑-3-基）-4-氟苯甲酸，1 - 甲基乙基酯。

30. 发明授权

US5532416A Benzoyl derivatives and synthesis thereof 失效
公开(公告)号：US5532416A
公开(公告)日：1996-07-02
申请号：US277725
申请日：1994-07-20
申请人： Bruce C. Hamper , Kindrick L. Leschinsky
发明人： Bruce C. Hamper , Kindrick L. Leschinsky
IPC分类号： C07B61/00 , C07C45/45 , C07C45/46 , C07C45/51 , C07C47/55 , C07C49/697 , C07C49/80 , C07C49/807 , C07C51/305 , C07C63/70 , C07C65/21 , C07C65/32
CPC分类号： C07C65/21 , C07C45/455 , C07C45/46 , C07C45/513 , C07C47/55 , C07C49/80 , C07C49/807 , C07C51/235 , C07C63/70
摘要： The present invention relates to novel 4-halo-2-fluoro-5-alkylbenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for an active class of aryl-haloalkylpyrazole and aryl alkylsulfonylpyrazole herbicides.

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