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21. 发明授权

US4827374A Flip out fuse assembly 失效
标题翻译：翻转保险丝组件
公开(公告)号：US4827374A
公开(公告)日：1989-05-02
申请号：US123252
申请日：1987-11-20
申请人： John J. Dunn
发明人： John J. Dunn
IPC分类号： H01H31/12 , H02B11/26 , H02B1/14
CPC分类号： H02B11/26 , H01H31/122
摘要： A dead front fuse mounting assembly supports the fuse on a hingedly mounted plate which can pivot through a 90.degree. arc to allow access to the fuse. The plate can be latched in a circuit closed position and cannot be released therefrom until a high voltage elbow connector is removed from across a latch operator. Pivotal motion of the plate from the closed circuit position disengages the fuse from a second high voltage contact and releases a shutter to isolate this contact from the remainder of the fuse enclosure. The shutter is opened when the plate pivots back to its closed circuit position.
摘要翻译：死前保险丝安装组件将保险丝支撑在铰接安装的板上，该板可以通过90°电弧转动以允许接近保险丝。板可以锁定在电路闭合位置，并且不能从板上释放，直到高压弯头连接器从闩锁操作器上移除。板从闭合位置的枢轴运动使熔丝与第二高压接触脱离，并释放快门以将该接触与保险丝外壳的其余部分隔离。当板旋转回其闭合位置时，快门打开。

22. 发明授权

US4762255A Bicycle equipment carrier apparatus 失效
标题翻译：自行车运输设备
公开(公告)号：US4762255A
公开(公告)日：1988-08-09
申请号：US938255
申请日：1986-12-05
申请人： John J. Dunn
发明人： John J. Dunn
IPC分类号： B62J9/00
CPC分类号： B62J9/00 , Y10S224/911 , Y10S224/919 , Y10S224/922
摘要： The bicycle equipment carrier apparatus which includes a support section adapted for mounting to a bicycle frame adjacent the rear wheel of the bicycle. The support section includes a plate portion and an elongate receptacle for accommodating items therein. A web is attached to the support section to form a container for holding items therein.
摘要翻译：一种自行车设备托架设备，其包括适于安装到邻近自行车的后轮的自行车车架上的支撑部分。支撑部分包括板部分和用于容纳物品的细长插座。纸幅连接到支撑部分以形成容纳物品的容器。

23. 发明授权

US09347121B2 High strength, corrosion resistant austenitic alloys 有权
标题翻译：高强度，耐腐蚀的奥氏体合金
公开(公告)号：US09347121B2
公开(公告)日：2016-05-24
申请号：US13331135
申请日：2011-12-20
申请人： Robin M. Forbes Jones , C. Kevin Evans , Henry E. Lippard , Adrian R. Mills , John C. Riley , John J. Dunn
发明人： Robin M. Forbes Jones , C. Kevin Evans , Henry E. Lippard , Adrian R. Mills , John C. Riley , John J. Dunn
IPC分类号： C22C38/00 , C22C38/42 , C22C38/44 , C22C38/46 , C22C38/48 , C22C38/52 , C22C38/58 , C22C38/02 , C22C38/04
CPC分类号： C22C38/58 , C21D2211/001 , C22C38/001 , C22C38/002 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/42 , C22C38/44 , C22C38/46 , C22C38/48 , C22C38/50 , C22C38/52 , C22C38/54
摘要： An austenitic alloy may generally comprise, in weight percentages based on total alloy weight: up to 0.2 carbon; up to 20 manganese; 0.1 to 1.0 silicon; 14.0 to 28.0 chromium; 15.0 to 38.0 nickel; 2.0 to 9.0 molybdenum; 0.1 to 3.0 copper; 0.08 to 0.9 nitrogen; 0.1 to 5.0 tungsten; 0.5 to 5.0 cobalt; up to 1.0 titanium; up to 0.05 boron; up to 0.05 phosphorus; up to 0.05 sulfur; iron; and incidental impurities.
摘要翻译：奥氏体合金通常可以基于总合金重量的重量百分比包括：高达0.2碳; 最多20个锰; 0.1〜1.0个硅; 14.0〜28.0铬; 15.0至38.0镍; 2.0〜9.0钼; 0.1〜3.0铜; 0.08至0.9氮; 0.1〜5.0钨; 0.5〜5.0钴; 高达1.0钛; 高达0.05硼; 高达0.05磷; 高达0.05硫; 铁; 和杂质。

24. 发明授权

US08877121B2 Corrosion resistant lean austenitic stainless steel 有权
标题翻译：耐腐蚀的奥氏体不锈钢
公开(公告)号：US08877121B2
公开(公告)日：2014-11-04
申请号：US12037199
申请日：2008-02-26
申请人： David S. Bergstrom , James M. Rakowski , Charles P. Stinner , John J. Dunn , John F. Grubb
发明人： David S. Bergstrom , James M. Rakowski , Charles P. Stinner , John J. Dunn , John F. Grubb
IPC分类号： C22C38/58 , C22C38/44 , C22C38/54 , C22C38/42 , C21D8/02 , C22C38/02 , C22C38/00 , C22C38/52
CPC分类号： C22C38/58 , C21D8/0205 , C22C38/001 , C22C38/002 , C22C38/02 , C22C38/42 , C22C38/44 , C22C38/52 , C22C38/54
摘要： An austenitic stainless steel composition having low nickel and molybdenum and exhibiting high corrosion resistance and good formability. The austenitic stainless steel includes, in weight %, up to 0.20 C, 2.0-6.0 Mn, up to 2.0 Si, 16.0-23.0 Cr, 5.0-7.0 Ni, up to 3.0 Mo, up to 3.0 Cu, 0.1-0.35 N, up to 4.0 W, up to 0.01 B, up to 1.0 Co, iron and impurities. The austenitic stainless steel has a ferrite number less than 11 and an MD30 value less than −10° C.
摘要翻译：具有低镍和钼的奥氏体不锈钢组合物，具有高耐腐蚀性和良好的成形性。奥氏体不锈钢以重量％计含有最高0.20C，2.0-6.0Mn，最高2.0Si，16.0-23.0Cr，5.0-7.0Ni，至多3.0Mo，高达3.0Cu，0.1-0.35N，高达4.0 W，最高可达0.01 B，最高可达1.0 Co，铁和杂质。奥氏体不锈钢的铁素体数小于11，MD30值小于-10℃。

25. 发明授权

US08680236B2 Altered OspA of borrelia burgdorferi 有权
标题翻译：改变了勃氏疏螺旋体的OspA
公开(公告)号：US08680236B2
公开(公告)日：2014-03-25
申请号：US12313443
申请日：2008-11-19
申请人： Benjamin J. Luft , John J. Dunn , Shohei Koide , Catherine L. Lawson
发明人： Benjamin J. Luft , John J. Dunn , Shohei Koide , Catherine L. Lawson
IPC分类号： C07K14/00 , C07K14/20 , C12N15/00 , C12N15/31
CPC分类号： C07K14/20 , A61K39/00 , C07K2319/00 , Y02A50/401
摘要： Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.
摘要翻译：本文提供了具有某些改变的来自莱姆病引起的疏螺旋体的OspA多肽。在一个实施方案中，所述改变增加含有所述改变的OspA多肽的构象稳定性，同时保持相应未改变的OspA多肽的至少一些抗原性。在另一个实施方案中，与相应的未改变的OspA多肽相比，改变的OspA多肽具有降低的与hLFA-1的交叉反应性。

26. 发明授权

US08361746B2 Methods for detection of methyl-CpG dinucleotides 有权
标题翻译：检测甲基CpG二核苷酸的方法
公开(公告)号：US08361746B2
公开(公告)日：2013-01-29
申请号：US12507522
申请日：2009-07-22
申请人： John J. Dunn
发明人： John J. Dunn
IPC分类号： C12P21/02
CPC分类号： C12P19/34 , C07K14/245 , C07K2319/40 , C12P19/36 , C12Q1/6827 , C12Q2523/125 , C12Q2522/101
摘要： The invention provides methods for enriching methyl-CpG sequences from a DNA sample. The method makes use of conversion of cytosine residues to uracil under conditions in which methyl-cytosine residues are preserved. Additional methods of the invention enable to preservation of the context of me-CpG dinucleotides. The invention also provides a recombinant, full length and substantially pure McrA protein (rMcrA) for binding and isolation of DNA fragments containing the sequence 5′-CMeCpGG-3′. Methods for making and using the rMcrA protein, and derivatives thereof are provided.
摘要翻译：本发明提供了从DNA样品中富集甲基CpG序列的方法。该方法利用在保留甲基 - 胞嘧啶残基的条件下将胞嘧啶残基转化成尿嘧啶。本发明的另外的方法能够保存me-CpG二核苷酸的上下文。本发明还提供了用于结合和分离含有5'-CMeCpGG-3'序列的DNA片段的重组全长和基本上纯的McrA蛋白（rMcrA）。提供了制备和使用rMcrA蛋白的方法及其衍生物。

27. 发明申请

US20110245465A1 Methods for Detection of Methyl-CpG Dinucleotides 有权
标题翻译：甲基CpG二核苷酸检测方法
公开(公告)号：US20110245465A1
公开(公告)日：2011-10-06
申请号：US13085219
申请日：2011-04-12
申请人： John J. Dunn
发明人： John J. Dunn
IPC分类号： C07K14/00
CPC分类号： C12P19/34 , C07K14/245 , C07K2319/40 , C12P19/36 , C12Q1/6827 , C12Q2523/125 , C12Q2522/101
摘要： The invention provides methods for enriching methyl-CpG sequences from a DNA sample. The method makes use of conversion of cytosine residues to uracil under conditions in which methyl-cytosine residues are preserved. Additional methods of the invention enable to preservation of the context of me-CpG dinucleotides. The invention also provides a recombinant, full length and substantially pure McrA protein (rMcrA) for binding and isolation of DNA fragments containing the sequence 5′-CMeCpGG-3′. Methods for making and using the rMcrA protein, and derivatives thereof are provided.
摘要翻译：本发明提供了从DNA样品中富集甲基CpG序列的方法。该方法利用在保留甲基 - 胞嘧啶残基的条件下将胞嘧啶残基转化成尿嘧啶。本发明的另外的方法能够保存me-CpG二核苷酸的上下文。本发明还提供了用于结合和分离含有5'-CMeCpGG-3'序列的DNA片段的重组全长和基本上纯的McrA蛋白（rMcrA）。提供了制备和使用rMcrA蛋白的方法及其衍生物。

28. 发明授权

US07605248B2 Recombinant constructs of Borrelia burgdorferi 失效
标题翻译：博氏疏螺旋体的重组构建体
公开(公告)号：US07605248B2
公开(公告)日：2009-10-20
申请号：US11527161
申请日：2006-09-26
申请人： Raymond J. Dattwyler , Maria J. C. Gomes-Solecki , Benjamin J. Luft , John J. Dunn
发明人： Raymond J. Dattwyler , Maria J. C. Gomes-Solecki , Benjamin J. Luft , John J. Dunn
IPC分类号： C07H21/04 , C07H21/02 , A61K39/02
CPC分类号： C07K16/1207 , A61K39/00 , A61K2039/53 , C07K14/20 , C07K2319/00 , Y02A50/401
摘要： Novel chimeric nucleic acids, encoding chimeric Borrelia proteins comprising OspC or an antigenic fragment thereof and OspA or an antigenic fragment thereof, are disclosed. Chimeric proteins encoded by the nucleic acid sequences are also disclosed. The chimeric proteins are useful as vaccine immunogens against Lyme borreliosis, as well as for immunodiagnostic reagents.
摘要翻译：公开了编码包含OspC或其抗原性片段的嵌合型疏螺旋体蛋白和OspA或其抗原性片段的新型嵌合核酸。还公开了由核酸序列编码的嵌合蛋白。嵌合蛋白质可用作针对莱姆硼芽孢杆菌病的疫苗免疫原，以及用于免疫诊断试剂。

29. 发明申请

US20090162238A1 CORROSION RESISTANT LEAN AUSTENITIC STAINLESS STEEL 有权
标题翻译：耐腐蚀耐磨奥氏体不锈钢
公开(公告)号：US20090162238A1
公开(公告)日：2009-06-25
申请号：US12037199
申请日：2008-02-26
申请人： David S. Bergstrom , James M. Rakowski , Charles P. Stinner , John J. Dunn , John F. Grubb
发明人： David S. Bergstrom , James M. Rakowski , Charles P. Stinner , John J. Dunn , John F. Grubb
IPC分类号： C22C38/58 , C22C38/44
CPC分类号： C22C38/58 , C21D8/0205 , C22C38/001 , C22C38/002 , C22C38/02 , C22C38/42 , C22C38/44 , C22C38/52 , C22C38/54
摘要： An austenitic stainless steel composition having low nickel and molybdenum and exhibiting high corrosion resistance and good formability. The austenitic stainless steel includes, in weight %, up to 0.20 C, 2.0-6.0 Mn, up to 2.0 Si, 16.0-23.0 Cr, 5.0-7.0 Ni, up to 3.0 Mo, up to 3.0 Cu, 0.1-0.35 N, up to 4.0 W, up to 0.01 B, up to 1.0 Co, iron and impurities. The austenitic stainless steel has a ferrite number less than 11 and an MD30 value less than −10° C.
摘要翻译：具有低镍和钼的奥氏体不锈钢组合物，具有高耐腐蚀性和良好的成形性。奥氏体不锈钢以重量％计含有最高0.20C，2.0-6.0Mn，最高2.0Si，16.0-23.0Cr，5.0-7.0Ni，至多3.0Mo，高达3.0Cu，0.1-0.35N，高达4.0 W，最高可达0.01 B，最高可达1.0 Co，铁和杂质。奥氏体不锈钢的铁素体数小于11，MD30值小于-10℃。

30. 发明授权

US5928908A Method for introducing unidirectional nested deletions 失效
标题翻译：引入单向嵌套缺失的方法
公开(公告)号：US5928908A
公开(公告)日：1999-07-27
申请号：US966958
申请日：1997-11-10
申请人： John J. Dunn , Mark A. Quesada , Matthew Randesi
发明人： John J. Dunn , Mark A. Quesada , Matthew Randesi
IPC分类号： C12N15/10 , C12N15/64
CPC分类号： C12N15/102
摘要： Disclosed is a method for the introduction of unidirectional deletions in a cloned DNA segment. More specifically, the method comprises providing a recombinant DNA construct comprising a DNA segment of interest inserted in a cloning vector, the cloning vector having an f1 endonuclease recognition sequence adjacent to the insertion site of the DNA segment of interest. The recombinant DNA construct is then contacted with the protein pII encoded by gene II of phage f1 thereby generating a single-stranded nick. The nicked DNA is then contacted with E. coli Exonuclease III thereby expanding the single-stranded nick into a single-stranded gap. The single-stranded gapped DNA is then contacted with a single-strand-specific endonuclease thereby producing a linearized DNA molecule containing a double-stranded deletion corresponding in size to the single-stranded gap. The DNA treated in this manner is then incubated with DNA ligase under conditions appropriate for ligation. Also disclosed is a method for producing single-stranded DNA probes. In this embodiment, single-stranded gapped DNA, produced as described above, is contacted with a DNA polymerase in the presence of labeled nucleotides to fill in the gap. This DNA is then linearized by digestion with a restriction enzyme which cuts outside the DNA segment of interest. The product of this digestion is then denatured to produce a labeled single-stranded nucleic acid probe.
摘要翻译：公开了在克隆的DNA片段中引入单向缺失的方法。更具体地，该方法包括提供包含插入克隆载体中的目标DNA片段的重组DNA构建体，该克隆载体具有与感兴趣的DNA片段的插入位点相邻的f1内切核酸酶识别序列。然后将重组DNA构建体与由噬菌体f1的基因II编码的蛋白质pII接触，从而产生单链切口。然后将切口的DNA与大肠杆菌外切核酸酶III接触，从而将单链缺口扩大为单链间隙。然后将单链间隙DNA与单链特异性内切核酸酶接触，从而产生含有与单链间隙大小相对应的双链缺失的线性化DNA分子。然后以适合于连接的条件，用这种方式处理的DNA与DNA连接酶一起温育。还公开了用于生产单链DNA探针的方法。在该实施方案中，如上所述制备的单链间隙DNA在DNA标记的核苷酸的存在下与DNA聚合酶接触以填充间隙。然后通过用限制性内切酶消化DNA直接切割该DNA，该限制性内切酶在感兴趣的DNA片段之外。然后将该消化产物变性以产生标记的单链核酸探针。

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