专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US5824698A Antibacterial dibenzimidazole derivatives 失效
标题翻译：抗菌二苯并咪唑衍生物
公开(公告)号：US5824698A
公开(公告)日：1998-10-20
申请号：US836423
申请日：1997-05-14
申请人： Walter Hasler , Yu-Hua Ji , Werner Leupin
发明人： Walter Hasler , Yu-Hua Ji , Werner Leupin
IPC分类号： C07D235/12 , A61K31/415 , A61K31/4184 , A61P31/04 , C07D235/14 , C07D235/16 , C07D235/20 , C07D405/04 , C07D405/14 , C07D235/18
CPC分类号： C07D405/14 , C07D235/20
摘要： Novel and known dibenzimidazoles of the formula ##STR1## wherein R.sup.1 and R.sup.2 can be the same or different and signify C.sub.6 H.sub.4 R.sup.3 --, C.sub.6 H.sub.3 (OH)R.sup.4 -- or heterocyclyl, R.sup.3 signifies hydroxy, amino, lower alkoxy or cyano and R.sup.4 signifies halogen, lower alkyl or lower alkoxy, as well as pharmaceutically usable salts of compounds of general formula I are antibacterials, especially against Staphylococcus, Enterococcus and Heliobacter pylori.
摘要翻译： PCT No.PCT / CH95 / 00255 Sec。 371日期1997年5月14日 102（e）日期1997年5月14日PCT提交1995年11月2日PCT公布。公开号WO96 / 16042 日期：1996年5月30日公知的新型和已知的二苯并咪唑不同，表示C6H4R3-，C6H3（OH）R4-或杂环基，R3表示羟基，氨基，低级烷氧基或氰基，R4表示卤素，低级烷基或低级烷氧基，通式I化合物的药学上可接受的盐是抗细菌剂，特别是抗葡萄球菌，肠球菌和幽门螺杆菌。

22. 发明授权

US08017783B2 Biphenyl compounds useful as muscarinic receptor antagonists 有权
公开(公告)号：US08017783B2
公开(公告)日：2011-09-13
申请号：US11899181
申请日：2007-09-05
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： C07D401/12
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

23. 发明授权

US07973055B2 Crystalline forms of a biphenyl compound 有权
标题翻译：联苯化合物的结晶形式
公开(公告)号：US07973055B2
公开(公告)日：2011-07-05
申请号：US11715569
申请日：2007-03-08
申请人： YongQi Mu , Yu-Hua Ji , Leticia Maria Preza
发明人： YongQi Mu , Yu-Hua Ji , Leticia Maria Preza
IPC分类号： A61K31/445 , C07D211/06
CPC分类号： C07D211/46
摘要： The invention provides crystalline forms of biphenyl-2-ylcarbamic acid 1-[2-({3-[2-(4-hydroxybenzylamino)ethylcarbamoyl]benzoyl}methylamino)ethyl]piperidin-4-yl ester, and pharmaceutically acceptable solvates thereof. The crystalline form can be a freebase (Form I or II), a salt such as a hemiedisylate salt or a heminapadisylate salt, or a solvate of a salt such as a heminapadisylate methanolate or a heminapadisylate ethanolate. The invention also provides pharmaceutical compositions comprising these crystalline compounds or prepared using these compounds; processes and intermediates for preparing the crystalline compounds; and methods of using these compounds to treat a pulmonary disorder.
摘要翻译：本发明提供联苯-2-基氨基甲酸1- [2 - （{3- [2-（4-羟基苄基氨基）乙基氨基甲酰基]苯甲酰基}甲基氨基）乙基]哌啶-4-基酯的结晶形式及其药学上可接受的溶剂合物。结晶形式可以是游离碱（I型或II型），盐如半乙二磺酸盐或海明二酸二甲酯盐，或盐的溶剂化物，例如甲酸甲基淀粉二甲酸盐或氢过敏二乙酸酯乙醇化物。本发明还提供包含这些结晶化合物或使用这些化合物制备的药物组合物; 制备结晶化合物的方法和中间体; 以及使用这些化合物治疗肺部疾病的方法。

24. 发明授权

US07858792B2 Biphenyl compounds useful as muscarinic receptor antagonists 有权
标题翻译：用作毒蕈碱受体拮抗剂的联苯化合物
公开(公告)号：US07858792B2
公开(公告)日：2010-12-28
申请号：US12402665
申请日：2009-03-12
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Viengkham Malathong
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Viengkham Malathong
IPC分类号： C07D215/02 , C07D217/02 , A61K31/47
CPC分类号： C07D211/46 , C07D211/60 , C07D211/62 , C07D401/12 , C07D405/12
摘要： This invention provides compounds of formula I: wherein a, b, c, m, p, r, R1, R2, R3, R4, R5, R6, W and X1 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译：本发明提供式I化合物：其中a，b，c，m，p，r，R1，R2，R3，R4，R5，R6，W和X1如说明书中所定义。式I化合物是毒蕈碱受体拮抗剂。本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

25. 发明授权

US07851632B2 Biphenyl compounds useful as muscarinic receptor antagonists 有权
标题翻译：用作毒蕈碱受体拮抗剂的联苯化合物
公开(公告)号：US07851632B2
公开(公告)日：2010-12-14
申请号：US11880048
申请日：2007-07-19
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： A61K31/05 , C07D411/08
CPC分类号： C07D211/46 , C07D401/12 , C07D405/12 , C07D409/12
摘要： This invention provides compounds of formula I: wherein a, b, c, m, p, s, t, W, Ar1, X1, R1, R2, R3, R4, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译：本发明提供式I化合物：其中a，b，c，m，p，s，t，W，Ar1，X1，R1，R2，R3，R4，R6和R7如说明书中所定义。式I化合物是毒蕈碱受体拮抗剂。本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

26. 发明授权

US07851631B2 Biphenyl compounds useful as muscarinic receptor antagonists 有权
公开(公告)号：US07851631B2
公开(公告)日：2010-12-14
申请号：US11879829
申请日：2007-07-19
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Eric L. Stangeland , Aaron Kushner , Craig Husfeld
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Eric L. Stangeland , Aaron Kushner , Craig Husfeld
IPC分类号： C07D401/12 , A61K31/454
CPC分类号： C07D211/62 , C07D211/60
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

27. 发明申请

US20100137325A1 BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：联苯化合物有效作为MUSCARINIC受体拮抗剂
公开(公告)号：US20100137325A1
公开(公告)日：2010-06-03
申请号：US12699539
申请日：2010-02-03
申请人： Yu-Hua Ji , Craig Husfeld , Mathai Mammen , YongQi Mu , Eric L. Stangeland
发明人： Yu-Hua Ji , Craig Husfeld , Mathai Mammen , YongQi Mu , Eric L. Stangeland
IPC分类号： A61K31/498 , C07D401/06 , A61K31/454 , C07D401/14 , A61P9/00
CPC分类号： C07D211/58 , C07D211/46 , C07D211/62 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D487/08 , C07D487/10
摘要： The invention provides compounds of formula I: wherein a, b, c, d, f, W, Q, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译：本发明提供式I化合物：其中a，b，c，d，f，W，Q，Y，R 1，R 2和R 3如说明书中所定义。式I化合物是毒蕈碱受体拮抗剂。本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

28. 发明授权

US07687519B2 Biphenyl compounds useful as muscarinic receptor antagonists 有权
标题翻译：用作毒蕈碱受体拮抗剂的联苯化合物
公开(公告)号：US07687519B2
公开(公告)日：2010-03-30
申请号：US11371803
申请日：2006-03-09
申请人： YongQi Mu , Yu-Hua Ji , Mathai Mammen , Viengkham Malathong
发明人： YongQi Mu , Yu-Hua Ji , Mathai Mammen , Viengkham Malathong
IPC分类号： A61K31/445 , C07D211/54
CPC分类号： C07D401/12 , C07D211/46 , C07D211/62 , C07D401/14 , C07D405/12 , C07D409/12
摘要： The invention provides compounds of formula I: wherein a, b, c, m, n, q, r, W, Z1, Ar1, Z2, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译：本发明提供式I化合物：其中a，b，c，m，n，q，r，w，Z1，Ar1，Z2，Y，R1，R2和R3如说明书中所定义。式I化合物是毒蕈碱受体拮抗剂。本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

29. 发明申请

US20100056541A1 BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS 有权
标题翻译：联苯化合物有效作为MUSCARINIC受体拮抗剂
公开(公告)号：US20100056541A1
公开(公告)日：2010-03-04
申请号：US12605854
申请日：2009-10-26
申请人： YongQi Mu , Yu-Hua Ji , Mathai Mammen , Viengkham Malathong
发明人： YongQi Mu , Yu-Hua Ji , Mathai Mammen , Viengkham Malathong
IPC分类号： A61K31/497 , C07D401/00 , A61K31/4523 , C07D409/12 , C07D401/12 , A61K31/4545
CPC分类号： C07D401/12 , C07D211/46 , C07D211/62 , C07D401/14 , C07D405/12 , C07D409/12
摘要： The invention provides compounds of formula I: wherein a, b, c, m, n, q, r, W, Z1, Ar1, Z2, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译：本发明提供式I化合物：其中a，b，c，m，n，q，r，w，Z1，Ar1，Z2，R1，R2和R3如说明书中所定义。式I化合物是毒蕈碱受体拮抗剂。本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

30. 发明授权

US07557126B2 Diphenylmethyl compounds useful as muscarinic receptor antagonists 有权
标题翻译：用作毒蕈碱受体拮抗剂的二苯甲基化合物
公开(公告)号：US07557126B2
公开(公告)日：2009-07-07
申请号：US11820153
申请日：2007-06-18
申请人： Mathai Mammen , Yu-Hua Ji , Yan Chen , Craig Husfeld
发明人： Mathai Mammen , Yu-Hua Ji , Yan Chen , Craig Husfeld
IPC分类号： A61K31/40 , C07D207/09
CPC分类号： C07D207/08 , C07D409/06
摘要： This invention provides compounds of formula I: wherein a, b, c, e, m, n, Ar1, R1, R2, R3, R4a, R4b, R5 and R6 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译：本发明提供式I化合物：其中a，b，c，e，m，n，Ar1，R1，R2，R3，R4a，R4b，R5和R6如说明书中所定义。式I化合物是毒蕈碱受体拮抗剂。本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式