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21. 发明申请

US20070179123A1 Methods and compositions for treating diseases associated with pathogenic proteins 审中-公开
标题翻译：用于治疗与致病性蛋白质相关疾病的方法和组合物
公开(公告)号：US20070179123A1
公开(公告)日：2007-08-02
申请号：US11595797
申请日：2006-11-08
申请人： Peter Chiang , Daniel Levy , Meng Guo , Valeri Martichonok , Brian Sefton
发明人： Peter Chiang , Daniel Levy , Meng Guo , Valeri Martichonok , Brian Sefton
IPC分类号： A61K31/551 , A61K31/502 , A61K31/498 , A61K31/496 , A61K31/4709 , A61K31/4745
CPC分类号： A61K31/551 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/498 , A61K31/502
摘要： Methods and compositions are provided comprising a therapeutically effective amount of a compound of formula I wherein R1-4, W, X, Y and Z are as defined in the specification, for inhibiting and treating diseases and disorders associated with pathogenic proteins causing neurodegenerative diseases and amyloid diseases, such as protease resistant prion proteins (PrPSc) and those associated with transmissible spongiform encephalopathies (TSEs), Alzheimer's Disease, amyloidosis, and the like.
摘要翻译：提供了包含治疗有效量的式I化合物的方法和组合物，其中R 1至4，W，X，Y和Z如本说明书中所定义，用于抑制和治疗疾病和障碍与导致神经变性疾病和淀粉样蛋白病的致病蛋白质相关，如蛋白酶抗性朊病毒蛋白（PrPSc）和与传染性海绵状脑病（TSEs），阿尔茨海默病，淀粉样变性等相关的病原体蛋白。

22. 发明授权

US06679485B2 Integrated air spring 有权
标题翻译：集成空气弹簧
公开(公告)号：US06679485B2
公开(公告)日：2004-01-20
申请号：US10067626
申请日：2002-02-04
申请人： Stan W. DeLizo , William D. Krusel , Michael David , Leo M. Schmidt , Jeffrey T. Capek , Daniel Levy , Daniel J. Leonard , Mohamad Taghizadeh
发明人： Stan W. DeLizo , William D. Krusel , Michael David , Leo M. Schmidt , Jeffrey T. Capek , Daniel Levy , Daniel J. Leonard , Mohamad Taghizadeh
IPC分类号： F16F904
CPC分类号： B60G11/28 , B60G2202/152 , B60G2202/412 , B60G2204/126 , B60G2204/201 , B60G2204/4502 , B60G2206/424 , F16F9/0454
摘要： An air spring (10) for use in a motor vehicle suspension system is provided. The air spring includes a generally cylindrical flexible bladder (12) having a circular upper opening (18), a support unit (14) sealingly connected to the flexible bladder (12), and a unitary integrated top assembly (16) connected to the upper opening (18) in an air-tight manner. The support unit (14) further includes an installation fastener (52) for connection to vehicle support brackets (78). The top assembly (16) includes a sealed body (34) having an interior open volume (23) and optional attachment components positioned on the body to connect the top assembly to a vehicle main frame. The top assembly further includes an optional connection port (28) adapted for pneumatic intercommunication with other air springs and an optional fill port (48) for connection to a pressurized air system.
摘要翻译：提供一种用于机动车悬架系统的空气弹簧（10）。空气弹簧包括具有圆形上部开口（18）的大致圆柱形的柔性气囊（12），密封地连接到柔性气囊（12）的支撑单元（14），以及连接到上部以气密的方式打开（18）。支撑单元（14）还包括用于连接到车辆支撑支架（78）的安装紧固件（52）。顶部组件（16）包括具有内部开放容积（23）的密封体（34）和位于主体上的可选附接部件，以将顶部组件连接到车辆主框架。顶部组件还包括适于与其它空气弹簧气动相通的可选连接端口（28）和用于连接到加压空气系统的可选填充口（48）。

23. 发明授权

US06513798B2 Integral bracket and end mounting plate for air spring 有权
公开(公告)号：US06513798B2
公开(公告)日：2003-02-04
申请号：US09995105
申请日：2001-11-27
申请人： Jeffrey T. Capek , Daniel Levy , Daniel J. Leonard , Mohamad Taghizadeh , Stan W. DeLizo , Michael David , Leo M. Schmidt , William D. Krusel
发明人： Jeffrey T. Capek , Daniel Levy , Daniel J. Leonard , Mohamad Taghizadeh , Stan W. DeLizo , Michael David , Leo M. Schmidt , William D. Krusel
IPC分类号： F16F904
CPC分类号： B60G11/28 , B60G2202/152 , B60G2202/412 , B60G2204/126 , B60G2204/201 , B60G2206/424 , F16F9/0454
摘要： An integral one-piece end plate and bracket combination is formed of a high strength plastic and is mounted in an airtight sealing engagement with an open end of a flexible elastomeric sleeve which forms the fluid pressure chamber of an air spring. The end plate includes a semi-circular wall which extends perpendicular to a longitudinal axis of the air spring and a semi-circular opening. The bracket includes an upstanding wall perpendicular to the semi-circular wall of the end plate and a half dome-shaped wall, which together with the upstanding wall, forms an auxiliary fluid chamber which is in fluid communication through the semi-circular opening with the main fluid chamber of the flexible sleeve. The upstanding wall includes attachments for securing the bracket and end plate to a support structure which aligns with a longitudinal axis of the air spring. A fluid inlet conduit extends outwardly from the upstanding bracket wall to provide fluid communication between the auxiliary fluid chamber of the bracket and an external source of pressurized fluid. A plurality of reinforcing ribs are formed on the walls of the bracket and on the end plate to provide a rigid structure.

24. 发明申请

US20070012467A1 Paste extruded insulator with air channels 有权
标题翻译：将挤压绝缘子与空气通道粘贴
公开(公告)号：US20070012467A1
公开(公告)日：2007-01-18
申请号：US11524115
申请日：2006-09-20
申请人： Daniel Levy , Kurt Aeschbach
发明人： Daniel Levy , Kurt Aeschbach
IPC分类号： H01B9/06
CPC分类号： H01B13/14 , B29C47/0004 , B29C47/0023 , B29C47/02 , B29C47/20 , B29C47/54 , B29K2027/18 , H01B3/445 , H01B11/1856 , H01B13/016
摘要： The invention provides an insulated wire having a conductor and an insulator of paste extruded PTFE fine powder around the conductor. The paste extruded insulator has at least one closed continuous longitudinal air channel spaced apart from the conductor. The invention further provides a process for forming an insulator around a conductor by paste extruding lubricated PTFE fine powder in an extrusion device comprising a die, mandrel, and at least one channel-forming member. The die and mandrel form a converging chamber leading to an extrusion orifice and the channel-forming member is positioned in the orifice. The mandrel has a central bore for supplying the conductor. Lubricated PTFE fine powder is forced through the chamber and out of the exit of the orifice as a lubricated green extrudate around the conductor forming an insulator with at least one closed longitudinal air channel spaced apart from the conductor.
摘要翻译：本发明提供了一种绝缘电线，其具有导体和导体周围的糊状PTFE细粉末的绝缘体。糊状挤出绝缘体具有与导体间隔开的至少一个封闭的连续纵向空气通道。本发明还提供了一种用于在包括模具，心轴和至少一个通道形成构件的挤出装置中通过糊料挤出润滑的PTFE细粉末来在导体周围形成绝缘体的方法。模具和心轴形成通向挤出孔的会聚室，并且通道形成构件定位在孔口中。心轴具有用于供应导体的中心孔。润滑的PTFE细粉末被迫通过孔并离开孔的出口，作为润滑的绿色挤出物围绕导体形成绝缘体，其具有与导体间隔开的至少一个封闭的纵向空气通道。

25. 发明申请

US20070023360A1 Removing fluorosurfactant from aqueous fluoropolymer dispersion using sorbent pouches 审中-公开
标题翻译：使用吸附剂袋从含氟聚合物含水分散体中除去含氟表面活性剂
公开(公告)号：US20070023360A1
公开(公告)日：2007-02-01
申请号：US11194401
申请日：2005-08-01
申请人： Charles Noelke , Clay Jones , Daniel Levy , Michael McClusky , David Johnson
发明人： Charles Noelke , Clay Jones , Daniel Levy , Michael McClusky , David Johnson
IPC分类号： B01D15/04
CPC分类号： B01J20/2805 , B01D15/00 , B01J41/04 , B01J41/05 , B01J41/07 , B01J49/07 , C02F2001/422 , C08F6/16 , C08L27/12
摘要： A process for reducing the fluorosurfactant content of an aqueous fluoropolymer dispersion by filling a container with fluoropolymer dispersion, inserting into the container a fabric pouch containing a fluorosurfactant sorbent so that the sorbent contacts the fluorosurfactant-containing aqueous fluoropolymer dispersion in the container and retains the fluorosurfactant to reduce fluorosurfactant content of said fluorosurfactant-containing aqueous fluoropolymer dispersion, and removing the fabric pouch from the container.
摘要翻译：通过用含氟聚合物分散体填充容器来降低含氟聚合物水分散体的含氟表面活性剂含量的方法，将含有含氟表面活性剂吸附剂的织物袋插入容器中，使得吸附剂与容器中的含氟表面活性剂的含水氟聚合物分散体接触并保留含氟表面活性剂以降低所述含氟表面活性剂的含水氟聚合物分散体的含氟表面活性剂含量，并从容器中除去织物袋。

26. 发明授权

US06505667B2 Louver laminated with a very thin film 失效
标题翻译：百叶窗用薄膜层合
公开(公告)号：US06505667B2
公开(公告)日：2003-01-14
申请号：US09772488
申请日：2001-01-29
申请人： Daniel Levy , Angelo Cianci
发明人： Daniel Levy , Angelo Cianci
IPC分类号： E06B308
CPC分类号： B29C63/044 , E06B9/266 , E06B9/386 , Y10S160/90
摘要： A louver laminated with a very thin film (i.e. a transfer film, very thin layer, etc . . . ) for use in the construction of window blinds such as Venetian blinds, and the like, the louver having opposed top and bottom surfaces, as well as opposed first and second side surfaces each laminated with a very thin film. More particularly, the film is so thin, that the boundary edges of the film, once laminated to a surface of the louver, are imperceptible to human touch, i.e. they are tactilely invisible. An apparatus and method for making a louver laminated with a very thin film is further proposed.
摘要翻译：用于构建百叶帘等百叶窗等的非常薄的薄膜（即，转印膜，非常薄的层等）的百叶窗，百叶窗具有相对的顶部和底部表面，如以及相当的第一和第二侧表面，每个层压有非常薄的膜。更具体地说，薄膜非常薄，一旦层压到百叶窗的表面上，薄膜的边界边缘对于人触感是不可察觉的，即它们是不可触觉的。进一步提出用于制造层压有非常薄膜的百叶窗的装置和方法。

27. 发明申请

US20070210550A1 Fluid spring assembly and method 失效
标题翻译：流体弹簧组件及方法
公开(公告)号：US20070210550A1
公开(公告)日：2007-09-13
申请号：US11370307
申请日：2006-03-08
申请人： Daniel Levy
发明人： Daniel Levy
IPC分类号： B60G11/27
CPC分类号： B60G11/28 , B60G11/27 , B60G2204/126 , B60G2206/424 , B60G2206/91 , F16F9/057
摘要： A fluid spring assembly includes a first end member and a second end member spaced from the first end member. A spring sleeve extends between the first and second end members. A third end member is disposed along the second end member and is axially displaceably secured thereto. The third end member engages the spring sleeve and is displaceable between a fully-assembled use condition and a fully-assembled adjustment condition in which the third end member and spring sleeve are disassociated with the second end member permitting approximately free rotation thereof. A method includes adjusting the rotational alignment of the fluid spring assembly.
摘要翻译：流体弹簧组件包括第一端部构件和与第一端构件间隔开的第二端构件。弹簧套筒在第一和第二端部件之间延伸。第三端构件沿着第二端构件设置并且可轴向移动地固定到其上。第三端构件接合弹簧套筒，并且可在完全组装的使用状态和完全组装的调节状态之间移动，其中第三端构件和弹簧套与第二端构件分离，允许其大约自由旋转。一种方法包括调整流体弹簧组件的旋转对准。

28. 发明授权

US06887880B2 Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions, and method of use thereof 失效
标题翻译：腺嘌呤环腺苷酸腺嘌呤抑制剂，药物组合物及其使用方法
公开(公告)号：US06887880B2
公开(公告)日：2005-05-03
申请号：US09989348
申请日：2001-11-20
申请人： Daniel Levy , Charles Marlowe , Kim Kane-Maguire , Robert M. Scarborough
发明人： Daniel Levy , Charles Marlowe , Kim Kane-Maguire , Robert M. Scarborough
IPC分类号： C07D473/34 , A61K31/52 , A61P9/04
CPC分类号： C07D473/34
摘要： The present invention relates to derivatives and analogues of adenine of the formula: wherein L, A, Y and Z are those defined herein. Compounds of the present invention are useful in inhibiting adenylyl cyclase activity. The present invention also relates to a method of preventing and inhibiting a patient's fibroproliferative vasculopathy following vascular injury or a vascular surgical operation which includes administering to the patient, an effective amount of a compound according to the invention subsequent to a vascular injury, or subsequent to a vascular surgical operation, for one to two weeks after the injury or surgical operation, effective to treat or prevent a patient's fibroproliferative vasculopathy such as chronic allograft rejection or vascular restenosis following vascular trauma. The present invention also relates to a method for measuring the inhibition of adenylyl cyclase activity and a method for treating congestive heart failure.
摘要翻译：本发明涉及下式的腺嘌呤的衍生物和类似物：其中L，A，Y和Z是本文定义的那些。本发明的化合物可用于抑制腺苷酸环化酶活性。本发明还涉及在血管损伤或血管外科手术之后预防和抑制患者的纤维增生性血管病变的方法，其包括向患者施用有效量的血管损伤后的本发明化合物或随后的在损伤或外科手术后一至两周进行血管外科手术，有效治疗或预防患者的纤维增生性血管病变，如血管创伤后的慢性同种异体移植排斥或血管再狭窄。本发明还涉及测定腺苷酸环化酶活性抑制的方法和治疗充血性心力衰竭的方法。

29. 发明申请

US20060226586A1 Air spring assembly and method 有权
公开(公告)号：US20060226586A1
公开(公告)日：2006-10-12
申请号：US11398835
申请日：2006-04-06
申请人： Daniel Levy
发明人： Daniel Levy
IPC分类号： F16F9/04
CPC分类号： F16F9/057 , B60G11/28 , B60G2202/152 , B60G2204/126 , B60G2204/4502 , B60G2206/424
摘要： A piston assembly for an air spring includes an outer shell and a structural insert. The outer shell includes a side wall and an end wall at least partially defining a shell cavity having an open end. The structural insert is received in the shell cavity and includes a central portion and a plurality of support walls extending outwardly from the central portion toward the side wall of the outer shell. The central portion includes first and second opposing ends with the first end disposed toward the end wall of the outer shell and the second end disposed toward the open end of the outer shell. An air spring assembly includes such a piston assembly. A method of manufacturing an air spring assembly is also included.

30. 发明申请

US20050153319A1 Estrogen receptor gene variation and disease 审中-公开
标题翻译：雌激素受体基因变异和疾病
公开(公告)号：US20050153319A1
公开(公告)日：2005-07-14
申请号：US10982726
申请日：2004-11-04
申请人： David Housman , Daniel Levy , Michael Mendelsohn , Amanda Shearman
发明人： David Housman , Daniel Levy , Michael Mendelsohn , Amanda Shearman
IPC分类号： C07H21/04 , C12N20060101 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： Methods for determining the presence of polymorphisms in estrogen receptor genes and assessing an individual's risk for developing a condition are provided herein.
摘要翻译：本文提供了确定雌激素受体基因多态性存在和评估个体发展病症风险的方法。

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