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21. 发明授权

US08290590B2 Dynamic morphology based atrial automatic threshold 有权
标题翻译：动态形态基于心房自动阈值
公开(公告)号：US08290590B2
公开(公告)日：2012-10-16
申请号：US11601217
申请日：2006-11-17
申请人： Derek D. Bohn , Ankur Garg , Eric K. Enrooth
发明人： Derek D. Bohn , Ankur Garg , Eric K. Enrooth
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61N1/3712
摘要： Methods and systems for performing capture threshold tests are described. During an initialization procedure a capture detection interval and capture detection threshold are determined based on peak values of cardiac signals sensed following the supracapture threshold initialization pulses. Following initialization, a plurality of pacing pulses to the atrium are delivered and the peak values of the cardiac signals sensed following each of the plurality of pacing pulses are determined. The peak values are compared to the pacing artifact threshold and the capture detection threshold. A timing of each of the peak values is compared to the capture detection interval. For each pacing pulse, discrimination between a captured response, a noncaptured response, and a fusion response is based on the peak value and timing comparisons.
摘要翻译：描述用于执行捕获阈值测试的方法和系统。在初始化过程期间，捕获检测间隔和捕获检测阈值是基于超标准阈值初始化脉冲之后感测的心脏信号的峰值来确定的。在初始化之后，传送到心房的多个起搏脉冲，并且确定在多个起搏脉冲之后检测到的心脏信号的峰值。将峰值与起搏伪像阈值和捕获检测阈值进行比较。将每个峰值的定时与捕获检测间隔进行比较。对于每个起搏脉冲，捕获的响应，非捕获响应和融合响应之间的区别基于峰值和时序比较。

22. 发明授权

US07957803B2 Atrial capture verification 有权
标题翻译：心房捕捉验证
公开(公告)号：US07957803B2
公开(公告)日：2011-06-07
申请号：US12540902
申请日：2009-08-13
申请人： Geng Zhang , Ankur Garg , Douglas R. Daum
发明人： Geng Zhang , Ankur Garg , Douglas R. Daum
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3714
摘要： Methods and systems for classifying cardiac responses to pacing stimulation and/or preventing retrograde cardiac conduction are described. Following delivery of a pacing pulse to an atrium of the patient's heart during a cardiac cycle, the system senses in the atrium for a retrograde P-wave. The system classifies the atrial response to the pacing pulse based on detection of the retrograde P-wave. The system may also sense for an atrial evoked response and utilize the atrial evoked response in classifying the cardiac pacing response.
摘要翻译：描述了用于将心脏反应分类为起搏刺激和/或预防逆行心脏传导的方法和系统。在心脏周期内将起搏脉搏递送到患者心脏的心房后，系统在心房感测逆行P波。该系统基于逆行P波的检测将起搏脉冲的心房响应分类。该系统还可以感知心房诱发反应并且利用心房诱发反应来分类心脏起搏反应。

23. 发明申请

US20070258989A1 Immunomodulatory pharmaceutical composition and a process for preparation thereof 审中-公开
标题翻译：免疫调节药物组合物及其制备方法
公开(公告)号：US20070258989A1
公开(公告)日：2007-11-08
申请号：US11634748
申请日：2006-12-05
申请人： Suman Khanuja , Anirban Pal , Sunil Chattopadhyay , Mahendra Darokar , Rajendra Patel , Anil Gupta , Arvind Negi , Tanpreet Kaur , Sudeep Tandon , Atul Kahol , Ankur Garg
发明人： Suman Khanuja , Anirban Pal , Sunil Chattopadhyay , Mahendra Darokar , Rajendra Patel , Anil Gupta , Arvind Negi , Tanpreet Kaur , Sudeep Tandon , Atul Kahol , Ankur Garg
IPC分类号： A61K39/00 , A61K36/31 , A61P43/00
CPC分类号： A61K31/37 , A61K2300/00
摘要： The present invention provides a novel pharmaceutical composition consisting of a combination of three coumarinolignoids of formula 1, 2 and 3 isolated from the seeds of the plant Cleome viscose along with a pharmaceutically acceptable carrier useful as a immunomodulator. The invention also describes the ability of the compounds to modulate humorral and cell mediated immune response. It further provides a process for the preparation of a novel pharmaceutical composition of the said three coumarinolignoids in an optimized ratio to modulate humorral and cell mediated immune response.
摘要翻译：本发明提供了一种新型药物组合物，其由从植物Cleome粘胶的种子中分离出的三种分子式1,2和3的香豆素类结合物以及可用作免疫调节剂的药学上可接受的载体组合。本发明还描述了化合物调节幽门和细胞介导的免疫应答的能力。它进一步提供了以优化的比例制备所述三种香豆素类黄酮的新型药物组合物以调节幽门和细胞介导的免疫应答的方法。

24. 发明申请

US20070123474A1 Novel loganin analogues and a process for the preparation thereof 有权
标题翻译：新的类胡萝卜素类似物及其制备方法
公开(公告)号：US20070123474A1
公开(公告)日：2007-05-31
申请号：US11366687
申请日：2006-03-02
申请人： Suman Khanuja , Santosh Srivastava , Ankur Garg , Merajuddin Khan , Mahendra Dardokar , Anirban Pal
发明人： Suman Khanuja , Santosh Srivastava , Ankur Garg , Merajuddin Khan , Mahendra Dardokar , Anirban Pal
IPC分类号： A61K31/7048 , C07H17/00
CPC分类号： C07H17/04
摘要： The present invention provides novel loganin analogues and a process for the preparation thereof. The present invention further provides the use of Iridoid glycoside loganin isolated from the fruit pulp of Strychnos nux-vomica and its bioactive semi-synthetic analogues against various human cancer cell lines grown in-vitro.
摘要翻译：本发明提供新的类胡萝卜素类似物及其制备方法。本发明还提供了从Strychnos nux-vomica的果实果肉中分离出的Iridoid苷苷和其生物活性半合成类似物对体外生长的各种人类癌细胞系的用途。

25. 发明授权

US07135590B2 Gallic acid derivative and process of preparing the same 有权
标题翻译：没食子酸衍生物及其制备方法
公开(公告)号：US07135590B2
公开(公告)日：2006-11-14
申请号：US10919567
申请日：2004-08-17
申请人： Suman Preet Singh Khanuja , Mahendra Pandurang Darokar , Ankur Garg , Togarrati Padmapriya , Ajit Kumar Shasany , Arvind Singh Negi , Sunia Kumar Chattopadhyay , Kachin Srivastava , Asish Kumar Bhattacharya
发明人： Suman Preet Singh Khanuja , Mahendra Pandurang Darokar , Ankur Garg , Togarrati Padmapriya , Ajit Kumar Shasany , Arvind Singh Negi , Sunia Kumar Chattopadhyay , Kachin Srivastava , Asish Kumar Bhattacharya
IPC分类号： C07C69/76 , C07C39/14
CPC分类号： C07C69/736 , A01N35/04 , A01N37/38 , C07C45/54 , C07C45/84 , C07C49/84 , C07C67/08 , C07C67/31 , C07C69/734 , C07C69/92
摘要： This invention provides a plant growth regulatory activity of a new biologically active synthetic molecule methanone-(3′,4′,5′-trimethoxy) phenyl, 1-naphthyl, 2-O-4″-ethyl but-2″-enoate. More particularly, the invention relates to the potent plant growth promoting activity of a gallic acid derivative having a structure represented by Formula 1 and a molecular formulae C26H26O7. This invention also provides a novel process for preparation of said molecule from a naturally occurring compound and testing it for growth regulating activity using Bacopa test system developed at CIMAP (Khanuja et al., 2001)
摘要翻译：本发明提供新的生物活性合成分子甲酮 - （3'，4'，5'-三甲氧基）苯基，1-萘基，2-O-4“ - 乙基-2” - 插嘴更具体地说，本发明涉及具有由式1表示的结构和分子式C 26 H 26的没食子酸衍生物的有效的植物生长促进活性 > 7 。本发明还提供了一种从天然存在的化合物制备所述分子的新方法，并使用在CIMAP开发的Bacopa测试系统（Khanuja等，2001）测试其用于生长调节活性，

26. 发明申请

US20060129197A1 Atrial capture verification 有权
公开(公告)号：US20060129197A1
公开(公告)日：2006-06-15
申请号：US11012433
申请日：2004-12-15
申请人： Geng Zhang , Ankur Garg , Douglas Daum
发明人： Geng Zhang , Ankur Garg , Douglas Daum
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3714
摘要： Methods and systems for classifying cardiac responses to pacing stimulation and/or preventing retrograde cardiac conduction are described. Following delivery of a pacing pulse to an atrium of the patient's heart during a cardiac cycle, the system senses in the atrium for a retrograde P-wave. The system classifies the atrial response to the pacing pulse based on detection of the retrograde P-wave. The system may also sense for an atrial evoked response and utilize the atrial evoked response in classifying the cardiac pacing response.

27. 发明授权

US08229561B2 Atrial retrograde management 有权
标题翻译：心房逆行管理
公开(公告)号：US08229561B2
公开(公告)日：2012-07-24
申请号：US11012692
申请日：2004-12-15
申请人： Geng Zhang , Ankur Garg
发明人： Geng Zhang , Ankur Garg
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3714
摘要： Methods and systems for classifying cardiac responses to pacing stimulation and/or preventing retrograde cardiac conduction are described. Following delivery of a pacing pulse to an atrium of the patient's heart during a cardiac cycle, the system senses in the atrium for a retrograde P-wave. The system classifies the atrial response to the pacing pulse based on detection of the retrograde P-wave. The system may also sense for an atrial evoked response and utilize the atrial evoked response in classifying the cardiac pacing response. If capture is not detected, the system may deliver additional atrial pacing pulses to reduce atrial retrograde conduction. A backup pace may be delivered to prevent the atrial retrograde conduction if an atrial evoked response is not detected during a cardiac cycle. Alternatively, retrograde management may involve delaying a next scheduled pace may be until expiration of an atrial effective refractory period.
摘要翻译：描述了用于将心脏反应分类为起搏刺激和/或预防逆行心脏传导的方法和系统。在心脏周期内将起搏脉搏递送到患者心脏的心房后，系统在心房感测逆行P波。该系统基于逆行P波的检测将起搏脉冲的心房响应分类。该系统还可以感知心房诱发反应并且利用心房诱发反应来分类心脏起搏反应。如果未检测到捕获，则系统可能会传递额外的心房起搏脉冲以减少心房逆行传导。如果在心动周期期间没有检测到心房诱发反应，则可以提供备份速度以防止心房逆行传导。或者，逆行管理可能涉及延迟下一预定速度，直到心房有效不应期结束。

28. 发明授权

US07801610B2 Methods and systems for management of atrial retrograde conduction and pacemaker mediated tachyarrhythmia 有权
标题翻译：用于管理心房逆行传导和起搏器介导的快速性心律失常的方法和系统
公开(公告)号：US07801610B2
公开(公告)日：2010-09-21
申请号：US11601092
申请日：2006-11-17
申请人： Derek D. Bohn , Ankur Garg , Eric K. Enrooth
发明人： Derek D. Bohn , Ankur Garg , Eric K. Enrooth
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61N1/3621 , A61N1/3712 , A61N1/3714
摘要： Methods and systems for classifying cardiac responses to pacing stimulation and managing retrograde conduction and pacemaker mediated tachyarrhythmia are described. An atrial pacing pulse and a ventricular pacing pulse are delivered during a paced cardiac cycle. A post ventricular atrial refractory period (PVARP) is timed following the ventricular pacing pulse. The system determines if the atrial pacing pulse captures the atrium. An atrial depolarization occurring after the paced cardiac cycle is sensed. Retrograde management is initiated if the atrial pacing pulse did not capture the atrium and the atrial depolarization occurred during the PVARP. Pacemaker mediated tachyarrhythmia (PMT) is initiated if the atrial pacing pulse did not capture the atrium and the atrial depolarization did not occur during the PVARP.
摘要翻译：描述了用于分类心脏起搏刺激响应和管理逆行传导和起搏器介导的快速性心律失常的方法和系统。心律起搏脉搏和心室起搏脉搏在心跳期间进行。心室起搏脉搏后定时心室心房不应期（PVARP）。该系统确定心房起搏脉冲是否捕获心房。感觉到起搏心动周期后出现心房去极化。如果心房起搏脉搏没有捕获心房并且在PVARP期间发生心房去极化，则开始逆行管理。如果心房起搏脉搏没有捕获心房并且在PVARP期间没有发生心房去极化，起搏器介导的快速性心律失常（PMT）开始。

29. 发明授权

US07767798B2 Loganin analogues and a process for the preparation thereof 有权
标题翻译： Loganin类似物及其制备方法
公开(公告)号：US07767798B2
公开(公告)日：2010-08-03
申请号：US11366687
申请日：2006-03-02
申请人： Suman Preet Singh Khanuja , Santosh Kumar Srivastava , Ankur Garg , Merajuddin Khan , Mahendra Pandurang Dardokar , Anirban Pal
发明人： Suman Preet Singh Khanuja , Santosh Kumar Srivastava , Ankur Garg , Merajuddin Khan , Mahendra Pandurang Dardokar , Anirban Pal
IPC分类号： C07H15/00
CPC分类号： C07H17/04
摘要： The present invention provides novel loganin analogues and a process for the preparation thereof. The present invention further provides the use of Iridoid glycoside loganin isolated from the fruit pulp of Strychnos nux-vomica and its bioactive semi-synthetic analogues against various human cancer cell lines grown in-vitro.
摘要翻译：本发明提供新的类胡萝卜素类似物及其制备方法。本发明还提供了从Strychnos nux-vomica的果实果肉中分离出的Iridoid苷苷和其生物活性半合成类似物对体外生长的各种人类癌细胞系的用途。

30. 发明授权

US07587240B2 Atrial capture verification 有权
标题翻译：心房捕捉验证
公开(公告)号：US07587240B2
公开(公告)日：2009-09-08
申请号：US11012433
申请日：2004-12-15
申请人： Geng Zhang , Ankur Garg , Douglas R. Daum
发明人： Geng Zhang , Ankur Garg , Douglas R. Daum
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3714
摘要： Methods and systems for classifying cardiac responses to pacing stimulation and/or preventing retrograde cardiac conduction are described. Following delivery of a pacing pulse to an atrium of the patient'heart during a cardiac cycle, the system senses in the atrium for a retrograde P-wave. The system classifies the atrial response to the pacing pulse based on detection of the retrograde P-wave. The system may also sense for an atrial evoked response and utilize the atrial evoked response in classifying the cardiac pacing response.
摘要翻译：描述了用于将心脏反应分类为起搏刺激和/或预防逆行心脏传导的方法和系统。在心脏周期内将起搏脉搏递送到患者心脏的心房后，系统在心房感测逆行P波。该系统基于逆行P波的检测将起搏脉冲的心房响应分类。该系统还可以感知心房诱发反应并且利用心房诱发反应来分类心脏起搏反应。

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