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21. 发明申请

US20050070771A1 Sample adapter 审中-公开
标题翻译：样品适配器
公开(公告)号：US20050070771A1
公开(公告)日：2005-03-31
申请号：US10900062
申请日：2004-07-27
申请人： Peter Rule , James Braig , Philip Hartstein , Jennifer Gable
发明人： Peter Rule , James Braig , Philip Hartstein , Jennifer Gable
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1455 , A61B5/1491
摘要： An adapter presents a sample of bodily fluid, such as whole blood, including an analyte to an analyzer window of a non-invasive monitor. The adapter comprises a base material that comprises a first side and a second side. The adapter also comprises a sample accommodating volume extending between an opening in the second side of the base material and an opening in the first side of the base material.
摘要翻译：适配器将诸如全血的体液样品（包括分析物）提供给非侵入性监测器的分析器窗口。适配器包括包括第一侧和第二侧的基材。适配器还包括在基材的第二侧的开口和基材的第一侧中的开口之间延伸的样品容纳体积。

22. 发明申请

US20060292650A1 Spectroscopic analysis of a biological fluid reacted with an enzyme 审中-公开
标题翻译：与酶反应的生物液体的光谱分析
公开(公告)号：US20060292650A1
公开(公告)日：2006-12-28
申请号：US11438902
申请日：2006-05-23
申请人： James Braig , Kenneth Witte , Margaret Magarian , Jane Sheill , Bernhard Sterling
发明人： James Braig , Kenneth Witte , Margaret Magarian , Jane Sheill , Bernhard Sterling
IPC分类号： C12Q1/54 , C12M1/34
CPC分类号： C12Q1/26 , C12Q1/32 , C12Q1/52 , C12Q1/54
摘要： An apparatus is presented for estimating the concentration of an analyte using a combined enzyme-spectroscopic method. Examples are provided for the detection of glucose and lactate. A sample of biological fluid is mixed or contacted with an enzyme specific to the analyte of interest, and the reacting fluid is probed with an optical system at wavelengths that includes at least one wavelength that is sensitive to the analyte concentration and at least one wavelength that is not sensitive to the analyte concentration. The optical system measures properties, such as optical density, and relates the measurements to concentration through a calibration of the system. A method is also provided for analyzing the data obtained from optical measurements of reactions of enzymes with biological fluids. These technologies may be applied to continuous or periodic patient sampling systems or to test strip type devices.
摘要翻译：提出了使用组合酶分光法估计分析物浓度的装置。提供葡萄糖和乳酸盐检测的实例。将生物流体样品与特定于目标分析物的酶混合或接触，并且反应流体用波长包括至少一种对分析物浓度敏感的波长和至少一种波长的光学系统进行探测对分析物浓度不敏感。光学系统测量诸如光密度的特性，并通过校准系统将测量值与浓度相关联。还提供了一种用于分析从酶与生物流体的反应的光学测量获得的数据的方法。这些技术可以应用于连续或周期性的患者采样系统或测试条型设备。

23. 发明申请

US20050036146A1 Sample element qualification 审中-公开
标题翻译：样品单元鉴定
公开(公告)号：US20050036146A1
公开(公告)日：2005-02-17
申请号：US10824933
申请日：2004-04-15
申请人： James Braig , Kenneth Witte , Philip Hartstein , Ken Li , Peter Rule
发明人： James Braig , Kenneth Witte , Philip Hartstein , Ken Li , Peter Rule
IPC分类号： G01N21/03 , G01N21/59 , G01N21/86 , G01N35/00 , G01N21/00
CPC分类号： G01N35/00732 , G01N21/03 , G01N21/5907 , G01N21/8483 , G01N2035/00752 , G01N2035/00762 , G01N2035/00772 , G01N2035/00782
摘要： A sample element includes first and second substantially parallel faces separated by an intermediate member. The parallel faces and the intermediate member at least partially define a sample chamber configured to hold a volume of fluid. The sample element further includes an optical path extending through the parallel faces and the intermediate member, such that electromagnetic radiation can propagate through the sample chamber. The sample element further includes an identifying compound disposed within or on at least one of the parallel faces. The identifying compound has at least one indexed optical absorbance feature, such that spectral analysis of electromagnetic radiation propagated through the sample chamber yields the indexed optical absorbance feature. Detection of the indexed optical absorbance feature in electromagnetic radiation propagated through the sample chamber indicates to an analyte detection system whether the sample element is configured for use with the analyte detection system.
摘要翻译：样品元件包括由中间构件分隔开的第一和第二基本上平行的面。平行面和中间构件至少部分地限定了构造成保持一定体积的流体的样品室。样本元件还包括延伸穿过平行面和中间构件的光路，使得电磁辐射可以传播通过样品室。样本元件还包括设置在至少一个平行面内或之中的识别化合物。识别化合物具有至少一个索引的光吸收特征，使得通过样品室传播的电磁辐射的光谱分析产生索引的光吸收特征。通过样品室传播的电磁辐射中的指示光吸收特征的检测表明分析物检测系统是否将样品元件配置为与分析物检测系统一起使用。

24. 发明申请

US20050197790A1 Method of determining an analyte concentration in a sample from an absorption spectrum 失效
标题翻译：从吸收光谱确定样品中分析物浓度的方法
公开(公告)号：US20050197790A1
公开(公告)日：2005-09-08
申请号：US11062110
申请日：2005-02-18
申请人： Bernhard Sterling , James Braig , Daniel Goldberger , Kenneth Witte
发明人： Bernhard Sterling , James Braig , Daniel Goldberger , Kenneth Witte
IPC分类号： A61B5/00 , G01N21/27 , G01N21/31 , G01N21/35 , G01N33/487 , G06F19/00 , G01N31/00
CPC分类号： A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B2562/0295 , G01N21/274 , G01N21/314 , G01N21/35 , G01N27/3271
摘要： A method determines an analyte concentration in a sample including the analyte and a substance. The method includes providing an absorption spectrum of the sample. The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range. The method further includes subtracting a substance contribution from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.
摘要翻译：一种方法确定包含分析物和物质的样品中的分析物浓度。该方法包括提供样品的吸收光谱。吸收光谱具有吸收基线。该方法还包括移动吸收光谱，使得吸收基线大约等于所选吸收波长范围内的选定吸收值。该方法还包括从吸收光谱中减去物质贡献。因此，该方法提供基本上不含该物质的贡献的校正吸收光谱。

25. 发明申请

US20050037482A1 Dual measurement analyte detection system 审中-公开
标题翻译：双测量分析物检测系统
公开(公告)号：US20050037482A1
公开(公告)日：2005-02-17
申请号：US10826006
申请日：2004-04-15
申请人： James Braig , Peter Rule , Kenneth Witte , Philip Hartstein , Bernhard Sterling
发明人： James Braig , Peter Rule , Kenneth Witte , Philip Hartstein , Bernhard Sterling
IPC分类号： A61B5/00 , C12M1/34
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546
摘要： An analyte detection system is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element. The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.
摘要翻译：分析物检测系统被配置为测量由样品元素支持的单个材料样品中的至少第一和第二分析物的浓度。第二分析物的测量可以对第一次测量的定量或定性结果进行调节。在一个实施方案中，第一分析物是葡萄糖，第二分析物是酮。根据这样的实施方案，如果葡萄糖测量结果超过预先规定的值或者超出预先规定的范围，则测量酮。

26. 发明申请

US20070083143A1 Anti-Clotting Apparatus and Methods for Fluid Handling System 有权
标题翻译：抗凝装置及流体处理系统的方法
公开(公告)号：US20070083143A1
公开(公告)日：2007-04-12
申请号：US11314731
申请日：2005-12-21
申请人： James Braig , Richard Keenan
发明人： James Braig , Richard Keenan
IPC分类号： A61M37/00
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61M5/14212 , A61M2230/20 , G01N21/35
摘要： A method for maintaining clear passageways in an extracorporeal blood flow system. The method comprises intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system. Also disclosed is an extracorporeal blood flow system. The system comprises a passageway, and a device operatively connected to provide one or more anti-clotting agents to a least a portion of said passageway.
摘要翻译：一种用于在体外血液流动系统中保持清晰通道的方法。该方法包括间歇地向体外血液流通系统的通道提供一种或多种抗凝血剂。还公开了一种体外血液流动系统。该系统包括通道和可操作地连接以向所述通道的至少一部分提供一种或多种抗凝血剂的装置。

27. 发明申请

US20060253097A1 Methods of treating diabetes 审中-公开
标题翻译：治疗糖尿病的方法
公开(公告)号：US20060253097A1
公开(公告)日：2006-11-09
申请号：US11256277
申请日：2005-10-21
申请人： James Braig , Kenneth Li , Peter Rule , Richard Keenan
发明人： James Braig , Kenneth Li , Peter Rule , Richard Keenan
IPC分类号： A61M31/00
CPC分类号： A61B5/14546 , A61B5/14532 , A61B5/1455
摘要： A method of treating a diabetic condition of a patient comprises providing a glucose detection system which is portable and usable by the patient, and which is configured to measure glucose levels with a standard error of less than about 30 mg/dL. The method further comprises making a plurality of measurements of the patient's glucose level with the portable, patient-usable glucose detection system. The method further comprises administering a diabetes treatment to the patient based on one or more of the measurements of the patient's glucose level.
摘要翻译：一种治疗患者糖尿病状况的方法包括提供可由患者携带和使用的葡萄糖检测系统，其被配置为以小于约30mg / dL的标准误差测量葡萄糖水平。该方法还包括利用便携式，病人可用的葡萄糖检测系统对患者的葡萄糖水平进行多次测量。该方法还包括基于对患者血糖水平的一个或多个测量值向患者施用糖尿病治疗。

28. 发明申请

US20110272352A1 MEMBRANE ELECTROLYZER AND HEMODIALYSIS SYSTEM USING THE SAME 审中-公开
标题翻译：使用相同的膜电解质和血液透析系统
公开(公告)号：US20110272352A1
公开(公告)日：2011-11-10
申请号：US13101808
申请日：2011-05-05
申请人： James Braig
发明人： James Braig
IPC分类号： B01D61/26 , C12M1/12 , C25B1/00 , B01D61/28
CPC分类号： B01D61/44 , A61M1/1696
摘要： A sorbent hemodialysis system includes a dialyzer configured to receive a flow of clean dialysate from a reservoir and to output an unclean dialysate flow. The system also includes a sorbent component having a urease section and a sorbent section through which the unclean dialysate flow from the dialyzer passes, wherein the sorbent component removes urea from the dialysate. The system further comprises a membrane electrolyzer that receives at least a portion of said clean dialysate flow and separates the dialysate flow into an acidic component flow and a base component flow. A mixing conduit combines the base component flow from the membrane electrolyzer and an output dialysate solution from the urease section of the sorbent component to separate the dialysate solution into an ammonia gas amount and ammonia liquid amount. A gas vent is used to vent the ammonia gas amount, and the sorbent section with a suitable amount of zirconium phosphate (ZrP) removes the ammonia liquid amount from the unclean dialysate flow before flowing the clean dialysate to the reservoir. The system can further include a second mixing conduit upstream of the sorbent section of the sorbent component, the second mixing conduit combining the acidic component flow and the ammonia liquid amount in the dialysate solution to increase the pH of the dialysate solution to about 7.5 prior to returning to the reservoir.
摘要翻译：吸附剂血液透析系统包括透析器，其构造成从储存器接收干净的透析液流并输出不洁净的透析液流。该系统还包括具有尿素酶部分和吸附剂部分的吸附剂组分，来自透析器的不洁透析液流过该吸附剂部分，其中吸附剂组分从透析液中除去尿素。所述系统还包括膜电解器，其接收所述清洁透析液流的至少一部分，并将透析液流分离成酸性组分流和碱组分流。混合导管结合来自膜电解器的基础组分流和来自吸附剂组分的脲酶部分的输出透析液，将透析液分离成氨气量和氨液量。使用排气口排出氨气量，并且使用适量的磷酸锆（ZrP）的吸附剂部分从清洁的透析液流中除去氨液体量，然后将清洁的透析液流入储存器。该系统还可以包括在吸附剂组分的吸附剂部分上游的第二混合管道，第二混合管道将酸性组分流和氨液体量结合在透析液中，以将透析液的pH值升高到约7.5，之后回到水库。

29. 发明申请

US20070258083A1 NOISE REDUCTION FOR ANALYTE DETECTION SYSTEMS 审中-公开
标题翻译：用于分析仪检测系统的噪声减少
公开(公告)号：US20070258083A1
公开(公告)日：2007-11-08
申请号：US11734261
申请日：2007-04-11
申请人： Kevin Heppell , James Braig
发明人： Kevin Heppell , James Braig
IPC分类号： G01N33/48
CPC分类号： A61B5/14532 , A61B5/1459 , G01N21/07 , G01N21/274 , G01N21/35
摘要： Methods and apparatus are provided for determining the concentration of an analyte in a sample, such as an analyte in a sample of bodily fluid. Some embodiments use a synchronous demodulator and digital filter to reduce microphonic signal content. Some embodiments monitor the microphonic signal content and “hold off” on making a measurement until vibrations subside. Monitoring can be performed using an accelerometer or other vibration sensor. An algorithm can be used to examine the detector output signal and detect excessive microphonic components, making an accelerometer unnecessary.
摘要翻译：提供了用于确定样品（例如体液样品中的分析物）中的分析物的浓度的方法和装置。一些实施例使用同步解调器和数字滤波器来减少麦克风信号内容。一些实施例监视麦克风信号内容并在进行测量时“保持”，直到振动消退。可以使用加速度计或其他振动传感器进行监视。可以使用一种算法来检测检测器输出信号并检测过多的麦克风分量，使加速度计不必要。

30. 发明申请

US20050238538A1 Analyte detection system with software download capabilities 审中-公开
公开(公告)号：US20050238538A1
公开(公告)日：2005-10-27
申请号：US11106352
申请日：2005-04-14
申请人： James Braig , Gary Hewett , Michael Munrow , Julian Cortella , Kamrava Azizi , Daniel Goldberger
发明人： James Braig , Gary Hewett , Michael Munrow , Julian Cortella , Kamrava Azizi , Daniel Goldberger
IPC分类号： A61B5/00 , G06F19/00 , G01N21/00
CPC分类号： A61B5/1495 , A61B5/0002 , A61B5/14532 , A61B5/1455 , A61B2560/0271 , A61B2562/0295 , G06F19/3418 , G16H40/40 , G16H40/63 , Y10S707/99945
摘要： An analyte concentration monitoring system having network-based communication features which provide a link between an analyte detection system and a centralized computer. The analyte detection system has a processor that calculates analyte concentration in accordance with software executable by the processor. Under certain conditions, the software needs to be updated. Accordingly, when the analyte detection system is connected to the centralized computer, the centralized computer determines whether a software update is needed. If a software update is needed, then the centralized computer conveniently provides the software update to the analyte detection system without intervention from a user.

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