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21. 发明授权

US08741661B2 Methods and devices for sampling flowable materials 有权
标题翻译：用于对可流动材料进行取样的方法和装置
公开(公告)号：US08741661B2
公开(公告)日：2014-06-03
申请号：US12438233
申请日：2007-09-12
申请人： Jean-Louis Viovy , Max Chabert
发明人： Jean-Louis Viovy , Max Chabert
IPC分类号： G01N1/16 , G01N1/18
CPC分类号： G01N35/1009 , B01F13/0072 , B01L3/021 , B01L3/0293 , B01L3/502715 , B01L3/502769 , B01L3/502784 , B01L7/525 , B01L2200/027 , B01L2200/0673 , B01L2300/0867 , B01L2400/0406 , B01L2400/0487 , G01N35/08 , G01N2035/00277 , Y10T137/0318 , Y10T137/85938 , Y10T436/25 , Y10T436/2575
摘要： A method including: a) providing a first well with a first layer of a first flowable material and a second layer of a second flowable material, and a second well with a first layer of a first flowable material different from the first flowable material of the first well, b) locating the flowable material inlet within the first layer, c) sampling a first volume of the first flowable material, d) displacing the flowable material inlet relative to the first well to locate the flowable material inlet within the second layer, e) sampling a second volume of the second flowable material, f) displacing the flowable material inlet relative to the first and second wells to locate the flowable material inlet within the first layer of the second well, and g) sampling or dispensing into the second well a third volume of the first flowable material of the second well.
摘要翻译：一种方法，包括：a）提供具有第一可流动材料的第一层和第二可流动材料的第二层的第一井，以及具有不同于所述第一可流动材料的第一可流动材料的第一可流动材料的第一层的第二井第一井，b）将所述可流动材料入口定位在所述第一层内，c）对所述第一可流动材料的第一体积进行取样，d）使所述可流动材料入口相对于所述第一井移动，以将所述可流动材料入口定位在所述第二层内， e）对第二可流动材料的第二体积进行取样，f）使可流动材料入口相对于第一和第二阱移动，以将可流动材料入口定位在第二孔的第一层内，以及g）以及第二个孔的第一可流动材料的第三体积。

22. 发明申请

US20100048839A1 Novel method for producing water-soluble comb-shaped copolymers 有权
公开(公告)号：US20100048839A1
公开(公告)日：2010-02-25
申请号：US11921000
申请日：2006-05-18
申请人： Olivier Braun , Paul Mallo , Jean-Louis Viovy , Jérémie Weber
发明人： Olivier Braun , Paul Mallo , Jean-Louis Viovy , Jérémie Weber
IPC分类号： C08F2/00
CPC分类号： G01N27/44747 , C08F267/10 , C08F290/046 , C08F220/56
摘要： The invention relates to a method for producing a comb-shaped copolymer whose skeleton is of an acrylamide, acrylic acid, acryloyl aminoethanol or dimethyl acrylamide type and on which poly(N-alkyl acrylamide) or poly(N,N-5 dialkyl acrylamide lateral segments are grafted. Said method is characterised in that it consists (a) in producing a telomer poly(N-alkyl acrylamide) or poly(N,N-dialkyl acrylamide) of formula (I) H2N—R1—Z—{CH2—C(R2)[C(=O)N(R3)(R4)]-}n—H (I) 10 by reacting in water a compound of formula (II) CH2=C(R2)—C(=O)—N(R3)(R4) (II) with a chain limiting compound of formula (III) Z—R1—NH2; (b) in isolating the telomer of formula (I) obtained at a stage (a); (c) in reacting in water the telomer of formula (I) obtained at stage (b) with an acid chloride of formula (IV) CH2=C(R5)—C(=O)—C, at a molar ratio (IV)/(III) equal to or less than 10 and equal to or greater than 1 in such a way that a macro monomer of formula (V) 20 CH2=C(R5)—C(=O)NH—R1—Z—{CH2—C(R2)[C(=O)N(R3)(R4)]-}n—H (V) is obtained; (d) in isolating the macro monomer of formula (V) obtained at stage (c); (e) in copolymerising in water the macro monomer of formula (V) isolated at stage (d) with a monomer selected from acrylamide, acrylic acid, acryloyl-aminoethanol or dimethyl-acrylamide and, if necessary, (f) in purifying the thus obtained copolymer.Method for producing a comb-shaped copolymer whose skeleton is of an acrylamide, acrylic acid, acryloyl aminoethanol or dimethyl acrylamide type and on which poly(N-alkyl acrylamide) or poly(N,N-5 dialkyl acrylamide lateral segments are grafted, includes (a) producing a telomer poly(N-alkyl acrylamide) or poly(N,N-dialkyl acrylamide) of formula (I) H2N—R1—Z—{CH2—C(R2) [C(=O)N(R3)(R4)]-}n—H (I) 10 by reacting in water a compound of formula (II) CH2=C(R2)—C(=O)—N(R3)(R4) (II) with a chain limiting compound of formula (III) Z—R1—NH2; (b) isolating the telomer of formula (I) obtained at a stage (a); (c) reacting in water the telomer of formula (I) obtained at stage (b) with an acid chloride of formula (IV) CH2=C(R5)—C(=O)—C1 at a molar ratio (IV)/(III) equal to or less than 10 and equal to or greater than 1 so that a macro monomer of formula (V) 20 CH2=C(R5)—C(=O) NH—R1—Z—{CH2—C(R2) [C(=O)N(R3) (R4)]-}n—H (V) is obtained; (d) isolating the macro monomer of formula (V) obtained at stage (c); (e) copolymerizing in water the macro monomer of formula (V) isolated at stage (d) with a monomer selected from acrylamide, acrylic acid, acryloyl-aminoethanol or dimethyl-acrylamide and, if necessary, (f) purifying the thus obtained copolymer.

23. 发明申请

US20090288710A1 METHODS AND DEVICES FOR SAMPLING FLOWABLE MATERIALS 有权
标题翻译：用于采样流动材料的方法和装置
公开(公告)号：US20090288710A1
公开(公告)日：2009-11-26
申请号：US12438233
申请日：2007-09-12
申请人： Jean-Louis Viovy , Max Chabert
发明人： Jean-Louis Viovy , Max Chabert
IPC分类号： F17D3/00 , F16L41/00
CPC分类号： G01N35/1009 , B01F13/0072 , B01L3/021 , B01L3/0293 , B01L3/502715 , B01L3/502769 , B01L3/502784 , B01L7/525 , B01L2200/027 , B01L2200/0673 , B01L2300/0867 , B01L2400/0406 , B01L2400/0487 , G01N35/08 , G01N2035/00277 , Y10T137/0318 , Y10T137/85938 , Y10T436/25 , Y10T436/2575
摘要： The present invention concern a method for sampling and mixing different flowable material materials from a plurality of wells in arbitrary order.
摘要翻译：本发明涉及从多个孔以任意顺序取样和混合不同的可流动材料材料的方法。

24. 发明授权

US06830670B1 Heat-sensitive medium for separating species in a separating channel and use thereof 失效
标题翻译：用于在分离通道中分离物质的热敏介质及其用途
公开(公告)号：US06830670B1
公开(公告)日：2004-12-14
申请号：US09869382
申请日：2001-10-01
申请人： Jean-Louis Viovy , Dominique Hourdet , Jan Sudor
发明人： Jean-Louis Viovy , Dominique Hourdet , Jan Sudor
IPC分类号： G01N27447
CPC分类号： G01N27/44747
摘要： A medium comprises an electrolyte wherein is dissolved at least an assembly of block copolymers characterized in that the block copolymers: are present in the electrolyte at a concentration level to provide the medium with the property of reversibly passing from a state of viscosity V1, obtained at a temperature T1, to a viscosity state V2 greater by at least 100% than V1, obtained at a temperature T2, and comprise in their structure at least: two non-contiguous polymeric segments having in the electrolyte a lower critical solubility temperature (LCST) and having an average number of atoms along their skeleton more than 50; and a polymeric segment soluble in the electrolyte at temperatures T1 and T2. The invention also concerns the use of the medium for separating analytes.
摘要翻译：介质包括电解质，其中至少溶解了嵌段共聚物的组合物，其特征在于所述嵌段共聚物以浓度水平存在于所述电解质中，以提供介质具有从粘度V1的状态可逆地通过的性质温度T1，在温度T2下达到比V1大至少100％的粘度状态V2，并且在其结构中包括至少两个在电解液中具有较低临界溶解度温度（LCST）的非连续聚合物链段，并且沿其骨架的平均原子数大于50; 和在温度T1和T2下可溶于电解质的聚合物链段。本发明还涉及介质用于分离分析物的用途。

25. 发明授权

US10767151B2 Device for cell culture 有权
公开(公告)号：US10767151B2
公开(公告)日：2020-09-08
申请号：US13123628
申请日：2009-10-12
申请人： Jean-Louis Viovy , Jean-Michel Peyrin , Bernard Brugg , Laure Saias , Paul Gougis , Maeva Vignes
发明人： Jean-Louis Viovy , Jean-Michel Peyrin , Bernard Brugg , Laure Saias , Paul Gougis , Maeva Vignes
IPC分类号： C12M3/00 , C12N5/0793 , C12Q1/02 , C12Q1/37 , C12Q1/68 , G01N33/566 , C12M1/00 , C12M3/06 , C12M1/42
摘要： A device for cell culture, in particular of neuronal cells, including: a substrate defining a first microfluidic chamber to be seeded with a first cell culture, and at least a second microfluidic chamber, a fluidic interconnection system connecting the first and second chambers and enabling cellular extensions, in particular axons, to extend from one chamber to the other, wherein the interconnection system of the device is made so as to promote the progression of at least one first type of cellular extension, the first and second types of extension being different either due to the microfluidic chamber from which they originate, or due to the type of cell of which they constitute an extension.

26. 发明申请

US20110306041A1 DEVICE FOR CELL CULTURE 审中-公开
标题翻译：细胞培养装置
公开(公告)号：US20110306041A1
公开(公告)日：2011-12-15
申请号：US13123628
申请日：2009-10-12
申请人： Jean-Louis Viovy , Jean-Michel Peyrin , Bernard Brugg , Laure Saias , Paul Gougis , Maeva Vignes
发明人： Jean-Louis Viovy , Jean-Michel Peyrin , Bernard Brugg , Laure Saias , Paul Gougis , Maeva Vignes
IPC分类号： C12Q1/68 , C12Q1/37 , C12Q1/02 , G01N33/566 , C12M3/00 , C12N5/0793
CPC分类号： C12M29/10 , C12M23/16 , C12M23/34 , C12M35/08 , C12N5/0619
摘要： A device for cell culture, in particular of neuronal cells, including: a substrate defining a first microfluidic chamber to be seeded with a first cell culture, and at least a second microfluidic chamber, a fluidic interconnection system connecting the first and second chambers and enabling cellular extensions, in particular axons, to extend from one chamber to the other, wherein the interconnection system of the device is made so as to promote the progression of at least one first type of cellular extension, the first and second types of extension being different either due to the microfluidic chamber from which they originate, or due to the type of cell of which they constitute an extension.
摘要翻译：一种用于细胞培养的装置，特别是神经元细胞的装置，包括：限定待接种第一细胞培养物的第一微流体室的基底，以及至少第二微流体室，连接第一和第二腔室的流体互连系统，细胞延伸部分，特别是轴突，从一个腔室延伸到另一个腔室，其中该装置的互连系统被制成以促进至少一个第一类型的细胞延伸部分的进展，第一和第二类型的延伸部分是不同的由于它们来自的微流体腔室，或者由于它们构成延伸部分的细胞的类型。

27. 发明申请

US20110285042A1 ENCAPSULATION MICROFLUIDIC DEVICE 有权
标题翻译：封装微流体装置
公开(公告)号：US20110285042A1
公开(公告)日：2011-11-24
申请号：US13120310
申请日：2008-09-22
申请人： Jean-Louis Viovy , Max Chabert
发明人： Jean-Louis Viovy , Max Chabert
IPC分类号： B01J13/02
CPC分类号： B01J13/04
摘要： A method for encapsulating or sorting colloidal objects, comprising the step of flowing said objects in a first flow stream partly or fully surrounded by at least one second flow stream in a channel comprising a narrow strait, wherein along an elongated part of the path of said first flow stream either (a) the bidimensional size of said first flow stream is smaller than the largest bidimensional size of at least some of said objects, either (b) the smallest unidimensional size of said first flow stream is smaller than the largest unidimensional size of at least some of said objects, either (c) said first flow stream is splitting, in the absence of said objects, into droplets with a volume smaller than the volume of at least some of said objects, or (d) said first flow stream would have in the absence of said particles, a shape that cannot entirely encompass some of said objects.
摘要翻译：一种用于封装或分选胶体物体的方法，包括以下步骤：在包含狭窄的海峡的通道中部分地或完全被至少一个第二流动流包围的第一流动流中流动所述物体，其中沿着所述（a）所述第一流动流的二维尺寸小于至少一些所述物体的最大二维尺寸，（b）所述第一流动流的最小一维尺寸小于最大一维尺寸（c）所述第一流动流在没有所述物体的情况下分裂成体积小于至少一些所述物体的体积的液滴，或（d）所述第一流动在没有所述颗粒的情况下，流将具有不能完全包含所述物体的一部分的形状。

28. 发明授权

US07972561B2 Microfluidic device 有权
标题翻译：微流控装置
公开(公告)号：US07972561B2
公开(公告)日：2011-07-05
申请号：US10557308
申请日：2004-05-19
申请人： Jean-Louis Viovy , Claus Futterer , Nicolas Davis Minc , Jean Rossier , Jean-Hugues Codarbox
发明人： Jean-Louis Viovy , Claus Futterer , Nicolas Davis Minc , Jean Rossier , Jean-Hugues Codarbox
IPC分类号： G05D7/00
CPC分类号： B01L3/502738 , B01F13/0059 , B01J19/0093 , B01J2219/00162 , B01J2219/00788 , B01J2219/00853 , B01J2219/00862 , B01J2219/00891 , B01J2219/0095 , B01L3/502715 , B01L2300/14 , B01L2400/0421 , B01L2400/0487 , Y10T137/4774 , Y10T137/479 , Y10T137/7303 , Y10T137/776 , Y10T137/7792
摘要： The invention relates to a microfluidic device comprising at least one micro-channel connected at one end to an enclosed area, characterized in that it also comprises an inlet circuit and an outlet circuit connected to the enclosed area and between which the fluid can be discharged without any contact with the micro-channel, wherein at least one of said inlet and outlet circuits can be controlled in such a way that the pressure at the end of the micro-channel can be modified independently from the pressure at the other end of the micro-channel.
摘要翻译：本发明涉及一种微流体装置，其包括在一端连接到封闭区域的至少一个微通道，其特征在于其还包括连接到封闭区域的入口电路和出口回路，在该区域之间可以排出流体，而没有任何与微通道的接触，其中可以以这样的方式控制所述入口和出口回路中的至少一个，使得微通道端部处的压力可以独立于微型微通道另一端的压力而被修改 -渠道。

29. 发明申请

US20080138248A1 Method for improving the bonding properties of microstructured substrates, and devices prepared with this method 审中-公开
标题翻译：用于改善微结构基材的粘合性能的方法，以及用该方法制备的装置
公开(公告)号：US20080138248A1
公开(公告)日：2008-06-12
申请号：US11636623
申请日：2006-12-11
申请人： Jean-Louis Viovy , Jeremie Weber , Djebani Paul
发明人： Jean-Louis Viovy , Jeremie Weber , Djebani Paul
IPC分类号： B32B27/04
CPC分类号： C08J7/02 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2300/16 , B29C65/4895 , B29C66/0242 , B29C66/54 , B29C66/71 , B29C66/73117 , B29C66/73751 , B29C66/73752 , B29C66/73755 , B29C66/73756 , B29C66/7392 , B29C66/73921 , B29C66/7394 , B29C66/73941 , B29L2031/756 , Y10T428/24744 , B29K2025/04 , B29K2069/00 , B29K2075/00 , B29K2067/003 , B29K2081/06 , B29K2067/00 , B29K2061/00 , B29K2063/00 , B29K2079/08 , B29K2033/12 , B29K2083/00 , B29K2071/00 , B29K2033/08 , B29K2027/12 , B29K2025/08 , B29K2025/06 , B29K2023/38 , B29K2005/00
摘要： A method for treating the surface of a polymeric substrate, including the following steps: providing a first polymeric substrate; contracting at least one part of one face of the first substrate with some liquid solvent system, the liquid solvent system containing at least a first volatile compound and at least a second compound having a low molecular weight and able to swell and/or soften the polymeric material forming the face; letting at least the volatile compound to evaporate from the face of the first substrate and; contacting the so-treated face of first substrate with a third material.
摘要翻译：一种用于处理聚合物基材表面的方法，包括以下步骤：提供第一聚合物基材; 用一些液体溶剂系统收缩第一底物的一个面的至少一部分，液体溶剂体系含有至少第一挥发性化合物和至少第二化合物，其具有低分子量并能够使聚合物溶胀和/或软化材料成型面; 使至少挥发性化合物从第一基板的表面蒸发; 使第一基板的经处理的面与第三材料接触。

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