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21. 发明申请

US20050085605A1 Functionalized polymers for medical applications 有权
公开(公告)号：US20050085605A1
公开(公告)日：2005-04-21
申请号：US10962274
申请日：2004-10-11
申请人： Aruna Nathan
发明人： Aruna Nathan
IPC分类号： C08G63/16 , A61L17/14 , A61L31/10 , C08G63/52 , C08G63/91 , C08F24/00
CPC分类号： A61L31/10 , A61L17/145 , C08G63/52 , C08G63/918
摘要： The present invention is directed to synthetic, biodegradable, biocompatible polymers that are the reaction product of an α,β-unsaturated polybasic acid or derivative thereof and a monoglyceride, and which further contain pended thereto a functional agent, and to medical devices and compositions containing such polymers.

22. 发明申请

US20050079202A1 Implantable elastomeric depot compositions and uses thereof 审中-公开
标题翻译：可植入弹性体贮库组合物及其用途
公开(公告)号：US20050079202A1
公开(公告)日：2005-04-14
申请号：US10857609
申请日：2004-05-28
申请人： Guohua Chen , Paul Houston , Lothar Kleiner , Aruna Nathan , Joel Rosenblatt
发明人： Guohua Chen , Paul Houston , Lothar Kleiner , Aruna Nathan , Joel Rosenblatt
IPC分类号： A61F2/00 , A61K9/00
CPC分类号： A61K9/0024
摘要： Methods and compositions for systemically or locally administering a beneficial agent to a subject are described, and include, for example, implantable elastomeric depot compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible, elastomeric polymer, a biocompatible solvent having low water miscibility that forms an elastomeric viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.
摘要翻译：描述了用于向受试者全身或局部施用有益剂的方法和组合物，并且包括例如可植入的弹性体贮库组合物，其可以注射到期望的位置并且可以在延长的持续时间内提供有益剂的受控释放时间。组合物包括生物相容的弹性体聚合物，具有低水混溶性的生物相容性溶剂，其与聚合物形成弹性体粘性凝胶并限制植入物吸收水分，以及有益剂。

23. 发明授权

US06866860B2 Cationic alkyd polyesters for medical applications 有权
标题翻译：阳离子醇酸聚酯用于医疗应用
公开(公告)号：US06866860B2
公开(公告)日：2005-03-15
申请号：US10323367
申请日：2002-12-19
申请人： Aruna Nathan
发明人： Aruna Nathan
IPC分类号： C08G63/685 , A61L27/18 , A61L27/58 , A61F2/00 , A61K31/70 , B32B7/02
CPC分类号： A61L27/58 , A61L27/18 , Y10S514/802 , Y10S514/816 , Y10T428/249921 , Y10T428/249953 , Y10T428/249958 , Y10T428/2982 , Y10T428/31786
摘要： The present invention is directed to medical devices or pharmaceutical composition, each containing a synthetic, biodegradable, biocompatible polymer that is the reaction product of a polybasic acid or derivative thereof, a monoglyceride, and a cationic polyol.
摘要翻译：本发明涉及医疗器械或药物组合物，其各自含有合成的，可生物降解的生物相容性聚合物，其是多元酸或其衍生物，单酸甘油酯和阳离子多元醇的反应产物。

24. 发明授权

US07326426B2 Compositions and medical devices utilizing bioabsorbable liquid polymers 有权
标题翻译：使用生物可吸收液体聚合物的组合物和医疗器械
公开(公告)号：US07326426B2
公开(公告)日：2008-02-05
申请号：US10112201
申请日：2002-03-29
申请人： Aruna Nathan , Joel Rosenblatt , Steven C. Arnold
发明人： Aruna Nathan , Joel Rosenblatt , Steven C. Arnold
IPC分类号： A61K9/14 , A61K31/74 , A61K47/30
CPC分类号： A61K9/0024 , A61K9/1647 , A61L27/18 , A61L27/58 , A61L31/06 , A61L31/148 , C08L67/08
摘要： The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry.
摘要翻译：本发明涉及包含合成的，生物可吸收的生物相容性液体聚合物的医疗装置和药物组合物，其是多元酸或其衍生物，多元醇和脂肪酸的反应产物，液体聚合物的熔点小于约 40℃，通过差示扫描量热法测定。

25. 发明申请

US20070299516A1 PUNCTAL PLUGS FOR THE DELIVERY OF ACTIVE AGENTS 有权
标题翻译：用于交付活性药剂的阴囊
公开(公告)号：US20070299516A1
公开(公告)日：2007-12-27
申请号：US11759269
申请日：2007-06-07
申请人： Han Cui , Zhigang Li , Edgar Menezes , Aruna Nathan , Michael Trezza
发明人： Han Cui , Zhigang Li , Edgar Menezes , Aruna Nathan , Michael Trezza
IPC分类号： A61F2/14
CPC分类号： A61F9/0017 , A61F9/00772 , A61K9/0051
摘要： The invention provides punctal plugs for the delivery of active agent to one or both of the tear fluid of the eye and to the nasolacrimal duct that comprise a body, at least one cap, and optionally a collarette.
摘要翻译：本发明提供了用于将活性剂递送到眼睛的泪液和包括身体，至少一个帽和任选的肩胛骨的鼻泪管的一个或两个的泪点。

26. 发明申请

US20070190101A1 Flowable bone grafts 审中-公开
标题翻译：可流动的骨移植物
公开(公告)号：US20070190101A1
公开(公告)日：2007-08-16
申请号：US10815000
申请日：2004-03-31
申请人： Chunlin Yang , Jacky Au-Yeung , Iksoo Chun , Mark Davis , Lu Liu , Aruna Nathan , Vivek Shenoy , Mark Timmer
发明人： Chunlin Yang , Jacky Au-Yeung , Iksoo Chun , Mark Davis , Lu Liu , Aruna Nathan , Vivek Shenoy , Mark Timmer
IPC分类号： A61K35/32 , A61K38/17 , A61K38/18
CPC分类号： A61K38/39 , A61K35/28 , A61K38/00 , A61L27/26 , A61L27/3608 , A61L27/365 , A61L27/46 , A61L27/50 , A61L2400/06 , A61L2430/02 , C08L89/06
摘要： The present invention is directed to bone graft compositions suitable for administration to the body via a cannula, where the compositions contain mineralized collagen particles and a fluid biocompatible carrier having the mineralized collagen particles substantially uniformly distributed there through, which particles contain bound mineralized collagen fibrils substantially uniformly distributed there through and a binder for the fibrils; and to methods of making such particles.
摘要翻译：本发明涉及适于通过插管向身体施用的骨移植组合物，其中组合物含有矿化胶原颗粒和具有基本均匀分布在其中的矿化胶原颗粒的流体生物相容性载体，该颗粒基本上包含结合的矿化胶原原纤维均匀地分布在那里，以及用于原纤维的粘合剂; 以及制备这种颗粒的方法。

27. 发明申请

US20070184084A1 IMPLANTABLE ELASTOMERIC CAPROLACTONE DEPOT COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：可植入式弹性体夹心剂组合物及其用途
公开(公告)号：US20070184084A1
公开(公告)日：2007-08-09
申请号：US11554540
申请日：2006-10-30
申请人： Guohua Chen , Lothar Kleiner , Paul Houston , Aruna Nathan , Joel Rosenblatt
发明人： Guohua Chen , Lothar Kleiner , Paul Houston , Aruna Nathan , Joel Rosenblatt
IPC分类号： A61K48/00 , A61K38/16 , A61K38/17 , A61K31/715 , A61K38/43 , A61K31/56
CPC分类号： A61K9/0024
摘要： Methods and compositions for systemically or locally administering a beneficial agent to a subject are described, and include, for example, implantable elastomeric depot compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible, elastomeric caprolactone copolymer, a biocompatible solvent having low water miscibility that forms an elastomeric viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.
摘要翻译：描述了用于向受试者全身或局部施用有益剂的方法和组合物，并且包括例如可植入的弹性体贮库组合物，其可以注射到期望的位置并且可以在延长的持续时间内提供有益剂的受控释放时间。组合物包括生物相容的弹性体己内酯共聚物，具有低水混溶性的生物相容性溶剂，其与聚合物形成弹性粘性凝胶并限制植入物吸收水分，以及有益剂。

28. 发明申请

US20060286171A1 Bone morphogenetic protein formulations 审中-公开
标题翻译：骨形态发生蛋白制剂
公开(公告)号：US20060286171A1
公开(公告)日：2006-12-21
申请号：US11156153
申请日：2005-06-17
申请人： Tianhong Zhou , Chunlin Yang , Jeffery Geesin , Aruna Nathan , Joseph Hammer
发明人： Tianhong Zhou , Chunlin Yang , Jeffery Geesin , Aruna Nathan , Joseph Hammer
IPC分类号： A61K38/17 , A61K31/724 , A61K31/4172 , A61K31/198
CPC分类号： A61K38/1841 , A61K38/1875 , A61L17/005 , A61L17/145 , A61L27/227 , A61L27/34 , A61L27/54 , A61L31/047 , A61L31/10 , A61L31/16 , A61L2300/414
摘要： Protein formulations that can be lyophilized and are stable in organic solvents. The formulations contain bone morphogenetic proteins, lyoprotectants, and oxidation/reduction stabilizers. Optionally, the formulations may also contain solvent environment stabilizers. The protein formulations can be incorporated into a polymeric matrix to make medical devices for delivering the protein, and coatings for medical devices.
摘要翻译：蛋白质制剂可以冻干，在有机溶剂中稳定。制剂含有骨形态发生蛋白，冻干保护剂和氧化/还原稳定剂。任选地，制剂还可以含有溶剂环境稳定剂。蛋白质制剂可以掺入聚合物基质中以制备用于递送蛋白质的医疗装置和用于医疗装置的涂层。

29. 发明申请

US20060141005A1 Compositions and medical devices utilizing bioabsorbable polymeric waxes 审中-公开
标题翻译：使用生物可吸收聚合物蜡的组合物和医疗装置
公开(公告)号：US20060141005A1
公开(公告)日：2006-06-29
申请号：US11342097
申请日：2006-03-10
申请人： Aruna Nathan , Joel Rosenblatt , Steven Arnold
发明人： Aruna Nathan , Joel Rosenblatt , Steven Arnold
IPC分类号： A61K38/18 , A61F2/00
CPC分类号： A61K9/7007 , A61K9/1647 , A61K9/204 , A61L17/005 , A61L17/145 , A61L27/18 , A61L27/46 , A61L27/58 , A61L31/06 , A61L31/148 , A61L2300/602 , Y10T428/1352 , C08L67/08
摘要： The present invention is directed to medical devices, pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry.
摘要翻译：本发明涉及医疗器械，药物或农业组合物和种子，其各自含有合成的，生物可吸收的生物相容性聚合物蜡，其是多元酸或其衍生物，多元醇和脂肪酸的反应产物，聚合物蜡具有通过差示扫描量热法测定的低于约70℃的熔点。

30. 发明授权

US5766584A Inhibition of vascular smooth muscle cell proliferation with implanted matrix containing vascular endothelial cells 失效
标题翻译：用含有血管内皮细胞的植入基质抑制血管平滑肌细胞增殖
公开(公告)号：US5766584A
公开(公告)日：1998-06-16
申请号：US458978
申请日：1995-06-02
申请人： Elazer R. Edelman , Aruna Nathan , Matthew A. Nugent
发明人： Elazer R. Edelman , Aruna Nathan , Matthew A. Nugent
IPC分类号： A61L27/00 , A61K35/12 , A61L27/50 , A61L31/00 , C12N5/071 , C12N11/00 , C12N11/08 , C12N5/00
CPC分类号： C12N5/069 , A61L27/507 , A61L31/005 , A61K35/12 , C12N2533/54
摘要： A composition and method are provided for inhibition of vascular smooth muscle cell proliferation following injury to the endothelial cell lining of a blood vessel such as resulting from angioplasty, vascular bypass surgery or organ transplantation. The composition is a matrix such as a biodegradable hydrogel made of a synthetic polymer, protein or polysaccharide seeded with vascular endothelial cells which can be xenografts, allografts or autografts, or genetically engineered cells. Attachment of cells to the matrix can be enhanced by coating with collagen, laminin, fibronectin, fibrin, basement membrane components or attachment peptides. Biologically active compounds such as anti-inflammatory agents may also be contained in the matrix. In the method, the matrix containing endothelial cells is implanted in a patient at a site adjacent the injury such as by wrapping the matrix around the blood vessel. The endothelial cells secrete products that diffuse into surrounding tissue but do not migrate to the endothelial cell lining of the blood vessel. The endothelial cells may be obtained by biopsy of the patient into which the matrix is implanted and the cells can be cultured in the matrix in vitro and then implanted in vivo.
摘要翻译：提供了一种组合物和方法，用于在血管成形术，血管旁路手术或器官移植导致的血管内皮细胞内膜损伤后抑制血管平滑肌细胞增殖。该组合物是一种基质，例如由可以是异种移植物，同种异体移植物或自体移植物或基因工程细胞的合成聚合物，蛋白质或多糖接种的血管内皮细胞制成的可生物降解的水凝胶。可以通过用胶原，层粘连蛋白，纤连蛋白，纤维蛋白，基底膜组分或附着肽进行包被来增强细胞对基质的附着。生物活性化合物如抗炎剂也可以包含在基质中。在该方法中，将包含内皮细胞的基质植入患者附近的部位，例如通过将基质缠绕在血管周围。内皮细胞分泌扩散到周围组织中的产物，但不迁移到血管的内皮细胞衬里。内皮细胞可以通过移植基质的患者的活组织检查获得，并且细胞可以在体外在基质中培养，然后在体内植入。

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