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21. 发明授权

US07288517B2 Treatment of dementia and neurodegenerative diseases with intermediate doses of LHRH antagonists 失效
标题翻译：用中等剂量的LHRH拮抗剂治疗痴呆和神经退行性疾病
公开(公告)号：US07288517B2
公开(公告)日：2007-10-30
申请号：US10133967
申请日：2002-04-27
申请人： Jürgen Engel , Rainer Voegeli
发明人： Jürgen Engel , Rainer Voegeli
IPC分类号： A01N37/18 , A61K38/00
CPC分类号： A61K38/09 , Y10S514/80
摘要： The present invention relates to the treatment of dementia and neurodegenerative diseases like Alzheimer's disease with intermediate doses of LHRH antagonists which do not cause a castration. A preferred LHRH antagonist is cetrorelix.
摘要翻译：本发明涉及治疗痴呆和神经退行性疾病如阿尔茨海默病与中等剂量的不引起阉割的LHRH拮抗剂。优选的LHRH拮抗剂是西曲瑞克。

22. 发明授权

US06506393B2 Methods of treating protozoal diseases 有权
标题翻译：治疗原生动物疾病的方法
公开(公告)号：US06506393B2
公开(公告)日：2003-01-14
申请号：US09799505
申请日：2001-03-07
申请人： Hansjörg Eibl , Clemens Unger , Jürgen Engel
发明人： Hansjörg Eibl , Clemens Unger , Jürgen Engel
IPC分类号： A61K600
CPC分类号： A61K31/685 , Y02A50/409 , Y02A50/411 , Y10S514/859 , Y10S514/928 , A61K2300/00
摘要： The invention concerns a new pharmaceutical agent for oral or topical administration in the treatment of protozoal diseases, in particular of leishmaniasis, which contains as the active substance one or several compounds having the general formula I in which R1 is a saturated or monounsaturated or polyunsaturated hydrocarbon residue with 12 to 20 C atoms and R2, R3 and R4 denote independently of one another hydrogen, a C1-C5 alkyl group, a C3-C6 cycloalkyl group or a C1-C5 hydroxyalkyl group whereby two of the residues R2, R3 and R4 can together form a C2-C5 alkylene group which, if desired, can be substituted with an —O—, —S— or NR5 group, in which R5 is hydrogen, a C1-C5 alkyl group, a C3-C6 cycloalkyl group or a C1-C5 hydroxyalkyl group as well as, if desired the usual pharmaceutical auxiliary, diluting, carrier or/and filling substances.
摘要翻译：本发明涉及用于治疗原生动物疾病，特别是利什曼病的新的药物，其含有作为活性物质的一种或几种具有通式Iin的化合物，其中R 1是饱和或不饱和或多不饱和烃残基具有12至20个C原子且R 2，R 3和R 4彼此独立地表示氢，C 1 -C 5烷基，C 3 -C 6环烷基或C 1 -C 5羟烷基，其中残基R 2，R 3和R 4中的两个可以一起形成C 2 -C 5亚烷基，如果需要，其可以被-O - ， - S-或NR 5基团取代，其中R 5是氢，C 1 -C 5烷基，C 3 -C 6环烷基或 C1-C5羟烷基，以及如果需要，通常的药物辅助剂，稀释剂，载体或/和填充物质。

23. 发明授权

US08921318B2 Application of initial doses of LHRH analogues and maintenance doses of LHRH antagonists for the treatment of hormone-dependent cancers and corresponding pharmaceutical kits 有权
标题翻译：应用初始剂量的LHRH类似物和维持剂量的LHRH拮抗剂用于治疗激素依赖性癌症和相应的药物试剂盒
公开(公告)号：US08921318B2
公开(公告)日：2014-12-30
申请号：US11834707
申请日：2007-08-07
申请人： Jürgen Engel , Oliver Bauer
发明人： Jürgen Engel , Oliver Bauer
IPC分类号： A61K38/09 , A61P5/04 , A61K38/24 , C07K7/23
CPC分类号： A61K38/09 , C07K7/23 , A61K2300/00
摘要： LHRH analogs and LHRH antagonists for use in the treatment or prophylaxis of hormone-dependent cancers, in particular prostate cancer, prostate carcinoma and/or advanced prostate carcinoma, by administering an initial dose of an LHRH analog over a first period sufficient to effect hormonal castration, then administering a maintenance dose of an LHRH antagonist over a second period, the dose being insufficient to achieve and/or maintain hormonal castration.
摘要翻译： LHRH类似物和LHRH拮抗剂，用于治疗或预防激素依赖性癌症，特别是前列腺癌，前列腺癌和/或晚期前列腺癌，通过在足以实现激素阉割的第一时期施用初始剂量的LHRH类似物，然后在第二时期内施用维持剂量的LHRH拮抗剂，所述剂量不足以实现和/或维持激素去势。

24. 发明授权

US07790686B2 Injection solution of an LHRH antagonist 有权
标题翻译： LHRH拮抗剂注射溶液
公开(公告)号：US07790686B2
公开(公告)日：2010-09-07
申请号：US11711235
申请日：2007-02-27
申请人： Werner Sarlikiotis , Horst Bauer , Matthias Rischer , Jürgen Engel , Frank Güthlein , Dominique Di Stefano
发明人： Werner Sarlikiotis , Horst Bauer , Matthias Rischer , Jürgen Engel , Frank Güthlein , Dominique Di Stefano
IPC分类号： A61K38/00
CPC分类号： A61K31/19 , A61K9/0019 , A61K38/09 , A61K47/26
摘要： An aqueous injectable solution of an LHRH antagonist, such as Cetrorelix, in an organic, pharmaceutically acceptable acid, such as gluconic acid.
摘要翻译： LHRH拮抗剂的注射用水溶液，例如Cetrorelix，在有机的药学上可接受的酸如葡萄糖酸中。

25. 发明申请

US20100189784A1 Use of Alkylphophocholine in Combination with Antitumor Medication for the Treatment of Benign and Malignant Oncoses in Humans and Mammals 有权
标题翻译：使用烷基磷酰胆碱与抗肿瘤药物联合治疗人类和哺乳动物中良性和恶性肿瘤
公开(公告)号：US20100189784A1
公开(公告)日：2010-07-29
申请号：US12751608
申请日：2010-03-31
申请人： Jürgen Engel , Eckhard Günther , Herbert Sindermann
发明人： Jürgen Engel , Eckhard Günther , Herbert Sindermann
IPC分类号： A61K9/28 , A61K31/685 , A61K31/7068 , A61K9/12 , A61P35/00
CPC分类号： A61K45/06 , A61K31/685 , A61K2300/00
摘要： The invention relates to pharmaceutical compositions comprising alkylphosphocholines and antimetabolite antitumor substances. The pharmaceutical compositions of the invention are useful for the treatment of benign and malignant oncoses in humans and animals. Preferred alkylphosphocholines are described by the Formula II. One such preferred alkylphosphocholine is perifosine.
摘要翻译：本发明涉及包含烷基磷酸胆碱和抗代谢物抗肿瘤物质的药物组合物。本发明的药物组合物可用于治疗人和动物中的良性和恶性肿瘤。优选的烷基磷酰胆碱由式II描述。一种这样优选的烷基磷酸胆碱是丝胶黄素。

26. 发明申请

US20100104828A1 Moulded Skin and Method for Production Thereof 审中-公开
标题翻译：成型皮肤及其生产方法
公开(公告)号：US20100104828A1
公开(公告)日：2010-04-29
申请号：US12582314
申请日：2009-10-20
申请人： Jürgen Engel , Norbert Bonhoff , Rob Chimelak , Godefroy Beau
发明人： Jürgen Engel , Norbert Bonhoff , Rob Chimelak , Godefroy Beau
IPC分类号： B44C1/26 , B44C5/04 , B29C45/14 , B29C70/84
CPC分类号： B44C1/26 , B29C44/146 , B29C45/1418 , B29C45/14262 , B29C51/04 , B29C51/08 , B29C51/10 , B29C51/12 , B29C70/78 , B29C2045/14245 , B29C2791/006 , B29K2705/00 , B29K2711/14 , B29L2031/3041 , B44C5/0453 , Y10T428/24802
摘要： A method is for production of a moulded skin. The method includes a) inserting a film into a clamping frame; b) moving a positive mould relative to the clamping frame for pre-shaping of the film; c) impressing an insert on a side of the film which is orientated away from the positive mould; d) moving the positive mould into a negative mould which corresponds at least in regions; and e) applying a low pressure from the negative mould in order to emboss at least one of a shape and a surface structure of the negative mould onto the film fitted with the insert.
摘要翻译：一种用于生产模制皮肤的方法。该方法包括：a）将胶片插入夹紧框架; b）相对于夹紧框架移动正模具以预成型薄膜; c）将胶片上的插入物压向远离正模的方向; d）将正模移动到至少对应于区域的负模具中; 以及e）从所述负模具施加低压以将所述负模具的形状和表面结构中的至少一个压印到装配有所述插入件的所述膜上。

27. 发明授权

US06780972B2 Method for the synthesis of peptide salts, their use and the pharmaceutical preparations, containing peptide salts 失效
标题翻译：合成肽盐的方法，其用途和药物制剂，含有肽盐
公开(公告)号：US06780972B2
公开(公告)日：2004-08-24
申请号：US09939532
申请日：2001-08-24
申请人： Michael Damm , Waldemar Salonek , Jürgen Engel , Horst Bauer , Gabriele Stach
发明人： Michael Damm , Waldemar Salonek , Jürgen Engel , Horst Bauer , Gabriele Stach
IPC分类号： C07K100
CPC分类号： C07K1/113 , A61K38/00 , C07K7/23
摘要： A method for producing peptide salts, including reacting an acid addition salt of a basic starting peptide in the presence of a diluent in a mixed bed ion exchanger, with a mixture of an acid and a basic ion exchanger during the formation of a free basic peptide, and then separating the ion exchanger and then the free basic peptide, with an inorganic or organic acid, and then forming the desired acid addition salt of the peptide, and removing the diluent.
摘要翻译：一种生产肽盐的方法，包括在混合床离子交换剂中的稀释剂存在下使碱性起始肽的酸加成盐与游离碱性肽形成期间的酸和碱式离子交换剂的混合物反应，然后用无机或有机酸分离离子交换剂然后游离碱性肽，然后形成肽的所需酸加成盐，并除去稀释剂。

28. 发明授权

US06696428B2 Use of dopamine receptor antagonists in palliative tumor therapy 失效
标题翻译：多巴胺受体拮抗剂在姑息性肿瘤治疗中的应用
公开(公告)号：US06696428B2
公开(公告)日：2004-02-24
申请号：US10210881
申请日：2002-08-02
申请人： Bernd Nickel , Peter Hilgard , Thomas Klenner , Jürgen Engel
发明人： Bernd Nickel , Peter Hilgard , Thomas Klenner , Jürgen Engel
IPC分类号： A61K31685
CPC分类号： A61K31/685 , A61K31/454 , A61K2300/00
摘要： The side effect of decrease in body weight caused by the alkylphosphocholines such as miltefosine can be antagonized by certain acetylcholine receptor antagonists such as domperidone and pimozide. The combination of alkylphosphocholine plus the antagonist does not have any effect on the anti-tumor action of the alkylphosphocholine. The combination also caused no new side effects in the animals.
摘要翻译：某些乙酰胆碱受体拮抗剂如多潘立酮和匹莫齐特可以拮抗由诸如米替芬等烷基磷酰胆碱引起的体重下降的副作用。烷基磷酸加上拮抗剂的组合对烷基磷酸胆碱的抗肿瘤作用没有任何影响。该组合也不会在动物中产生新的副作用。

29. 发明授权

US06693119B2 Indolyl-3-glyoxylic acid derivatives having therapeutically valuable properties 失效
标题翻译：具有治疗有价值性质的吲哚基-3-乙醛酸衍生物
公开(公告)号：US06693119B2
公开(公告)日：2004-02-17
申请号：US09492531
申请日：2000-01-27
申请人： Bernd Nickel , Gerald Bacher , Thomas Klenner , Thomas Beckers , Peter Emig , Jürgen Engel , Erik Bruyneel , Günter Kamp , Kirsten Peters
发明人： Bernd Nickel , Gerald Bacher , Thomas Klenner , Thomas Beckers , Peter Emig , Jürgen Engel , Erik Bruyneel , Günter Kamp , Kirsten Peters
IPC分类号： A61K3144
CPC分类号： A61K31/496 , A61K31/404 , A61K31/4178 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4709
摘要： The invention relates to the use of N-substituted indole-3-glyoxylamides of the general Formula I and to pharmaceutical compositions having antitumor action.
摘要翻译：本发明涉及通式I的N-取代吲哚-3-乙醛酰胺与具有抗肿瘤作用的药物组合物的用途。

30. 发明授权

US06436924B1 Antihistamine leukotriene combinations 有权
公开(公告)号：US06436924B1
公开(公告)日：2002-08-20
申请号：US09784640
申请日：2001-02-15
申请人： Hildegard Poppe , Jürgen Engel , István Szelényi
发明人： Hildegard Poppe , Jürgen Engel , István Szelényi
IPC分类号： A61K3155
摘要： The invention relates to a pharmaceutical composition for the treatment of allergic rhinitis, vasomotor rhinitis, and allergic conjunctivitis, which comprises (a) a nonsedating antihistamine or a pharmaceutically acceptable salt thereof, (b) a leukotriene D4 antagonist, or a 5-lipoxygenase inhibitor, or a FLAP antagonist, or a pharmaceutically acceptable salt thereof, and (c) one or more of a conventional pharmaceutical vehicle, extender, and excipient, and to its use for manufacturing a composition for the treatment of allergic rhinitis, vasomotor rhinitis, and allergic conjunctivitis.

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