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21. 发明授权

US5146334A Video signal processing device for image editing using memory 失效
标题翻译：用于使用存储器进行图像编辑的视频信号处理装置
公开(公告)号：US5146334A
公开(公告)日：1992-09-08
申请号：US481982
申请日：1990-02-20
申请人： Tsutomu Fukatsu , Tadayoshi Nakayama , Yoshihiro Nakatani , Hisataka Hirose , Chikara Sato , Kenichi Nagasawa
发明人： Tsutomu Fukatsu , Tadayoshi Nakayama , Yoshihiro Nakatani , Hisataka Hirose , Chikara Sato , Kenichi Nagasawa
IPC分类号： H04N5/262 , H04N5/265
CPC分类号： H04N5/2621 , H04N5/262 , H04N5/2622 , H04N5/2628 , H04N5/265
摘要： A video signal processing device is arranged to obtain a signal representing a difference between an input video signal and a signal read out from a memory to which either the input video signal or an input video signal is supplied, to supply the difference signal to a multiplier which uses a variable coefficient, and to add the output of the multiplier to the input video signal.
摘要翻译：视频信号处理装置被配置为获得表示输入视频信号和从输入视频信号或输入视频信号所提供的存储器读出的信号之间的差异的信号，以将差分信号提供给乘法器其使用可变系数，并将乘法器的输出添加到输入视频信号。

22. 发明授权

US10766937B2 Compositions and methods of treating cancer 有权
公开(公告)号：US10766937B2
公开(公告)日：2020-09-08
申请号：US14343022
申请日：2012-09-06
申请人： Yoshihiro Nakatani
发明人： Yoshihiro Nakatani
IPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides compositions and methods of treating various disorders associated with aberrant cell growth.

23. 发明申请

US20150045308A1 Compositions and Methods of Treating Cancer 审中-公开
标题翻译：治疗癌症的组合物和方法
公开(公告)号：US20150045308A1
公开(公告)日：2015-02-12
申请号：US14343022
申请日：2012-09-06
申请人： Yoshihiro Nakatani
发明人： Yoshihiro Nakatani
IPC分类号： C07K14/47
CPC分类号： C07K14/4747 , A61K38/00 , C07K14/4702
摘要： The present invention provides compositions and methods of treating various disorders associated with aberrant cell growth.
摘要翻译：本发明提供了治疗与异常细胞生长相关的各种疾病的组合物和方法。

24. 发明授权

US08213791B2 Communication light detecting device 有权
标题翻译：通信光检测装置
公开(公告)号：US08213791B2
公开(公告)日：2012-07-03
申请号：US12465735
申请日：2009-05-14
申请人： Seiji Kojima , Kanako Suzuki , Yoshihiro Nakatani , Toshihiko Ishikawa , Takao Nishikawa , Kojiro Ito , Tetsuya Sueoka
发明人： Seiji Kojima , Kanako Suzuki , Yoshihiro Nakatani , Toshihiko Ishikawa , Takao Nishikawa , Kojiro Ito , Tetsuya Sueoka
IPC分类号： H04B10/08
CPC分类号： G02B6/4201 , G02B6/4219 , G02B6/424 , G02B6/4259 , G02B6/4286 , G02B6/429
摘要： A communication light detecting device interconnecting light transmission paths and collocated therebetween, comprises: an optical coupling body including a core portion for photo coupling with the light transmission paths, and a light extracting portion for extracting a part of the communication light as a leakage light; and a light detecting portion having a light receiving member for receiving the leakage light. The light extracting portion is preferable to possess a lower refractive index than that of the core portion. Besides, the light extracting portion is preferable to include a light detecting use groove with a groove width of 50 μm or more and 140 μm or less formed by cutting and separating the core portion. Besides, the light extracting portion is preferable to be the optical coupling body in which outer diameter of the core portion is different from the outer diameter of a core of the light transmission path.
摘要翻译：一种将光传输路径互连并配置在其间的通信光检测装置，包括：光耦合体，包括用于与所述光传输路径进行光耦合的芯部;以及光提取部，用于将所述通信光的一部分提取为泄漏光; 以及具有用于接收泄漏光的光接收部件的光检测部。光提取部优选具有比芯部更低的折射率。此外，光提取部优选包括通过切割和分离芯部而形成的沟宽度为50μm以上且140μm以下的光检测用槽。此外，光提取部优选为芯部的外径与光传输路径的芯的外径不同的光耦合体。

25. 发明申请

US20060160984A1 Biodegradable material and process for producing the same 审中-公开
标题翻译：生物降解材料及其生产方法
公开(公告)号：US20060160984A1
公开(公告)日：2006-07-20
申请号：US10569966
申请日：2004-10-20
申请人： Naotsugu Nagasawa , Toshiaki Yagi , Fumio Yoshii , Shin-ichi Kanazawa , Kiyoshi Kawano , Yoshihiro Nakatani , Hiroshi Mitomo
发明人： Naotsugu Nagasawa , Toshiaki Yagi , Fumio Yoshii , Shin-ichi Kanazawa , Kiyoshi Kawano , Yoshihiro Nakatani , Hiroshi Mitomo
IPC分类号： C08G63/02
CPC分类号： C08F283/02 , C08F226/06
摘要： A biodegradable aliphatic polyester, such as polylactic acid, is mixed with a monomer having allyl and molded into a molding having the crosslinking degree of the biodegradable aliphatic polyester increased. Thereafter, the molding is exposed to ionizing radiation to thereby obtain a molding excelling in heat resistance. Triallyl isocyanurate or triallyl cyanurate is used as the monomer having allyl.
摘要翻译：将可生物降解的脂肪族聚酯如聚乳酸与具有烯丙基的单体混合并成型为具有可生物降解的脂肪族聚酯的交联度增加的成型体。此后，将模制品暴露于电离辐射，从而获得耐热性优异的模制品。三烯丙基异氰脲酸酯或三烯丙基氰脲酸酯用作具有烯丙基的单体。

26. 发明授权

US07067646B2 Methods and compositions for modulating tumor suppression 失效
公开(公告)号：US07067646B2
公开(公告)日：2006-06-27
申请号：US10107521
申请日：2002-03-25
申请人： Yoshihiro Nakatani
发明人： Yoshihiro Nakatani
IPC分类号： C07H19/00 , C07H21/04
CPC分类号： C07K14/4736 , A61K38/00 , C07K14/47
摘要： The purification of native RB (retinoblastoma) as a complex, including P107, P130, and a 600 kDa subunit, termed MTAF600 (microtubule associated factor 600) is described. MTAF600 binds to RB regardless of the phosphorylation status of RB, and binds to RB without disrupting the interaction between RB and E2F. It is further shown that E2F and DP proteins co-purified with MTAF600 and RB, such that hypophosphorylated RB may gain access to E2F as a complex with MTAF600. In addition, MTAF600 binds to microtubules and plays a role in active repression of E2F-responsive genes, cell cycle arrest, and genomic stability. The sequence of MTAF600 is described herein, along with its binding properties to proteins such as RB and microtubules, and its sequence homology. Further, methods and reagents for assaying the presence of MTAF600 or mutants thereof, pharmaceutical formulations, and methods for treating disease are also described.

27. 发明授权

US6014179A Apparatus and method for processing video signals with different aspect ratios 失效
标题翻译：用于处理不同宽高比的视频信号的装置和方法
公开(公告)号：US6014179A
公开(公告)日：2000-01-11
申请号：US822504
申请日：1997-03-24
申请人： Takashi Kobayashi , Hiroyuki Takimoto , Taizou Hori , Hiroyuki Fukuoka , Yoshihiro Nakatani , Jun Makino , Shinichi Koyama
发明人： Takashi Kobayashi , Hiroyuki Takimoto , Taizou Hori , Hiroyuki Fukuoka , Yoshihiro Nakatani , Jun Makino , Shinichi Koyama
IPC分类号： H04N5/44 , H04N7/01 , H04N7/087 , H04N7/088 , H04N9/79 , H04N9/82 , H04N5/46
CPC分类号： H04N7/0122 , H04N7/0135 , H04N7/087 , H04N7/088 , H04N9/7925 , H04N9/8205 , H04N9/8233
摘要： An apparatus and method for inputting one or more video signals, synthesizing the video signals and outputting the synthesized video signals with aspect information. The aspect information represents an aspect ratio of the synthesized video signal. The aspect information may be superposed within the vertical blanking period.
摘要翻译：一种用于输入一个或多个视频信号的装置和方法，合成视频信号并用方面信息输出合成的视频信号。方面信息表示合成视频信号的宽高比。方面信息可以叠加在垂直消隐期内。

28. 发明授权

US5627047A Astrocyte-specific transcription of human genes 失效
标题翻译：人类基因的星形胶质细胞特异性转录
公开(公告)号：US5627047A
公开(公告)日：1997-05-06
申请号：US197463
申请日：1994-02-16
申请人： Michael Brenner , Francois Besnard , Yoshihiro Nakatani
发明人： Michael Brenner , Francois Besnard , Yoshihiro Nakatani
IPC分类号： C07K14/47 , C12N15/85 , C12N15/10 , C12N15/62
CPC分类号： C12N15/85 , C07K14/47 , C07K14/4711 , C12N15/8509 , A01K2217/05 , A01K2227/10 , A01K2267/03 , A01K2267/0318 , C12N2830/008 , C12N2830/85
摘要： Three unique control DNA sequences of the glial fibrillary acidic (gfa) protein gene have been identified upstream of its basal promoter that are capable of regulating astrocyte-specific transcription of the human gene for glial fibrillary acidic protein (GFAP). One or more of those three regions alone or together with the SV40 early promoter and SV40 enhancer control expression of endogenous or heterologous protein in astrocytes. Transgenic animals expressing amyloid protein can be prepared and used as a model for evaluating Alzheimer's disease. Many heterologous proteins can be expressed in the astrocytes so as to take advantage of the growing list of astrocyte functions. Such proteins include hormones, growth factors, and their receptors. Examples include basic fibroblast growth factor (bFGF), acidic FGF (aFGF), platelet derived growth factor (PDGF), insulin like growth factors 1 and 2 (IGF-1, IGF-2), epidermal growth factor (EGF), transforming growth factors .beta.-1 and .beta.-2 (TGF.beta.1, TGF.beta.2), and S100.beta.; other examples totalled proteins encoded by oncogenes like myc, fos, and erb-a, ion channels, like the calcium channel and the potassium channel, and metabolic enzymes, especially ones involved in processing drugs or neurotransmitters; e.g., glutamine synthetase. Additionally, in each case, a dominant dysfunctional protein, an antisense RNA, or a ribozyme, all of which can inhibit the function or production of the protein, can be expressed in astrocytes.
摘要翻译：已经在其基础启动子的上游鉴定了胶质纤维酸性（gfa）蛋白基因的三个独特的对照DNA序列，其能够调节神经胶质纤维酸性蛋白（GFAP）的人类基因的星形胶质细胞特异性转录。这三个区域中的一个或多个单独或与SV40早期启动子和SV40增强子一起控制内源或异源蛋白质在星形胶质细胞中的表达。可以制备表达淀粉样蛋白的转基因动物并用作评价阿尔茨海默病的模型。许多异源蛋白质可以在星形胶质细胞中表达，以便利用增长的星形胶质细胞功能列表。这些蛋白质包括激素，生长因子及其受体。实例包括碱性成纤维细胞生长因子（bFGF），酸性FGF（aFGF），血小板衍生生长因子（PDGF），胰岛素样生长因子1和2（IGF-1，IGF-2），表皮生长因子（EGF）因子β-1和β-2（TGFβ1，TGFβ2）和S100β; 其他实例总共由癌基因如myc，fos和erb-a编码的蛋白质，离子通道，如钙通道和钾通道，以及代谢酶，特别是涉及加工药物或神经递质的代谢酶; 例如谷氨酰胺合成酶。此外，在每种情况下，可以在星形胶质细胞中表达所有可以抑制蛋白质的功能或产生的显性功能障碍蛋白质，反义RNA或核酶。

29. 发明授权

US5132798A Special effect apparatus with power control 失效
标题翻译：具有电源控制功能的特殊效果器
公开(公告)号：US5132798A
公开(公告)日：1992-07-21
申请号：US624719
申请日：1990-12-03
申请人： Katsuji Yoshimura , Yoshihiro Nakatani , Tadayoshi Nakayama
发明人： Katsuji Yoshimura , Yoshihiro Nakatani , Tadayoshi Nakayama
IPC分类号： H04N5/225 , H04N5/262 , H04N5/265 , H04N5/77 , H04N5/92
CPC分类号： H04N5/2621 , H04N5/265 , H04N5/77 , H04N5/9205 , Y10S358/906
摘要： A special effect device comprising a first signal source, a second signal source, subtracting circuit, coefficient multiplying circuit, adding circuit, switch circuit and control circuit. The subtracting circuit is arranged to produce a difference signal between the signals of the first signal source and the second signal source. The coefficient multiplying circuit multiplies the difference from the subtracting circuit by a predetermined coefficient and the adding circuit adds the signals output from the first and second signal sources to the signal output from the multiplying circuit. The switch circuit selectively outputs the output of the first signal source or an output of the adding circuit. The control circuit is arranged to stop the supply of power to at least the subtracting circuit when the switch circuit is selectively outputting the output of the first signal source.
摘要翻译：一种特效装置，包括第一信号源，第二信号源，减法电路，系数乘法电路，加法电路，开关电路和控制电路。减法电路被布置成在第一信号源和第二信号源的信号之间产生差分信号。系数乘法电路将来自减法电路的差值乘以预定系数，并且加法电路将从第一和第二信号源输出的信号与从乘法电路输出的信号相加。开关电路选择性地输出第一信号源的输出或加法电路的输出。控制电路被布置为当开关电路选择性地输出第一信号源的输出时，停止向至少减法电路的电力供应。

30. 发明授权

US5003404A Video camera 失效
标题翻译：录影机
公开(公告)号：US5003404A
公开(公告)日：1991-03-26
申请号：US328872
申请日：1989-03-27
申请人： Katsuji Yoshimura , Yoshihiro Nakatani , Tadayoshi Nakayama
发明人： Katsuji Yoshimura , Yoshihiro Nakatani , Tadayoshi Nakayama
IPC分类号： H04N5/225 , H04N5/262 , H04N5/265 , H04N5/77 , H04N5/92
CPC分类号： H04N5/2621 , H04N5/265 , H04N5/77 , H04N5/9205 , Y10S358/906
摘要： A video camera includes in combination an image sensor, an image memory, a special effect circuit arranged to impart a special effect to the output signal of the image sensor by using the image memory, a selection circuit arranged to select either the output of the image sensor or that of the special effect circuit, and a control circuit which, in response to a pause of an image recording action, causes an image obtained when the pause is made to be stored in the image memory when the output of the special effect circuit is selected by the selection circuit.
摘要翻译：视频摄像机包括图像传感器，图像存储器，特殊效果电路，其被布置为通过使用图像存储器对图像传感器的输出信号赋予特殊效果;选择电路，被配置为选择图像的输出传感器或特殊效果电路的传感器，以及控制电路，其响应于图像记录动作的暂停，当在特殊效果电路的输出时使得暂停时获得的图像被存储在图像存储器中由选择电路选择。

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