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21. 发明授权

US08629126B2 Quinolone derivative or pharmaceutically acceptable salt thereof 失效
标题翻译：喹诺酮衍生物或其药学上可接受的盐
公开(公告)号：US08629126B2
公开(公告)日：2014-01-14
申请号：US13364815
申请日：2012-02-02
申请人： Yuji Koga , Takao Okuda , Susumu Watanuki , Takashi Kamikubo , Fukushi Hirayama , Hiroyuki Moritomo , Jiro Fujiyasu , Michihito Kageyama , Toshio Uemura , Jun Takasaki
发明人： Yuji Koga , Takao Okuda , Susumu Watanuki , Takashi Kamikubo , Fukushi Hirayama , Hiroyuki Moritomo , Jiro Fujiyasu , Michihito Kageyama , Toshio Uemura , Jun Takasaki
IPC分类号： A61K31/675 , A61K31/47
CPC分类号： C07D513/04 , C07D215/22 , C07D215/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07F7/1804 , C07F9/60
摘要： Disclosed are quinolone derivatives characterized in that these have lower alkyl, cycloalkyl or the like at the 1-position; —N(R0)C(O)-lower alkylene-CO2R0, lower alkylene-CO2R0, lower alkenylene-CO2R0, —O-lower alkylene-CO2R0, —O-(lower alkylene which may be substituted with —CO2R0)-aryl or —O-lower alkenylene-CO2R0 (wherein R0 is H or lower alkyl) at the 3-position; halogen at the 6-position; and amino group substituted with a substituent group having a ring structure at the 7-position, respectively, or pharmaceutically acceptable salts thereof, has excellent P2Y12 inhibitory activity. The quinolone derivatives have excellent platelet aggregation inhibitory activity. A method of using the compounds is also disclosed.
摘要翻译：公开了喹诺酮衍生物，其特征在于它们在1-位具有低级烷基，环烷基等; -N（R 0）C（O） - 低级亚烷基-CO 2 R 0，低级亚烷基-CO 2 R 0，低级亚烯基-CO 2 R O，-O-低级亚烷基-CO 2 R O，-O-（可被-CO 2 R 0取代的低级亚烷基） - 芳基或 O-低级亚烯基-CO 2 R 0（其中R 0是H或低级烷基）在3-位; 6位卤素; 分别被具有7位具有环结构的取代基取代的氨基或其药学上可接受的盐具有优异的P2Y12抑制活性。喹诺酮衍生物具有优异的血小板聚集抑制活性。还公开了使用该化合物的方法。

22. 发明授权

US08133882B2 Quinolone derivative or pharmaceutically acceptable salt thereof 失效
标题翻译：喹诺酮衍生物或其药学上可接受的盐
公开(公告)号：US08133882B2
公开(公告)日：2012-03-13
申请号：US12293055
申请日：2007-03-14
申请人： Yuji Koga , Takao Okuda , Susumu Watanuki , Takashi Kamikubo , Fukushi Hirayama , Hiroyuki Moritomo , Jiro Fujiyasu , Michihito Kageyama , Toshio Uemura , Jun Takasaki
发明人： Yuji Koga , Takao Okuda , Susumu Watanuki , Takashi Kamikubo , Fukushi Hirayama , Hiroyuki Moritomo , Jiro Fujiyasu , Michihito Kageyama , Toshio Uemura , Jun Takasaki
IPC分类号： A61K31/675 , A61K31/47 , C07D215/22 , C07F9/60
CPC分类号： C07D513/04 , C07D215/22 , C07D215/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07F7/1804 , C07F9/60
摘要： Provided are quinolone derivatives having a lower alkyl or cycloalkyl at the 1-position; —N(R0)C(O)-lower alkylene-CO2R0, lower alkylene-CO2R0, lower alkenylene-CO2R0, —O-lower alkylene-CO2R0, —O-(lower alkylene which may be substituted with —CO2R0)-aryl or —O-lower alkenylene-CO2R0 (wherein R0 is H or lower alkyl) at the 3-position; halogen at the 6-position; and amino group substituted with a substituent group having a ring structure at the 7-position, respectively, or pharmaceutically acceptable salts thereof. Pharmaceutical composition containing the quinolone derivatives and methods of using the compositions are provided.
摘要翻译：提供在1-位具有低级烷基或环烷基的喹诺酮衍生物; -N（R 0）C（O） - 低级亚烷基-CO 2 R 0，低级亚烷基-CO 2 R 0，低级亚烯基-CO 2 R O，-O-低级亚烷基-CO 2 R O，-O-（可被-CO 2 R 0取代的低级亚烷基） - 芳基或 O-低级亚烯基-CO 2 R 0（其中R 0是H或低级烷基）在3-位; 6位卤素; 分别被具有7-位上的环结构的取代基取代的氨基或其药学上可接受的盐。提供了含有喹诺酮衍生物的药物组合物和使用该组合物的方法。

23. 发明申请

US20100179137A1 PYRIDONE COMPOUND 审中-公开
标题翻译：吡咯烷酮化合物
公开(公告)号：US20100179137A1
公开(公告)日：2010-07-15
申请号：US12663246
申请日：2008-06-06
申请人： Takashi Kamikubo , Fukushi Hirayama , Masanori Miura , Yuriko Komiya , Takao Okuda , Keisuke Maki
发明人： Takashi Kamikubo , Fukushi Hirayama , Masanori Miura , Yuriko Komiya , Takao Okuda , Keisuke Maki
IPC分类号： A61K31/541 , C07D213/69 , A61K31/4412 , C07D213/64 , C07D401/10 , A61K31/4439 , C07D413/10 , C07D405/12 , A61K31/5377 , A61K31/444 , C07D401/12 , C07D409/06 , A61K31/4436 , C07D417/12 , A61K31/4545 , A61P9/10
CPC分类号： C07D213/64 , C07D213/69 , C07D401/10 , C07D405/12 , C07D409/06 , C07D413/10
摘要： [Solving Means] The present inventors have conducted extensive studies on an EP4 receptor agonist, and as a result, found that a novel pyridone compound characterized in that the 1-position in the pyridone ring is substituted with a group having an acidic group such as a carboxyl group and the 6-position is bonded with an aromatic ring group via lower alkyl, lower alkylene, ether, or thioether, has an excellent EP4 receptor agonistic action, thereby completing the present invention. Since the compound of the present invention has an excellent EP4 receptor agonistic action and a blood flow increasing action in the hindlimb of a rat, it is useful as a pharmaceutical, in particular, an agent for treating peripheral arterial occlusive disease.
摘要翻译：本发明人对EP4受体激动剂进行了广泛的研究，结果发现，新的吡啶酮化合物的特征在于吡啶酮环中的1位被具有酸性基团的基团取代，例如羧基和6-位通过低级烷基，低级亚烷基，醚或硫醚与芳环结合，具有优异的EP4受体激动作用，从而完成了本发明。由于本发明的化合物在大鼠的后肢中具有优异的EP4受体激动作用和血流增加作用，因此作为药物特别是治疗外周动脉闭塞性疾病的药物是有用的。

24. 发明授权

US07488739B2 Quinolone derivative or salt thereof 失效
标题翻译：喹诺酮衍生物或其盐
公开(公告)号：US07488739B2
公开(公告)日：2009-02-10
申请号：US10562128
申请日：2004-07-22
申请人： Susumu Watanuki , Yuji Koga , Hiroyuki Moritomo , Issei Tsukamoto , Daisuke Kaga , Takao Okuda , Fukushi Hirayama , Yumiko Moritani , Jun Takasaki
发明人： Susumu Watanuki , Yuji Koga , Hiroyuki Moritomo , Issei Tsukamoto , Daisuke Kaga , Takao Okuda , Fukushi Hirayama , Yumiko Moritani , Jun Takasaki
IPC分类号： A61K31/47 , C07D215/233 , C07D237/28 , C07D407/02
CPC分类号： C07D237/28 , A61K31/4709 , A61K31/4725 , C07D215/56 , C07D405/04 , C07F9/5765 , C07F9/60 , C07F9/650947
摘要： A platelet aggregation inhibitor comprising a quinolone derivative or a pharmaceutically acceptable salt thereof as an active ingredient, and a novel quinolone derivative or a pharmaceutically acceptable salt thereof useful as a platelet aggregation inhibitor.
摘要翻译：包含喹诺酮衍生物或其药学上可接受的盐作为活性成分的血小板聚集抑制剂和用作血小板聚集抑制剂的新型喹诺酮衍生物或其药学上可接受的盐。

25. 发明授权

US07361658B2 2-acylaminothiazole derivative or salt thereof 失效
标题翻译： 2-酰基氨基噻唑衍生物或其盐
公开(公告)号：US07361658B2
公开(公告)日：2008-04-22
申请号：US10564520
申请日：2004-07-15
申请人： Keizo Sugasawa , Yuji Koga , Kazuyoshi Obitsu , Takao Okuda , Koichiro Harada , Hideki Kubota , Fukushi Hirayama , Masaki Abe , Ken-ichi Suzuki
发明人： Keizo Sugasawa , Yuji Koga , Kazuyoshi Obitsu , Takao Okuda , Koichiro Harada , Hideki Kubota , Fukushi Hirayama , Masaki Abe , Ken-ichi Suzuki
IPC分类号： A61K31/4427 , A61K31/4523 , A61K31/496 , C07D403/12 , C07D401/12 , C07D211/26 , C07D401/14
CPC分类号： C07D417/14 , C07D417/04
摘要： 2-Acylaminothiazole derivatives or salts thereof which have a platelet increasing activity based on an excellent human c-mpl-Ba/F3 cell growth function and a function of accelerating formation of megakaryocytic colonies and which are useful for treating thrombocytopenia are provided.
摘要翻译：提供了基于优异的人c-mpl-Ba / F3细胞生长功能具有血小板增加活性的2-酰基氨基噻唑衍生物或其盐，并且具有促进巨核细胞集落形成并且可用于治疗血小板减少症的功能。

26. 发明申请

US20060075431A1 Apparatus, method, and computer program for processing information 有权
标题翻译：用于处理信息的装置，方法和计算机程序
公开(公告)号：US20060075431A1
公开(公告)日：2006-04-06
申请号：US11224962
申请日：2005-09-14
申请人： Tatsuo Nagamatsu , Kunitoshi Shimizu , Takao Okuda , Tsutomu Teranishi , Hiroshi Kawaguchi , Atsushi Mitsuzawa
发明人： Tatsuo Nagamatsu , Kunitoshi Shimizu , Takao Okuda , Tsutomu Teranishi , Hiroshi Kawaguchi , Atsushi Mitsuzawa
IPC分类号： H04N5/445 , H04N7/10 , H04N7/025 , G06F3/00
CPC分类号： G11B27/28 , G11B27/105 , G11B2220/20 , Y10S358/908
摘要： An information processing apparatus includes a selector for selecting removal information concerning contents to be removed, the removal information prepared on a per content basis for the contents to be removed and including a value uniquely determined from data within a data range of whole or part of a content to be removed, a first range that is the data range, and a second range that is a removal range represented by the position of the first range, a detector for detecting a range at a predetermined position within the whole content, having the same range as the first range contained in the removal information selected by the selector and the same value as the value uniquely determined and contained in the removal information, and a remover for removing a predetermined content based on the second range contained in the removal information selected by the selector if the detector detects the range at the predetermined position.
摘要翻译：一种信息处理装置，包括：选择器，用于选择关于要移除的内容的删除信息;按照内容准备的要删除的内容的删除信息，并且包括从全部或部分的数据范围内的数据唯一确定的值要删除的内容，作为数据范围的第一范围，以及作为第一范围的位置表示的移除范围的第二范围，用于检测在整个内容内的预定位置的范围的检测器，具有相同的范围作为由选择器选择的删除信息中包含的第一范围和与删除信息中唯一确定和包含的值相同的值;以及删除器，用于基于由删除信息选择的删除信息中包含的第二范围来删除预定内容如果检测器检测到在预定位置处的范围，则选择器。

27. 发明授权

US4540866A Induction heating apparatus 失效
标题翻译：感应加热装置
公开(公告)号：US4540866A
公开(公告)日：1985-09-10
申请号：US556110
申请日：1983-11-29
申请人： Takao Okuda
发明人： Takao Okuda
IPC分类号： H05B6/12 , A47J27/00 , H05B6/06 , H05B6/64 , H05B1/02
CPC分类号： H05B6/062
摘要： An induction heating apparatus which is adapted to stop heating when a load is abnormal and adjust the time period of turning on a switching element of an inverter circuit including an induction heating coil for the load to thereby adjust the input power for heating or the input power for the inverter circuit, so that the signal for controlling the switching element to be on-off is compared with the input of the load or the input of inverter circuit, thereby discriminating normality and abnormality of the load on the basis of the comparison results. Hence, the comparison is carried out under the reference corresponding to the intensity of the input to the load or the input to the inverter circuit, thereby enabling the rapid and reliable detection of abnormal load.
摘要翻译：一种感应加热装置，其适用于在负载异常时停止加热，并且调节将包括用于负载的感应加热线圈的逆变器电路的开关元件接通的时间段，从而调整用于加热的输入功率或输入功率对于逆变器电路，将用于控制开关元件的开关信号与开关元件的输入或逆变器电路的输入进行比较，从而基于比较结果来区分负载的正常和异常。因此，在与负载的输入强度或逆变器电路的输入强度对应的基准下进行比较，能够快速，可靠地检测异常负载。

28. 发明授权

US4390535A Antimicrobial 7-(.alpha.-acylamino-.alpha.-arylacetamido)-3-(substituted methyl)cephalosporin compounds 失效
标题翻译：抗菌剂7-（α-酰基氨基-α-芳基乙酰氨基）-3-（取代甲基）头孢菌素化合物
公开(公告)号：US4390535A
公开(公告)日：1983-06-28
申请号：US240666
申请日：1981-03-05
申请人： Hirotada Yamada , Kiyokazu Jimpo , Takao Okuda , Hiroshi Noguchi , Hisao Tobiki
发明人： Hirotada Yamada , Kiyokazu Jimpo , Takao Okuda , Hiroshi Noguchi , Hisao Tobiki
IPC分类号： A61K31/545 , C07D501/36 , C07D501/56
CPC分类号： C07D501/36 , C07D501/46
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or a (C.sub.1 -C.sub.4) alkyl group, X is a straight or branched chain C.sub.1 -C.sub.4 alkylene group and R.sub.2 is a carboxyl group or a sulfo group; and the pharmaceutically acceptable salts thereof exhibit strong inhibitory activities against a wide variety of Gram-positive and Gram-negative bacteria including Psendomonas aeruginosa, indolepositive Proteus and Enterobacter aerogenes, and also have an increased and prolonged serum level in a living body. The compounds are therefore useful as antibacterial agents for the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.
摘要翻译：其中R 1为氢或（C 1 -C 4）烷基，X为直链或支链C 1 -C 4亚烷基，R 2为羧基或磺基; 其药学上可接受的盐显示出对各种革兰氏阳性和革兰氏阴性细菌（包括铜绿假单胞菌，吲哚阳性变形杆菌和产气肠杆菌）的抑制活性，并且在活体中也具有增加和延长的血清水平。因此，这些化合物可用作治疗由革兰氏阳性和革兰氏阴性菌引起的感染性疾病的抗菌剂。

29. 发明授权

US4384055A Hard vinyl chloride resin composition for information signal recording media 失效
标题翻译：用于信息信号记录介质的硬质氯乙烯树脂组合物
公开(公告)号：US4384055A
公开(公告)日：1983-05-17
申请号：US302849
申请日：1981-09-16
申请人： Takao Okuda , Nobuhide Hada
发明人： Takao Okuda , Nobuhide Hada
IPC分类号： C08L27/00 , C08K3/02 , C08K3/04 , C08L1/00 , C08L27/06 , C08L33/00 , C08L33/02
CPC分类号： C08K3/04 , C08L27/06 , C08L2205/02
摘要： A hard vinyl chloride resin composition for information signal recording media, said composition consisting essentially of(A) 100 parts by weight of a copolymer having a specific viscosity of 0.16 to 0.31 and composed of 75 to 99% by weight of vinyl chloride, 1 to 10% by weight of ethylene and 0 to 15% by weight of another monomer copolymerizable with said monomers, and/or a polymer mixture having a specific viscosity of 0.16 to 0.31 and composed of at least two polymers selected so that the proportions of monomer components are the same as above, and(B) 15 to 30 parts by weight of carbon black having an oil absorption of 300 to 400 ml/100g and a surface area of at least 900 m.sup.2 /g.
摘要翻译：一种用于信息信号记录介质的硬质氯乙烯树脂组合物，所述组合物基本上由（A）100重量份的比粘度为0.16至0.31的共聚物和75至99重量％的氯乙烯组成，1至 10重量％的乙烯和0至15重量％的可与所述单体共聚的另一单体，和/或比粘度为0.16至0.31并由至少两种聚合物组成的聚合物混合物，其选择为使得单体成分与上述相同，（B）15〜30重量份的吸油量为300〜400ml / 100g，表面积为900m 2 / g以上的炭黑。

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