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    • 25. 发明授权
    • Carbamazepine hapten analogues
    • 卡马西平半抗原类似物
    • US5395933A
    • 1995-03-07
    • US926205
    • 1992-08-07
    • Ignazio S. PonticelloMohan S. Saini
    • Ignazio S. PonticelloMohan S. Saini
    • C07D223/26C07D403/12G01N33/53G01N33/94C07D223/22
    • C07D403/12G01N33/9486
    • New carbamazepine hapten analogues are described comprising:(A) an active ester group;(B) a carbamazepine nucleus; and(C) a linking chain (i) linking the carboxamide group of the carbamazepine nucleus to the active ester group, said linking chain having about 4 to about 40 atoms consisting of:(1) alkylene groups; and(2) 5 to 7 membered heterocyclic ring groups, each group being joined into the linking group through chemical groups selected from(a) esters,(b) amides,(c) hetero atoms selected from --0--, --S--, and --NR--; wherein R represents hydrogen or C.sub.1 to C.sub.6 alkyl; and(d) carbonyl groups.The carbamazepine-active ester analogues are useful in preparing labeled carbamazepines. The labeled carbamazepines are useful in immunoassay elements and processes for the detection of carbamazepine drugs, for example, in body fluids.
    • 描述了新的卡马西平半抗原类似物,其包括:(A)活性酯基; (B)卡马西平核; 和(C)将卡马西平核的羧酰胺基与活性酯基连接的连接链(i),所述连接链具有约4至约40个原子,由以下组成:(1)亚烷基; 每个基团通过选自(a)酯,(b)酰胺,(c)选自以下的杂原子的化学基团连接到连接基团中:-O-,-S-, 和-NR-; 其中R表示氢或C1至C6烷基; 和(d)羰基。 卡马西平 - 活性酯类似物可用于制备标记的卡马西平。 标记的卡马西平可用于免疫测定元件和用于检测卡马西平药物(例如体液)的方法。