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21. 发明授权

US5523368A Weakly basic polymerizable monomers and polymers prepared therefrom 失效
公开(公告)号：US5523368A
公开(公告)日：1996-06-04
申请号：US435739
申请日：1995-05-05
申请人： Ignazio S. Ponticello , Jerome C. Swartz , Tobias E. Ekeze
发明人： Ignazio S. Ponticello , Jerome C. Swartz , Tobias E. Ekeze
IPC分类号： C07D233/61 , C07D233/70 , C07D521/00 , C08F20/52 , C08F20/56 , C08F26/06 , C08F220/10 , C08F226/02
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Weakly basic ethylenically unsaturated polymerizable monomers and polymers have been prepared. The monomers are represented by the structure (I): ##STR1## wherein R is hydrogen or methyl, and R.sup.1 is alkylene of 1 to 3 carbon atoms. The resulting polymers are water-soluble and cationic at acidic pH, but water-insoluble and neutral in charge at basic pH. The polymers are useful for precipitating nucleic acids.

22. 发明授权

US5395933A Carbamazepine hapten analogues 失效
标题翻译：卡马西平半抗原类似物
公开(公告)号：US5395933A
公开(公告)日：1995-03-07
申请号：US926205
申请日：1992-08-07
申请人： Ignazio S. Ponticello , Mohan S. Saini
发明人： Ignazio S. Ponticello , Mohan S. Saini
IPC分类号： C07D223/26 , C07D403/12 , G01N33/53 , G01N33/94 , C07D223/22
CPC分类号： C07D403/12 , G01N33/9486
摘要： New carbamazepine hapten analogues are described comprising:(A) an active ester group;(B) a carbamazepine nucleus; and(C) a linking chain (i) linking the carboxamide group of the carbamazepine nucleus to the active ester group, said linking chain having about 4 to about 40 atoms consisting of:(1) alkylene groups; and(2) 5 to 7 membered heterocyclic ring groups, each group being joined into the linking group through chemical groups selected from(a) esters,(b) amides,(c) hetero atoms selected from --0--, --S--, and --NR--; wherein R represents hydrogen or C.sub.1 to C.sub.6 alkyl; and(d) carbonyl groups.The carbamazepine-active ester analogues are useful in preparing labeled carbamazepines. The labeled carbamazepines are useful in immunoassay elements and processes for the detection of carbamazepine drugs, for example, in body fluids.
摘要翻译：描述了新的卡马西平半抗原类似物，其包括：（A）活性酯基; （B）卡马西平核; 和（C）将卡马西平核的羧酰胺基与活性酯基连接的连接链（i），所述连接链具有约4至约40个原子，由以下组成：（1）亚烷基; 每个基团通过选自（a）酯，（b）酰胺，（c）选自以下的杂原子的化学基团连接到连接基团中：-O-，-S-，和-NR-; 其中R表示氢或C1至C6烷基; 和（d）羰基。卡马西平 - 活性酯类似物可用于制备标记的卡马西平。标记的卡马西平可用于免疫测定元件和用于检测卡马西平药物（例如体液）的方法。

23. 发明授权

US5262297A Specific binding analytical and separation methods using carboxy containing polymers 失效
标题翻译：使用含羧基聚合物的特异性结合分析和分离方法
公开(公告)号：US5262297A
公开(公告)日：1993-11-16
申请号：US876672
申请日：1992-04-30
申请人： Richard C. Sutton , Susan J. Danielson , John B. Findlay , Fred. T. Oakes , Marsha D. B. Oenick , Ignazio S. Ponticello , Harold C. Warren, III
发明人： Richard C. Sutton , Susan J. Danielson , John B. Findlay , Fred. T. Oakes , Marsha D. B. Oenick , Ignazio S. Ponticello , Harold C. Warren, III
IPC分类号： C12Q1/68 , C12Q1/70 , G01N33/543 , G01N33/545 , G01N83/545 , G01N33/546 , G01N33/547
CPC分类号： G01N33/54313 , C12Q1/6876 , C12Q1/701 , C12Q1/703 , G01N33/545 , Y10S436/804 , Y10S436/814 , Y10S436/817 , Y10S436/818 , Y10S436/824
摘要： Specific binding methods are used for diagnostic assays and purification separations whereby the specific binding capture reagent is prepared from copolymers having highly reactive carboxy groups. These groups are extended from the polymer surface with a linking group having from 8 to 50 atoms in the chain and two or more alkylene, arylene, alkylenearylene or arylenealkylene groups. To these reactive groups is attached a biologically active substance such as a protein or oligonucleotide which then participates in the diagnostic assays or purification separation methods.
摘要翻译：特异性结合方法用于诊断测定和纯化分离，由此特异性结合捕获试剂由具有高反应性羧基的共聚物制备。这些基团从聚合物表面延伸，在链中具有8至50个原子的连接基团和两个或更多个亚烷基，亚芳基，亚烷基亚芳基或亚芳基亚烷基。将这些反应性基团连接到生物活性物质如蛋白质或寡核苷酸上，然后参与诊断测定或纯化分离方法。

24. 发明授权

US5149737A Carboxy containing monomers and polymers and latices prepared from same 失效
标题翻译：含羧基的单体和聚合物以及由其制备的胶乳
公开(公告)号：US5149737A
公开(公告)日：1992-09-22
申请号：US654112
申请日：1991-02-12
申请人： Ignazio S. Ponticello , Richard C. Sutton
发明人： Ignazio S. Ponticello , Richard C. Sutton
IPC分类号： C07C69/40 , C07C69/007 , C07C69/42 , C07C233/05 , C07C233/49 , C07C251/24 , C07C275/38 , C07C323/12 , C07C323/41 , C07C323/50 , C07C323/52 , C07C323/56 , C08F12/00 , C08F12/04 , C08F12/14 , C08F20/02 , C08F20/64 , C12Q1/68 , G01N33/53 , G01N33/543
CPC分类号： C07C69/007 , C07C323/12 , C07C323/52 , C07C323/56 , C08F12/14 , G01N33/54313
摘要： Certain ethylenically unsaturated polymerizable monomers having a reactive carboxy group are useful for preparing homo- and copolymers for a variety of uses, including diagnostic assays. The polymers can be supplied as latex particles in aqueous compositions. The monomers are represented by the structure: ##STR1## wherein: R is hydrogen, halo or alkyl or 1 to 3 carbon atoms,M is hydrogen, an alkali metal ion or an ammonium ion, andL is a linking group having from 8 to 50 atoms in its linking chain, and comprises two or more divalent hydrocarbon groups connected or terminated with one or more nitrogen, oxygen or sulfur atoms, or with one or more groups containing such atoms in the linking chain, provided L has at least one arylene which is not directly connected to the terminal ##STR2## and further provided that none of the hydrocarbon groups has non-aromatic unsaturation.

25. 发明授权

US5073603A Method of using dithiothreitol as a crosslinking agent for electrophoresis media 失效
标题翻译：使用二硫苏糖醇作为电泳介质的交联剂的方法
公开(公告)号：US5073603A
公开(公告)日：1991-12-17
申请号：US430996
申请日：1989-11-02
申请人： Ignazio S. Ponticello
发明人： Ignazio S. Ponticello
IPC分类号： C08F220/54 , G01N27/447
CPC分类号： C08F220/54 , G01N27/44747
摘要： Dithiothreitol, a bis-mercaptan, is a surprisingly superior crosslinking agent for preparing electrophoresis media from aqueous solutions of preformed, water-soluble, acrylamide based copolymers comprising a minor proportion of a comonomer, which comonomer contains a site that will react in a crosslinking reaction with a bis-mercaptan.
摘要翻译：二硫苏糖醇是双硫醇，是一种出人意料的优异的交联剂，用于从包含少量共聚单体的预先形成的水溶性丙烯酰胺基共聚物的水溶液中制备电泳介质，该共聚单体含有将在交联反应中反应的位点与双硫醇。

26. 发明授权

US4599389A Polymeric mordant containing nitrogen-coordinating ligand for metallizable dyes 失效
标题翻译：含有金属化染料的氮配位配体的聚合媒染剂
公开(公告)号：US4599389A
公开(公告)日：1986-07-08
申请号：US791018
申请日：1985-10-24
申请人： James A. Reczek , Ignazio S. Ponticello , Philip S. Bryan
发明人： James A. Reczek , Ignazio S. Ponticello , Philip S. Bryan
IPC分类号： G03C8/56 , C08F26/06 , C08F26/08 , C08F26/12 , C08F126/06
CPC分类号： G03C8/56
摘要： Photographic elements and diffusion transfer assemblages described which contain a novel mordant comprising a polymeric backbone having appended thereto nitrogen-coordinating ligands having the formula: ##STR1## wherein D.sup.1, D.sup.2, and D.sup.3 each independently represents the atoms necessary to complete an aromatic heterocyclic nucleus having at least one ring of 5 to 7 atoms.In a preferred embodiment, the mordant comprises recurring units having the formula: ##STR2## wherein: R.sup.1 and R.sup.2 each independently represents hydrogen or an alkyl or substituted alkyl group having from 1 to about 6 carbon atoms;Link represents a bivalent linking group; andLIG represents a nitrogen-coordinating ligand as described above.
摘要翻译：描述的摄影元件和扩散转移组合物，其包含新颖的媒染剂，其包含具有附加有下式的氮配位配体的聚合物主链：其中D1，D2和D3各自独立地表示完成芳族杂环核所必需的原子，至少一个5至7个原子的环。在优选的实施方案中，媒染剂包含具有下式的重复单元：其中：R 1和R 2各自独立地表示氢或具有1至约6个碳原子的烷基或取代的烷基; Link表示二价连接基团; 并且LIG表示如上所述的氮配位配体。

27. 发明授权

US4088499A Selectively permeable layers for diffusion transfer film units 失效
标题翻译：用于扩散转移膜单元的选择性渗透层
公开(公告)号：US4088499A
公开(公告)日：1978-05-09
申请号：US701935
申请日：1976-07-01
申请人： David P. Brust , Tsang J. Chen , Ignazio S. Ponticello , Zona R. Pierce
发明人： David P. Brust , Tsang J. Chen , Ignazio S. Ponticello , Zona R. Pierce
IPC分类号： G03C8/52 , G03C7/00 , G03C1/40 , G03C1/48 , G03C5/54
CPC分类号： G03C8/52
摘要： Disclosed herein is an image-transfer film unit comprising:(1) a photosensitive element comprising a support, having thereon at least one silver halide emulsion layer;(2) an image-receiving layer:(3) interposed between any silver halide emulsion layer and said image-receiving layer, at least one pH selectively permeable layer comprising:(a) from about 1 to 100 mole percent of a polymerized monomer containing at least one active methylene group and having the formula: ##STR1## wherein n is 0 or 1; R is hydrogen or methyl; R.sup.1 is substituted or unsubstituted arylenethylene having the structure: ##STR2## wherein Ar is arylene and R.sup.2 is hydrogen, alkyl, aryl or cycloalkyl, or R.sup.1 has the formula: ##STR3## wherein R.sup.3 is alkylene, arylene or cycloalkylene; and R.sup.4 is alkyl, alkoxy or amino when n is equal to 0, and R.sup.4 is alkyl, alkoxy, amino, cycloalkyl or aryl when n is equal to 1;(b) from 0 to about 90 mole percent of at least one additional hydrophilic polymerized ethylenically unsaturated monomer; and(c) from 0 to about 80 mole percent of at least one additional hydrophobic polymerized ethylenically unsaturated monomer; and(4) means containing an alkaline processing composition adapted to discharge its contents within said film unit.
摘要翻译：本文公开了一种图像转印膜单元，包括：

28. 发明授权

US4011201A Polymers of monomers containing active methylene groups and other ethylenically unsaturated monomers 失效
标题翻译：含有活性亚甲基基团和其他乙烯基不饱和单体的单体聚合物
公开(公告)号：US4011201A
公开(公告)日：1977-03-08
申请号：US631801
申请日：1975-11-13
申请人： Ignazio S. Ponticello
发明人： Ignazio S. Ponticello
IPC分类号： C08F12/22 , G03C1/053 , C08F28/00 , C08G75/00
CPC分类号： G03C1/053 , C08F12/22 , Y10S430/108
摘要： Disclosed herein is a polymer comprisingA. from about 1 to 100% by weight of a polymerized monomer containing at least one active methylene group and having the formula ##STR1## wherein n is 0 or 1, R is hydrogen or methyl, R' is substituted or unsubstituted arylenethylene having the structure ##STR2## wherein Ar is arylene, R.sup.2 is hydrogen, alkyl, aryl, or cycloalkyl, R.sup.3 is alkoxy or amino when n is equal to 0, and R.sup.3 is alkyl, alkoxy, amino, cycloalkyl or aryl when n is equal to 1; andB. from 0 to about 99% by weight of at least one additional polymerized ethylenically unsaturated monomer.

29. 发明授权

US5601994A Immunoassay with novel labeled drug hapten analogues 失效
标题翻译：用新型标记的药物半抗原类似物免疫测定
公开(公告)号：US5601994A
公开(公告)日：1997-02-11
申请号：US235114
申请日：1994-04-28
申请人： Marsha D. B. Oenick , Ignazio S. Ponticello , Susan J. Danielson , Barbara A. Brummond , David A. Hilborn
发明人： Marsha D. B. Oenick , Ignazio S. Ponticello , Susan J. Danielson , Barbara A. Brummond , David A. Hilborn
IPC分类号： G01N33/535 , G01N33/532 , G01N33/543 , G01N33/94
CPC分类号： G01N33/532 , G01N33/54386 , G01N33/94 , G01N33/948 , Y10S436/816
摘要： The invention is directed to labeled drug hapten analogues comprising:(A) a label, of the type used in immunoassays, having an amine or sulfhydryl group;(B) a drug hapten nucleus selected from barbiturates or hydantoins and(C) a linking chain linking the 3-position of the drug hapten nucleus to the label through a carbonyl bridge.
摘要翻译：本发明涉及标记的药物半抗原类似物，包括：（A）在免疫测定中使用的具有胺或巯基的类型的标记; （B）选自巴比妥酸盐或乙内酰脲的药物半抗原核，（C）通过羰基桥连接药物半抗原核的3位与衔接标记的连接链。

30. 发明授权

US5582988A Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same 失效
标题翻译：使用弱碱性聚合物捕获和选择性释放核酸的方法及其扩增
公开(公告)号：US5582988A
公开(公告)日：1996-12-10
申请号：US306870
申请日：1994-09-15
申请人： John W. Backus , Tobias E. Ekeze , Jerome C. Swartz , Richard C. Sutton , Ignazio S. Ponticello , JoAnne H. Kerschner , John B. Findlay
发明人： John W. Backus , Tobias E. Ekeze , Jerome C. Swartz , Richard C. Sutton , Ignazio S. Ponticello , JoAnne H. Kerschner , John B. Findlay
IPC分类号： C12N15/09 , C07H21/04 , C07K14/045 , C07K14/16 , C07K14/35 , C08F20/34 , C08F20/60 , C12N15/10 , C12P19/34 , C12Q1/68 , C12Q1/70 , G01N33/543 , G01N33/569
CPC分类号： C12N15/1003 , C07K14/005 , C07K14/35 , C08F20/34 , C08F20/60 , C12N15/1006 , C12Q1/6806 , C12N2710/16122 , C12N2740/16022
摘要： Nucleic acids can be made available for amplification or other treatment after lysis by contacting the lysate with specific weakly basic polymers to form a precipitate with the nucleic acids at acidic pH. After removing non-precipitated materials, the pH is then made basic, thereby releasing the nucleic acids from the polymer. This method for preparing specimen samples is simple and quite rapid, and the released nucleic acids can be further treated in hybridization assays or amplification procedures. The weakly basic polymers are water-soluble and cationic at acidic pH, but neutral in charge at basic pH.
摘要翻译：通过使溶解产物与特定的弱碱性聚合物接触以在酸性pH下与核酸形成沉淀物，使核酸可用于扩增或裂解后的其它处理。除去非沉淀物后，将pH调至碱性，从而将聚合物中的核酸释放出来。制备标本样品的这种方法是简单且相当快速的，并且释放的核酸可以在杂交测定或扩增程序中进一步处理。弱碱性聚合物在酸性pH下为水溶性和阳离子型，而在碱性pH下为负电荷。

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