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21. 发明申请

US20100093061A1 Assays for Improved Fungal Strains 审中-公开
标题翻译：改良真菌菌株的分析
公开(公告)号：US20100093061A1
公开(公告)日：2010-04-15
申请号：US12519870
申请日：2007-12-18
申请人： Elizabeth A. Bodie
发明人： Elizabeth A. Bodie
IPC分类号： C12N1/15
CPC分类号： C12N15/80 , C12N1/14 , C12N9/0061 , C12N15/01 , C12R1/885
摘要： The invention relates to methods for obtaining improved strains of filamentous ascomycete fungus, such as Trichoderma reesei, and the product of said method. The method includes contacting ascomycete cells comprising a reporter gene construct with a mutagen, wherein said reporter gene construct comprises a promoter operably linked with a reporter gene; culturing said ascomycete cells under conditions that repress activity of the promoter; and isolating said ascomycete cells that produce the reporter in amounts detectably higher than ascomycete cells which have not been contacted with the mutagen.
摘要翻译：本发明涉及获得丝状子囊菌真菌如里氏木霉的改良菌株的方法和所述方法的产物。该方法包括使包含报告基因构建体的子囊菌细胞与诱变剂接触，其中所述报道基因构建体包含与报告基因可操作地连接的启动子; 在抑制启动子活性的条件下培养所述子囊细胞; 并且以可检测地高于未与诱变剂接触的子囊菌细胞的量分离产生报道分子的所述子囊菌细胞。

22. 发明申请

US20090311752A1 Conditioning Biomass for Microbial Growth 有权
标题翻译：微生物生长调理生物质
公开(公告)号：US20090311752A1
公开(公告)日：2009-12-17
申请号：US12521786
申请日：2007-12-17
申请人： Elizabeth A. Bodie , George England
发明人： Elizabeth A. Bodie , George England
IPC分类号： C12N1/22 , C12P19/00
CPC分类号： C12N1/22 , C12N1/38 , C12N9/001 , C12N9/0059 , C12N9/0061 , C12N9/0071 , C12N9/2437
摘要： The present invention relates to methods for improving the yield of microbial processes that use lignocellulose biomass as a nutrient source. The methods comprise conditioning a composition comprising lignocellulose biomass with an enzyme composition that comprises a phenol oxidizing enzyme. The conditioned composition can support a higher rate of growth of microorganisms in a process. In one embodiment, a laccase composition is used to condition lignocellulose biomass derived from non-woody plants, such as corn and sugar cane. The invention also encompasses methods for culturing microorganisms that are sensitive to inhibitory compounds in lignocellulose biomass. The invention further provides methods of making a product by culturing the production microorganisms in conditioned lignocellulose biomass.
摘要翻译：本发明涉及提高使用木素纤维素生物质作为营养源的微生物过程产量的方法。所述方法包括用包含酚氧化酶的酶组合物调理包含木质纤维素生物质的组合物。经调理的组合物可以在一个过程中支持更高的微生物生长速率。在一个实施方案中，漆酶组合物用于调节源自非木本植物如玉米和甘蔗的木质纤维素生物质。本发明还包括培养对木质纤维素生物质中抑制性化合物敏感的微生物的方法。本发明还提供了通过在调理的木质纤维素生物质中培养生产微生物来制备产品的方法。

23. 发明授权

US06936449B2 Regulatable growth of filamentous fungi 失效
公开(公告)号：US06936449B2
公开(公告)日：2005-08-30
申请号：US10100252
申请日：2002-03-14
申请人： Ali R. Akin , Elizabeth A. Bodie , Shirley Burrow , Nigel Dunn-Coleman , Geoffrey Turner , Michael Ward
发明人： Ali R. Akin , Elizabeth A. Bodie , Shirley Burrow , Nigel Dunn-Coleman , Geoffrey Turner , Michael Ward
IPC分类号： C07K14/38 , C12N9/12 , C12N15/80 , C12P21/02 , C12N9/10 , C07H21/04 , C07K1/00 , C12N1/12 , C12N1/14
CPC分类号： C12N9/1205 , C07K14/38 , C12N15/80 , C12P21/02
摘要： The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal growth. Specifically, the present invention is directed to a full length cotA gene, its gene product and methods of use.

24. 发明授权

US4399160A Thickening composition from fermented whey 失效
标题翻译：发酵乳清增稠组合物
公开(公告)号：US4399160A
公开(公告)日：1983-08-16
申请号：US290767
申请日：1981-08-07
申请人： Robert D. Schwartz , Elizabeth A. Bodie
发明人： Robert D. Schwartz , Elizabeth A. Bodie
IPC分类号： A23C21/02 , A23L29/269 , C12P19/04 , C12P19/06 , A23L1/28 , C12N1/20
CPC分类号： C12P19/06 , A23C21/02 , A23L29/273 , C12P19/04 , Y10S435/91
摘要： A synergistic thickening composition for use in foods is prepared by forming a mixture of a dried fermented whey product produced with Xanthomonas campestris ATCC 31923 and a dried fermented whey product produced with Leuconostoc mesenteroides ATCC 14935.
摘要翻译：制备用于食品的协同增稠组合物，其通过形成由野油菜黄单胞菌ATCC 31923生产的干燥的发酵乳清产物和由肠型肠系膜菌肠杆菌ATCC 14935产生的干燥的发酵乳清制品的混合物来制备。

25. 发明授权

US09725727B2 Filamentous fungi having an altered viscosity phenotype 有权
公开(公告)号：US09725727B2
公开(公告)日：2017-08-08
申请号：US14112879
申请日：2012-04-20
申请人： Elizabeth A. Bodie , Robert James Pratt, II
发明人： Elizabeth A. Bodie , Robert James Pratt, II
IPC分类号： C12N1/36 , C12N15/80 , C12N9/12
CPC分类号： C12N15/80 , C12N1/36 , C12N9/1241 , C12Y207/07013
摘要： Described are compositions and methods relating to variant filamentous fungi having altered growth characteristics. Such variants are well-suited for growth in submerged cultures, e.g., for the large-scale production of enzymes and other proteins for commercial applications.

26. 发明授权

US09587242B2 Filamentous fungi having an altered viscosity phenotype 有权
标题翻译：具有改变的粘度表型的丝状真菌
公开(公告)号：US09587242B2
公开(公告)日：2017-03-07
申请号：US14113930
申请日：2012-04-20
申请人： Elizabeth A. Bodie , Robert James Pratt, II
发明人： Elizabeth A. Bodie , Robert James Pratt, II
IPC分类号： C12N1/00 , C12N15/79 , C12N1/14 , C12N15/80 , C12N1/36 , C12N9/24
CPC分类号： C12N15/79 , C12N1/14 , C12N1/36 , C12N9/2405 , C12N15/80
摘要： Described are compositions and methods relating to variant filamentous fungi having altered growth characteristics. Such variants are well-suited for growth in submerged cultures, e.g., for the large-scale production of enzymes and other proteins for commercial applications.
摘要翻译：描述了与具有改变的生长特性的变体丝状真菌有关的组合物和方法。这样的变体非常适合浸没培养物中的生长，例如用于大规模生产用于商业应用的酶和其它蛋白质。

27. 发明申请

US20140099721A1 FILAMENTOUS FUNGI HAVING AN ALTERED VISCOSITY PHENOTYPE 有权
公开(公告)号：US20140099721A1
公开(公告)日：2014-04-10
申请号：US14111615
申请日：2012-04-20
申请人： Elizabeth A. Bodie , Robert James Pratt, II
发明人： Elizabeth A. Bodie , Robert James Pratt, II
IPC分类号： C12N15/80
CPC分类号： C12N15/80 , C12N1/36 , C12N9/1241 , C12Y207/07013
摘要： Described are compositions and methods relating to variant filamentous fungi having altered growth characteristics. Such variants are well-suited for growth in submerged cultures, e.g., for the large-scale production of enzymes and other proteins for commercial applications.

28. 发明授权

US08216844B2 Compositions and methods for improved protein production 失效
标题翻译：用于改善蛋白质生产的组合物和方法
公开(公告)号：US08216844B2
公开(公告)日：2012-07-10
申请号：US12376558
申请日：2007-08-28
申请人： Elizabeth A. Bodie , Steve Kim
发明人： Elizabeth A. Bodie , Steve Kim
IPC分类号： C12N15/80
CPC分类号： C12N15/80 , C07K14/37 , C12N9/2437 , C12N15/01 , C12P21/00 , C12P21/02 , Y02P20/52
摘要： The present invention relates to the identification of novel nucleic acid sequences, designated herein as 7p, 8k, 7E, 9G, 8Q and 203, in a host cell which effect protein production. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding 7p, 8k, 7E, 9G, 8Q and 203, which are presented in FIG. 1, and are SEQ ID NOS.: 1-6, respectively. The present invention also provides host cells further comprising a nucleic acid encoding a desired heterologous protein such as an enzyme.
摘要翻译：本发明涉及在影响蛋白质产生的宿主细胞中鉴定新的核酸序列（本文称为7p，8k，7E，9G，8Q和203）。本发明还提供具有编码7p，8k，7E，9G，8Q和203的基因的部分或全部的突变或缺失的宿主细胞，其在图1中示出。 1，分别为SEQ ID NO：1-6。本发明还提供宿主细胞，其进一步包含编码所需异源蛋白质如酶的核酸。

29. 发明申请

US20110045526A1 SELECTION OF USEFUL FUNGAL STRAINS 审中-公开
标题翻译：选择有用的真菌菌株
公开(公告)号：US20110045526A1
公开(公告)日：2011-02-24
申请号：US12663488
申请日：2008-06-10
申请人： Elizabeth A. Bodie , Edmund A. Larenas
发明人： Elizabeth A. Bodie , Edmund A. Larenas
IPC分类号： C12Q1/04 , C12N1/14
CPC分类号： C12Q1/04 , C12Q1/34
摘要： The present invention provides methods for screening for a desired filamentous fungus that produces cellulase more efficiently and/or with increased specific activity. It also provides filamentous fungi that produce cellulase more efficiently.
摘要翻译：本发明提供了筛选更有效和/或具有更高比活性产生纤维素酶的所需丝状真菌的方法。它还提供更有效地生产纤维素酶的丝状真菌。

30. 发明申请

US20100279346A1 Compositions and Methods for Improved Protein Production 失效
标题翻译：改进蛋白质生产的组合物和方法
公开(公告)号：US20100279346A1
公开(公告)日：2010-11-04
申请号：US12376558
申请日：2007-08-28
申请人： Elizabeth A. Bodie , Steve Kim
发明人： Elizabeth A. Bodie , Steve Kim
IPC分类号： C12P21/00 , C12N1/14 , C07H21/04 , C12N15/63 , C12N5/10 , C12N9/42 , C12N15/64 , C02F3/34
CPC分类号： C12N15/80 , C07K14/37 , C12N9/2437 , C12N15/01 , C12P21/00 , C12P21/02 , Y02P20/52
摘要： The present invention relates to the identification of novel nucleic acid sequences, designated herein as 7p,8k, 7E, 9G, 8Q and 203, in a host cell which effect protein production. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding 7p,8k, 7E, 9G, 8Q and 203, which are presented in FIG. 1, and are SEQ ID NOS.: 1-6, respectively. The present invention also provides host cells further comprising a nucleic acid encoding a desired heterologous protein such as an enzyme.
摘要翻译：本发明涉及在影响蛋白质产生的宿主细胞中鉴定新的核酸序列（本文称为7p，8k，7E，9G，8Q和203）。本发明还提供具有编码7p，8k，7E，9G，8Q和203的基因的部分或全部的突变或缺失的宿主细胞，其在图1中示出。 1，分别为SEQ ID NO：1-6。本发明还提供宿主细胞，其进一步包含编码所需异源蛋白质如酶的核酸。

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