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21. 发明申请

US20060118714A1 Ion source frequency feedback device and method 失效
公开(公告)号：US20060118714A1
公开(公告)日：2006-06-08
申请号：US11333213
申请日：2006-01-18
申请人： Daniel Sobek , Jing Cai , Kevin Killeen , Hongfeng Yin
发明人： Daniel Sobek , Jing Cai , Kevin Killeen , Hongfeng Yin
IPC分类号： H01J49/00
CPC分类号： H01J49/165
摘要： An ion source for an analytical instrument is described. The ion source comprises a capillary tip and counter-electrode interface and a feedback loop control device connected to the capillary tip and counter-electrode interface. The feedback loop control device comprises a transimpedance amplifier, a DC de-coupler, a frequency to voltage converter, a controller, and a voltage-controlled high-voltage power supply that provides a tip to counter-electrode voltage to the capillary tip and counter-electrode interface. The feedback loop control device measures the modulation frequency of ionization currents and provides a feedback adjustment of the tip-to-counter-electrode voltage to maintain ionization efficiency.

22. 发明授权

US06958119B2 Mobile phase gradient generation microfluidic device 有权
标题翻译：流动相梯度生成微流体装置
公开(公告)号：US06958119B2
公开(公告)日：2005-10-25
申请号：US10085598
申请日：2002-02-26
申请人： Hongfeng Yin , Kevin Killeen , Daniel Sobek
发明人： Hongfeng Yin , Kevin Killeen , Daniel Sobek
IPC分类号： G01N30/20 , G01N30/28 , G01N30/34 , G01N30/60 , B01D15/08
CPC分类号： G01N30/34 , G01N30/6095 , G01N2030/201 , G01N2030/202 , G01N2030/285
摘要： The present invention relates to a microfluidic device for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, which, in combination with a microchannel formed in the first surface, defines a separation conduit for separating the components of the fluid sample. An inlet port in fluid communication with the separation conduit allows a mobile phase containing a gradient of a selected mobile-phase component to be introduced from an integrated gradient-generation means to the separation conduit. A method is also provided for separating the components of a fluid sample using a mobile phase containing a gradient of a selected mobile-phase component, wherein the gradient is generated within a small volume of mobile phase.
摘要翻译：本发明涉及用于分离流体样品的组分的微流体装置。盖板布置在衬底的第一表面上，其与形成在第一表面中的微通道组合，限定用于分离流体样品的部件的分离管道。与分离管道流体连通的入口允许将包含所选流动相组分的梯度的流动相从积分的梯度产生装置引入分离导管。还提供了一种用于使用包含所选流动相成分的梯度的流动相分离流体样品的组分的方法，其中在少量流动相中产生梯度。

23. 发明授权

US06845968B2 Flow-switching microdevice 有权
标题翻译：流量切换微型设备
公开(公告)号：US06845968B2
公开(公告)日：2005-01-25
申请号：US10785336
申请日：2004-02-23
申请人： Kevin Killeen , Hongfeng Yin
发明人： Kevin Killeen , Hongfeng Yin
IPC分类号： F15C5/00 , F16K99/00 , F16K31/02
CPC分类号： F16K99/0001 , F15C5/00 , F16K99/0011 , F16K99/0013 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , Y10T137/86863
摘要： A microdevice is provided for controlling fluid flow. The microdevice includes a substantially planar contact surface and a plurality of fluid-transporting features associated therewith. Also included is a substrate having a substantially planar contact surface and a fluid-transporting feature associated therewith. The contact surfaces are positioned in slidable and fluid-tight contact to allow for controllable formation of a plurality of different flow paths upon alignment of the substrate fluid-transporting feature with each cover plate fluid-transporting features in succession. Typically, at least one of the cover plate and substrate is comprised of a biofouling resistant polymer, and the flow paths are of different lengths. Optionally, a plurality of fluid-transporting features is associated with the substrate so that flow paths are formed as a result of a different alignment of the fluid-transporting features.
摘要翻译：提供微型装置用于控制流体流动。微型装置包括基本上平面的接触表面和与其相关联的多个流体输送特征。还包括具有基本上平面的接触表面和与其相关联的流体输送特征的基底。接触表面定位在可滑动和流体密封的接触中，以允许在衬底流体输送特征与每个盖板流体输送特征相继对准时可控地形成多个不同的流动路径。通常，盖板和衬底中的至少一个由耐生物结垢的聚合物组成，并且流动路径具有不同的长度。可选地，多个流体输送特征与基底相关联，使得由于流体输送特征的不同对准而形成流动路径。

24. 发明授权

US06702256B2 Flow-switching microdevice 有权
标题翻译：流量切换微型设备
公开(公告)号：US06702256B2
公开(公告)日：2004-03-09
申请号：US09908292
申请日：2001-07-17
申请人： Kevin Killeen , Hongfeng Yin
发明人： Kevin Killeen , Hongfeng Yin
IPC分类号： F16K500
CPC分类号： F16K99/0001 , F15C5/00 , F16K99/0011 , F16K99/0013 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , Y10T137/86863
摘要： The present invention relates to a microdevice having a valve structure that contains low or no dead volume. The microdevice comprises a substrate and a cover plate each having a substantially planar contact surface and each contact surface having a fluid-transporting feature associated therewith. The substrate contact surface is positioned in slidable and fluid-tight contact with the cover plate contact surface to allow for controllable alignment between the fluid-transporting features. As a result, fluid communication is provided therebetween through a small area. Where the cover plate fluid-transporting feature comprises a conduit, the conduit may have a substantially constant cross-sectional area. The controllable alignment between the fluid-transporting features may form an alignment-dependent variable-length flow path.
摘要翻译：本发明涉及具有低或非死体积的阀结构的微型装置。微型装置包括基板和盖板，每个底板具有基本上平面的接触表面，并且每个接触表面具有与其相关联的流体输送特征。衬底接触表面定位成与盖板接触表面可滑动和流体密封地接触，以允许流体输送特征之间的可控制的对准。结果，通过小区域在它们之间提供流体连通。在盖板流体输送特征包括导管的情况下，导管可具有基本恒定的横截面积。流体输送特征之间的可控对准可以形成取决于可变长度的流动路径。

25. 发明申请

US20080190840A1 Microfluidic Device with at Least One Retaining Device 审中-公开
标题翻译：具有至少一个固定装置的微流体装置
公开(公告)号：US20080190840A1
公开(公告)日：2008-08-14
申请号：US11547696
申请日：2005-02-03
申请人： Jan Eickhoff , Patrick Mueller , Jose Angel Mora-Fillat , Karsten Kraiczek , Kevin Killeen , Hongfeng Yin
发明人： Jan Eickhoff , Patrick Mueller , Jose Angel Mora-Fillat , Karsten Kraiczek , Kevin Killeen , Hongfeng Yin
IPC分类号： B01D35/00 , B32B37/00 , B01J19/12 , B29C39/02
CPC分类号： B01L3/502753 , Y10T156/10
摘要： A microfluidic device comprising at least one inlet port, at least one flow path coupled to the inlet port, and at least one fluid separation element coupled to the flow path, wherein the fluid separation element comprises a packing material and is adapted for separating different components of a fluid, wherein the microfluidic device comprises at least one retaining device for keeping the packing material of the fluid separation element fixed in place and protecting the microfluidic device from debris polluting the analyte.
摘要翻译：一种微流体装置，包括至少一个入口端口，连接到入口端口的至少一个流动路径，以及耦合到流动路径的至少一个流体分离元件，其中流体分离元件包括填充材料，并且适于分离不同的部件的流体，其中所述微流体装置包括至少一个保持装置，用于将所述流体分离元件的包装材料固定就位并保护所述微流体装置免受污染所述分析物的碎屑。

26. 发明申请

US20060097151A1 ELECTROSPRAY DEVICES FOR MASS SPECTROMETRY 有权
标题翻译：用于大量光谱的电子设备
公开(公告)号：US20060097151A1
公开(公告)日：2006-05-11
申请号：US10982189
申请日：2004-11-05
申请人： Karen Seaward , Hongfeng Yin , Kevin Killeen , Daniel Sobek , Daniel Roitman
发明人： Karen Seaward , Hongfeng Yin , Kevin Killeen , Daniel Sobek , Daniel Roitman
IPC分类号： H01J49/04
CPC分类号： H01J49/165
摘要： An electrospray device for a mass spectrometry system is described. The electrospray device comprises a body portion and a tip portion extending from the body portion. The tip portion comprises a polymeric material. The electrospray device also comprises a hydrophobic coating substantially selectively covering the tip portion. The hydrophobic coating is electrically nonconductive.
摘要翻译：描述了用于质谱系统的电喷雾装置。电喷雾装置包括主体部分和从主体部分延伸的尖端部分。尖端部分包括聚合材料。电喷雾装置还包括基本上选择性地覆盖尖端部分的疏水涂层。疏水涂层是不导电的。

27. 发明授权

US06935192B2 Microfluidic bulk flow determinations based on converting heat tracer measurements 失效
标题翻译：基于转换热示踪剂测量的微流量大流量测定
公开(公告)号：US06935192B2
公开(公告)日：2005-08-30
申请号：US10675037
申请日：2003-09-30
申请人： Daniel Sobek , Hongfeng Yin , Roy D. Rocklin , Kevin Killeen
发明人： Daniel Sobek , Hongfeng Yin , Roy D. Rocklin , Kevin Killeen
IPC分类号： G01F1/708 , G01P5/06
CPC分类号： G01F1/7084
摘要： The fluid flow rate within a microfluidic passageway of a microfabricated device is determined by measuring the time-of-flight of a heat pulse coupled into the fluid. Since the propagation velocity of the heat trace is generally slower than the mean flow rate of the flow, additional processing provides the appropriate scaling needed to obtain an accurate fluid flow rate measurement. The scaling factor is based on the geometry of the structure and the thermal properties of the fluid and the materials used for the device.
摘要翻译：通过测量耦合到流体中的热脉冲的飞行时间来确定微加工装置的微流体通道内的流体流速。由于热迹线的传播速度通常比流动的平均流速慢，所以额外的处理提供了获得准确的流体流量测量所需的适当的缩放比例。缩放因子基于结构的几何形状和流体和用于该装置的材料的热性质。

28. 发明申请

US20050072671A1 Devices and methods for separating constituents 有权
标题翻译：用于分离成分的装置和方法
公开(公告)号：US20050072671A1
公开(公告)日：2005-04-07
申请号：US10678332
申请日：2003-10-03
申请人： Roy Rocklin , Kevin Killeen , Hongfeng Yin
发明人： Roy Rocklin , Kevin Killeen , Hongfeng Yin
IPC分类号： G01N27/26 , G01N30/32 , G01N30/34 , G01N30/60 , G01N30/64
CPC分类号： G01N30/34 , G01N30/6095 , G01N2030/324 , G01N2030/347 , G01N2030/645
摘要： The subject invention includes constituent separation apparatuses that include a fluid pathway and a pair of spaced-apart electrodes positioned within the pathway for detecting current flow within a mobile phase present in the pathway. Coupled to the pair of spaced-apart electrodes is a mix ratio determinator for determining the mix ratio of the mobile phase from the detected current flow. Also provided are methods that include contacting a mobile phase with an apparatus for separating constituents of a mobile phase, detecting the current flow of the mobile phase when the mobile phase is in contact with the apparatus and determining the mix ratio of the mobile phase from the detected current flow. The mix ratio may be adjusted based on the determined mix ratio. Algorithms for practicing the subject methods are also provided on computer readable mediums. Systems and kits for practicing the subject methods are also provided.
摘要翻译：本发明包括构成分离装置，其包括流体通道和位于通路内的一对间隔开的电极，用于检测存在于通路中的流动相中的电流。耦合到一对间隔开的电极是用于确定流动相与检测到的电流的混合比的混合比率确定器。还提供了包括使流动相与用于分离流动相的组分的装置接触的方法，当移动相与装置接触时检测流动相的当前流量，并确定流动相与装置的混合比检测电流。可以基于所确定的混合比来调节混合比。用于实践主题方法的算法也提供在计算机可读介质上。还提供了用于实践主题方法的系统和套件。

29. 发明授权

US07413709B2 PAEK-based microfluidic device with integrated electrospray emitter 有权
标题翻译：具有集成电喷雾发射器的基于PAEK的微流体装置
公开(公告)号：US07413709B2
公开(公告)日：2008-08-19
申请号：US10365734
申请日：2003-02-12
申请人： Daniel B. Roitman , Kevin Killeen , Hongfeng Yin , Karen L. Seaward
发明人： Daniel B. Roitman , Kevin Killeen , Hongfeng Yin , Karen L. Seaward
IPC分类号： B01L3/02
CPC分类号： B29C66/324 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/00862 , B01J2219/00891 , B01J2219/00957 , B01L3/0268 , B01L3/502707 , B01L2200/0689 , B01L2300/0816 , B01L2300/0887 , B01L2300/12 , B01L2400/0622 , B01L2400/0644 , B29C65/48 , B29C65/4835 , B29C66/001 , B29C66/02 , B29C66/1122 , B29C66/53461 , B29C66/54 , B29C66/71 , B29C66/82661 , B29K2071/00 , B29L2031/756 , B81B1/00 , G01N30/20 , G01N30/6095 , G01N30/7266
摘要： A polyaryl-ether-ketone (PAEK)-based microfluidic device having an integrated electrospray emitter is disclosed. Bonding of at least one PAEK substrate forming the microfluidic device is accomplished using a solvent-resistant adhesive, such as a polyimide-based adhesive, in combination with an adhesion enhancement treatment. By providing the PAEK-based microfluidic device with an integrated electrospray emitter, efficient and effective analysis of fluid samples is enabled.
摘要翻译：公开了一种具有集成电喷雾发射体的聚芳基醚酮（PAEK）基微流体装置。形成微流体装置的至少一个PAEK基材的粘合是使用耐溶剂粘合剂（例如聚酰亚胺基粘合剂）与粘合增强处理相结合来完成的。通过为基于PAEK的微流体装置提供集成的电喷雾发射器，能够对流体样品进行有效和有效的分析。

30. 发明授权

US07022982B2 Ion source frequency feedback device and method 失效
标题翻译：离子源频率反馈装置及方法
公开(公告)号：US07022982B2
公开(公告)日：2006-04-04
申请号：US10896981
申请日：2004-07-23
申请人： Daniel Sobek , Jing Cai , Kevin Killeen , Hongfeng Yin
发明人： Daniel Sobek , Jing Cai , Kevin Killeen , Hongfeng Yin
IPC分类号： H01J49/10
CPC分类号： H01J49/165
摘要： An ion source for an analytical instrument is described. The ion source comprises a capillary tip and counter-electrode interface and a feedback loop control device connected to the capillary tip and counter-electrode interface. The feedback loop control device comprises a transimpedance amplifier, a DC de-coupler, a frequency to voltage converter, a controller, and a voltage-controlled high-voltage power supply that provides a tip to counter-electrode voltage to the capillary tip and counter-electrode interface. The feedback loop control device measures the modulation frequency of ionization currents and provides a feedback adjustment of the tip-to-counter-electrode voltage to maintain ionization efficiency.
摘要翻译：描述了用于分析仪器的离子源。离子源包括毛细管尖端和对电极界面以及连接到毛细管尖端和对电极界面的反馈回路控制装置。反馈回路控制装置包括跨阻抗放大器，直流去耦合器，频率 - 电压转换器，控制器和电压控制的高压电源，其提供针对毛细管尖端和计数器的对电极电压的尖端电极接口。反馈回路控制装置测量电离电流的调制频率，并提供端对电极电压的反馈调整，以维持电离效率。

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