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21. 发明授权

US07053389B2 Charged particle therapy system, range modulation wheel device, and method of installing range modulation wheel device 失效
标题翻译：带电粒子治疗系统，范围调制轮装置以及安装范围调制轮装置的方法
公开(公告)号：US07053389B2
公开(公告)日：2006-05-30
申请号：US10917458
申请日：2004-08-13
申请人： Masaki Yanagisawa , Hiroshi Akiyama , Koji Matsuda , Hisataka Fujimaki
发明人： Masaki Yanagisawa , Hiroshi Akiyama , Koji Matsuda , Hisataka Fujimaki
IPC分类号： G21G5/00
CPC分类号： G21K1/10 , A61N2005/1087 , A61N2005/1095 , G21K1/043
摘要： The invention provides a charged particle therapy system capable of increasing the number of patients treated. An irradiation filed forming apparatus for irradiating a charged particle beam extracted from a charged particle beam generator to an irradiation target includes an RMW device. The RMW device comprises a housing and an RMW disposed within the housing. A rotary shaft of the RMW is rotatably mounted to the housing. The RMW device is detachably installed in an RMW holding member provided in a casing of the irradiation filed forming apparatus. The housing can be placed in contact with the RMW holding member, and hence positioning of the rotary shaft of the RMW to a predetermined position can be performed in a short time. This contributes to cutting a time required for treatment per patient and increasing the number of patients treated.
摘要翻译：本发明提供一种能够增加治疗患者数量的带电粒子治疗系统。用于将从带电粒子束发生器提取的带电粒子束照射到照射目标的照射成像装置包括RMW装置。 RMW装置包括壳体和设置在壳体内的RMW。 RMW的旋转轴可旋转地安装在壳体上。 RMW装置可拆卸地安装在设置在照射区域形成装置的壳体中的RMW保持构件中。壳体可以放置成与RMW保持构件接触，因此可以在短时间内将RMW的旋转轴定位到预定位置。这有助于减少患者治疗所需的时间并增加治疗患者的数量。

22. 发明申请

US20050167616A1 Particle beam irradiation system and method of adjusting irradiation field forming apparatus 有权
公开(公告)号：US20050167616A1
公开(公告)日：2005-08-04
申请号：US11090206
申请日：2005-03-28
申请人： Masaki Yanagisawa , Hiroshi Akiyama , Koji Matsuda , Hisataka Fujimaki
发明人： Masaki Yanagisawa , Hiroshi Akiyama , Koji Matsuda , Hisataka Fujimaki
IPC分类号： G21K3/00 , A23L5/30 , A61N1/44 , A61N5/00 , A61N5/10 , G21K1/10 , G21K5/04 , G21K5/10
CPC分类号： G21K1/10 , A61N1/44 , A61N2005/1087 , A61N2005/1095
摘要： A particle therapy system, as one example of a particle beam irradiation system, comprises a charged particle beam generator and an irradiation field forming apparatus. An ion beam from the charged particle beam generator is irradiated to a diseased part in the body of a patient through the irradiation field forming apparatus. A scattering compensator and a range modulation wheel (RMW) are disposed on the upstream side in a direction of beam advance and are movable along a beam axis. The movement of the scattering compensator and the RMW adjusts a size of the ion beam entering a scatterer device, whereby a change in scattering intensity of the ion beam in the scatterer device is adjusted. As a result, a penumbra in dose distribution is reduced and a more uniform dose distribution in a direction perpendicular to the direction of beam advance is obtained in the diseased part.

23. 发明授权

US07589334B2 Ion beam delivery equipment and an ion beam delivery method 有权
标题翻译：离子束输送设备和离子束输送方法
公开(公告)号：US07589334B2
公开(公告)日：2009-09-15
申请号：US11714219
申请日：2007-03-06
申请人： Kazuo Hiramoto , Hiroshi Akiyama , Masaki Yanagisawa , Hisataka Fujimaki , Alfred Smith , Wayne Newhauser
发明人： Kazuo Hiramoto , Hiroshi Akiyama , Masaki Yanagisawa , Hisataka Fujimaki , Alfred Smith , Wayne Newhauser
IPC分类号： G21G5/00
CPC分类号： A61N5/10 , A61N2005/1087 , A61N2005/1095 , G21K5/04 , H05H7/04
摘要： The invention is intended to increase the number of patients treatable using one wheel having a thickness varied in the rotating direction to change energy of an ion beam passing the wheel. Ion beam delivery equipment for irradiating an ion beam to a patient for treatment comprises a beam generator for producing and accelerating the ion beam, an beam delivery nozzle including a range modulation wheel which has a predetermined thickness distribution in the rotating direction and is rotated on a travel passage of the ion beam generated from the beam generator to control a range of the ion beam, and an irradiation controller for controlling the beam producing and accelerating operation of the beam generator in accordance with the phase of rotation of the range modulation wheel.
摘要翻译：本发明旨在增加使用具有在旋转方向上变化的厚度的一个车轮来治疗的患者数量，以改变通过车轮的离子束的能量。用于将离子束照射到患者进行治疗的离子束输送设备包括用于产生和加速离子束的束发生器，包括在旋转方向上具有预定厚度分布并在旋转方向上旋转的范围调制轮的束输送喷嘴从光束发生器产生的离子束的行进通过，以控制离子束的范围;以及照射控制器，用于根据范围调制轮的旋转相位控制光束发生器的光束产生和加速操作。

24. 发明授权

US07576342B2 Ion beam delivery equipment and ion beam delivery method 有权
标题翻译：离子束输送设备和离子束输送方法
公开(公告)号：US07576342B2
公开(公告)日：2009-08-18
申请号：US11758755
申请日：2007-06-06
申请人： Kazuo Hiramoto , Hiroshi Akiyama , Masaki Yanagisawa , Hisataka Fujimaki , Alfred P. Smith , Wayne Newhauser
发明人： Kazuo Hiramoto , Hiroshi Akiyama , Masaki Yanagisawa , Hisataka Fujimaki , Alfred P. Smith , Wayne Newhauser
IPC分类号： A61N5/01 , A61N5/00 , H01J37/08
CPC分类号： A61N5/10 , A61N2005/1087 , A61N2005/1095 , G21K5/04 , H05H7/04
摘要： The invention is intended to increase the number of patients treatable using one wheel having a thickness varied in the rotating direction to change energy of an ion beam passing the wheel. Ion beam delivery equipment for irradiating an ion beam to a patient for treatment comprises a beam generator for producing and accelerating the ion beam, an beam delivery nozzle including a range modulation wheel which has a predetermined thickness distribution in the rotating direction and is rotated on a travel passage of the ion beam generated from the beam generator to control a range of the ion beam, and an irradiation controller for controlling the beam producing and accelerating operation of the beam generator in accordance with the phase of rotation of the range modulation wheel.
摘要翻译：本发明旨在增加使用具有在旋转方向上变化的厚度的一个车轮来治疗的患者数量，以改变通过车轮的离子束的能量。用于将离子束照射到患者进行治疗的离子束输送设备包括用于产生和加速离子束的束发生器，包括在旋转方向上具有预定厚度分布并在旋转方向上旋转的范围调制轮的束输送喷嘴从光束发生器产生的离子束的行进通过，以控制离子束的范围;以及照射控制器，用于根据范围调制轮的旋转相位控制光束发生器的光束产生和加速操作。

25. 发明授权

US07449701B2 Particle beam irradiation equipment and particle beam irradiation method 有权
标题翻译：粒子束照射设备和粒子束照射法
公开(公告)号：US07449701B2
公开(公告)日：2008-11-11
申请号：US10822767
申请日：2004-04-13
申请人： Hisataka Fujimaki , Koji Matsuda , Masaki Yanagisawa , Hiroshi Akiyama
发明人： Hisataka Fujimaki , Koji Matsuda , Masaki Yanagisawa , Hiroshi Akiyama
IPC分类号： A61N5/00 , H01J33/00
CPC分类号： G21K5/04 , A61N5/10 , A61N2005/1087 , A61N2005/1095 , A61N2005/1096
摘要： Particle beam irradiation equipment and a method of adjusting irradiation nozzle, which can ensure a long range and high dose uniformity at any field size are provided. The particle beam irradiation equipment comprises charged particle beam generation equipment and an irradiation nozzle for irradiating a charged particle beam extracted from the charged particle beam generation equipment to an irradiation target. The irradiation nozzle comprises a first scatterer device including a first scatterer for spreading out the charged particle beam into a Gaussian-like distribution, and multiple stages of second scatterer devices including second scatterers for producing a uniform intensity distribution of the charged particle beam having been spread out into a Gaussian-like distribution by the first scatterer. For forming irradiation fields having sizes different from each other, the second scatterer devices are disposed downstream of the first scatterer device in the direction of travel of the charged particle beam at the spacing depending on the difference in the field size.
摘要翻译：提供粒子束照射设备和调节照射喷嘴的方法，其可以确保任何场尺寸的长距离和高剂量均匀性。粒子束照射设备包括带电粒子束产生设备和用于将从带电粒子束产生设备提取的带电粒子束照射到照射目标的照射喷嘴。照射喷嘴包括第一散射体装置，其包括用于将带电粒子束扩展成高斯状分布的第一散射体，以及包括第二散射体的多级第二散射体装置，用于产生已扩散的带电粒子束的均匀强度分布由第一个散射体组成高斯状分布。为了形成尺寸彼此不同的照射场，根据场尺寸的差异，第二散射体装置沿着带电粒子束的行进方向设置在第一散射体装置的下游。

26. 发明申请

US20060192146A1 Charged particle therapy system, range modulation wheel device, and method of installing range modulation wheel device 失效
标题翻译：带电粒子治疗系统，范围调制轮装置以及安装范围调制轮装置的方法
公开(公告)号：US20060192146A1
公开(公告)日：2006-08-31
申请号：US11399371
申请日：2006-04-07
申请人： Masaki Yanagisawa , Hiroshi Akiyama , Koji Matsuda , Hisataka Fujimaki
发明人： Masaki Yanagisawa , Hiroshi Akiyama , Koji Matsuda , Hisataka Fujimaki
IPC分类号： G21G5/00
CPC分类号： G21K1/10 , A61N2005/1087 , A61N2005/1095 , G21K1/043
摘要： The invention provides a charged particle therapy system capable of increasing the number of patients treated. An irradiation filed forming apparatus for irradiating a charged particle beam extracted from a charged particle beam generator to an irradiation target includes an RMW device. The RMW device comprises a housing and an RMW disposed within the housing. A rotary shaft of the RMW is rotatably mounted to the housing. The RMW device is detachably installed in an RMW holding member providied in a casing of the irradiation filed forming apparatus. The housing can be placed in contact with the RMW holding member, and hence positioning of the rotary shaft of the RMW to a predetermined position can be performed in a short time. This contributed to cutting a time required for treatment per patient and increasing the number of patients treated.
摘要翻译：本发明提供一种能够增加治疗患者数量的带电粒子治疗系统。用于将从带电粒子束发生器提取的带电粒子束照射到照射目标的照射成像装置包括RMW装置。 RMW装置包括壳体和设置在壳体内的RMW。 RMW的旋转轴可旋转地安装在壳体上。 RMW装置可拆卸地安装在提供在照射成形装置的壳体中的RMW保持构件中。壳体可以放置成与RMW保持构件接触，因此可以在短时间内将RMW的旋转轴定位到预定位置。这有助于减少患者治疗所需的时间，并增加治疗患者的数量。

27. 发明授权

US07071479B2 Particle beam irradiation system and method of adjusting irradiation apparatus 有权
公开(公告)号：US07071479B2
公开(公告)日：2006-07-04
申请号：US11052195
申请日：2005-02-08
申请人： Masaki Yanagisawa , Hiroshi Akiyama , Koji Matsuda , Hisataka Fujimaki
发明人： Masaki Yanagisawa , Hiroshi Akiyama , Koji Matsuda , Hisataka Fujimaki
IPC分类号： H05H9/00
CPC分类号： A61N5/1042 , A61N2005/1087 , A61N2005/1095 , G21K1/10 , G21K5/04
摘要： The present invention provides an increased degree of uniformity of radiation dose distribution for the interior of a diseased part. A particle beam therapy system includes a charged particle beam generation apparatus and an irradiation apparatus. An ion beam is generated by the charged particle beam generation apparatus. The irradiation apparatus exposes a diseased part to the generated ion beam. A scattering device, a range adjustment device, and a Bragg peak spreading device are installed upstream of a first scanning magnet and a second scanning magnet. The scattering device and the range adjustment device are combined together and moved along a beam axis, whereas the Bragg peak spreading device is moved independently along the beam axis. The scattering device moves to adjust the degree of ion beam scattering. The range adjustment device moves to adjust ion beam scatter changes caused by an absorber thickness adjustment. The Bragg peak spreading device moves to adjust ion beam scatter changes arising out of an SOBP device. These adjustments provide uniformity of radiation dose distribution for the diseased part.

28. 发明授权

US07026636B2 Particle beam irradiation system and method of adjusting irradiation apparatus 有权
标题翻译：粒子束照射系统及照射装置调整方法
公开(公告)号：US07026636B2
公开(公告)日：2006-04-11
申请号：US10760422
申请日：2004-01-21
申请人： Masaki Yanagisawa , Hiroshi Akiyama , Koji Matsuda , Hisataka Fujimaki
发明人： Masaki Yanagisawa , Hiroshi Akiyama , Koji Matsuda , Hisataka Fujimaki
IPC分类号： H05H9/00
CPC分类号： A61N5/1042 , A61N2005/1087 , A61N2005/1095 , G21K1/10 , G21K5/04
摘要： The present invention provides an increased degree of uniformity of radiation dose distribution for the interior of a diseased part. A particle beam therapy system includes a charged particle beam generation apparatus and an irradiation apparatus. An ion beam is generated by the charged particle beam generation apparatus. The irradiation apparatus exposes a diseased part to the generated ion beam. A scattering device, a range adjustment device, and a Bragg peak spreading device are installed upstream of a first scanning magnet and a second scanning magnet. The scattering device and the range adjustment device are combined together and moved along a beam axis, whereas the Bragg peak spreading device is moved independently along the beam axis. The scattering device moves to adjust the degree of ion beam scattering. The range adjustment device moves to adjust ion beam scatter changes caused by an absorber thickness adjustment. The Bragg peak spreading device moves to adjust ion beam scatter changes arising out of an SOBP device. These adjustments provide uniformity of radiation dose distribution for the diseased part.
摘要翻译：本发明提供了患病部位的内部的辐射剂量分布的增加的均匀度。粒子束治疗系统包括带电粒子束产生装置和照射装置。由带电粒子束产生装置产生离子束。照射装置将患病部分暴露于产生的离子束。散射装置，量程调节装置和布拉格峰扩展装置安装在第一扫描磁体和第二扫描磁体的上游。散射装置和范围调节装置组合在一起并沿着光束轴线移动，而布拉格峰扩展装置沿着光束轴线独立地移动。散射装置移动以调节离子束散射的程度。范围调整装置移动以调节由吸收体厚度调整引起的离子束散射变化。布拉格峰扩展装置移动以调整由SOBP装置引起的离子束散射变化。这些调整提供了患病部位的辐射剂量分布的均匀性。

29. 发明授权

US07838855B2 Charged particle irradiation system 有权
标题翻译：带电粒子照射系统
公开(公告)号：US07838855B2
公开(公告)日：2010-11-23
申请号：US12141603
申请日：2008-06-18
申请人： Yusuke Fujii , Hisataka Fujimaki , Kazuo Hiramoto
发明人： Yusuke Fujii , Hisataka Fujimaki , Kazuo Hiramoto
IPC分类号： A61N5/00 , H05H13/04 , G21K5/10
CPC分类号： A61N5/1048 , A61N2005/1087 , G21K5/04
摘要： A charged particle irradiation system that positions the beam at a target position to avoid irradiation of normal tissue includes an acceleration system 6 for extracting a charged particle beam, scanning magnets 24 and 25, and charged particle beam position monitors 26 and 27. On the basis of signals received from the charged particle beam position monitors 26 and 27, the control unit 70 calculates a beam position at a target position and then controls the scanning magnets 24 and 25 so that the charged particle beam is moved to a desired irradiation position at the target position. The control unit 70 corrects the value of an excitation current applied to each of the scanning magnets 24 and 25 on a specified cycle basis on the basis of information about the position and the angle of the charged particle beam.
摘要翻译：将光束定位在目标位置以避免正常组织照射的带电粒子照射系统包括用于提取带电粒子束的加速系统6，扫描磁体24和25以及带电粒子束位置监视器26和27.在此基础上从充电的粒子束位置监视器26和27接收的信号，控制单元70计算目标位置处的光束位置，然后控制扫描磁体24和25，使得带电粒子束移动到所需的照射位置目标位置。控制单元70基于关于带电粒子束的位置和角度的信息，在指定的周期基础上校正施加到每个扫描磁体24和25的激励电流的值。

30. 发明授权

US07692168B2 Device and method for outputting charged particle beam 有权
标题翻译：用于输出带电粒子束的装置和方法
公开(公告)号：US07692168B2
公开(公告)日：2010-04-06
申请号：US11774085
申请日：2007-07-06
申请人： Kunio Moriyama , Noriaki Ouchi , Masahiro Tadokoro , Hisataka Fujimaki
发明人： Kunio Moriyama , Noriaki Ouchi , Masahiro Tadokoro , Hisataka Fujimaki
IPC分类号： A61N5/10
CPC分类号： H05H7/12 , A61N5/1048 , A61N2005/1087
摘要： The present invention improves the accuracy of therapy by checking in real time whether an spread-out Bragg peak (SOBP) width agrees with a desired width during irradiation with a beam. The device for outputting a charged particle beam includes a charged particle beam generator 1 including a synchrotron 4; a range modulation device such as a range modulation wheel (RMW) 28 which forms a Bragg peak of an ion beam extracted from this charged particle beam generator 1; an irradiation device 16 which is located in the direction of ion beam propagation of this RMW device 28 and includes a dose monitor 31 for detecting a dose of the ion beam; and an SOBP width calculation device 73 which calculates ion beam Bragg peak formed by the RMW device 28 based on a detection value of the dose monitor 31.
摘要翻译：本发明通过实时检查展开的布拉格峰（SOBP）宽度是否与用束照射期间的期望宽度一致而提高了治疗的准确性。用于输出带电粒子束的装置包括：包括同步加速器4的带电粒子束发生器1; 范围调制装置，例如形成从该带电粒子束发生器1提取的离子束的布拉格峰的范围调制轮（RMW）28; 照射装置16，其位于该RMW装置28的离子束传播方向上，并包括用于检测离子束剂量的剂量监测器31; 以及SOBP宽度计算装置73，其基于剂量监视器31的检测值计算由RMW装置28形成的离子束布拉格峰。

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