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21. 发明授权

US08329451B2 Cell electrophysiological sensor and method for manufacturing the same 有权
标题翻译：细胞电生理传感器及其制造方法
公开(公告)号：US08329451B2
公开(公告)日：2012-12-11
申请号：US11914685
申请日：2007-04-12
申请人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka , Akiyoshi Oshima
发明人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka , Akiyoshi Oshima
IPC分类号： C12M1/00 , C12M1/42 , C12M3/00 , C12M1/34
CPC分类号： G01N33/48728
摘要： In a cell electrophysiological sensor having a thin plate with a through hole, a support plate with a through hole and a container plate with a through hole stuck to an upper portion of this support plate, the support plate and the container plate are stuck to each other through fusion with a portion of the outer shape of a first electrode in a ring shape intervening in a portion of the interface. In this configuration, a cell electrophysiological sensor which allows for measurement with high precision can be attained, and a manufacturing method which is excellent in terms of mass production can be provided.
摘要翻译：在具有带有通孔的薄板的细胞电生理传感器中，具有通孔的支撑板和具有粘附在该支撑板的上部的通孔的容器板，支撑板和容器板粘附到每个另一个通过与介于界面的一部分中的环形的第一电极的外部形状的一部分融合。在该结构中，可以实现能够高精度地进行测定的细胞电生理学传感器，并且可以提供在批量生产方面优异的制造方法。

22. 发明授权

US08202439B2 Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm 有权
标题翻译：膜片和用于测量细胞电位的装置使用相同的膜片的制造方法
公开(公告)号：US08202439B2
公开(公告)日：2012-06-19
申请号：US12359426
申请日：2009-01-26
申请人： Masaya Nakatani , Soichiro Hiraoka , Hiroshi Ushio , Akiyoshi Oshima , Hiroaki Oka , Fumiaki Emoto
发明人： Masaya Nakatani , Soichiro Hiraoka , Hiroshi Ushio , Akiyoshi Oshima , Hiroaki Oka , Fumiaki Emoto
IPC分类号： B44C1/22 , H01L21/302
CPC分类号： G01N33/48728 , Y10T428/24322
摘要： A diaphragm is formed by etching a substrate. This substrate has a first surface provided with a depression by isotropic dry etching, and a second surface opposite the first surface. Furthermore, a through-hole is formed from the depression to the second surface by anisotropic dry etching. The depression and the through-hole are formed by using one resist mask. The depression has a hemispherical shape or a semi-elliptical spherical shape.
摘要翻译：通过蚀刻基板形成隔膜。该基板具有通过各向同性干蚀刻设置有凹部的第一表面和与第一表面相对的第二表面。此外，通过各向异性干蚀刻从凹陷形成通孔到第二表面。通过使用一个抗蚀剂掩模形成凹陷和通孔。凹陷具有半球形或半椭圆形球形。

23. 发明授权

US07927474B2 Cell electrophysiological sensor 有权
标题翻译：细胞电生理传感器
公开(公告)号：US07927474B2
公开(公告)日：2011-04-19
申请号：US12828532
申请日：2010-07-01
申请人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka
发明人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka
IPC分类号： C12M1/00 , C12M1/34 , C12Q1/00 , G01N27/00
CPC分类号： G01N33/48728
摘要： A cell electrophysiological sensor is provided with: a well having a wall formed by at least one curved face, with opening sections being formed on the two ends thereof; a frame substrate having a through hole and an electrode; a cell electrophysiological sensor chip that is provided with a thin plate having a second through hole; and a void substrate, and in this structure, the frame substrate has a thickness greater than the thickness of the cell electrophysiological sensor chip and the opening diameter of the third opening section is made larger than the opening diameter of the fourth opening section.
摘要翻译：细胞电生理传感器设置有：具有由至少一个曲面形成的壁的孔，其两端形成开口部分; 具有通孔和电极的框架基板; 细胞电生理传感器芯片，其具有具有第二通孔的薄板; 和空隙基板，在该结构中，框架基板的厚度大于单元电生理传感器芯片的厚度，并且第三开口部分的开口直径大于第四开口部分的开口直径。

24. 发明授权

US07776193B2 Cell electrophysiological sensor 有权
标题翻译：细胞电生理传感器
公开(公告)号：US07776193B2
公开(公告)日：2010-08-17
申请号：US11719610
申请日：2006-12-19
申请人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka
发明人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka
IPC分类号： C12M1/00 , C12M1/34 , C12Q1/00 , G01N27/00
CPC分类号： G01N33/48728
摘要： A cell electrophysiological sensor is provided with: a well having a wall formed by at least one curved face, with opening sections being formed on the two ends thereof; a frame substrate having a through hole and an electrode; a cell electrophysiological sensor chip that is provided with a thin plate having a second through hole; and a void substrate, and in this structure, the frame substrate has a thickness greater than the thickness of the cell electrophysiological sensor chip and the opening diameter of the third opening section is made larger than the opening diameter of the fourth opening section.
摘要翻译：细胞电生理传感器设置有：具有由至少一个曲面形成的壁的孔，其两端形成开口部分; 具有通孔和电极的框架基板; 细胞电生理传感器芯片，其具有具有第二通孔的薄板; 和空隙基板，在该结构中，框架基板的厚度大于单元电生理传感器芯片的厚度，并且第三开口部分的开口直径大于第四开口部分的开口直径。

25. 发明申请

US20090081765A1 CELL ELECTROPHYSIOLOGICAL SENSOR AND METHOD FOR MANUFACTURING THE SAME 有权
标题翻译：细胞电生理传感器及其制造方法
公开(公告)号：US20090081765A1
公开(公告)日：2009-03-26
申请号：US11914685
申请日：2007-04-12
申请人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka , Akiyoshi Oshima
发明人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka , Akiyoshi Oshima
IPC分类号： C12M1/34 , B32B37/06
CPC分类号： G01N33/48728
摘要： In a cell electrophysiological sensor having a thin plate with a through hole, a support plate with a through hole and a container plate with a through hole stuck to an upper portion of this support plate, the support plate and the container plate are stuck to each other through fusion with a portion of the outer shape of a first electrode in a ring shape intervening in a portion of the interface. In this configuration, a cell electrophysiological sensor which allows for measurement with high precision can be attained, and a manufacturing method which is excellent in terms of mass production can be provided.
摘要翻译：在具有带有通孔的薄板的细胞电生理传感器中，具有通孔的支撑板和具有粘附在该支撑板的上部的通孔的容器板，支撑板和容器板粘附到每个另一个通过与介于界面的一部分中的环形的第一电极的外部形状的一部分融合。在该结构中，可以实现能够高精度地进行测定的细胞电生理学传感器，并且可以提供在批量生产方面优异的制造方法。

26. 发明申请

US20120325657A1 SENSOR DEVICE 审中-公开
标题翻译：传感器设备
公开(公告)号：US20120325657A1
公开(公告)日：2012-12-27
申请号：US13603145
申请日：2012-09-04
申请人： Takeki Yamamoto , Masaya Nakatani , Hiroshi Ushio , Yoshiki Yamada , Yusuke Nakano
发明人： Takeki Yamamoto , Masaya Nakatani , Hiroshi Ushio , Yoshiki Yamada , Yusuke Nakano
IPC分类号： G01N27/28
CPC分类号： G01N33/48728 , G01N27/08
摘要： A sensor device includes a substrate and a sensor chip held on the substrate. The substrate includes a flow channel. The sensor chip includes a plate. The plate includes a first surface and a second surface opposite to the first surface. A plurality of through holes each penetrates through the first surface and the second surface. A direction of a line segment connecting centers of any two adjacent through holes among the plurality of through holes is neither parallel nor perpendicular to the center line of the flow channel.
摘要翻译：传感器装置包括基板和保持在基板上的传感器芯片。衬底包括流动通道。传感器芯片包括一个板。板包括与第一表面相对的第一表面和第二表面。多个通孔各自穿过第一表面和第二表面。连接多个通孔中任意两个相邻通孔的中心的线段的方向既不平行也不垂直于流动通道的中心线。

27. 发明申请

US20090178922A1 CELL ELECTROPHYSIOLOGICAL SENSOR 有权
标题翻译：细胞电生理传感器
公开(公告)号：US20090178922A1
公开(公告)日：2009-07-16
申请号：US11719610
申请日：2006-12-19
申请人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka
发明人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka
IPC分类号： G01N33/48
CPC分类号： G01N33/48728
摘要： A cell electrophysiological sensor is provided with: a well having a wall formed by at least one curved face, with opening sections being formed on the two ends thereof; a frame substrate having a through hole and an electrode; a cell electrophysiological sensor chip that is provided with a thin plate having a second through hole; and a void substrate, and in this structure, the frame substrate has a thickness greater than the thickness of the cell electrophysiological sensor chip and the opening diameter of the third opening section is made larger than the opening diameter of the fourth opening section.
摘要翻译：细胞电生理传感器设置有：具有由至少一个曲面形成的壁的孔，其两端形成开口部分; 具有通孔和电极的框架基板; 细胞电生理传感器芯片，其具有具有第二通孔的薄板; 和空隙基板，在该结构中，框架基板的厚度大于单元电生理传感器芯片的厚度，并且第三开口部分的开口直径大于第四开口部分的开口直径。

28. 发明申请

US20090152110A1 Chip For Cell Electrophysiological Sensor, Cell Electrophysiological Sensor Using The Same, and Manufacturing Method of Chip for Cell Electrophysiological Sensor 有权
标题翻译：芯片用于细胞电生理传感器，细胞电生理学传感器及其制造方法用于细胞电生理传感器
公开(公告)号：US20090152110A1
公开(公告)日：2009-06-18
申请号：US11914283
申请日：2007-05-21
申请人： Soichiro Hiraoka , Masaya Nakatani , Hiroshi Ushio , Akiyoshi Oshima
发明人： Soichiro Hiraoka , Masaya Nakatani , Hiroshi Ushio , Akiyoshi Oshima
IPC分类号： G01N27/327 , H01L21/306
CPC分类号： G01N33/48728
摘要： A chip for a cell electrophysiological sensor has a substrate. The substrate has a through-hole formed from the upside to the downside, and the opening of the through-hole is formed in a curved surface curved from the upside and downside of the substrate toward the inner side of the through-hole. In this configuration, the electrolyte solution (first electrolyte solution and second electrolyte solution) flows more smoothly, and the sample cell can be sucked accurately, and the trapping rate of the sample cells is improved.
摘要翻译：用于细胞电生理学传感器的芯片具有基底。基板具有从上侧到下侧形成的通孔，并且通孔的开口形成为从基板的上侧和下侧朝向通孔的内侧弯曲的弯曲表面。在这种结构中，电解质溶液（第一电解质溶液和第二电解质溶液）流畅地流动，可以精确地吸取样品池，提高了样品池的捕获率。

29. 发明申请

US20070108478A1 Cell electro-physiological sensor and method of manufacturing the same 有权
标题翻译：细胞电生理传感器及其制造方法
公开(公告)号：US20070108478A1
公开(公告)日：2007-05-17
申请号：US11272892
申请日：2005-11-14
申请人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka , Abdellah Menikh
发明人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka , Abdellah Menikh
IPC分类号： H01L23/58
CPC分类号： G01N33/48728
摘要： A cell electro-physiological sensor includes a sensor chip including a partition board having a first surface and a second surface opposite to the first surface, a member for forming a first region provided on the first surface of the partition board, and a member for forming a second region provided on the second surface of the partition board. The partition board has a through-hole provided therein, the through-hole having a first opening which opens to the first surface, a second opening which opens to the second surface, and a wall. The first region contacts the first opening of the through-hole. The first region is arranged to contain cell suspension. The atomic ratio of carbon at the first surface of the partition board is not greater than 15 atomic percent of the composition of the first surface. The cell electro-physiological sensor causes the cell to be tightly held at the first opening of the through-hole in the partition board, thereby measuring a potential of the cell efficiently.
摘要翻译：细胞电生理传感器包括传感器芯片，其包括具有第一表面和与第一表面相对的第二表面的隔板，用于形成设置在隔板的第一表面上的第一区域的构件和用于形成设置在隔板的第二表面上的第二区域。分隔板具有设置在其中的通孔，该通孔具有通向第一表面的第一开口，通向第二表面的第二开口和壁。第一区域接触通孔的第一开口。第一个区域被设置成包含细胞悬浮液。分隔板的第一表面处的碳的原子比不大于第一表面的组成的15原子％。细胞电生理传感器使细胞紧密地保持在隔板的通孔的第一开口处，从而有效地测量细胞的电位。

30. 发明授权

US08702930B2 Sensor chip and storage method thereof 有权
标题翻译：传感器芯片及其存储方法
公开(公告)号：US08702930B2
公开(公告)日：2014-04-22
申请号：US13636976
申请日：2012-01-11
申请人： Kiyoshi Hashimotodani , Yusuke Nakano , Masaya Nakatani , Takeki Yamamoto , Yoshiki Yamada , Takuya Oka , Hiroshi Ushio
发明人： Kiyoshi Hashimotodani , Yusuke Nakano , Masaya Nakatani , Takeki Yamamoto , Yoshiki Yamada , Takuya Oka , Hiroshi Ushio
IPC分类号： G01N33/487 , G01N27/28
CPC分类号： G01N33/48728 , Y10T428/31663
摘要： A sensor chip is a sensor device for measuring a property of a substance by adsorbing the substance on a surface of the sensor chip. The sensor chip includes a diaphragm having a first surface, a second surface, and at least one through hole penetrating from the first surface to the second surface. At least a part of the first surface, the second surface, and an inner wall surface of the through hole is covered with a noncrystalline solid layer including SiOX as a main component, in which substance X is an element having higher electronegativity than that of silicon.
摘要翻译：传感器芯片是用于通过将物质吸附在传感器芯片的表面上来测量物质的性质的传感器装置。传感器芯片包括具有第一表面，第二表面和从第一表面穿透到第二表面的至少一个通孔的隔膜。第一表面，第二表面和通孔的内壁表面的至少一部分被包括SiO x作为主要成分的非结晶固体层覆盖，其中物质X是比硅的电负性高的元素。

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