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21. 发明授权

US08781583B2 Vagal stimulation 有权
公开(公告)号：US08781583B2
公开(公告)日：2014-07-15
申请号：US13353919
申请日：2012-01-19
申请人： Richard N. M. Cornelussen , Xiaohong Zhou , Robert Stadler , Lilian Kornet
发明人： Richard N. M. Cornelussen , Xiaohong Zhou , Robert Stadler , Lilian Kornet
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36053 , A61N1/36585
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

22. 发明授权

US08781582B2 Vagal stimulation 有权
标题翻译：迷走神经刺激
公开(公告)号：US08781582B2
公开(公告)日：2014-07-15
申请号：US13353802
申请日：2012-01-19
申请人： Paul D. Ziegler , Lilian Kornet , Xiaohong Zhou , Richard N. M. Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
发明人： Paul D. Ziegler , Lilian Kornet , Xiaohong Zhou , Richard N. M. Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
IPC分类号： A61N1/37
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3702 , A61N1/37235 , A61N1/3962
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
摘要翻译：本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。

23. 发明授权

US08744548B2 Lead apparatus 有权
标题翻译：铅装置
公开(公告)号：US08744548B2
公开(公告)日：2014-06-03
申请号：US12795236
申请日：2010-06-07
申请人： Rogier Receveur , Jean Joseph Gerardus Rutten , Karel F. A. A. Smits , Nicolaas M Lokhoff , Sylvia Weijzen-Engels , Didier Billy , Tim Dirk Jan Jongen , Lilian Kornet
发明人： Rogier Receveur , Jean Joseph Gerardus Rutten , Karel F. A. A. Smits , Nicolaas M Lokhoff , Sylvia Weijzen-Engels , Didier Billy , Tim Dirk Jan Jongen , Lilian Kornet
IPC分类号： A61B5/042 , A61N1/05
CPC分类号： A61N1/056 , A61N1/3756
摘要： A lead including one or more electrodes having circuitry associated therewith. Each such electrode includes a circuit extending along and conforming to at least a portion of an inner surface of the electrode. The circuit includes an isolation substrate contacting at least a portion of the inner surface of the cylindrical electrode portion, a first contact electrically isolated from the electrode portion by the isolation substrate and an integrated circuit electrically coupled to the first contact and the electrode.
摘要翻译：包括具有与其相关的电路的一个或多个电极的引线。每个这样的电极包括沿着电极的内表面的至少一部分延伸并且与电极的内表面的至少一部分一致的电路。电路包括与圆柱形电极部分的内表面的至少一部分接触的隔离衬底，通过隔离衬底与电极部分电隔离的第一接触和电耦合到第一接触和电极的集成电路。

24. 发明授权

US08620425B2 Nerve signal differentiation in cardiac therapy 有权
标题翻译：心脏治疗神经信号分化
公开(公告)号：US08620425B2
公开(公告)日：2013-12-31
申请号：US12848010
申请日：2010-07-30
申请人： Xiaohong Zhou , John Edward Burnes , Lilian Kornet , Richard N. M. Cornelussen
发明人： Xiaohong Zhou , John Edward Burnes , Lilian Kornet , Richard N. M. Cornelussen
IPC分类号： A61N1/05
CPC分类号： A61N1/36139 , A61B5/04001 , A61N1/36114 , A61N1/36514 , A61N1/3684 , A61N1/3686 , A61N1/3962
摘要： Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.
摘要翻译：神经信号分化方法，使用这种神经信号分化的治疗方法，以及用于执行这些方法的系统和装置。神经信号分化可能包括将两个电极定位在神经组织附近，并使用两个电极来监测神经信号的传出和传入分量。

25. 发明授权

US08504161B1 Modulate vagal signals to reduce inflammation 有权
标题翻译：调制迷走神经信号以减轻炎症
公开(公告)号：US08504161B1
公开(公告)日：2013-08-06
申请号：US13568281
申请日：2012-08-07
申请人： Lilian Kornet , Sergio Valsecchi
发明人： Lilian Kornet , Sergio Valsecchi
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36185
摘要： A medical device is configured to perform a method for modulating vagal nerve signals to reduce inflammation. A sensing module of the medical device is enabled to receive an electrical signal from selected electrodes electrically coupled to the medical device. A controller coupled to the sensing module is configured to determine an inflammation metric from the sensed electrical signal. The metric is compared to an inflammation detection threshold. A pulse generator is controlled to selectively deliver electrical stimulation pulses via the plurality of electrodes in response to the metric meeting the inflammation detection threshold to modulate vagal nerve signals to cause an anti-inflammatory response.
摘要翻译：医疗装置被配置为执行调节迷走神经信号以减少炎症的方法。医疗装置的感测模块能够从电耦合到医疗装置的所选择的电极接收电信号。耦合到感测模块的控制器被配置为从所感测的电信号确定炎症度量。将度量与炎症检测阈值进行比较。控制脉冲发生器以响应于满足炎症检测阈值的量度，经由多个电极选择性地递送电刺激脉冲，以调制迷走神经信号以引起抗炎反应。

26. 发明申请

US20110106195A1 ARRHYTHMIA PREDICTION BASED ON HEART RATE TURBULENCE 有权
标题翻译：基于心率波动的ARRHYTHMIA预测
公开(公告)号：US20110106195A1
公开(公告)日：2011-05-05
申请号：US12608855
申请日：2009-10-29
申请人： Lilian Kornet , Raphael Schneider
发明人： Lilian Kornet , Raphael Schneider
IPC分类号： A61N1/365 , A61B5/02
CPC分类号： A61N1/3621 , A61B5/02 , A61B5/02405 , A61B5/0402 , A61B5/046 , A61B5/6801 , A61B5/686 , A61N1/36592
摘要： In general, the disclosure describes techniques for predicting the occurrence of an arrhythmia based on an indication of heart rate turbulence. An example method comprises sensing a parameter indicative of heart rate turbulence, measuring heart rate turbulence based on the sensed parameter, and predicting an occurrence of an arrhythmia based on the measured heart rate turbulence.
摘要翻译：通常，本公开描述了基于心率湍流指示来预测心律失常发生的技术。示例性方法包括感测指示心率湍流的参数，基于所感测的参数来测量心率湍流，以及基于所测量的心率湍流来预测心律不齐的发生。

27. 发明申请

US20110024186A1 LEAD APPARATUS 有权
标题翻译：铅装置
公开(公告)号：US20110024186A1
公开(公告)日：2011-02-03
申请号：US12795236
申请日：2010-06-07
申请人： Rogier Receveur , Jean Joseph Gerardus Rutten , Karel F.A.A. Smits , Nicolaas M. Lokhoff , Sylvia Weijzen-Engels , Didier Billy , Tim Dirk Jan Jongen , Lilian Kornet
发明人： Rogier Receveur , Jean Joseph Gerardus Rutten , Karel F.A.A. Smits , Nicolaas M. Lokhoff , Sylvia Weijzen-Engels , Didier Billy , Tim Dirk Jan Jongen , Lilian Kornet
IPC分类号： H01B5/00 , H01R43/00
CPC分类号： A61N1/056 , A61N1/3756
摘要： A lead including one or more electrodes (e.g., electrodes, such as those having circuitry associated therewith).
摘要翻译：包括一个或多个电极（例如，电极，例如具有与其相关联的电路的电极）的引线。

28. 发明申请

US20110022107A1 AUTOMATIC ENABLING OF POST LONG PAUSE OVERDRIVE PACING 有权
标题翻译：自动启动后期长暂停过滤
公开(公告)号：US20110022107A1
公开(公告)日：2011-01-27
申请号：US12844531
申请日：2010-07-27
申请人： Lilian Kornet , Roger Kessels
发明人： Lilian Kornet , Roger Kessels
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/395 , A61N1/3962
摘要： A method and apparatus for controlling an atrial overdrive pacing therapy include detecting an atrial arrhythmia episode and determining if the atrial arrhythmia episode is an early recurring episode. Delivery of the atrial overdrive pacing therapy is enabled in response to the early recurring episode and commences upon detection of an atrial arrhythmia episode or a long pause.
摘要翻译：用于控制心房超速起搏治疗的方法和装置包括检测心房心律失常发作并确定房性心律失常发作是否是早期的复发发作。心房超速起搏治疗的交付是为了响应早期的复发性发作，并且在检测到心房心律失常发作或长时间停顿时开始。

29. 发明申请

US20100114254A1 SUBCLAVIAN ANSAE STIMULATION 有权
标题翻译： SUBCLAVIAN ANSAE刺激
公开(公告)号：US20100114254A1
公开(公告)日：2010-05-06
申请号：US12262867
申请日：2008-10-31
申请人： Lilian Kornet
发明人： Lilian Kornet
IPC分类号： A61N1/36
CPC分类号： A61N1/36114
摘要： Techniques for improving cardiac performance by applying stimulation to the subclavian ansae nerve of a patient are disclosed. In one example, a method comprises identifying a human patient as having a cardiac condition, and delivering stimulation therapy to a subclavian ansae nerve of a human patient with a stimulation electrode.
摘要翻译：公开了通过对患者的锁骨下神经进行刺激来改善心脏性能的技术。在一个实例中，一种方法包括将人类患者识别为具有心脏病状，并且用刺激电极将刺激治疗递送给患有人类患者的锁骨下神经的神经。

30. 发明授权

US09433791B2 AV nodal stimulation during atrial tachyarrhythmia to prevent inappropriate therapy delivery 有权
标题翻译：房性心律失常期间AV淋巴结刺激，以防止不适当的治疗传播
公开(公告)号：US09433791B2
公开(公告)日：2016-09-06
申请号：US13105689
申请日：2011-05-11
申请人： Eduardo N. Warman , John E. Burnes , Koen J. Michels , Paul D. Ziegler , Lilian Kornet
发明人： Eduardo N. Warman , John E. Burnes , Koen J. Michels , Paul D. Ziegler , Lilian Kornet
IPC分类号： A61N1/365 , A61N1/362 , A61N1/36
CPC分类号： A61N1/3622 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3624
摘要： The disclosure describes techniques for delivering electrical stimulation to decrease the ventricular rate response during an atrial tachyarrhythmia, such as atrial fibrillation. AV nodal stimulation is employed during an atrial tachyarrhythmia episode with rapid ventricular conduction to distinguish ventricular tachyarrhythmia from supraventricular tachycardia and thereby prevent delivering inappropriate therapy to a patient.
摘要翻译：本公开描述了用于递送电刺激以降低心房速发性心律失常（例如心房颤动）期间的心室率反应的技术。在房性快速性心律失常发作期间采用AV淋巴结刺激，其具有快速的心室传导以区分室上性快速性心律失常与室上性心动过速，从而阻止对患者传递不适当的治疗。

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