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21. 发明授权

US08334408B2 Analogs of alpha galactosylceramide and uses thereof 有权
标题翻译： α半乳糖神经酰胺的类似物及其用途
公开(公告)号：US08334408B2
公开(公告)日：2012-12-18
申请号：US13464299
申请日：2012-05-04
申请人： Vincenzo Cerundolo , Richard Schmidt , Gopal Reddy , Rengarajan Balamurugan , Gerd Ritter , Gurdyal Besra , Mariolina Salio , Jonathan Silk
发明人： Vincenzo Cerundolo , Richard Schmidt , Gopal Reddy , Rengarajan Balamurugan , Gerd Ritter , Gurdyal Besra , Mariolina Salio , Jonathan Silk
IPC分类号： C07C233/18 , C07C233/20 , C07C305/20 , C07F9/09 , A61K31/66 , A61K31/661 , A61K31/16
CPC分类号： C07H15/00
摘要： Compounds of formula wherein the variables are defined in the specification, are used in compositions which stimulate T cell responses.
摘要翻译：变量在说明书中定义的式的化合物用于刺激T细胞应答的组合物中。

22. 发明申请

US20110293511A1 SPECIFIC BINDING PROTEINS AND USES THEREOF 审中-公开
公开(公告)号：US20110293511A1
公开(公告)日：2011-12-01
申请号：US13078781
申请日：2011-04-01
申请人： Terrance Grant Johns , Andrew Mark Scott , Gerd Ritter , Achim Jungbluth , Elizabeth Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark , Lloyd J. Old , Edward B. Reilly , Andrew C. Phillips , Jonathan A. Meulbroek , Fritz G. Buchanan , Stephen Stockert
发明人： Terrance Grant Johns , Andrew Mark Scott , Gerd Ritter , Achim Jungbluth , Elizabeth Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark , Lloyd J. Old , Edward B. Reilly , Andrew C. Phillips , Jonathan A. Meulbroek , Fritz G. Buchanan , Stephen Stockert
IPC分类号： A61K39/395 , A61K38/21 , A61K38/20 , A61K103/20 , A61K103/40 , A61K103/30 , A61K103/32 , A61K103/00 , A61P35/00
CPC分类号： C07K16/4266 , A61K39/39558 , A61K51/103 , A61K51/1045 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/2863 , C07K16/30 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express the truncated version of the EGFR receptor, de2-7 EGF. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

23. 发明申请

US20110097271A1 Colon Cancer Associated Transcript 1 (CCAT1) As A Cancer Marker 审中-公开
标题翻译：结肠癌相关记录1（CCAT1）作为癌症标记
公开(公告)号：US20110097271A1
公开(公告)日：2011-04-28
申请号：US12867035
申请日：2009-02-11
申请人： Aviram Nissan , Stella Mitrani-Rosenbaum , Herbert Rudolf Freund , Tamar Peretz-Yablonsky , Marina Roistacher , Lloyd J. Old , Gerd Ritter , Ali O. Gure
发明人： Aviram Nissan , Stella Mitrani-Rosenbaum , Herbert Rudolf Freund , Tamar Peretz-Yablonsky , Marina Roistacher , Lloyd J. Old , Gerd Ritter , Ali O. Gure
IPC分类号： A61K49/00 , C12Q1/68 , C07H21/04 , C12N15/63 , C12N5/10
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to the identification, isolation, and sequencing of a unique nucleic acid transcript termed Colon Cancer Associated Transcript 1 (CCAT-1) that is specifically expressed in cancer cells, in particular in colon, rectal, and lung cancer, as well as in precancerous lesions. The present invention thus provides methods for diagnosing cancer by detecting the expression of CCAT-1 as well as isolated polynucleotides, compositions and kits for use in the detection methods of the invention.
摘要翻译：本发明涉及在癌细胞特别是结肠癌，直肠癌和肺癌中特异性表达的称为结肠癌相关转录物1（CCAT-1）的独特核酸转录物的鉴定，分离和测序，以及如癌前病变。因此，本发明提供了通过检测CCAT-1的表达以及用于本发明的检测方法的分离的多核苷酸，组合物和试剂盒来诊断癌症的方法。

24. 发明申请

US20060269960A1 Isolated peptides corresponding to amino acid requirements of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof 有权
标题翻译：对应于结合MHC I类和II类II类分子的NY-ESO-1的氨基酸要求的分离肽及其用途
公开(公告)号：US20060269960A1
公开(公告)日：2006-11-30
申请号：US11499547
申请日：2006-08-04
申请人： Alexander Knuth , Elke Jager , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd Old , Jan Drijfhout
发明人： Alexander Knuth , Elke Jager , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd Old , Jan Drijfhout
IPC分类号： C12Q1/68 , A61K38/16 , A61K38/10 , C07K14/47 , C07K7/08 , C07H21/04 , C12P21/06
CPC分类号： C07K14/4748 , A61K38/00 , Y10S435/81
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译：本发明涉及结合MHC I类和MHC II类分子的肽。这些肽可用于不同的治疗和诊断情境。

25. 发明授权

US07115729B2 Isolated nucleic acid molecules which encode peptides which bind to MHC class II molecules, such as HLA-DR53 有权
标题翻译：编码与MHC II类分子结合的肽的分离的核酸分子，例如HLA-DR53
公开(公告)号：US07115729B2
公开(公告)日：2006-10-03
申请号：US10751088
申请日：2004-01-02
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
IPC分类号： C12N15/09 , C12N15/63 , C12N5/02 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K16/18
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译：本发明涉及结合MHC I类和MHC II类分子的肽。这些肽可用于不同的治疗和诊断情境。

26. 发明申请

US20060149725A1 Managing electronic documents 审中-公开
标题翻译：管理电子文件
公开(公告)号：US20060149725A1
公开(公告)日：2006-07-06
申请号：US11027178
申请日：2005-01-03
申请人： Gerd Ritter
发明人： Gerd Ritter
IPC分类号： G06F17/30
CPC分类号： G06F16/93
摘要： A method of reducing a user's work load relating to administrating an electronic document includes displaying an electronic document to a user in a computer system, and receiving an input from the user, the input specifying a future time when a predefined action is to be automatically taken with regard to the electronic document. The specified future time is recorded in the computer system for automatically taking the predefined action with regard to the electronic document. The predefined action may involve deleting, archiving, or changing a status or classification of the electronic document. There may be specified a condition for taking the predefined action at the specified future time.
摘要翻译：减少与管理电子文档有关的用户工作负荷的方法包括：在计算机系统中向用户显示电子文档，以及从用户接收输入，指定将要自动采取预定动作的未来时间的输入关于电子文件。指定的未来时间记录在计算机系统中，用于自动对电子文档采取预定义的动作。预定义的动作可能涉及删除，存档或更改电子文档的状态或分类。可以指定在指定的未来时间采取预定义动作的条件。

27. 发明授权

US06291235B1 Isolated nucleic acid which encodes protein which binds to A33 antibody 有权
标题翻译：编码结合A33抗体的蛋白质的分离的核酸
公开(公告)号：US06291235B1
公开(公告)日：2001-09-18
申请号：US09068051
申请日：1998-12-10
申请人： Sydney Welt , Sara White , Cameron Johnstone , Lloyd J Old , Gerd Ritter , Bruno Catimel , Hong Ji , Antony Burgess , Joan Heath , Richard J Simpson , Edouard Nice , R. L Moritz
发明人： Sydney Welt , Sara White , Cameron Johnstone , Lloyd J Old , Gerd Ritter , Bruno Catimel , Hong Ji , Antony Burgess , Joan Heath , Richard J Simpson , Edouard Nice , R. L Moritz
IPC分类号： C12N1563
CPC分类号： C07K16/3046 , C07K14/47 , C07K14/705
摘要： This invention relates to isolated proteins and to peptides which are found on the surface of colon cells and colon cancer cells, as well as to nucleic acid molecules encoding said protein and peptides. The protein and peptides bind to tumor associated antibodies, such as mAb 33. The monomeric protein has a molecular weight of about 43 kD as determined by SDS gel electrophoresis under non-reducing conditions. In addition, this invention relates to the use of said nucleic acid molecules, protein, in monomeric or multimeric form, and to antibodies to said peptides in diagnostic, screening and therapeutic methods. This invention further relates to antibodies specific for said protein, in monomeric or multimeric form, and to antibodies to said peptides.
摘要翻译：本发明涉及分离的蛋白质和在结肠细胞和结肠癌细胞表面上发现的肽，以及编码所述蛋白质和肽的核酸分子。蛋白质和肽结合肿瘤相关抗体，例如mAb 33.单体蛋白质在非还原条件下通过SDS凝胶电泳测定的分子量为约43kD。此外，本发明涉及在诊断，筛选和治疗方法中所述核酸分子，蛋白质，单体或多聚体形式以及所述肽的抗体的用途。本发明还涉及以单体或多聚体形式对所述蛋白质特异性的抗体以及针对所述肽的抗体。

28. 发明授权

US5977329A Methods of synthesizing GM3 失效
标题翻译： GM3合成方法
公开(公告)号：US5977329A
公开(公告)日：1999-11-02
申请号：US24528
申请日：1998-02-17
申请人： Richard Schmidt , Julio C. Castro-Palomino , Gerd Ritter , Lloyd J. Old
发明人： Richard Schmidt , Julio C. Castro-Palomino , Gerd Ritter , Lloyd J. Old
IPC分类号： C07H15/10 , A61P35/00 , A61P37/02 , C07B61/00 , C07H1/00 , C07H3/06 , C07H13/04 , C07H15/18 , C07H15/00
CPC分类号： C07H13/04 , C07H1/00 , C07H3/06
摘要： The invention describes an improved method for making monosialoganglioside GM3 and its intermediates. Following reaction of a neuraminic acid donor and a lactose acceptor in the presence of an acid catalyst, the .alpha. and .beta. isomers of GM3 are formed. The .alpha. isomer is converted to a lactone, via action of a ring forming basic catalyst, which is then separable from the .beta. isomer. The lactone is then treated with a basic catalyst in the presence of an alcohol, to form GM3 or a GM3 intermediate.
摘要翻译：本发明描述了制备单唾液酸神经节苷脂GM3及其中间体的改进方法。在酸催化剂存在下，神经氨酸供体和乳糖受体反应后，形成GM3的α和β异构体。通过形成碱性催化剂的作用，将α异构体转化成内酯，然后将其与β异构体分离。然后在醇的存在下用碱性催化剂处理内酯，形成GM3或GM3中间体。

29. 发明申请

US20170362336A1 Membrane Transporter NaPi2b (SCL34A2) Epitope for Antibody Therapy, Antibodies Directed Thereto, and Target for Cancer Therapy 审中-公开
公开(公告)号：US20170362336A1
公开(公告)日：2017-12-21
申请号：US15609839
申请日：2017-05-31
申请人： Gerd Ritter , Beatrice Yin , Anne Murray , George Mark , Lloyd J. Old , Kenneth Lloyd , Serhiy Souchelnytskiy , Ivan Gout , Valeriy Filonenko , Ramziya Kiyamova
发明人： Gerd Ritter , Beatrice Yin , Anne Murray , George Mark , Lloyd J. Old , Kenneth Lloyd , Serhiy Souchelnytskiy , Ivan Gout , Valeriy Filonenko , Ramziya Kiyamova
IPC分类号： C07K16/30 , A61K39/00 , A61K39/395 , G01N33/574 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C07K7/08
CPC分类号： C07K16/3069 , A61K39/00 , A61K39/0011 , A61K39/39558 , A61K2039/505 , A61K2039/53 , C07K7/08 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , G01N33/57449 , G01N2333/705 , G01N2500/04
摘要： The present invention relates generally to the membrane transporter NaPi2b (SLC34A2) as a target for therapy, including immunotherapy, and particularly cancer therapy. The SLC34A2 epitope peptide encompassing amino acids 312-340 of SLC34A2 has been identified as an ovarian cancer epitope using the monoclonal antibody MX35. The invention also relates to the use of SLC34A2 and particularly SLC34A2 peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against NaPi2b (SLC34A2) and the SLC34A2 peptide(s), including veneered, chimeric, single chain and humanized antibodies. Methods for generating an immune response and for treatment of tumors and cancer are also provided. Assays for screening and identifying compounds directed against SLC34A2, including the SLC34A2 epitope peptide, and additional antibodies are provided.

30. 发明授权

US09032001B2 Field transformations for user interface data elements 有权
标题翻译：用户界面数据元素的字段转换
公开(公告)号：US09032001B2
公开(公告)日：2015-05-12
申请号：US13331039
申请日：2011-12-20
申请人： Dirk Stumpf , Tim Kornmann , Gerd Ritter , Rene Gross
发明人： Dirk Stumpf , Tim Kornmann , Gerd Ritter , Rene Gross
IPC分类号： G06F17/30
CPC分类号： G06F17/30398
摘要： A method and system, the method may include determining a user interface to be displayed, the user interface including a user interface data element associated with a service input parameter. Information about the service input parameter may be provided to a field transformation as a transformation input, and a transformation output may be received from the field transformation.
摘要翻译：一种方法和系统，所述方法可以包括确定要显示的用户界面，所述用户界面包括与服务输入参数相关联的用户界面数据元素。可以将关于服务输入参数的信息提供给作为变换输入的场变换，并且可以从场变换接收变换输出。

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