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21. 发明申请

US20100003297A1 Implantable Drug Delivery Device and Methods of Treating Male Genitourinary and Surrounding Tissues 审中-公开
标题翻译：可植入药物输送装置和处理男性泌尿生殖和周围组织的方法
公开(公告)号：US20100003297A1
公开(公告)日：2010-01-07
申请号：US12538580
申请日：2009-08-10
申请人： Irene Sophie Tobias , Heejin Lee , Michael J. Cima , Jordan Dimitrakov
发明人： Irene Sophie Tobias , Heejin Lee , Michael J. Cima , Jordan Dimitrakov
IPC分类号： A61K9/00 , A61P43/00
CPC分类号： A61L31/06 , A61K9/0034 , A61L29/06 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/00 , A61M31/002 , C08L83/04 , C08L67/00
摘要： A method is provided for local controlled delivery of a drug to the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of a patient in need of treatment. In one embodiment, the method includes implanting a resorbable drug delivery device within the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of the patient. The drug delivery device may include an elastic device body housing at least one drug reservoir which contains at least one drug. In a preferred embodiment, the method further includes releasing the drug from the device in a controlled manner to, typically directly to, the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens.
摘要翻译：提供了一种用于将药物局部控制递送至需要治疗的患者的精囊，前列腺，射精管或输精管的方法。在一个实施例中，该方法包括将可再吸收的药物递送装置植入患者的精囊，前列腺，射精管或输精管内。药物递送装置可以包括容纳至少一个含有至少一种药物的药物储存器的弹性装置主体。在优选的实施方案中，该方法还包括以受控的方式将药物从装置释放，通常直接进入精囊，前列腺，射精管或输精管。

22. 发明申请

US20130324946A1 IMPLANTABLE DRUG DELIVERY DEVICE AND METHODS 审中-公开
标题翻译：可植入药物递送装置和方法
公开(公告)号：US20130324946A1
公开(公告)日：2013-12-05
申请号：US13910730
申请日：2013-06-05
申请人： Irene Sophie Tobias , Heejin Lee , Michael J. Cima , Jordan Dimitrakov
发明人： Irene Sophie Tobias , Heejin Lee , Michael J. Cima , Jordan Dimitrakov
IPC分类号： A61L31/06 , A61L31/16
CPC分类号： A61L31/06 , A61K9/0034 , A61L29/06 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/00 , A61M31/002 , C08L83/04 , C08L67/00
摘要： A method is provided for local controlled delivery of a drug to the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of a patient in need of treatment. In one embodiment, the method includes implanting a resorbable drug delivery device within the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of the patient. The drug delivery device may include an elastic device body housing at least one drug reservoir which contains at least one drug. In a preferred embodiment, the method further includes releasing the drug from the device in a controlled manner to, typically directly to, the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens.
摘要翻译：提供了一种用于将药物局部控制递送至需要治疗的患者的精囊，前列腺，射精管或输精管的方法。在一个实施例中，该方法包括将可再吸收的药物递送装置植入患者的精囊，前列腺，射精管或输精管内。药物递送装置可以包括容纳至少一个含有至少一种药物的药物储存器的弹性装置主体。在优选的实施方案中，该方法还包括以受控的方式将药物从装置释放，通常直接进入精囊，前列腺，射精管或输精管。

23. 发明授权

US08182464B2 Method for intravesical drug delivery 有权
标题翻译：膀胱内药物输送方法
公开(公告)号：US08182464B2
公开(公告)日：2012-05-22
申请号：US12709551
申请日：2010-02-22
申请人： Heejin Lee , Karen Danielle Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
发明人： Heejin Lee , Karen Danielle Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
IPC分类号： A61M31/00 , A01N43/04 , A01N37/12 , A01N37/44 , A01N43/38 , A01N37/18 , A01N59/02 , A61K31/24 , A61K31/40 , A61K31/16 , A61K33/04
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

24. 发明授权

US09586035B2 Implantable drug delivery device and methods for treatment of the bladder and other body vesicles or lumens 有权
标题翻译：可植入药物递送装置和治疗膀胱和其他体内囊泡或内腔的方法
公开(公告)号：US09586035B2
公开(公告)日：2017-03-07
申请号：US12333182
申请日：2008-12-11
申请人： Michael J. Cima , Heejin Lee
发明人： Michael J. Cima , Heejin Lee
IPC分类号： A61M31/00 , A61K9/00 , A61K31/167
CPC分类号： A61M25/0102 , A61F2250/0068 , A61K9/0024 , A61K9/0034 , A61K31/167 , A61M25/0108 , A61M31/002 , A61M2205/0216 , A61M2210/1085
摘要： An implantable medical device is provided for controlled drug delivery within the bladder, or other body vesicle. The device may include at least one drug reservoir component comprising a drug; and a vesicle retention frame which comprises an elastic wire having a first end, an opposing second end, and an intermediate region therebetween, wherein the drug reservoir component is attached to the intermediate region of the vesicle retention frame. The retention frame prevents accidental voiding of the device from the bladder, and it preferably has a spring constant selected for the device to effectively stay in the bladder during urination while minimizing the irritation of the bladder.
摘要翻译：提供可植入的医疗装置用于膀胱或其他体内囊泡内的受控药物输送。该装置可以包括至少一个包含药物的药物储存器部件; 以及囊泡保持框架，其包括具有第一端，相对的第二端和在其间的中间区域的弹性线，其中所述药物储存部件附接到所述囊泡保持框架的中间区域。保持框架防止装置从膀胱意外排空，并且其优选地具有选择用于装置的弹簧常数，以在排尿期间有效地停留在膀胱中，同时使膀胱的刺激最小化。

25. 发明申请

US20090149833A1 Implantable Drug Delivery Device and Methods for Treatment of the Bladder and Other Body Vesicles or Lumens 有权
标题翻译：可植入药物递送装置和治疗膀胱和其他体液或流明的方法
公开(公告)号：US20090149833A1
公开(公告)日：2009-06-11
申请号：US12333182
申请日：2008-12-11
申请人： Michael J. Cima , Heejin Lee
发明人： Michael J. Cima , Heejin Lee
IPC分类号： A61M25/00 , A61K31/167
CPC分类号： A61M25/0102 , A61F2250/0068 , A61K9/0024 , A61K9/0034 , A61K31/167 , A61M25/0108 , A61M31/002 , A61M2205/0216 , A61M2210/1085
摘要： An implantable medical device is provided for controlled drug delivery within the bladder, or other body vesicle. The device may include at least one drug reservoir component comprising a drug; and a vesicle retention frame which comprises an elastic wire having a first end, an opposing second end, and an intermediate region therebetween, wherein the drug reservoir component is attached to the intermediate region of the vesicle retention frame. The retention frame prevents accidental voiding of the device from the bladder, and it preferably has a spring constant selected for the device to effectively stay in the bladder during urination while minimizing the irritation of the bladder.
摘要翻译：提供可植入的医疗装置用于膀胱或其他体内囊泡内的受控药物输送。该装置可以包括至少一个包含药物的药物储存器部件; 以及囊泡保持框架，其包括具有第一端，相对的第二端和在其间的中间区域的弹性线，其中所述药物储存部件附接到所述囊泡保持框架的中间区域。保持框架防止装置从膀胱意外排空，并且其优选地具有选择用于装置的弹簧常数，以在排尿期间有效地停留在膀胱中，同时使膀胱的刺激最小化。

26. 发明申请

US20070202151A1 INTRAVESICAL DRUG DELIVERY DEVICE AND METHOD 有权
标题翻译：内窥镜药物递送装置及方法
公开(公告)号：US20070202151A1
公开(公告)日：2007-08-30
申请号：US11463956
申请日：2006-08-11
申请人： Heejin Lee , Karen Daniel , Hong Ho Duc , Michael Cima , Mario Casillo-Ortiz , Steven Floelich , Jordan Dimitrakov
发明人： Heejin Lee , Karen Daniel , Hong Ho Duc , Michael Cima , Mario Casillo-Ortiz , Steven Floelich , Jordan Dimitrakov
IPC分类号： A61F2/02
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

27. 发明授权

US09107816B2 Implantable device for controlled dissolution and diffusion of low solubility drug 有权
标题翻译：用于低溶解度药物的受控溶解和扩散的可植入装置
公开(公告)号：US09107816B2
公开(公告)日：2015-08-18
申请号：US13366981
申请日：2012-02-06
申请人： Heejin Lee , Hong Linh Ho Duc , Matthew Sansone
发明人： Heejin Lee , Hong Linh Ho Duc , Matthew Sansone
IPC分类号： A61M31/00 , A61K9/00 , A61K31/337 , A61K31/407 , A61K31/46 , A61K31/555 , A61K31/7064 , A61K33/24 , A61M37/00
CPC分类号： A61K9/0024 , A61K9/0034 , A61K31/337 , A61K31/407 , A61K31/46 , A61K31/555 , A61K31/7064 , A61K33/24 , A61M31/002 , A61M37/0069 , A61M2210/1085 , A61M2210/1089
摘要： Implantable drug delivery devices are provided that are deformable between a relatively straightened shape suitable for deployment and a retention shape suited to retain the device within the bladder or other body cavity. While in the body cavity, the devices release drug from solid drug units housed in the devices. The devices are designed to house the solid drug units in a way that exposes one or more sides of the solid drug units to the fluid at the in vivo site of deployment. Methods for using the devices for administering drug and making the devices also are provided.
摘要翻译：提供可植入药物递送装置，其可在适于展开的相对矫直形状和适于将装置保持在囊或其它体腔内的保持形状之间变形。在体腔中，装置将药物从容纳在装置中的固体药物单元释放出来。这些装置被设计成以固定药物单元的一侧或多侧将暴露在体内部位的液体的方式容纳固体药物单元。还提供了使用用于给药的装置和制造装置的方法。

28. 发明申请

US20120089121A1 Implantable Drug Delivery Device with Bladder Retention Feature 有权
标题翻译：具有膀胱保留特征的可植入药物输送装置
公开(公告)号：US20120089121A1
公开(公告)日：2012-04-12
申请号：US13267469
申请日：2011-10-06
申请人： Heejin Lee , Hong Linh Ho Duc
发明人： Heejin Lee , Hong Linh Ho Duc
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61K9/0034 , A61K9/0065 , A61K9/20 , A61K31/167 , A61L31/10 , A61L31/16 , A61L2300/402 , A61M2210/1085
摘要： Implantable devices and methods for controlled drug delivery are provided. The device includes a device structure deformable between a retention shape and a low profile shape for deployment in the bladder of a patient and has a drug reservoir lumen in which a drug formulation is housed. The device also includes a buoyancy retention portion, which includes a volume of entrapped air or a gas-generating or effervescent powder Which will generate a volume of entrapped air following contact with urine in the bladder. The buoyancy retention portion may include a water permeable and/or biodegradable wall, which can release the entrapped air following drug release, to cause the device to sink into the bladder neck to facilitate device expulsion without the need for a device retrieval medical procedure.
摘要翻译：提供了用于受控药物递送的可植入装置和方法。该装置包括可在保持形状和低轮廓形状之间变形的装置结构，用于展开在患者的膀胱中，并且具有容纳药物制剂的药物储存器腔。该装置还包括浮力保持部分，其包括一定量的夹带空气或气体产生或泡腾粉末，其将在与膀胱中的尿液接触之后产生一定量的夹带空气。浮力保持部分可以包括水可渗透的和/或可生物降解的壁，其可以在药物释放之后释放夹带的空气，以使得装置沉入膀胱颈部以促进装置排出而不需要装置取回医学程序。

29. 发明申请

US20110052497A1 Minimally Invasive Systems and Methods for In Vivo Testing of Materials 审中-公开
标题翻译：微创体系和材料体内检测方法
公开(公告)号：US20110052497A1
公开(公告)日：2011-03-03
申请号：US12870261
申请日：2010-08-27
申请人： Heejin Lee
发明人： Heejin Lee
IPC分类号： A61K49/00 , C12Q1/02 , C12M1/34 , G01N31/00
CPC分类号： A61M31/002 , A61M2210/1085
摘要： Implantable material testing devices and method of testing materials in an animals are provided. In one embodiment, a method of testing a material in an animal includes associating the material with a retention frame to form a testing device. The retention frame movable between a first shape suited for insertion through a deployment instrument and a second shape suited for retention in the animal. The testing device is inserted in the first shape into the deployment instrument and is driven through the deployment instrument into the animal. Once in the animal, the testing device is permitted to assume the second shape so that the testing device is retained in the animal for a testing period. The testing device is removed from the animal after the testing period is complete, and the material is analyzed. The material may be analyzed for biofilm formation, encrustation, or degradation. The animal also may be analyzed for infection or other reactions to the material. Tissue may be collected from the animal, and the tissue may be analyzed. The testing period may be between about 1 day and about 90 days.
摘要翻译：提供植入材料测试装置和动物材料测试方法。在一个实施例中，测试动物中的材料的方法包括将材料与保持框架相关联以形成测试装置。保持框架可在适于通过展开装置插入的第一形状和适于保持在动物中的第二形状之间移动。测试装置以第一形状插入到展开仪器中，并通过展开仪器被驱动到动物体内。一旦在动物中，允许测试装置呈现第二形状，使得测试装置保留在动物中一段测试期间。试验期间完成后，从动物中取出试验装置，对材料进行分析。可以分析该材料的生物膜形成，结垢或降解。也可以分析动物感染或其他反应物质。可以从动物收集组织，并且可以分析组织。测试期可在约1天至约90天之间。

30. 发明授权

US08115291B2 Semiconductor package 有权
标题翻译：半导体封装
公开(公告)号：US08115291B2
公开(公告)日：2012-02-14
申请号：US12461093
申请日：2009-07-31
申请人： Joonghyun Baek , Sungjun Im , Heejin Lee
发明人： Joonghyun Baek , Sungjun Im , Heejin Lee
IPC分类号： H01L23/02
CPC分类号： H01L23/49816 , H01L23/3128 , H01L23/481 , H01L24/16 , H01L24/45 , H01L24/48 , H01L24/49 , H01L24/73 , H01L25/0657 , H01L25/105 , H01L25/18 , H01L2224/04042 , H01L2224/0554 , H01L2224/05554 , H01L2224/0557 , H01L2224/05571 , H01L2224/05573 , H01L2224/13025 , H01L2224/16145 , H01L2224/16225 , H01L2224/32145 , H01L2224/32225 , H01L2224/45144 , H01L2224/48091 , H01L2224/48227 , H01L2224/49175 , H01L2224/73265 , H01L2225/0651 , H01L2225/06513 , H01L2225/06517 , H01L2225/06586 , H01L2225/06589 , H01L2225/1023 , H01L2225/1058 , H01L2924/00014 , H01L2924/01013 , H01L2924/01014 , H01L2924/01028 , H01L2924/0105 , H01L2924/01078 , H01L2924/01079 , H01L2924/10253 , H01L2924/14 , H01L2924/15153 , H01L2924/1517 , H01L2924/15311 , H01L2924/15331 , H01L2924/181 , H01L2924/00 , H01L2924/00012 , H01L2224/05599 , H01L2224/0555 , H01L2224/0556
摘要： Provided is a semiconductor package including a first substrate including a first substrate pad and a second substrate pad spaced apart from each other, first semiconductor chips stacked on the first substrate and having a first side surface and a second side surface, first chip pads disposed on the first substrate pad and adjacent to the first side surface and provided to the respective first semiconductor chips in the peripheral circuit region and electrically connected to the first substrate pad, and a second semiconductor chip disposed toward the second side surface and including a second chip pad spaced apart from the first chip pad and electrically connected to the second substrate pad, and a heat insulation member provided to the first substrate between the at least one first substrate pad and the at least one second substrate pad.
摘要翻译：提供了一种半导体封装，其包括第一衬底，第一衬底包括第一衬底焊盘和彼此间隔开的第二衬底焊盘，第一半导体芯片堆叠在第一衬底上并具有第一侧表面和第二侧表面，第一芯片焊盘设置在所述第一基板焊盘并且与所述第一侧表面相邻并且设置在所述外围电路区域中的各个第一半导体芯片并且电连接到所述第一基板焊盘;以及第二半导体芯片，朝向所述第二侧表面设置，并且包括第二芯片焊盘与第一芯片焊盘间隔开并电连接到第二衬底焊盘，以及在至少一个第一衬底焊盘和至少一个第二衬底焊盘之间设置到第一衬底的隔热构件。

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