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21. 发明授权

US08333960B2 Treatment of degenerated disc with autologous cells 有权
标题翻译：用自体细胞治疗退化椎间盘
公开(公告)号：US08333960B2
公开(公告)日：2012-12-18
申请号：US12291016
申请日：2008-10-31
申请人： Mohamed Attawia , Hassan Serhan , Thomas M. DiMauro , Melissa Grace , David Urbahns
发明人： Mohamed Attawia , Hassan Serhan , Thomas M. DiMauro , Melissa Grace , David Urbahns
IPC分类号： A61K35/28 , A61K38/18
CPC分类号： A61K35/19 , A61K35/28 , A61K35/32 , A61K35/33 , A61K38/1841 , A61K2300/00
摘要： The present invention relates to administering autologous uncultured cells into a diseased intervertebral disc.
摘要翻译：本发明涉及将自体未培养的细胞施用于患病的椎间盘。

22. 发明授权

US08067397B2 Transdiscal administration of cycline compounds 有权
标题翻译：跨周期给药的细胞周期素化合物
公开(公告)号：US08067397B2
公开(公告)日：2011-11-29
申请号：US12454200
申请日：2009-05-14
申请人： Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Gregory Collins , Laura J. Brown , Jeffrey C. Geesin
发明人： Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Gregory Collins , Laura J. Brown , Jeffrey C. Geesin
IPC分类号： A61K31/65 , A61K38/46
CPC分类号： A61K31/65 , A61K38/20 , A61K45/06 , A61K2300/00
摘要： The present invention relates to administering a doxycycline compound into a diseased intervertebral disc.
摘要翻译：本发明涉及将多西环素化合物给予患病的椎间盘。

23. 发明申请

US20100317948A1 Photocatalytic Implant Having a Sensor 有权
标题翻译：具有传感器的光催化植入物
公开(公告)号：US20100317948A1
公开(公告)日：2010-12-16
申请号：US12817585
申请日：2010-06-17
申请人： Thomas M. DiMauro , Jeffrey K. Sutton , Mohamed Attawia , Hassan Serhan , John Daniel Malone , Timothy Beardsley
发明人： Thomas M. DiMauro , Jeffrey K. Sutton , Mohamed Attawia , Hassan Serhan , John Daniel Malone , Timothy Beardsley
IPC分类号： A61B5/1459
CPC分类号： A61L31/146 , A61B17/866 , A61F2/30767 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/38 , A61F2/4455 , A61F2002/30663 , A61F2002/30929 , A61F2002/30981 , A61F2002/3611 , A61F2002/3625 , A61F2002/443 , A61F2310/00023 , A61F2310/00604 , A61F2310/0061 , A61F2310/00616 , A61L27/06 , A61L27/427 , A61L27/56 , A61L31/022 , A61L31/124 , A61M5/158 , A61N5/0601 , A61N5/0624 , A61N2005/0651 , A61N2005/0661 , B01J35/004
摘要： An implant comprises a photocatalytic layer on at least one surface and is adapted to act as a sensor. In some embodiments, the photocatalytic layer is a semiconductor oxide that is doped. According to some embodiments, the implant comprises a wave guide. According to some embodiments the implant comprises a light port. According to some embodiments, the implant comprises a reflective material on a surface of the waveguide. According to some embodiments the implant comprises a composite material comprising a first material that has a transmissivity when exposed to a predetermined wavelength of light and a second material that has photocatalytic activity when exposed to the predetermined wavelength of light. According to some embodiments the implant comprises a light source adapted to irradiate the photocatalytic surface.
摘要翻译：植入物包括在至少一个表面上的光催化层，并且适于作为传感器。在一些实施方案中，光催化层是掺杂的半导体氧化物。根据一些实施例，植入物包括波导。根据一些实施例，植入物包括光端口。根据一些实施例，植入物在波导的表面上包括反射材料。根据一些实施例，植入物包括复合材料，其包括当暴露于预定波长的光时具有透射率的第一材料和当暴露于预定波长的光时具有光催化活性的第二材料。根据一些实施例，植入物包括适于照射光催化表面的光源。

24. 发明申请

US20090324558A1 Transdiscal administration of cycline compounds 有权
标题翻译：跨周期给药的细胞周期素化合物
公开(公告)号：US20090324558A1
公开(公告)日：2009-12-31
申请号：US12454200
申请日：2009-05-14
申请人： Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Gregory Collins , Laura J. Brown , Jeffrey C. Geesin
发明人： Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Gregory Collins , Laura J. Brown , Jeffrey C. Geesin
IPC分类号： A61K31/65 , A61K38/18 , A61K38/00 , A61P25/00
CPC分类号： A61K31/65 , A61K38/20 , A61K45/06 , A61K2300/00
摘要： The present invention relates to administering a doxycycline compound into a diseased intervertebral disc.
摘要翻译：本发明涉及将多西环素化合物给予患病的椎间盘。

25. 发明授权

US08734498B2 Intranasal red light probe for treating alzheimer's disease 有权
标题翻译：用于治疗阿尔茨海默病的鼻内红光探针
公开(公告)号：US08734498B2
公开(公告)日：2014-05-27
申请号：US12822788
申请日：2010-06-24
申请人： Thomas M. DiMauro , Mohamed Attawia , Sean Lilienfeld , Chantal Holy
发明人： Thomas M. DiMauro , Mohamed Attawia , Sean Lilienfeld , Chantal Holy
IPC分类号： A61N5/06
CPC分类号： A61N5/0603 , A61N2005/0607 , A61N2005/0644 , A61N2005/0659
摘要： A method of treating disease in which intranasal red light devices are used to shine red light upon the brain structures in the basal prefrontal cortex.
摘要翻译：一种治疗疾病的方法，其中使用鼻内红光装置将红光照射在基底前额叶皮层的脑结构上。

26. 发明申请

US20140088367A1 NIR/RED LIGHT FOR LATERAL NEUROPROTECTION 有权
标题翻译：近红外/红外线进行侧向神经保护
公开(公告)号：US20140088367A1
公开(公告)日：2014-03-27
申请号：US13784059
申请日：2013-03-04
申请人： Thomas M. DiMauro , William Horton
发明人： Thomas M. DiMauro , William Horton
IPC分类号： A61N5/06
CPC分类号： A61B17/025 , A61B5/4893 , A61B5/746 , A61B17/0206 , A61B17/0293 , A61B2017/00907 , A61B2017/0262 , A61N5/0601 , A61N5/0622 , A61N2005/063 , A61N2005/0651 , A61N2005/0659 , A61N2005/0663
摘要： The use of red or near infrared light upon neurons of the lumbar plexus that are in distress due to retraction-induced ischemia. The surgeon may protect nerves made ischemic in the surgery by: a) making an incision in a patient, b) inserting an access device into the patient through the incision to at least partially create a path to a spine of the patient, and c) irradiating nervous tissue adjacent the path with an amount of NIR or red light effective to provide neuroprotection.
摘要翻译：使用红色或近红外光对由于收缩引起的局部缺血而处于困扰状态的腰丛神经元。外科医生可以通过以下方式来保护手术中缺血的神经：a）在患者中进行切口，b）通过切口将进入装置插入到患者体内，以至少部分地创建通向患者脊柱的路径，以及c）用一定量的NIR或红光照射路径附近的神经组织，以有效提供神经保护作用。

27. 发明授权

US08581001B2 Metformin-cysteine prodrug 有权
标题翻译：二甲双胍半胱氨酸前药
公开(公告)号：US08581001B2
公开(公告)日：2013-11-12
申请号：US13087673
申请日：2011-04-15
申请人： Thomas M. DiMauro
发明人： Thomas M. DiMauro
IPC分类号： C07C323/58 , C07C323/59
CPC分类号： C07C323/58 , C07C323/59 , C07C381/00
摘要： A metformin-cysteine prodrug. It is believed that the prodrug of the present invention will transport in the LAT1 and LAT2 transporter system. Because the LAT1 and LAT2 transporters are important and effective transporters of amino acids in both the small intestine and colon, it is believed that the LAT-transportable prodrugs of the present invention will be effectively absorbed both in small intestine and in the colon. The increased absorption window provided by the present invention should result in highly sustained plasma concentrations of metformin, thereby increasing the effectiveness of the medication and allowing for a single daily dose.
摘要翻译：二甲双胍半胱氨酸前药。据信本发明的前药将在LAT1和LAT2转运体系中运输。因为LAT1和LAT2转运蛋白是小肠和结肠中氨基酸的重要且有效的转运蛋白，所以相信本发明的LAT可转运前体药物将被有效地吸收在小肠和结肠中。由本发明提供的增加的吸收窗口应该导致二甲双胍的高度持续的血浆浓度，从而增加药物的有效性并允许单次日剂量。

28. 发明授权

US08333773B2 Remotely-activated vertebroplasty injection device 有权
标题翻译：远程激活椎体成形术注射装置
公开(公告)号：US08333773B2
公开(公告)日：2012-12-18
申请号：US11847488
申请日：2007-08-30
申请人： Thomas M. DiMauro , John Crombie , Richard Pellegrino , Martin A. Reynolds
发明人： Thomas M. DiMauro , John Crombie , Richard Pellegrino , Martin A. Reynolds
IPC分类号： A61B17/58
CPC分类号： A61B17/8822 , A61F2/4601 , A61F2002/3008 , A61F2002/30523 , A61F2002/48 , A61F2220/0025 , A61F2250/0098
摘要： A remotely-activated injection device for use in vertebroplasty is provided to inject a flourescent probe material into a patient. The injection device includes a pump defining an injection chamber having an exit opening; an actuator; and a cable having a first end coupled to the actuator, and a second end remotely engaging the pump. The actuator remotely controls the pump by responsive movement of the cable to thereby cause injection of a flourescent probe material from the injection chamber of the pump through the exit opening to the patient.
摘要翻译：提供用于椎体成形术的远程激活的注射装置以将荧光探针材料注射到患者体内。注射装置包括限定具有出口的注射室的泵; 执行机构以及电缆，其具有联接到所述致动器的第一端，以及远离所述泵的第二端。致动器通过电缆的响应运动远程地控制泵，从而使得荧光探针材料从泵的注射室通过出口向患者注入。

29. 发明申请

US20120310352A1 IN-SITU INTERVERTEBRAL FUSION DEVICE AND METHOD 审中-公开
标题翻译：现场互锁融合器件及方法
公开(公告)号：US20120310352A1
公开(公告)日：2012-12-06
申请号：US13490743
申请日：2012-06-07
申请人： Thomas M. DiMauro , John D. Malone
发明人： Thomas M. DiMauro , John D. Malone
IPC分类号： A61F2/44
摘要： An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon.In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.
摘要翻译：一种用于在相邻椎骨之间植入的整形外科装置，包括：弧形气囊和所述气囊内的可硬化材料。在一些实施例中，气囊具有基本上对应于椎骨终板的周边的足迹。充气装置通过插管插入到椎间空间中并且定向成使得在膨胀时，椎骨之间的自然角度将被至少部分恢复。选自承载组分和骨生物成分的组中的至少一种成分通过流体连通装置引导到可充气装置中。

30. 发明授权

US08167920B2 Intranasal delivery of compounds that reduce intrancranial pressure 有权
标题翻译：鼻内递送减少颅内压的化合物
公开(公告)号：US08167920B2
公开(公告)日：2012-05-01
申请号：US11552201
申请日：2006-10-24
申请人： Thomas M. DiMauro , Mohamed Attawia , Sean Lilienfeld , Terri A. Kapur
发明人： Thomas M. DiMauro , Mohamed Attawia , Sean Lilienfeld , Terri A. Kapur
IPC分类号： A61N5/06
CPC分类号： A61B17/688 , A61B17/8625 , A61K9/0043
摘要： Increasing intranasal lymphatic circulation as a means of decreasing intracranial pressure in traumatic brain injury.
摘要翻译：增加鼻内淋巴循环作为降低创伤性脑损伤颅内压的手段。

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