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21. 发明申请

US20090012093A1 Receptor Function Regulator 有权
标题翻译：受体功能调节器
公开(公告)号：US20090012093A1
公开(公告)日：2009-01-08
申请号：US10534081
申请日：2003-11-06
申请人： Kohji Fukatsu , Shinobu Sasaki , Shuji Hinuma , Yasuaki Ito , Nobuhiro Suzuki , Masataka Harada , Tsuneo Yasuma
发明人： Kohji Fukatsu , Shinobu Sasaki , Shuji Hinuma , Yasuaki Ito , Nobuhiro Suzuki , Masataka Harada , Tsuneo Yasuma
IPC分类号： A61K31/4965 , C07C62/34 , C07D241/18 , C07D277/42 , G01N33/566 , A61K31/427 , A61K31/192
CPC分类号： C07C255/24 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/343 , A61K31/381 , A61K31/401 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/437 , C07C59/64 , C07C59/68 , C07C59/72 , C07C59/74 , C07C59/76 , C07C59/90 , C07C65/24 , C07C69/734 , C07C69/736 , C07C217/48 , C07C217/58 , C07C217/76 , C07C235/42 , C07C255/54 , C07C317/28 , C07C323/19 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D209/12 , C07D277/36 , C07D277/42 , C07D277/64 , C07D295/13 , C07D307/91 , C07D333/32 , C07D333/54 , C07D333/62 , C07D333/78 , C07D471/04
摘要： The GPR40 receptor function regulator of the present invention, which comprises a compound having an aromatic ring and a group capable of releasing cation is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.
摘要翻译：本发明的GPR40受体功能调节剂包含具有芳香环的化合物和能释放阳离子的基团，可用作胰岛素促分泌素或预防或治疗糖尿病等的药剂。

22. 发明授权

US06187788B1 Condensed-ring thiophene derivatives, their production and use 失效
标题翻译：缩环噻吩衍生物，其生产和使用
公开(公告)号：US06187788B1
公开(公告)日：2001-02-13
申请号：US09164349
申请日：1998-10-01
申请人： Shuichi Furuya , Nobuo Choh , Koichi Kato , Shuji Hinuma
发明人： Shuichi Furuya , Nobuo Choh , Koichi Kato , Shuji Hinuma
IPC分类号： A61K31437
CPC分类号： C07D495/04
摘要： A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a contraceptive of male or female, as an ovulation-inducing agent of female; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; is useful as modulating estrous cycles in animals in the field of animal husbandry, as an agent fro improving the quality of edible meat or promoting the growth of animals; is useful as an agent of spawning promotion in fish.
摘要翻译：促性腺激素释放激素拮抗组合物，其包含任选取代的稠合双环化合物，其由同质或杂的5至7元环和同质或异构的5至7元环组成，作为用于预防或治疗几种激素依赖性疾病，例如性激素依赖性癌症（例如前列腺癌，子宫颈癌，乳腺癌，垂体腺瘤），良性前列腺肥大，子宫肌瘤，子宫内膜异位症，早熟性青春期，闭经，经前综合征，多囊卵巢综合征和寻常型痤疮; 作为两性生育调节剂（例如妊娠控制剂和月经周期控制剂）是有效的; 可作为男性或女性的避孕方法，作为女性的排卵诱导剂; 可以通过使用由于其施用停止而产生的反弹效应而用作不育处理剂; 可用作调整动物饲养领域的发情周期，作为提高食用肉质量或促进动物生长的药剂; 作为鱼类产卵促销的代理人是有用的。

23. 发明授权

US06180792B2 Condensed-ring thiophene derivatives and thienopyrimide derivatives, their production and use 有权
标题翻译：缩环噻吩衍生物和噻吩并吡啶衍生物，其生产和使用
公开(公告)号：US06180792B2
公开(公告)日：2001-01-30
申请号：US09481535
申请日：2000-01-12
申请人： Shuichi Furuya , Nobuo Choh , Koichi Kato , Shuji Hinuma
发明人： Shuichi Furuya , Nobuo Choh , Koichi Kato , Shuji Hinuma
IPC分类号： C07D49504
CPC分类号： C07D495/04
摘要： The thienopyrimidine derivatives of the present invention are described in the following formula: The thienopyrimidine derivatives of the present invention are useful for treating mammals suffering from disorders related to gonadotropin realeasing hormone (GnRH).
摘要翻译：本发明的噻吩并嘧啶衍生物描述于下式中：本发明的噻吩并嘧啶衍生物可用于治疗患有与促性腺激素释放激素（GnRH）相关的疾病的哺乳动物。

24. 发明授权

US6048711A Human G-protein coupled receptor polynucleotides 失效
标题翻译：人类G蛋白偶联受体多核苷酸
公开(公告)号：US6048711A
公开(公告)日：2000-04-11
申请号：US959381
申请日：1997-10-28
申请人： Shuji Hinuma , Shoji Fukusumi , Yuji Kawamata
发明人： Shuji Hinuma , Shoji Fukusumi , Yuji Kawamata
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K48/00 , A61P43/00 , C07H21/04 , C07K14/705 , C07K16/28 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , G01N33/566
CPC分类号： C07K14/705 , A61K38/00
摘要： A novel G-protein coupled receptor protein, a partial peptide and their salts are disclosed. DNA encoding the receptor protein, production of the receptor protein, determination of a ligand to the receptor protein, a method for screening for compounds which inhibit ligand binding to the receptor protein, a kit for screening for such compounds are also disclosed. The receptor protein, its partial peptide and their salts are used for screening for candidate compounds of drugs and the like.
摘要翻译：公开了一种新型的G蛋白偶联受体蛋白，部分肽及其盐。编码受体蛋白质的DNA，受体蛋白质的产生，受体蛋白质的配体的测定，抑制配体与受体蛋白质结合的化合物的筛选方法，用于筛选这些化合物的试剂盒。受体蛋白质，其部分肽及其盐用于筛选候选药物化合物等。

25. 发明授权

US5556946A Interleukin-2/viral antigen protein chimers 失效
标题翻译：白细胞介素-2 /病毒抗原蛋白质切割器
公开(公告)号：US5556946A
公开(公告)日：1996-09-17
申请号：US386354
申请日：1995-02-08
申请人： Yukio Fujisawa , Shuji Hinuma , Aki Aono
发明人： Yukio Fujisawa , Shuji Hinuma , Aki Aono
IPC分类号： A61K39/00 , C07K14/035 , C07K14/04 , C07K14/16 , C07K14/55 , C07K16/08 , C12N1/21 , C12N15/26 , C12N15/38 , C12N15/48 , A61K38/20 , C12N15/62
CPC分类号： C07K16/08 , C07K14/005 , C07K14/55 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/75 , C12N2710/16122 , C12N2710/16622 , C12N2710/16722 , C12N2740/16122 , C12N2740/16222
摘要： Disclosed are (1) a fused protein obtained by combining an antigen used for vaccine and a lymphokine by the application of gene engineering, (2) a recombinant DNA containing a nucleotide sequence coding for the above fused protein, (3) a transformant bearing the above recombinant DNA, (4) a method for producing the fused protein which comprises cultivating the above transformant, producing and accumulating the above fused protein in a culture, and collecting the fused protein, and (5) a hybrid protein obtained by chemically combining an antigen used for vaccine with a lymphokine. The resulting fused and hybrid proteins have strong immunogenicity.
摘要翻译：公开的（1）通过应用基因工程将用于疫苗的抗原与淋巴因子组合而获得的融合蛋白，（2）含有编码上述融合蛋白的核苷酸序列的重组DNA，（3）（4）生产融合蛋白的方法，其包括培养上述转化体，在培养物中产生和积累上述融合蛋白，并收集融合蛋白，和（5）将化合物用于具有淋巴因子的疫苗的抗原。所得的融合蛋白和杂交蛋白具有很强的免疫原性。

26. 发明授权

US07625887B2 Receptor agonists 失效
标题翻译：受体激动剂
公开(公告)号：US07625887B2
公开(公告)日：2009-12-01
申请号：US10543997
申请日：2004-01-27
申请人： Fumio Itoh , Shuji Hinuma , Naoyuki Kanzaki , Yuji Kawamata , Taisuke Tawaraishi , Yuji Ishichi , Mariko Hirohashi
发明人： Fumio Itoh , Shuji Hinuma , Naoyuki Kanzaki , Yuji Kawamata , Taisuke Tawaraishi , Yuji Ishichi , Mariko Hirohashi
IPC分类号： A61K31/553 , A61K45/00 , C07D267/22 , C07D281/02
CPC分类号： C07D267/14 , A61K31/4353 , A61K31/5513 , A61K31/553
摘要： It is intended to provide a TGR5 receptor agonist containing a fused ring compound represented by the following general formula, its salt or a prodrug thereof: (1) wherein ring A represents an optionally substituted aromatic ring; and the ring B′ represents a 5- to 8-membered ring having one or more substituents; which is useful in treating various diseases.
摘要翻译：本发明提供一种TGR5受体激动剂，其含有下述通式表示的稠环化合物，其盐或其前药：（1）其中环A表示任选取代的芳环; 环B'表示具有一个或多个取代基的5-至8-元环; 其用于治疗各种疾病。

27. 发明授权

US07598351B2 Antibody and use thereof 失效
标题翻译：抗体及其用途
公开(公告)号：US07598351B2
公开(公告)日：2009-10-06
申请号：US11004336
申请日：2004-12-03
申请人： Hirokazu Matsumoto , Chieko Kitada , Shuji Hinuma
发明人： Hirokazu Matsumoto , Chieko Kitada , Shuji Hinuma
IPC分类号： C12P21/08
CPC分类号： G01N33/74 , C07K16/18 , C07K16/26 , G01N33/6854
摘要： The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2 ligand. Therefore, they can be used, among others, as diagnostic, prophylactic and/or therapeutic agents for various diseases caused by some or other abnormality in the pituitary function modulating activity (e.g. prolactin secretion promoting activity), central nervous system modulating activity and pancreatic function modulating activity, among others, supposedly possessed by the 19P2 ligand.
摘要翻译：本发明的抗-19P2配体单克隆抗体（特别是P2L-1Ca）具有非常高的结合能力，可中和19P2配体的花生四烯酸代谢物释放活性。因此，它们可以用作垂体功能调节活性（例如催乳素分泌促进活性），中枢神经系统调节活性和胰腺功能的一些或其他异常引起的各种疾病的诊断，预防和/或治疗剂 19P2配体据称具有调节活性。

28. 发明申请

US20090239839A1 RECEPTOR ANTAGONIST 审中-公开
标题翻译：受体拮抗剂
公开(公告)号：US20090239839A1
公开(公告)日：2009-09-24
申请号：US12391520
申请日：2009-02-24
申请人： Fumio ITOH , Shuji Hinuma , Naoyuki Kanzaki , Hiroshi Mabuchi , Hiromi Yoshida , Hirokazu Matsumoto , Takeshi Wakabayashi
发明人： Fumio ITOH , Shuji Hinuma , Naoyuki Kanzaki , Hiroshi Mabuchi , Hiromi Yoshida , Hirokazu Matsumoto , Takeshi Wakabayashi
IPC分类号： A61K31/553 , A61P25/04
CPC分类号： C07D267/08
摘要： An agent for modulating the function of an RFRP receptor, characterized by containing either a compound represented by the formula (I) [wherein ring A represents an optionally substituted aromatic ring; ring B represents an optionally substituted benzene ring; X represents oxygen, S(O)n (n is an integer of 0 to 2), or NR3 (R3 represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group); and R1 and R2 each represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group] or a salt of the compound.
摘要翻译：用于调节RFRP受体功能的试剂，其特征在于含有由式（I）表示的化合物[其中环A表示任选取代的芳环; 环B表示任选取代的苯环; X表示氧，S（O）n（n为0〜2的整数）或NR 3（R 3表示氢，任选取代的烃基或任意取代的杂环基）。并且R 1和R 2各自表示氢，任选取代的烃基或任选取代的杂环基]或该化合物的盐。

29. 发明授权

US07517661B2 Methods of screening for ligands for FPRL2 失效
标题翻译：筛选FPRL2配体的方法
公开(公告)号：US07517661B2
公开(公告)日：2009-04-14
申请号：US10554234
申请日：2004-04-22
申请人： Makoto Kobayashi , Yugo Habata , Ryo Fujii , Shuji Hinuma
发明人： Makoto Kobayashi , Yugo Habata , Ryo Fujii , Shuji Hinuma
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： G01N33/74 , A61K38/177 , G01N2333/726 , G01N2500/04
摘要： The use of a G-protein coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof and a ligand peptide comprising the amino acid sequence represented by any of SEQ ID NO: 3 to 7, or a salt thereof, enables efficient screening of an agonist or antagonist for the above receptor protein or a salt thereof.
摘要翻译：使用包含与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白或其盐和配体肽，所述配体肽包含由SEQ ID NO： SEQ ID NO：3至7或其盐能够有效筛选上述受体蛋白质的激动剂或拮抗剂或其盐。

30. 发明申请

US20090075334A1 POLYPEPTIDES, THEIR PRODUCTION AND USE 失效
标题翻译：聚氨酯，其生产和使用
公开(公告)号：US20090075334A1
公开(公告)日：2009-03-19
申请号：US12166444
申请日：2008-07-02
申请人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
发明人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
IPC分类号： C12P21/02 , C07K7/08 , C07K14/47 , C07K7/06 , C07K5/10 , G01N33/68 , C07K16/18 , C07H21/04 , C12N15/63 , C12N1/21
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K14/4702
摘要： This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.
摘要翻译：本发明涉及一种涉及调节中枢神经系统功能，循环功能，免疫功能，胃肠功能，代谢功能，生殖功能等的新型多肽，可用作治疗或预防各种疾病的药物，例如艾滋病毒感染或艾滋病（获得性免疫缺陷综合征）等。

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