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21. 发明申请

US20130237564A1 Combinations of Glycopyrrolate and Beta2 Adrenoceptor Agonists 审中-公开
标题翻译：乙酰胆碱酯酶和β2肾上腺素受体激动剂的组合
公开(公告)号：US20130237564A1
公开(公告)日：2013-09-12
申请号：US13862529
申请日：2013-04-15
申请人： Stephen Paul Collingwood
发明人： Stephen Paul Collingwood
IPC分类号： A61K31/4704 , A61K31/40
CPC分类号： A61K31/4704 , A61K31/40 , A61K31/4015 , A61K31/402 , A61K2300/00
摘要： A medicament comprising, separately or together (A) glycopyrrolate; and (B) either a compound of formula I in free or salt or solvate form, wherein W, Rx, Ry, R1, R2, R3, R4, R5, R6 and R7 have the meanings as indicated in the specification, or a compound of formula II in free or salt or solvate form, wherein X has the meaning as indicated in the specification, for simultaneous, sequential or separate administration in the treatment of an inflammatory or obstructive airways disease. Pharmaceutical compositions that contain (A) and (B) are also described.
摘要翻译：一种药物，其单独或一起（A）格隆溴铵; 和（B）游离或盐或溶剂化物形式的式I化合物，其中W，Rx，Ry，R 1，R 2，R 3，R 4，R 5，R 6和R 7具有如说明书中所示的含义，或化合物式II的游离或盐或溶剂合物形式，其中X具有说明书中指出的含义，用于在治疗炎性或阻塞性气道疾病中同时，连续或分开施用。还描述了含有（A）和（B）的药物组合物。

22. 发明申请

US20130237519A1 BICYCLIC HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 有权
公开(公告)号：US20130237519A1
公开(公告)日：2013-09-12
申请号：US13599267
申请日：2012-08-30
申请人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
发明人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
IPC分类号： C07D471/04 , A61K31/4545 , A61K31/444 , A61K45/06 , A61K31/5377 , A61K31/496
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. wherein A is and R1, R1a, R2, R3, R4, R5, R6 and X are as defined herein.

23. 发明申请

US20090264459A1 Organic Compounds 审中-公开
标题翻译：有机化合物
公开(公告)号：US20090264459A1
公开(公告)日：2009-10-22
申请号：US12308231
申请日：2007-06-28
申请人： Stephen Paul Collingwood , Robin Alec Fairhurst , Neil John Press
发明人： Stephen Paul Collingwood , Robin Alec Fairhurst , Neil John Press
IPC分类号： A61K31/4375 , C07D471/04 , C07D417/14 , C07D417/12 , A61K31/454 , A61K31/428 , A61P11/00
CPC分类号： C07D471/04 , C07D277/68 , C07D417/14
摘要： Compounds of formula (I) in free or a pharmaceutically acceptable salt form, wherein X1, L and Q have the meanings as indicated in the specification, are useful for treating obstructive or inflammatory airways diseases. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译：游离的或其药学上可接受的盐形式的式（I）化合物，其中X1，L和Q具有说明书中指出的含义，可用于治疗阻塞性或炎症性气道疾病。还描述了含有化合物的药物组合物和用于制备化合物的方法。

24. 发明申请

US20080279948A1 Treatment of Asthma and Copd Using Triple-Combination Therapy 审中-公开
标题翻译：使用三重组合治疗哮喘和复合治疗
公开(公告)号：US20080279948A1
公开(公告)日：2008-11-13
申请号：US12093663
申请日：2006-11-20
申请人： Stephen Paul Collingwood , Barbara Haeberlin
发明人： Stephen Paul Collingwood , Barbara Haeberlin
IPC分类号： A61K9/14 , A61K31/58 , A61P11/00 , A61P29/00 , A61K9/12
CPC分类号： A61K31/40 , A61K31/4704 , A61K31/58 , A61K2300/00
摘要： A medicament comprising, separately or together (A) a compound of formula I in free or salt or solvate form, wherein W, Rx, Ry, R1, R2, R3, R4, R5, R6 and R7 have the meanings as indicated in the specification; (B) a glycopyrronium salt; and (C) mometasone furoate; for simultaneous, sequential or separate administration in the treatment of an inflammatory or obstructive airways disease.
摘要翻译：一种药物，其包含分别或一起（A）游离或盐或溶剂合物形式的式I化合物，其中W，R x，R y， 1，R 2，R 3，R 4，R 5，R 5， 6和R 7具有说明书中指出的含义; （B）格隆铵盐; 和（C）糠酸莫米松; 用于在治疗炎性或阻塞性气道疾病中同时，顺次或分开施用。

25. 发明申请

US20080267886A1 Combinations of Glycopyrrolate and Beta2 Adrenoceptor Agonists 审中-公开
标题翻译：乙酰胆碱酯酶和β2肾上腺素受体激动剂的组合
公开(公告)号：US20080267886A1
公开(公告)日：2008-10-30
申请号：US11568559
申请日：2005-05-17
申请人： Stephen Paul Collingwood
发明人： Stephen Paul Collingwood
IPC分类号： A61K31/428 , A61K31/47 , A61K9/12 , A61P11/00
CPC分类号： A61K31/4704 , A61K31/40 , A61K31/4015 , A61K31/402 , A61K2300/00
摘要： A medicament comprising, separately or together (A) glycopyrrolate; and(B) either a compound of formula I in free or salt or solvate form, wherein W, Rx, Ry, R1, R2, R3, R4, R5, R6 and R7 have the meanings as indicated in the specification, or a compound of formula II in free or salt or solvate form, wherein X has the meaning as indicated in the specification, for simultaneous, sequential or separate administration in the treatment of an inflammatory or obstructive airways disease. Pharmaceutical compositions that contain (A) and (B) are also described.
摘要翻译：一种药物，其单独或一起（A）格隆溴铵; 和（B）游离或盐或溶剂合物形式的式I化合物，其中W，R x，R y，R 1， R 2，R 3，R 4，R 5，R 6，和R 7具有如说明书中所示的含义或游离或盐或溶剂化物形式的式II化合物，其中X具有说明书中指出的含义，用于同时，顺序或分别用于治疗炎性或阻塞性气道疾病。还描述了含有（A）和（B）的药物组合物。

26. 发明授权

US06329519B1 Intermediates for oligonucleotide synthesis 有权
标题翻译：寡核苷酸合成中间体
公开(公告)号：US06329519B1
公开(公告)日：2001-12-11
申请号：US09202294
申请日：1999-03-15
申请人： Stephen Paul Collingwood , Heinz Ernst Moser , Karl-Heinz Altmann , Mark Edward Douglas
发明人： Stephen Paul Collingwood , Heinz Ernst Moser , Karl-Heinz Altmann , Mark Edward Douglas
IPC分类号： C07H1920
CPC分类号： C07H19/04 , Y02P20/55
摘要： A compound of formula (I) wherein B1 is a radical of a nucleoside base, R1 is hydrogen or a hydroxy-protecting group, R2 is hydrogen, hydroxy or a 2′-nucleoside-modifying atom or group, R3 is an unsubstituted or substituted C1 to C10 alkyl, C2 to C10 alkenyl, C4 to C10 cycloalkylalkyl, C6 to C10 aryl or C7 to C13 aralkyl group, and Z is halogen or a group of formula (II) where R4 and R5 are each independently an unsubstituted or substituted C1 to C10 alkyl, C2 to C10 alkenyl, C4 to C10 cycloalkylalkyl, C6 to C10 aryl or C7 to C13 aralkyl group, or R4 is said group and R5 is hydrogen or R4 and R5 together with the nitrogen atom to which they are attached denote a five- to thirteen-membered heterocyclic ring, or Z is a group of formula (III): Nuc-O—, where Nuc is the residue of a natural or synthetic nucleoside or oligonucleotide after removal of a 5′-hydroxyl group therefrom attached through a 5′-methylene thereof to the indicated oxygen atom.
摘要翻译：式（I）的化合物，其中B1是核苷碱基的基团，R1是氢或羟基保护基，R2是氢，羟基或2'-核苷修饰的原子或基团，R3是未取代或取代的 C1至C10烷基，C2至C10烯基，C4至C10环烷基烷基，C6至C10芳基或C7至C13芳烷基，Z为卤素或式（Ⅱ）基团，其中R4和R5各自独立地为未取代或取代的C1 C 10至C 10链烯基，C 4至C 10环烷基烷基，C 6至C 10芳基或C 7至C 13芳烷基，或R 4为所述基团，R 5为氢或R 4和R 5与它们所连接的氮原子一起表示 5至13元杂环，或Z为式（III）的基团：Nuc-O-，其中Nuc是除去其中的5'-羟基之后天然或合成的核苷或寡核苷酸的残基，其通过其指示氧原子的5'-亚甲基。

27. 发明申请

US20160101097A1 Combinations of Glycopyrrolate and Beta2 Adrenoceptor Agonists 审中-公开
标题翻译：乙酰胆碱酯酶和β2肾上腺素受体激动剂的组合
公开(公告)号：US20160101097A1
公开(公告)日：2016-04-14
申请号：US14973778
申请日：2015-12-18
申请人： Stephen Paul Collingwood
发明人： Stephen Paul Collingwood
IPC分类号： A61K31/4704 , A61K31/4015
CPC分类号： A61K31/4704 , A61K31/40 , A61K31/4015 , A61K31/402 , A61K2300/00
摘要： A medicament comprising, separately or together (A) glycopyrrolate; and(B) either a compound of formula I in free or salt or solvate form, wherein W, Rx, Ry, R1, R2, R3, R4, R5, R8 and R7 have the meanings as indicated in the specification, or a compound of formula II in free or salt or solvate form, wherein X has the meaning as indicated in the specification, for simultaneous, sequential or separate administration in the treatment of an inflammatory or obstructive airways disease. Pharmaceutical compositions that contain (A) and (B) are also described.
摘要翻译：一种药物，其单独或一起（A）格隆溴铵; 和（B）游离或盐或溶剂化物形式的式I化合物，其中W，Rx，Ry，R 1，R 2，R 3，R 4，R 5，R 8和R 7具有说明书中所示的含义，或化合物式II的游离或盐或溶剂合物形式，其中X具有说明书中指出的含义，用于在治疗炎性或阻塞性气道疾病中同时，连续或分开施用。还描述了含有（A）和（B）的药物组合物。

28. 发明授权

US07723356B2 Quinuclidine derivatives and their use as muscarinic m3 receptor antagonists 有权
标题翻译：奎宁环衍生物及其作为毒蕈碱咪唑受体拮抗剂的用途
公开(公告)号：US07723356B2
公开(公告)日：2010-05-25
申请号：US11577417
申请日：2005-10-31
申请人： Neil John Press , Stephen Paul Collingwood , Urs Baettig , Brian Cox , Sudhakar Devidasrao Garad , Hyungchul Kim , Dimitris Papoutsakis , Simon James Watson
发明人： Neil John Press , Stephen Paul Collingwood , Urs Baettig , Brian Cox , Sudhakar Devidasrao Garad , Hyungchul Kim , Dimitris Papoutsakis , Simon James Watson
IPC分类号： A61K31/44
CPC分类号： C07D453/02
摘要： Compounds of Formula (I); in salt or zwitterionic form wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译：式（I）化合物; 盐或两性离子形式，其中R 1，R 2，R 3和R 4具有说明书中指出的含义，可用于治疗由毒蕈碱M3受体介导的病症，特别是炎性或阻塞性气道疾病。还描述了含有化合物的药物组合物和制备该化合物的方法。

29. 发明申请

US20100041887A1 QUINUCLIDINE DERIVATIVES BINDING TO MUCARINIC M3 RECEPTORS 失效
标题翻译：喹诺酮衍生物与MUCARINIC M3受体结合
公开(公告)号：US20100041887A1
公开(公告)日：2010-02-18
申请号：US12582291
申请日：2009-10-20
申请人： Stephen Paul Collingwood , Brian Cox , Urs Baettig , Gurdip Bhalay , Nicholas James Devereux
发明人： Stephen Paul Collingwood , Brian Cox , Urs Baettig , Gurdip Bhalay , Nicholas James Devereux
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： Compounds of formula I in salt or zwitterionic form wherein, wherein R1, R2, R3, and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译：盐或两性离子形式的式I化合物，其中R1，R2，R3和R4具有说明书中所示的含义，可用于治疗由毒蕈碱M3受体介导的病症。还描述了含有化合物的药物组合物和制备该化合物的方法。

30. 发明申请

US20080317862A1 Organic Compounds Comprising a Glycopyrrolium Salt 审中-公开
标题翻译：包含糖基吡喃鎓盐的有机化合物
公开(公告)号：US20080317862A1
公开(公告)日：2008-12-25
申请号：US12094389
申请日：2006-11-20
申请人： Stephen Paul Collingwood , Barbara Haeberlin
发明人： Stephen Paul Collingwood , Barbara Haeberlin
IPC分类号： A61K9/12 , A61K9/14 , A61K31/58 , A61K31/40 , A61P11/00
CPC分类号： A61K9/0075 , A61K9/008 , A61K31/40 , A61K31/58 , A61K2300/00
摘要： Medicaments comprising (A) an antimuscarinic agent and (B) a corticosteroid for the treatment of inflammatory or obstructive airways diseases.
摘要翻译：药物包含（A）抗毒蕈碱剂和（B）用于治疗炎性或阻塞性气道疾病的皮质类固醇。

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