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21. 发明申请

US20050239770A1 N-heterocyclic inhibitors of TNF-alpha expression 有权
标题翻译： TNF-α表达的N-杂环抑制剂
公开(公告)号：US20050239770A1
公开(公告)日：2005-10-27
申请号：US11143430
申请日：2005-06-02
申请人： Kevin Moriarty , Yvonne Shimshock , Gulzar Ahmed , Junjun Wu , James Wen , Wei Li , Shawn Erickson , Jeffrey Letourneau , Edward McDonald , Katerina Leftheris , Stephen Wrobleski , Zahid Hussain , Ian Henderson , Axel Metzger , John Baldwin , Alaric Dyckman
发明人： Kevin Moriarty , Yvonne Shimshock , Gulzar Ahmed , Junjun Wu , James Wen , Wei Li , Shawn Erickson , Jeffrey Letourneau , Edward McDonald , Katerina Leftheris , Stephen Wrobleski , Zahid Hussain , Ian Henderson , Axel Metzger , John Baldwin , Alaric Dyckman
IPC分类号： A61K31/40 , A61K31/551 , C07D251/52 , C07D251/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D521/00
CPC分类号： C07D251/52 , C07D231/12 , C07D233/56 , C07D249/08 , C07D251/48 , C07D251/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
摘要翻译：公开了通过抑制p38激酶阻断细胞因子产生的N-杂环化合物。在一个实施方案中，本发明的化合物由式I表示：还公开了使用本发明化合物的生产方法，药物组合物和治疗与不适当的p38激酶活性或TNF-α表达相关的病症的方法。

22. 发明授权

US5409101A Variably-controlled vibratory conveyor 失效
标题翻译：可变控制振动输送机
公开(公告)号：US5409101A
公开(公告)日：1995-04-25
申请号：US192276
申请日：1994-02-03
申请人： Gulzar Ahmed , Gregory L. Branch , James F. Bausch , Richard T. Symer , Joseph J. Stupak, Jr.
发明人： Gulzar Ahmed , Gregory L. Branch , James F. Bausch , Richard T. Symer , Joseph J. Stupak, Jr.
IPC分类号： B65G27/32 , H02K33/16 , B65G27/00
CPC分类号： B65G27/32 , H02K33/16
摘要： An elongate vibratory conveyor for moving products is reciprocated by driving a motor with a cyclical nonuniform motion by supplying power nonuniformly to the motor. The conveyor is reciprocated in opposite lengthwise directions, without any substantial movement of the conveyor normal to the lengthwise direction. Motor control circuitry variably drives the motor automatically in response to feedback from a sensor which senses a motion related to the conveyor motion. The feedback signal is compared to a selected one of a set of predetermined different motion patterns, and the motor is driven by supplying power nonuniformly thereto in accordance with the selected motion pattern. The conveyor system readily enables instantaneous reversibility of the product flow at the same average velocity, and instantaneous variable control for modifying the motion of the conveyor to obtain either different desired average product velocities or the same average product velocity at different conveyor inclinations or reciprocating frequencies, all irrespective of changes in conveyor loading or resistance to slip of the products conveyed. Separate motors driving either the same conveyor or separate conveyors are driven with cyclical nonuniform motions in synchronization by synchronizing their respective power supplies.
摘要翻译：用于移动产品的细长振动输送机通过不均匀地向马达供电而驱动具有周期性不均匀运动的马达而往复运动。输送机在相反的长度方向上往复运动，而输送机垂直于长度方向没有任何实质的运动。电动机控制电路根据来自传感器的反馈自动地驱动电动机，该传感器检测与输送机运动相关的运动。将反馈信号与一组预定的不同运动模式中的所选择的一个进行比较，并且通过根据所选择的运动模式不均匀地向其提供电力来驱动电动机。输送机系统能够以相同的平均速度实现产品流动的瞬时可逆性，以及瞬时可变控制，用于改变输送机的运动以获得不同的期望平均产品速度或在不同输送机倾斜或往复频率下的相同的平均产品速度，所有这些都不管传送带的变化和传送的产品的滑动阻力。驱动同一输送机或单独输送机的独立电机通过同步其各自的电源同步地以循环不均匀运动来驱动。

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