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21. 发明授权

US08679827B2 Apparatus and methods for analyte measurement and immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US08679827B2
公开(公告)日：2014-03-25
申请号：US13495224
申请日：2012-06-13
申请人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
IPC分类号： C12M3/00
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to methods for measuring an amount of an analyte using an electrochemical assay in a conduit comprising a sensor, wherein said sensor comprises an electrode having a surface layer of immobilized antibody that binds said analyte, and a counter/reference electrode disposed within said conduit. A solution comprising a substrate for said enzyme and at least one air segment contacts the sensor to remove unbound analyte and labeled antibody from a region of the sensor. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及用于在包括传感器的导管中使用电化学测定来测量分析物的量的方法，其中所述传感器包括具有结合所述分析物的固定化抗体表面层的电极，以及设置在说导管。包含用于所述酶的底物和至少一个空气区段的溶液与传感器接触以从传感器的区域去除未结合的分析物和标记的抗体。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

22. 发明授权

US08222024B2 Apparatus and methods for analyte measurement and immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US08222024B2
公开(公告)日：2012-07-17
申请号：US13198253
申请日：2011-08-04
申请人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
IPC分类号： C12M3/00
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成能够适用于各种实时测定方案的单次使用的盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

23. 发明授权

US08472693B2 Method for determining at least one hemoglobin related parameter of a whole blood sample 有权
标题翻译：用于确定全血样品的至少一种血红蛋白相关参数的方法
公开(公告)号：US08472693B2
公开(公告)日：2013-06-25
申请号：US13051705
申请日：2011-03-18
申请人： Graham Davis , Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten Lalpuria , Paul G. Mitsis
发明人： Graham Davis , Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten Lalpuria , Paul G. Mitsis
IPC分类号： G06K9/00
CPC分类号： G01N33/726 , G01N15/1475 , G01N2015/0073
摘要： A method and apparatus for determining at least one hemoglobin related parameter of a whole blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by an interior surface of a first panel, and an interior surface of a second panel, and the chamber has a height extending between the interior surfaces of the panels, wherein the chamber is configured to increase the oxygenation state of the sample to a substantially oxygenated state within a predetermined amount of time after entry into the chamber; b) imaging the at least one red blood cell contacting the interior surfaces, and producing image signals; c) determining an optical density of at least a portion of the imaged red blood cell contacting both interior surfaces; and d) determining the at least one hemoglobin related parameter of the red blood cell contacting the interior surfaces, using the determined optical density and a molar extinction coefficient for oxygenated hemoglobin.
摘要翻译：提供了一种用于确定全血样品的至少一种血红蛋白相关参数的方法和装置。该方法包括以下步骤：a）将样品沉积到适于静态保持样品进行分析的分析室中，所述室由第一面板的内表面和第二面板的内表面限定，并且所述室具有在所述面板的内表面之间延伸的高度，其中所述腔被配置为在进入所述腔室之后的预定量的时间内将所述样品的氧合状态增加到基本上氧合状态; b）对与内表面接触的至少一个红细胞进行成像，并产生图像信号; c）确定接触两个内表面的成像红细胞的至少一部分的光密度; 以及d）使用确定的光密度和氧合血红蛋白的摩尔消光系数来确定与内表面接触的红细胞的至少一种血红蛋白相关参数。

24. 发明授权

US08389293B2 Reducing leukocyte interference in competitive immunoassays 有权
标题翻译：减少竞争性免疫测定中的白细胞干扰
公开(公告)号：US08389293B2
公开(公告)日：2013-03-05
申请号：US12620230
申请日：2009-11-17
申请人： John Lewis Emerson Campbell , Graham Davis
发明人： John Lewis Emerson Campbell , Graham Davis
IPC分类号： G01N33/53 , G01N1/00
CPC分类号： G01N33/54313 , G01N33/54393 , Y10T436/25125
摘要： The invention is directed to methods and devices for reducing interference from leukocytes in competitive analyte immunoassays. In one embodiment, the invention is to a method comprising the steps of (a) amending a biological sample such as a whole blood sample with sacrificial beads opsonized for leukocytes; and (b) performing a competitive immunoassay on the amended sample to determine the concentration of said analyte in said sample. Preferably, the sample is amended with IgG-coated sacrificial beads.
摘要翻译：本发明涉及减少竞争性分析物免疫测定中白细胞干扰的方法和装置。在一个实施方案中，本发明涉及一种方法，包括以下步骤：（a）用生物样品（例如全血样品）修饰用于白细胞调理的牺牲珠; 和（b）对经修改的样品进行竞争性免疫测定以确定所述样品中所述分析物的浓度。优选地，用IgG涂覆的牺牲珠改变样品。

25. 发明授权

US06971931B2 Amphibious vehicle 失效
标题翻译：两栖车
公开(公告)号：US06971931B2
公开(公告)日：2005-12-06
申请号：US10692998
申请日：2003-10-24
申请人： Graham Davis
发明人： Graham Davis
IPC分类号： B60F3/00 , B63B43/14 , B63B1/00
CPC分类号： B63B43/14 , B60F3/0038
摘要： An amphibious vehicle for land and water use comprises a main mono hull section and a pair of port and starboard sponsons which are movable from a stowed position under a main vehicle deck adjacent to the mono hull and a fully deployed position in which the sponsons are spaced apart from the mono hull by at least one hull width. The sponsons are each pivotally connected to the main hull by means of a pair of respective arms which together with the sponson and the hull define a parallel type four bar linkage. The sponsons stabilise the vehicle on water and are readily stowed to allow vehicle mobility on land.
摘要翻译：用于陆地和水的水陆两用车辆包括主单体船体部分和一对端口和右舷支架，其可以从邻近单体船体的主车辆甲板下方的收起位置移动，并且完全展开位置，在该位置上，至少一个船体宽度除了单体船体外。支架各自通过一对相应的臂枢转地连接到主船体，这些臂与支架和船体一起限定了平行的四杆连杆。赞助商将车辆稳定在水面上，并且容易收起，以允许在陆地上的车辆行驶。

26. 发明授权

US5727548A Strip electrode with screen printing 失效
标题翻译：带电极丝网印刷
公开(公告)号：US5727548A
公开(公告)日：1998-03-17
申请号：US469205
申请日：1995-06-06
申请人： Hugh Allen Oliver Hill , Irving John Higgins , James Michael McCann , Graham Davis
发明人： Hugh Allen Oliver Hill , Irving John Higgins , James Michael McCann , Graham Davis
IPC分类号： A61B5/00 , C12Q1/00 , C12Q1/68 , G01N27/403 , G01N33/487 , G01N33/543
CPC分类号： G01N33/5438 , A61B5/1486 , A61B5/6848 , C12Q1/001 , C12Q1/004 , C12Q1/6825 , G01N27/4035 , A61B2560/0418 , Y10T29/4914 , Y10T29/49153 , Y10T29/49169 , Y10T29/49224
摘要： A sensor system that detects a current representative of a compound in a liquid mixture features a two-electrode strip adapted for releasable attachment to signal readout circuitry. The strip comprises an elongated support (preferably flat) adapted for releasable attachment to the readout circuitry; a first conductor and a second conductor each extend along the support and comprise means for connection to the circuitry. An active electrode, positioned to contact the liquid mixture and the first conductor, comprises a single layer deposit of an enzyme capable of catalyzing a reaction involving the compound, a conductive material, and an electron mediator, capable of transferring electrons between the enzyme-catalyzed reaction and the first conductor. A reference electrode is positioned to contact the mixture and the second conductor. The system includes circuitry adapted to provide an electrical signal representative of the current. The two-electrode strip is manufactured, e.g., by screen printing, an admixture of an enzyme a conductive material, and a mediator as a single layer onto the substrate.
摘要翻译：检测液体混合物中的化合物的当前代表的传感器系统具有适于可释放地附接到信号读出电路的双电极条。条带包括适于可释放地附接到读出电路的细长支撑件（优选是平坦的）; 第一导体和第二导体各自沿着支撑件延伸并且包括用于连接到电路的装置。定位成接触液体混合物和第一导体的活性电极包括能够催化涉及化合物，导电材料和电子介体的反应的酶的单层沉积物，其能够在酶催化的反应和第一个导体。定位参考电极以接触混合物和第二导体。该系统包括适于提供代表电流的电信号的电路。双电极条例如通过丝网印刷，酶导电材料的混合物和作为单层的介体制成在基底上。

27. 发明授权

US5593638A Apparatus for estimating the change in an analyte from hemolysis in a fluid sample 失效
标题翻译：用于估计流体样品中溶血的分析物变化的装置
公开(公告)号：US5593638A
公开(公告)日：1997-01-14
申请号：US359595
申请日：1994-12-20
申请人： Graham Davis
发明人： Graham Davis
IPC分类号： G01N33/48 , G01N27/416 , G01N33/483 , G01N33/487 , G01N33/49 , G01N33/493 , G01N33/50 , G01N33/52 , G01N33/72 , G01N33/84 , G01N21/01 , G01N31/22 , G01N33/20
CPC分类号： G01N33/726 , G01N33/725 , Y10T436/25125 , Y10T436/25375
摘要： The present invention concerns a method of detecting hemolysis in a whole-blood sample, a method of determining an elevation in the potassium ion concentration of a whole-blood sample, an apparatus for detecting hemolysis and/or determining an elevation in the potassium ion concentration in a fluid sample, an apparatus for detecting hemolysis and/or determining an elevation in the potassium ion concentration in a whole-blood sample, and a single-use cartridge containing a plurality of microfabricated biosensors which further contains a hemolysis detection unit.
摘要翻译：本发明涉及检测全血样品中的溶血的方法，确定全血样品的钾离子浓度升高的方法，检测溶血和/或测定钾离子浓度升高的装置在流体样品中，用于检测溶血和/或确定全血样品中的钾离子浓度的升高的装置和还含有溶血检测单元的多个微细生物传感器的一次性盒。

28. 发明授权

US07263501B2 Point-of-care inventory management system and method 有权
标题翻译：关键点库存管理系统和方法
公开(公告)号：US07263501B2
公开(公告)日：2007-08-28
申请号：US10384820
申请日：2003-03-11
申请人： Jody Ann Tirinato , Michael P. Zelin , Paul Andrew Gibson , Lyudmila Zaltsman , Graham Davis
发明人： Jody Ann Tirinato , Michael P. Zelin , Paul Andrew Gibson , Lyudmila Zaltsman , Graham Davis
IPC分类号： G06Q99/00 , H04K1/00
CPC分类号： G01K13/00 , G01K1/02 , G01K3/04 , G06Q10/087 , G06Q20/203 , G06Q30/0223 , G06Q30/0639 , Y10S707/99931
摘要： A system and method are disclosed for controlling an inventory of a plurality of point-of-care diagnostic devices. The plurality of devices includes at least one type of device. Each device is configured to perform at least one sample analysis. Each device has a usable lifetime. The inventory includes a main inventory and at least one subinventory. The inventory control system comprises a data input interface for entering data associated with the devices and a data output interface for displaying data associated with the devices. A memory stores data associated with the devices and stores steps of a computer program to automatically update the current number of devices in the at least one subinventory in response to an occurrence of an event that causes a change in the current number of devices in the at least one subinventory. The inventory control system comprises a processor for accessing the memory to execute the computer program.
摘要翻译：公开了一种用于控制多个点护理诊断装置的库存的系统和方法。多个装置包括至少一种类型的装置。每个设备被配置为执行至少一个样本分析。每个设备都有可用的使用寿命。库存包括主要库存和至少一个子库存。库存控制系统包括用于输入与设备相关联的数据的数据输入接口和用于显示与设备相关联的数据的数据输出接口。存储器存储与设备相关联的数据，并且存储计算机程序的步骤，以响应于导致当前数量的当前设备数量变化的事件的发生自动更新至少一个子库中的当前设备数量至少一个子库存。库存控制系统包括用于访问存储器以执行计算机程序的处理器。

29. 发明授权

US5682884A Strip electrode with screen printing 失效
标题翻译：带电极丝网印刷
公开(公告)号：US5682884A
公开(公告)日：1997-11-04
申请号：US281131
申请日：1994-07-27
申请人： Hugh Allen Oliver Hill , Irving John Higgins , James Michael McCann , Graham Davis
发明人： Hugh Allen Oliver Hill , Irving John Higgins , James Michael McCann , Graham Davis
IPC分类号： A61B5/00 , C12Q1/00 , C12Q1/68 , G01N27/403 , G01N33/487 , G01N33/543 , A61B5/05
CPC分类号： A61B5/1486 , A61B5/14865 , A61B5/6848 , C12Q1/001 , C12Q1/004 , G01N27/4035 , G01N33/5438 , A61B2560/0418
摘要： A sensor system that detects a current representative of a compound in a liquid mixture features a two-electrode strip adapted for releasable attachment to signal readout circuitry. The strip comprises an elongated support (preferably flat) adapted for releasable attachment to the readout circuitry; a first conductor and a second conductor each extend along the support and comprise means for connection to the circuitry. An active electrode, positioned to contact the liquid mixture and the first conductor, comprises a deposit of an enzyme capable of catalyzing a reaction involving the compound and (preferably) an electron mediator, capable of transferring electrons between the enzyme-catalyzed reaction and the first conductor. A reference electrode is positioned to contact the mixture and the second conductor. The system includes circuitry adapted to provide an electrical signal representative of the current. The two-electrode strip is manufactured, e.g., by screen printing the enzyme (and preferably the mediator) onto the substrate.
摘要翻译：检测液体混合物中的化合物的当前代表的传感器系统具有适于可释放地附接到信号读出电路的双电极条。条带包括适于可释放地附接到读出电路的细长支撑件（优选是平坦的）; 第一导体和第二导体各自沿着支撑件延伸并且包括用于连接到电路的装置。定位成接触液体混合物和第一导体的活性电极包括能够催化涉及化合物和（优选）电子介体的反应的酶的沉积物，其能够在酶催化的反应和第一个导体。定位参考电极以接触混合物和第二导体。该系统包括适于提供代表电流的电信号的电路。例如通过将酶（优选介体）丝网印刷到基底上来制造双电极条。

30. 发明授权

US5416026A Method for detecting the change in an analyte due to hemolysis in a fluid sample 失效
标题翻译：用于检测流体样品中因溶血引起的分析物变化的方法
公开(公告)号：US5416026A
公开(公告)日：1995-05-16
申请号：US131527
申请日：1993-10-04
申请人： Graham Davis
发明人： Graham Davis
IPC分类号： G01N33/48 , G01N27/416 , G01N33/483 , G01N33/487 , G01N33/49 , G01N33/493 , G01N33/50 , G01N33/52 , G01N33/72 , G01N33/84 , G01N33/20
CPC分类号： G01N33/726 , G01N33/725 , Y10T436/25125 , Y10T436/25375
摘要： The present invention concerns a method of detecting hemolysis in a whole-blood sample, a method of determining an elevation in the potassium ion concentration of a whole-blood sample, an apparatus for detecting hemolysis and/or determining an elevation in the potassium ion concentration in a fluid sample, an apparatus for detecting hemolysis and/or determining an elevation in the potassium ion concentration in a whole-blood sample, and a single-use cartridge containing a plurality of microfabricated biosensors which further contains a hemolysis detection unit.
摘要翻译：本发明涉及检测全血样品中的溶血的方法，确定全血样品的钾离子浓度升高的方法，检测溶血和/或测定钾离子浓度升高的装置在流体样品中，用于检测溶血和/或确定全血样品中的钾离子浓度的升高的装置和还含有溶血检测单元的多个微细生物传感器的一次性盒。

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