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21. 发明授权

US08536160B2 Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders 有权
标题翻译：雄激素和雄激素的氮杂环基衍生物作为心血管疾病的药物
公开(公告)号：US08536160B2
公开(公告)日：2013-09-17
申请号：US12296532
申请日：2007-04-11
申请人： Alberto Cerri , Giorgio Fedrizzi , Alessandra Benicchio , Giuseppe Bianchi , Patrizia Ferrari , Mauro Gobbini , Rosamaria Micheletti , Marco Pozzi , Piero Enrico Scotti
发明人： Alberto Cerri , Giorgio Fedrizzi , Alessandra Benicchio , Giuseppe Bianchi , Patrizia Ferrari , Mauro Gobbini , Rosamaria Micheletti , Marco Pozzi , Piero Enrico Scotti
IPC分类号： A61K31/58 , A61P9/12 , C07J43/00
CPC分类号： C07J43/003
摘要： Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
摘要翻译：式（I）化合物其中：所述基团如说明书中所定义，可用于制备用于治疗心血管疾病，特别是心力衰竭和高血压的药物。这些化合物是Na +，K + -ATP酶的酶活性的抑制剂。它们可用于制备用于治疗由内源性哇巴因的高血压作用引起的疾病的药物，例如常染色体显性多囊肾病（ADPKD）的肾衰竭进展，先兆子痫高血压和蛋白尿和肾衰竭进展 adducin多态性。

22. 发明申请

US20130018024A1 METHODS AND SYSTEMS FOR PHARMACOGENOMIC TREATMENT OF CARDIOVASCULAR CONDITIONS 有权
标题翻译：药物治疗心血管事件的方法与系统
公开(公告)号：US20130018024A1
公开(公告)日：2013-01-17
申请号：US13502518
申请日：2010-10-18
申请人： Giuseppe Bianchi , Patrizia Ferrari , Fabio MacCiardi
发明人： Giuseppe Bianchi , Patrizia Ferrari , Fabio MacCiardi
IPC分类号： A61K31/58 , C07H21/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/08 , A61P13/12 , A61P25/00 , A61P13/02 , A61P27/16 , A61P25/18 , A61P25/24 , C12Q1/68 , C40B30/04 , C40B40/06 , C07J17/00
CPC分类号： A61K31/56 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： Methods and systems are provided herein that are based on the effects of genetic variations on the biological activities associated to rostafuroxin in an individual. In particular, compositions, methods and systems are herein described that are based on an indentified influence on an individual response to rostafuroxin of one or more polymorphisms in an intergenic or intragenic region of a gene selected from the group consisting of KCNS3, THSD7A, FAM46A, LOC389970, HLA-G, and TTC29, and/or a genetic variation in linkage disequilibrium therewith.
摘要翻译：本文提供的方法和系统是基于遗传变异对与个体中罗夫沙罗毒素相关的生物活性的影响。特别地，本文描述了基于对选自KCNS3，THSD7A，FAM46A的基因或基因内区域中的一种或多种多态性的罗夫沙罗的单个应答的影响的组合物，方法和系统， LOC389970，HLA-G和TTC29，和/或与其连锁不平衡的遗传变异。

23. 发明申请

US20090209506A1 AMINO DERIVATIVES OF BETA-HOMOANDROSTANES AND BETA-HETEROANDROSTANES 有权
标题翻译：氨基苯甲酸和氨基甲酸酯的氨基衍生物
公开(公告)号：US20090209506A1
公开(公告)日：2009-08-20
申请号：US12305571
申请日：2007-05-31
申请人： Alberto Cerri , Barbara Moro , Maco Torri , Giulio Carzana , Giuseppe Bianchi , Mara Ferrandi , Patrizia Ferrari , Maria Pia Zappavigna , Leonardo Banfi , Giuseppe Giacalone
发明人： Alberto Cerri , Barbara Moro , Maco Torri , Giulio Carzana , Giuseppe Bianchi , Mara Ferrandi , Patrizia Ferrari , Maria Pia Zappavigna , Leonardo Banfi , Giuseppe Giacalone
IPC分类号： A61K31/566 , C07J41/00
CPC分类号： C07J73/005 , C07J63/004 , C07J73/003
摘要： New aminoalkoxyimino derivatives at position 3 of substituted B-homoandrostanes and B-heteroandrostanes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.
摘要翻译：取代的β-异雄甾烷砜和B-异雄甾烷砜的3位的新的氨基烷氧基亚氨基衍生物，其制备方法以及含有它们用于治疗心力衰竭和高血压的心血管疾病的药物组合物。特别地描述了具有通式（I）的化合物，其中基团具有本申请中详细描述的含义。

24. 发明授权

US5705662A 17-(3-imino-2-alkylpropenyl)-5.beta., 14.beta.-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same 失效
标题翻译：对心血管系统有活性的17-（3-亚氨基-2-烷基丙烯基）-5β，14β-雄甾烷衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5705662A
公开(公告)日：1998-01-06
申请号：US559291
申请日：1995-11-15
申请人： Alberto Cerri , Giuseppe Bianchi , Patrizia Ferrari , Piero Melloni , Maria Luisa Quadri
发明人： Alberto Cerri , Giuseppe Bianchi , Patrizia Ferrari , Piero Melloni , Maria Luisa Quadri
IPC分类号： A61K31/575 , A61K31/58 , A61P9/00 , C07J41/00 , C07J43/00 , C07J9/00 , A01N45/00
CPC分类号： C07J43/003 , C07J41/0055
摘要： New 17-�3-imino-2-alkyl propenyl!-14.beta.-hydroxy-5.beta.-androstane derivatives active on the cardiovascular system by inhibiting Na+,K+-ATPase, a process for their preparation, and to pharmaceutical compositions for the treatment of cardiovascular disorders, such as heart failure and hypertension.
摘要翻译：通过抑制Na +，K + -ATP酶，其制备方法和用于治疗的药物组合物，对心血管系统上活性的新的17- [3-亚氨基-2-烷基丙烯基]-14β-羟基-5β-雄甾烷衍生物的心血管疾病，如心力衰竭和高血压。

25. 发明授权

US5538960A Hydrazono-5.beta., 14.beta.-androstane derivatives active on the cardiovascular system, and pharmaceutical compositions containing same 失效
标题翻译：对心血管系统有活性的肼基-5β，14β-雄甾烷衍生物和含有它们的药物组合物
公开(公告)号：US5538960A
公开(公告)日：1996-07-23
申请号：US106638
申请日：1993-08-16
申请人： Alberto Cerri , Luigi Bernardi , Giuseppe Bianchi , Patrizia Ferrari , Elena Folpini , Piero Melloni
发明人： Alberto Cerri , Luigi Bernardi , Giuseppe Bianchi , Patrizia Ferrari , Elena Folpini , Piero Melloni
IPC分类号： A61K31/565 , A61K31/58 , A61P9/00 , A61P9/12 , C07J31/00 , C07J41/00 , C07J43/00 , C07J75/00 , C07D43/00 , A61K31/57
CPC分类号： C07J41/0088 , C07J41/0005 , C07J41/0038 , C07J43/003
摘要： The present invention relates to new 17-hydrazonomethyl- and 17-hydrazono-14.beta.-hydroxy-5.beta.-androstane derivatives active on the cardiovascular system, to a process for their preparation and to pharmaceutical compositions containing same for the treatment of cardiovascular disorders, such as heart failure and hypertension.
摘要翻译：本发明涉及在心血管系统上活性的新的17-亚肼基甲基和17-亚肼基-14β-羟基-5β-雄甾烷衍生物，其制备方法以及含有其用于治疗心血管疾病的药物组合物，如心力衰竭和高血压。

26. 发明授权

US4690497A Underwater optical fiber cable with segmented protective tube 失效
标题翻译：水下光缆与分段保护管
公开(公告)号：US4690497A
公开(公告)日：1987-09-01
申请号：US738059
申请日：1985-05-24
申请人： Elio Occhini , Giuseppe Bianchi
发明人： Elio Occhini , Giuseppe Bianchi
IPC分类号： H01B7/14 , G02B6/44
CPC分类号： G02B6/4427 , G02B6/4494
摘要： An underwater optical fiber cable for laying at great depths in which an optical fiber core containing a plurality of optical fibers is protected by a peripherally segmented metal tube, each metal segment, in cross-section, having the shape of a sector of an annular, which is surrounded by at least one layer of elongated metal elements wound helicoidally around the tube, each element having radially extending sides which have radial lengths less than the peripheral lengths of the peripheral surfaces of the element. The layer or layers are surrounded by a watertight, conductive metal sheath and preferably, the sheath is surrounded by a plastic sheath.
摘要翻译：一种水下光纤缆线，用于铺设在其中包含多根光纤的光纤芯线的大深度处被外围分段的金属管保护，每个金属段的横截面具有环形扇形的形状，其被围绕管缠绕的至少一层细长金属元件围绕，每个元件具有径向延伸的侧面，其径向长度小于该元件的周边表面的周长。该层被水密的导电金属护套包围，优选地，护套由塑料护套包围。

27. 发明授权

US4493760A Electrolytic cell having nonporous partition 失效
标题翻译：电解槽具有无孔分隔
公开(公告)号：US4493760A
公开(公告)日：1985-01-15
申请号：US559025
申请日：1983-12-07
申请人： Giuseppe Bianchi
发明人： Giuseppe Bianchi
IPC分类号： A47L15/42 , C02F1/461 , C02F1/467 , C25B9/06 , C25B13/02 , C25B1/26
CPC分类号： C02F1/4674 , A47L15/4229 , C25B9/06 , C02F1/46104 , C02F1/46109
摘要： An electrolytic cell for the production of chlorine gas by the electrolysis of a sodium chloride solution includes a cell body having therein a cathode compartment having a cathode electrode for the formation of hydrogen gas during electrolysis and an anode compartment having an anode electrode for the formation of chlorine gas during electrolysis. Apertures or conduits are provided for charging sodium chloride solution into the compartments, for discharging hydrogen and chlorine gases from the compartments, and for discharging from the compartments solutions resulting from the electrolysis operation. A nonporous wall provides for physical and electrolytic communication between the bottoms of the compartments, while preventing physical and electrolytic communication between the compartments above the bottoms thereof.
摘要翻译：通过电解氯化钠溶液来生产氯气的电解池包括：电池体，其中具有阴极室，该阴极室具有用于在电解期间形成氢气的阴极电极和具有形成阳极电极的阳极室; 电解过程中的氯气。提供孔或导管用于将氯化钠溶液装入室中，用于从室中排出氢气和氯气，并从隔室排出电解操作产生的溶液。无孔壁提供隔室的底部之间的物理和电解连通，同时防止其底部之间的隔室之间的物理和电解连通。

28. 发明授权

US4481086A Dishwasher with electrochemical cell 失效
标题翻译：带电化学电池的洗碗机
公开(公告)号：US4481086A
公开(公告)日：1984-11-06
申请号：US444816
申请日：1982-11-23
申请人： Giuseppe Bianchi , Claudio Milocco
发明人： Giuseppe Bianchi , Claudio Milocco
IPC分类号： A47L15/42 , C02F1/467 , D06F39/02 , C25B1/26
CPC分类号： C02F1/4674 , A47L15/4229 , C02F2201/4613
摘要： A dish washing machine includes a wash tank for receipt of dishes to be washed and a hydraulic circuit for receiving water from a water supply source and for supplying water to the wash tank. An electrochemical cell for generating chlorine gas by the electrolysis of a brine solution is connected to the hydraulic circuit. A salt container is connected to the hydraulic circuit by at least one valve and forms brine to be supplied to the electrochemical cell. At least one chlorine gas supply conduit connects the electrochemical cell to the wash tank to thereby supply chlorine gas from the electrochemical cell to the interior of the wash tank.
摘要翻译：洗碗机包括用于接收要洗涤的菜肴的洗涤槽和用于从供水源接收水并用于向洗涤槽供水的液压回路。通过电解盐水溶液产生氯气的电化学电池连接到液压回路。盐容器通过至少一个阀连接到液压回路，并形成供给电化学电池的盐水。至少一个氯气供应管道将电化学电池连接到洗涤槽，从而将氯气从电化学电池供应到洗涤槽的内部。

29. 发明授权

US4415764A Submarine electric cable with tubular stiffening means and method of applying the stiffening means 失效
标题翻译：具有管状加强装置的海底电缆和施加加强装置的方法
公开(公告)号：US4415764A
公开(公告)日：1983-11-15
申请号：US318258
申请日：1981-11-04
申请人： Paolo G. Priaroggia , Giuseppe Bianchi , Angelo Sala
发明人： Paolo G. Priaroggia , Giuseppe Bianchi , Angelo Sala
IPC分类号： H01B7/14 , H02G1/10 , H02G9/02 , H01B7/24
CPC分类号： H02G1/10 , H02G9/02
摘要： A submarine electric cable installation in which the cable is protected from damaging stresses to which it would be subjected if it were permitted to be suspended between projections on the water bottom by enclosing the portion of the cable which would normally engage the projections with a tubular stiffening means, the stiffening means having a rigidity greater than the rigidity of the cable and providing a space between it and the cable for cooling water flow. The stiffening means may comprise one or more tube and, preferably, comprises a plurality of tubes having their ends secured to the adjacent ends of other tubes, each tube comprising a pair of C-shaped shells with annular corrugations and secured together. Also, a method of applying the tubes to the cable in which the tubes are applied to the cable, as it is laid, between the laying ship and the surface of the water.
摘要翻译：一种海底电缆设备，其中电缆被保护不会损坏其将受到的应力，如果允许电缆通过将通常与突起接合的电缆的一部分与管状加强件意味着加强装置具有大于电缆的刚度的刚性，并且在其与电缆之间提供用于冷却水流的空间。加强装置可以包括一个或多个管，并且优选地包括多个管，其端部固定到其它管的相邻端，每个管包括一对具有环形波纹并且固定在一起的C形壳。而且，一种将管施加到电缆的方法，其中管被敷设在敷设船和水面之间的电缆中。

30. 发明授权

US4204937A Novel electrolytic amalgam denuder apparatus 失效
标题翻译：新型电解汞合金破碎机
公开(公告)号：US4204937A
公开(公告)日：1980-05-27
申请号：US16191
申请日：1979-02-28
申请人： Giuseppe Bianchi , Oronzio deNora , Placido M. Spaziante
发明人： Giuseppe Bianchi , Oronzio deNora , Placido M. Spaziante
IPC分类号： C25B1/36 , C25B1/42 , C25B1/44 , C25B11/12 , C25B11/18
CPC分类号： C25B1/42 , C25B1/36
摘要： An improved process for the production of halogens and alkali metal hydroxide by electrolysis of aqueous solution of alkali metal halides in a flowing mercury electrolysis cell wherein the salt solutions do not have to purified and to novel amalgam denuders and a mercury electrolytic cell plant without a salt purification step.
摘要翻译：通过在流动的水银电解池中电解碱金属卤化物的水溶液来生产卤素和碱金属氢氧化物的改进方法，其中盐溶液不需要纯化和新的汞齐溶解剂和没有盐的汞电解池设备净化步骤。

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