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21. 发明授权

US06610052B2 Laser system and method for treatment of biologic targets 有权
公开(公告)号：US06610052B2
公开(公告)日：2003-08-26
申请号：US09925589
申请日：2001-08-09
申请人： Horace W. Furumoto
发明人： Horace W. Furumoto
IPC分类号： A61B1818
CPC分类号： H01S3/092 , A61B18/203 , A61B2017/00172 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , H01S3/08072 , H01S3/1633 , H01S2301/08
摘要： A long pulse alexandrite laser for treating dermatological specimens is disclosed. The use of alexandrite allows operation in the near-infrared, specifically in a 50 nm range surrounding 755. Infrared in this range allows good penetration while still achieving an acceptable ratio of hemoglobin to melanin absorption. In operation, the laser generates pulses having a durations between 5 and 100 msec and fluences between 10 and 50 J/cm2. A light delivery system is provided that transmits the laser light output pulse to dermatological targets of a patient. The invention is also directed to a hair removal system. Here, it is desirable to use an index-matching application on the skin sections to be treated, and a visual indicator is thermo- or photo-responsive or otherwise responsive to the laser light pulse to generate a visible change. Also, the invention is directed to a combined sclerotherapy and light treatment method and kit for unwanted veins. Substantially increased success has been achieved by implementing a dwell time of between 12 hours and 6 months between the light-based therapy and the sclerotherapy. Finally, the invention relates to pulse periodic heating of biologic targets, including systems and methods for generating an effective light output pulse comprising a series of sub-pulses with a limited duty cycle and a periodicity that is less than the thermal relaxation time of the targeted structure.

22. 发明授权

US06391022B1 Ultra long pulsed dye laser device for treatment of ectatic vessels and method therefor 失效
标题翻译：用于治疗血管的超长脉冲染料激光装置及其方法
公开(公告)号：US06391022B1
公开(公告)日：2002-05-21
申请号：US09007929
申请日：1998-01-16
申请人： Horace W. Furumoto , Harry L. Ceccon
发明人： Horace W. Furumoto , Harry L. Ceccon
IPC分类号： A61B1818
CPC分类号： A61B18/203 , A61B18/20 , A61B18/22 , A61B2018/00452 , A61B2018/207
摘要： A long pulsed dye laser device for selective photothermolysis comprises at least two pulsed dye lasers, such as flash lamp excited dye lasers, each generating corresponding pulsed laser beams successively in time. These laser can be coordinated by a synchronizer that sequentially triggers the lasers. A combining network merges the pulse laser beams into a combined beam and a delivery system conveys the combined pulse laser beam to a patient. An example of a delivery device is a single optical fiber. This invention enables production of the necessary pulse widths, on the order of 2 msec, which can not be achieved by individual dye lasers, generally lower than 0.8 msec. Also disclosed is a selective photothermolysis method. This method comprises irradiating a tissue section of a patient with a pulsed laser beam having a changing color across a time period of the pulse. This pulse color is selected to maximize absorption in a target tissue of a patient in response to heating caused by a preceding portion of the pulse.
摘要翻译：用于选择性光热解的长脉冲染料激光装置包括至少两个脉冲染料激光器，例如闪光灯激发的染料激光器，每个脉冲染料激光器在时间上连续产生相应的脉冲激光束。这些激光器可以由顺序地触发激光器的同步器来协调。组合网络将脉冲激光束合并成组合光束，并且传送系统将组合的脉冲激光束传送给患者。输送装置的一个实例是单根光纤。本发明能够生产大约为2毫秒的必需脉冲宽度，这些脉冲宽度通常为低于0.8毫秒，单个染料激光器无法实现。还公开了选择性光热解法。该方法包括在脉冲的时间段内照射具有变化颜色的脉冲激光束的患者的组织部分。选择该脉冲颜色以响应于由脉冲的前一部分引起的加热而使患者的靶组织中的吸收最大化。

23. 发明授权

US6077294A Method for non-invasive wrinkle removal and skin treatment 失效
标题翻译：非侵入性除皱和皮肤治疗方法
公开(公告)号：US6077294A
公开(公告)日：2000-06-20
申请号：US95789
申请日：1998-06-11
申请人： George Cho , Horace W. Furumoto
发明人： George Cho , Horace W. Furumoto
IPC分类号： A61B18/20 , A61N5/00
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/0047
摘要： A method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the epidermis layer, comprising the steps of: arranging a pulsed dye laser generator in light communication with a pulsed dye laser delivery device. The pulsed dye laser delivery device is applied against tissue having wrinkles. The pulsed dye laser generator generates a pulsed dye laser light. A pulsed dye laser light from the pulsed dye laser delivery device is directed onto the tissue, to reach hemoglobin in a collagen layer up to about 1.2 mm. beneath the surface of the tissue to effect growth changes therein.
摘要翻译：一种通过刺激表皮层下面的胶原生长来治疗人皮肤皱纹的方法，包括以下步骤：将脉冲染料激光发生器与脉冲染料激光输送装置进行光连通。将脉冲染料激光输送装置施加到具有皱纹的组织上。脉冲染料激光发生器产生脉冲染料激光。来自脉冲染料激光输送装置的脉冲染料激光被引导到组织上，以达到高达约1.2mm的胶原层中的血红蛋白。在组织的表面下方以实现其中的生长变化。

24. 发明授权

US6045548A Alexandrite laser system for hair removal and method therefor 有权
标题翻译：用于脱毛的Alexandrite激光系统及其方法
公开(公告)号：US6045548A
公开(公告)日：2000-04-04
申请号：US158056
申请日：1998-09-22
申请人： Horace W. Furumoto , George Cho , Eric Koschmann , Antonio G. Rizzo
发明人： Horace W. Furumoto , George Cho , Eric Koschmann , Antonio G. Rizzo
IPC分类号： A61B17/00 , A61B17/22 , A61B18/20 , H01S3/08 , H01S3/092 , H01S3/16 , A61N5/06
CPC分类号： H01S3/092 , A61B18/203 , A61B2017/00172 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , H01S2301/08 , H01S3/08072 , H01S3/1633
摘要： A long pulse alexandrite laser hair removal system is disclosed using light pulses of greater than 1 msec and fluences between 10 and 50 J/cm.sup.2. The use of an alexandrite laser allows good penetration while still achieving an acceptable combination of hemoglobin and melanin absorption. The use an index-matching application on the skin sections to be treated is also described. This substance will be absorbed into the epidermal layer to provide better coupling of the laser light into the skin. Also, and most advantageously, it will reduce reflections at the epidermal-dermal junction, which can lead to the damage of the skin. Also a topical thermal or photochromic indicator is suggested since skin irradiation in the near-infrared generally does not produce any characteristic skin color change as is found when using pulsed dye lasers, for example.
摘要翻译：公开了使用大于1毫秒的光脉冲和10至50J / cm 2之间的通量的长脉冲亚历山大激光脱毛系统。使用亚历山大雕刻激光器可以很好地渗透，同时仍能达到可接受的血红蛋白和黑色素吸收的组合。还将描述在待治疗的皮肤部分上使用折射率匹配应用。该物质将被吸收到表皮层中以提供更好的激光与皮肤的耦合。此外，并且最有利地，它将减少表皮 - 皮肤接合处的反射，其可导致皮肤的损伤。建议使用局部热或光致变色指示剂，因为例如在使用脉冲染料激光时，近红外线中的皮肤辐射通常不会产生任何特征的肤色变化。

25. 发明授权

US5871479A Alexandrite laser system for hair removal and method therefor 失效
公开(公告)号：US5871479A
公开(公告)日：1999-02-16
申请号：US744344
申请日：1996-11-07
申请人： Horace W. Furumoto , George Cho , David H. McDaniel , Eric Koschmann , Antonio G. Rizzo
发明人： Horace W. Furumoto , George Cho , David H. McDaniel , Eric Koschmann , Antonio G. Rizzo
IPC分类号： A61B17/00 , A61B17/22 , A61B18/20 , H01S3/08 , H01S3/092 , H01S3/16 , A61N5/06
CPC分类号： H01S3/092 , A61B18/203 , A61B2017/00172 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , H01S2301/08 , H01S3/08072 , H01S3/1633
摘要： A long pulse alexandrite laser hair removal system is disclosed using light pulses of greater than 1 msec and fluences between 10 and 50 J/cm.sup.2. The use of an alexandrite laser allows good penetration while still achieving an acceptable combination of hemoglobin and melanin absorption. The use an index-matching application on the skin sections to be treated is also described. This substance will be absorbed into the epidermal layer to provide better coupling of the laser light into the skin. Also, and most advantageously, it will reduce reflections at the epidermal-dermal junction, which can lead to the damage of the skin. Also a topical thermal or photochromic indicator is suggested since skin irradiation in the near-infrared generally does not produce any characteristic skin color change as is found when using pulsed dye lasers, for example.

26. 发明授权

US5749868A Near infra-red selective photothermolysis for ectatic vessels and method therefor 失效
标题翻译：近红外选择性光热裂解法及其方法
公开(公告)号：US5749868A
公开(公告)日：1998-05-12
申请号：US720267
申请日：1996-09-26
申请人： Horace W. Furumoto
发明人： Horace W. Furumoto
IPC分类号： A61N5/06 , A61B18/20 , A61B18/22 , A61N5/067
CPC分类号： A61B18/203 , A61B18/22 , A61B2018/00452 , A61B2018/00458 , A61N2005/0659 , A61N2005/067
摘要： Near-infrared selective photothermolysis for the treatment of ectatic blood vessels, for example, blood vessels of a portwine stain birthmark. This technique is especially applicable to deeper lying blood vessels in view of the better penetration of the near infrared light. Consequently, vessels are below a dermal/epidermal boundary can be reached. Near-infrared is defined as a range of approximately 700 to 1,200 nm. The optimal colors are near 760 or between 980 to 990 nm for most populations.
摘要翻译：近红外选择性光热解用于治疗血管的血管，例如血管斑块污点胎记。考虑到近红外光的穿透更好，这种技术特别适用于较深的躺卧血管。因此，可以达到血管在皮肤/表皮边界以下。近红外线被定义为约700至1,200nm的范围。对于大多数人群，最佳颜色接近760或980至990 nm之间。

27. 发明授权

US4977571A Dye laser solution circulation system 失效
标题翻译：染料激光溶液循环系统
公开(公告)号：US4977571A
公开(公告)日：1990-12-11
申请号：US174729
申请日：1988-03-29
申请人： Horace W. Furumoto , Harry L. Ceccon , James C. Hsia
发明人： Horace W. Furumoto , Harry L. Ceccon , James C. Hsia
IPC分类号： H01S3/02
CPC分类号： H01S3/022
摘要： A dye laser fluid dye solution replenishment system in which the portion of the lasing fluid passing through the laser head which has been activated to a lasing condition is separated from the remainder of the unactivated dye solution and is separately restored before being recombined into the fluid flow path. The thus separated and degraded dye solution, representing only the degraded component of the flowing dye solution, is filtered to remove the degradation products and restored to the desired dye solution component concentrations. The thus restored solution is reinserted into the fluid flow path through the laser head.
摘要翻译：一种染料激光流体染料溶液补充系统，其中通过已激活到激光条件的激光头的激光弹射部分与未活化的染料溶液的其余部分分离，并在再次混合到流体流中之前分别还原路径。过滤分离和降解的染料溶液，其仅代表流动染料溶液的降解组分，以除去降解产物并恢复到所需的染料溶液组分浓度。将如此恢复的溶液重新插入到通过激光头的流体流动路径中。

28. 发明授权

US4364015A Compact reservoir system for dye lasers 失效
标题翻译：用于染料激光器的紧凑型储存系统
公开(公告)号：US4364015A
公开(公告)日：1982-12-14
申请号：US243200
申请日：1981-03-12
申请人： J. Michael Drake , Horace W. Furumoto
发明人： J. Michael Drake , Horace W. Furumoto
IPC分类号： H01S3/02 , H01S3/05
CPC分类号： H01S3/022
摘要： A dye solution reservoir system for a dye laser comprises a dye solution reservoir, main fluid circuit means for circulating dye solution between the reservoir and a dye laser, and a by-pass dye replenishment loop between the reservoir and the laser for (1) diverting a portion of the solution from the main circuit, (2) filtering substantially all solute, including the dye and other particles from that portion of the solution, (3) replenishing the solution by adding fresh dye solute, and (4) returning the replenished solution to the main circuit. In a preferred embodiment, the solution is filtered by a first filter for removing the dye solute and a second filter for removing degradation by-products and particulate matter. Reverse osmosis may be advantageously used as a part of this filtrate system. The advantage of such systems is a substantial reduction in the required reservoir capacity and enhanced dye recoverability.
摘要翻译：用于染料激光的染料溶液储存系统包括染料溶液储存器，用于在储存器和染料激光器之间循环染料溶液的主流体回路装置，以及储存器和激光器之间的旁路染料补充回路，用于（1）转向来自主电路的溶液的一部分，（2）基本上过滤所有溶质，包括溶液中的染料和其他颗粒，（3）通过加入新鲜的染料溶质补充溶液，和（4）将补充的解决方案到主电路。在优选的实施方案中，溶液通过用于除去染料溶质的第一过滤器和用于除去降解副产物和颗粒物质的第二过滤器过滤。反渗透可以有利地用作该滤液系统的一部分。这种系统的优点是显着减少所需的储存容量和增强的染料可回收性。

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