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21. 发明申请

US20060205069A1 Compositions comprising a first agent which provides a primary activation signal to T cells and a second agent which stimulates an accessory molecule on the surface of T cells 审中-公开
标题翻译：包含向T细胞提供主要激活信号的第一药剂和刺激T细胞表面上的辅助分子的第二药剂的组合物
公开(公告)号：US20060205069A1
公开(公告)日：2006-09-14
申请号：US11364102
申请日：2006-02-28
申请人： Carl June , Craig Thompson , Gary Gray , Paul Rennert
发明人： Carl June , Craig Thompson , Gary Gray , Paul Rennert
IPC分类号： G01N33/551 , C12N5/06
CPC分类号： C12N5/0636 , A61K35/17 , A61K38/00 , A61K48/00 , A61K2039/505 , A61K2039/5158 , C07K14/705 , C07K14/70521 , C07K14/70532 , C07K16/00 , C07K16/2806 , C07K16/2809 , C07K16/2812 , C07K16/2815 , C07K16/2818 , C07K16/2833 , C07K16/2866 , C07K16/289 , C07K16/2896 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/73 , C07K2317/74 , C07K2319/00 , C07K2319/30 , C12N2501/51 , C12N2501/515 , C12N2501/599 , C12N2740/16011 , C12N2795/00011
摘要： Compositions for inducing a population of T cells to proliferate in vitro by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population of T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the composition of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis
摘要翻译：描述了通过激活T细胞群并用结合辅助分子的配体刺激T细胞表面上的辅助分子来诱导T细胞群体在体外增殖的组合物。 T细胞增殖发生在没有外源生长因子或附属细胞的情况下。通过刺激T细胞受体（TCR）/ CD3复合物或CD2表面蛋白来完成T细胞活化。为了诱导活化的T细胞群体的增殖，T细胞表面上的辅助分子例如CD28用与配体分子结合的配体刺激。通过本发明的组合物扩增的T细胞群体可以被遗传转导并用于免疫治疗或可用于诊断方法

22. 发明申请

US20060158639A1 Eye tracker and pupil characteristic measurement system and associated methods 审中-公开
标题翻译：眼动仪和瞳孔特征测量系统及相关方法
公开(公告)号：US20060158639A1
公开(公告)日：2006-07-20
申请号：US11252191
申请日：2005-10-17
申请人： John Campin , Young Kwon , Phuoc Khanh Nguyen , Haizhang Li , Gary Gray
发明人： John Campin , Young Kwon , Phuoc Khanh Nguyen , Haizhang Li , Gary Gray
IPC分类号： G01P3/36 , A61B18/18
CPC分类号： A61F9/008 , A61F9/00804 , A61F2009/00846 , A61F2009/00872 , A61F2009/00897
摘要： Systems and methods for tracking eye movement includes directing an incident light beam onto each facet of a pyramidal prism to produce a plurality of beams that form a plurality of light spots, at least two of the light spots having different diameters. The prism is translatable to effect a change in spacing of the light spots. Intensities of light reflected from the light spots is used to retain the light spots upon a pupil/iris boundary. A relative intensity of the spots indicates a change in pupil size. A second light spot positioned on a predetermined eye sector can also be used to calculate a pupil characteristic and an environmental effect on light received from the eye.
摘要翻译：用于跟踪眼睛运动的系统和方法包括将入射光束引导到锥体棱镜的每个小面上以产生形成多个光斑的多个光束，至少两个具有不同直径的光点。棱镜可以平移以实现光斑间距的变化。使用从光点反射的光的强度来将光点保持在瞳孔/虹膜边界上。斑点的相对强度表示瞳孔大小的变化。位于预定眼部的第二光点也可用于计算从眼睛接收的光的光瞳特性和对环境的影响。

23. 发明授权

US08962545B2 Enzyme treatment of foodstuffs for celiac sprue 有权
公开(公告)号：US08962545B2
公开(公告)日：2015-02-24
申请号：US13053120
申请日：2011-03-21
申请人： Felix Hausch , Gary Gray , Lu Shan , Chaitan Khosla
发明人： Felix Hausch , Gary Gray , Lu Shan , Chaitan Khosla
IPC分类号： C07D413/12 , G01N33/564 , A61K38/00 , A23L1/03 , A23L1/30 , A61K31/42 , A61K38/48 , C07D261/04 , C07K14/415 , C07K16/16
CPC分类号： A61K38/482 , A23L29/06 , A23L33/10 , A23V2002/00 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K9/2866 , A61K9/4825 , A61K9/485 , A61K9/4891 , A61K31/42 , A61K38/4813 , C07D261/04 , C07D413/12 , C07K14/415 , C07K16/16 , C07K2317/34 , C12Y304/14005 , C12Y304/15001 , C12Y304/21026 , G01N33/564 , G01N33/6854 , G01N2800/06 , G01N2800/202 , Y02A50/473
摘要： Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.

24. 发明授权

US07928056B2 Enzyme treatment of foodstuffs for Celiac Sprue 有权
标题翻译：芹菜汁食品酶处理
公开(公告)号：US07928056B2
公开(公告)日：2011-04-19
申请号：US11927533
申请日：2007-10-29
申请人： Felix Hausch , Gary Gray , Lu Shan , Chaitan Khosla
发明人： Felix Hausch , Gary Gray , Lu Shan , Chaitan Khosla
IPC分类号： A61K38/00 , A61K51/00 , A61K38/48 , G01N33/573 , C12Q1/37 , A01N37/18
CPC分类号： A61K38/482 , A23L29/06 , A23L33/10 , A23V2002/00 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K9/2866 , A61K9/4825 , A61K9/485 , A61K9/4891 , A61K31/42 , A61K38/4813 , C07D261/04 , C07D413/12 , C07K14/415 , C07K16/16 , C07K2317/34 , C12Y304/14005 , C12Y304/15001 , C12Y304/21026 , G01N33/564 , G01N33/6854 , G01N2800/06 , G01N2800/202 , Y02A50/473
摘要： Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
摘要翻译：将有效剂量的谷蛋白酶施用于腹腔炎或疱疹样皮炎患者可降低毒性麸质寡肽的含量，从而减弱或消除麸质的破坏作用。

25. 发明申请

US20080213822A1 METHODS FOR DIAGNOSING CELIAC SPRUE AND REAGENTS USEFUL THEREIN 有权
标题翻译：用于诊断CELIAC SPRUE和有用的试剂的方法
公开(公告)号：US20080213822A1
公开(公告)日：2008-09-04
申请号：US11927527
申请日：2007-10-29
申请人： Felix Hausch , Gary Gray , Lu Shan , Chaitan Khosla
发明人： Felix Hausch , Gary Gray , Lu Shan , Chaitan Khosla
IPC分类号： C12Q1/06 , C07K14/00 , C12Q1/04 , C07K16/00 , C07K7/00 , G01N33/53 , G01N33/68
CPC分类号： A61K38/482 , A23L29/06 , A23L33/10 , A23V2002/00 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K9/2866 , A61K9/4825 , A61K9/485 , A61K9/4891 , A61K31/42 , A61K38/4813 , C07D261/04 , C07D413/12 , C07K14/415 , C07K16/16 , C07K2317/34 , C12Y304/14005 , C12Y304/15001 , C12Y304/21026 , G01N33/564 , G01N33/6854 , G01N2800/06 , G01N2800/202 , Y02A50/473
摘要： Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
摘要翻译：将有效剂量的谷蛋白酶施用于腹腔炎或疱疹样皮炎患者可降低毒性麸质寡肽的含量，从而减弱或消除麸质的破坏作用。

26. 发明申请

US20080095710A1 ENZYME TREATMENT OF FOODSTUFFS FOR CELIAC SPRUE 有权
公开(公告)号：US20080095710A1
公开(公告)日：2008-04-24
申请号：US11775824
申请日：2007-07-10
申请人： Lu Shan , Michael Bethune , Chaitan Khosla , Jonathan Gass , Gail Pyle , Gary Gray , Indu Isaacs , Gregg Strohmeier
发明人： Lu Shan , Michael Bethune , Chaitan Khosla , Jonathan Gass , Gail Pyle , Gary Gray , Indu Isaacs , Gregg Strohmeier
IPC分类号： A61K49/00 , A61K38/48 , A61P37/00
CPC分类号： A61K38/4813 , A61K38/482
摘要： Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.

27. 发明申请

US20070173795A1 System and apparatus for treating the lens of an eye 有权
标题翻译：用于治疗眼睛晶状体的系统和装置
公开(公告)号：US20070173795A1
公开(公告)日：2007-07-26
申请号：US11414819
申请日：2006-05-01
申请人： Rudolph Frey , Gary Gray , Dennis Pape , George Downes , Jorge De Castro , Jerome Kuszak
发明人： Rudolph Frey , Gary Gray , Dennis Pape , George Downes , Jorge De Castro , Jerome Kuszak
IPC分类号： A61B18/18
CPC分类号： A61F9/00834 , A61B90/30 , A61B90/361 , A61B2018/20351 , A61F9/00736 , A61F9/008 , A61F2009/0087 , A61F2009/00887 , A61F2009/00897
摘要： A system and apparatus for increasing the amplitude of accommodation and/or changing the refractive power and/or enabling the removal of the clear or cataractous lens material of a natural crystalline lens is provided. Generally, the system comprises a laser, optics for delivering the laser beam and a control system for delivering the laser beam to the lens in a particular pattern. There is further provided apparatus for determining the shape and position of the lens with respect to the laser. There is yet further provided a method and system for delivering a laser beam in the lens of the eye in a predetermined shot pattern.
摘要翻译：提供了一种用于增加调节幅度和/或改变折射力的系统和装置和/或能够去除天然晶状体的透明或白内障透镜材料。通常，该系统包括激光器，用于传送激光束的光学器件和用于以特定图案将激光束传送到透镜的控制系统。还提供了用于确定透镜相对于激光器的形状和位置的装置。还提供了一种用于以预定的射击图案将眼睛的透镜中的激光束传送的方法和系统。

28. 发明申请

US20070050165A1 System and method for automatic self-alignment of a surgical laser 审中-公开
标题翻译：手术激光自动对准的系统和方法
公开(公告)号：US20070050165A1
公开(公告)日：2007-03-01
申请号：US11510909
申请日：2006-08-28
申请人： Gary Gray , John Bowes , Ricardo Omori
发明人： Gary Gray , John Bowes , Ricardo Omori
IPC分类号： G01M19/00 , G01D3/00 , G06F19/00 , G01P21/00 , G01R35/00 , A61F9/008
CPC分类号： A61B3/00 , A61F9/00804 , A61F2009/00846 , A61F2009/00872 , G16H50/50
摘要： Embodiments of the present invention provide an alignment system operable to align a laser associated with a laser vision correction system. One embodiment of the alignment system comprises a laser source, a beam steering device, a system controller, a partially reflective surface, focusing optics, and an optical detector. The laser source generates a laser beam that the beam steering device receives and redirects along either a surgical pathway or an alignment pathway. The system controller couples to the beam steering device and directs the beam steering device to choose which pathway to be utilized. Additionally, the system controller may control the pulse repetition rate, intensity, beam profile and alignment of the laser beam. The partially reflective surface, within the alignment pathway, partially reflects the laser beam towards alignment coordinates on the surface of the optical detector. Focusing optics, if needed, may further be utilized to focus the partially reflected laser beam on the surface of the optical detector. The optical detector senses the coordinates associated with the illuminated portion of the surface of the optical detector. The system controller compares the coordinates associated with the alignment coordinates and the sensed coordinates and generates a position offset which is used to align the laser beam/steering device.
摘要翻译：本发明的实施例提供了可对准与激光视力校正系统相关联的激光器的对准系统。对准系统的一个实施例包括激光源，光束转向装置，系统控制器，部分反射表面，聚焦光学器件和光学检测器。激光源产生激光束，光束转向装置沿着外科路径或对准路径接收和重定向。系统控制器耦合到光束转向装置并引导光束转向装置选择要使用的通路。此外，系统控制器可以控制激光束的脉冲重复率，强度，光束分布和对准。在对准路径内的部分反射表面部分地将激光束反射到光学检测器表面上的对准坐标。如果需要，可以进一步利用聚焦光学器件将部分反射的激光束聚焦在光学检测器的表面上。光学检测器感测与光学检测器的表面的照射部分相关联的坐标。系统控制器比较与对准坐标和感测坐标相关联的坐标，并产生用于对准激光束/转向装置的位置偏移。

29. 发明申请

US20060165706A1 Antibodies against CTLA4 and uses therefor 审中-公开
公开(公告)号：US20060165706A1
公开(公告)日：2006-07-27
申请号：US11321444
申请日：2005-12-29
申请人： Beatriz Carreno , Clive Wood , Katherine Turner , Mary Collins , Gary Gray , Donna Morris , Denise O'Hara , Paul Hinton , Naoya Tsurushita
发明人： Beatriz Carreno , Clive Wood , Katherine Turner , Mary Collins , Gary Gray , Donna Morris , Denise O'Hara , Paul Hinton , Naoya Tsurushita
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： A61K51/1027 , A61K47/6827 , A61K47/6829 , A61K47/6849 , A61K2039/505 , C07K16/2818 , C07K2317/24 , C07K2317/34
摘要： The invention provides an antibody-toxic moiety conjugates comprising an antibody that specifically recognizes a molecule expressed on the surface of a T cell which is expressed only on T cells and is only expressed transiently on T cells upon T cell activation. Preferably, the T cell molecule is CTLA4. The invention further provides anti-CTLA4 antibodies and humanized forms thereof.

30. 发明申请

US20060140919A1 Methods for selectively stimulating proliferation of T cells 有权
公开(公告)号：US20060140919A1
公开(公告)日：2006-06-29
申请号：US11366331
申请日：2006-03-02
申请人： Carl June , Craig Thompson , Gary Nabel , Gary Gray , Paul Rennert
发明人： Carl June , Craig Thompson , Gary Nabel , Gary Gray , Paul Rennert
IPC分类号： A61K39/395 , A61K35/14
CPC分类号： C07K14/705 , A61K2039/5158 , C07K16/2806 , C07K16/2809 , C07K16/2818 , C07K16/2896 , C07K2317/34 , C12N5/0636 , C12N2501/51 , C12N2501/515 , C12N2501/599
摘要： Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

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