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21. 发明授权

US07404821B2 Treatment for post partum hemorrhage 有权
公开(公告)号：US07404821B2
公开(公告)日：2008-07-29
申请号：US10355809
申请日：2003-01-30
申请人： Fred H. Burbank , Michael L. Jones , Jill Uyeno
发明人： Fred H. Burbank , Michael L. Jones , Jill Uyeno
IPC分类号： A61B17/00
CPC分类号： A61B17/12 , A61B17/2812 , A61B17/42 , A61B2017/00057 , A61B2017/2837 , A61B2090/064 , A61B2090/378
摘要： The invention is directed to instruments and procedures using such instruments for temporarily reducing or terminating blood flow through a female patient's uterine artery to treat post partum hemorrhage (PPH). The uterine artery is occluded by a clamping device which includes a pair of pivotally connected clamping members, with each of the clamping members having a handle and a clamping element at the distal end of the handle. The clamping elements are inclined with respect to the longitudinal axes of the handles at an included obtuse angle between about 120° and about 170°, preferably between about 130° and 160°. An artery locating sensor is provided on the distal end of at least one of the clamping elements. Preferably, the artery locating sensor is a Doppler ultrasound blood flow sensor. After birth, the clamping device is inserted into the female patient's post partum vaginal canal and advanced therein until one of the clamping elements Is in the patient's uterine cervix and the other clamping element is on the exterior of the uterine cervix. The clamping element on the exterior of the patient's uterine cervix is pressed against the patient's vaginal fornix and the clamping device closed so as to occlude the uterine artery disposed within tissue grasped by the clamping device. The clamping device is locked in the closed configuration and maintained in the condition until the patient's uterus is sufficiently clotted up to ensure termination of the hemorrhaging, typically about 5 minutes to about 7 hours.

22. 发明授权

US07223279B2 Methods for minimally-invasive, non-permanent occlusion of a uterine artery 失效
标题翻译：方法用于子宫动脉的微创，非永久性闭塞
公开(公告)号：US07223279B2
公开(公告)日：2007-05-29
申请号：US09908815
申请日：2001-07-20
申请人： Fred Burbank , Greig E. Altieri , Michael L. Jones
发明人： Fred Burbank , Greig E. Altieri , Michael L. Jones
IPC分类号： A61B17/28
CPC分类号： A61B17/12009 , A61B17/12 , A61B17/2812 , A61B17/282 , A61B17/42 , A61B17/4241
摘要： Non-permanent occlusion of the uterine arteries is sufficient to cause the demise of uterine myomata without unnecessarily exposing other tissues and anatomical structures to hypoxia attendant to prior permanent occlusion techniques. A therapeutically effective transient time of occlusion of a uterine artery to treat uterine fibroid tumors is from 1 hours to 24 hours, and preferably is at least about 4 hours. A therapeutically effective temporary time of occlusion of a uterine artery to treat uterine fibroid tumors is from 1 day (24 hours) to 7 days (168 hours), and preferably is about 4 days (96 hours). By invaginating the tissues of the vaginal wall up to or around a uterine artery, collapse of the uterine artery can be achieved without penetrating tissue of the patient.
摘要翻译：子宫动脉的非永久性闭塞足以引起子宫肌瘤的消失，而不会不必要地将其他组织和解剖结构暴露于先前永久闭塞技术所伴随的缺氧。子宫动脉阻塞治疗子宫肌瘤的治疗有效瞬时时间为1小时至24小时，优选为至少约4小时。子宫动脉闭塞治疗子宫肌瘤的治疗有效临时时间是1天（24小时）至7天（168小时），优选约4天（96小时）。通过将阴道壁的组织插入子宫动脉直到或周围，可以在不穿透患者组织的情况下实现子宫动脉的塌陷。

23. 发明授权

US07594890B2 Multi-axial uterine artery identification, characterization, and occlusion devices 失效
标题翻译：多轴子宫动脉鉴别，表征和闭塞装置
公开(公告)号：US07594890B2
公开(公告)日：2009-09-29
申请号：US10107800
申请日：2002-03-28
申请人： Fred Burbank , Greig E. Altieri , Michael L. Jones
发明人： Fred Burbank , Greig E. Altieri , Michael L. Jones
IPC分类号： A61B8/06
CPC分类号： A61B17/12 , A61B5/026 , A61B5/415 , A61B5/418 , A61B8/06 , A61B8/12 , A61B17/00234 , A61B17/122 , A61B17/128 , A61B17/1285 , A61B17/2812 , A61B17/42 , A61B2017/0046 , A61B2017/4216
摘要： A system is provided for compressing one or both of the uterine arteries of a patient which is at least in part shaped to complement the shape of the exterior of the cervix, which allows the system to be self-positioning. One or more Doppler chips can be mounted or incorporated into the system which permit the practitioner to better identify the uterine artery and monitor blood flow therein. A tenaculum-like element can be further included which secures the system to the patient's cervix.
摘要翻译：提供了一种用于压缩患者的一个或两个子宫动脉的系统，其至少部分地形状以补充子宫颈外部的形状，这允许系统自我定位。可以将一个或多个多普勒芯片安装或并入系统中，这允许从业者更好地识别子宫动脉并监测其中的血液流动。可以进一步包括将系统固定到患者的子宫颈上的一个类似神经元的元件。

24. 发明申请

US20080200924A1 METHODS FOR MINIMALLY INVASIVE, NON-PERMANENT OCCLUSION OF A UTERINE ARTERY 审中-公开
标题翻译：用于微量入侵，非永久性肛门动脉闭塞的方法
公开(公告)号：US20080200924A1
公开(公告)日：2008-08-21
申请号：US12107652
申请日：2008-04-22
申请人： Fred Burbank , Greig E. Altieri , Michael L. Jones
发明人： Fred Burbank , Greig E. Altieri , Michael L. Jones
IPC分类号： A61B17/42
CPC分类号： A61B17/12136 , A61B17/12009 , A61B17/12022 , A61B17/1204 , A61B17/12186 , A61B17/1219 , A61B2017/00004 , A61B2017/4216 , A61K31/045 , A61K31/10 , A61K31/734 , A61K45/06 , A61L24/0031 , A61L24/0042
摘要： A method of treating a uterine disorder comprising non-permanently occluding a uterine artery with a resorbable embolic mass for a therapeutically effective time period. The occluding step includes selectively positioning the resorbable embolic mass within the uterine artery, and monitoring positioning of the resorbable embolic mass at a desired location within the uterine artery. The monitoring step may include using ultrasound or magnetic resonance imaging (MRI) for positioning the resorbable embolic mass at the desired location within the uterine artery. The resorbable embolic mass may be swellable and may be formed of a polymeric material selected from the group consisting of polylactic acid, polyglycolic acid, polyethylene glycol, or copolymers thereof.
摘要翻译：一种治疗子宫疾病的方法，包括非永久性闭塞具有可吸收栓塞物质的子宫动脉用于治疗有效时间段。闭塞步骤包括将可再吸收的栓塞质量选择性地定位在子宫动脉内，以及监测可再吸收的栓塞物质在子宫动脉内的期望位置的定位。监测步骤可以包括使用超声或磁共振成像（MRI）来将可再吸收的栓塞物质定位在子宫动脉内的期望位置。可再吸收的栓塞质量可以是可溶胀的，并且可以由选自聚乳酸，聚乙醇酸，聚乙二醇或其共聚物的聚合材料形成。

25. 发明授权

US06550482B1 Methods for non-permanent occlusion of a uterine artery 失效
标题翻译：非永久性闭塞子宫动脉的方法
公开(公告)号：US06550482B1
公开(公告)日：2003-04-22
申请号：US09556934
申请日：2000-04-21
申请人： Fred Burbank , Greig E. Altieri , Michael L. Jones
发明人： Fred Burbank , Greig E. Altieri , Michael L. Jones
IPC分类号： A61B1900
CPC分类号： A61B17/12136 , A61B17/12009 , A61B17/12022 , A61B17/1204 , A61B17/12186 , A61B17/1219 , A61B2017/00004 , A61B2017/4216 , A61K31/045 , A61K31/10 , A61K31/734 , A61K45/06 , A61L24/0031 , A61L24/0042
摘要： Non-permanent occlusion of the uterine arteries is sufficient to cause the demise of uterine myomata without unnecessarily exposing other tissues and anatomical structures to hypoxia attendant to prior permanent occlusion techniques. A therapeutically effective transient time of occlusion of a uterine artery to treat uterine fibroid tumors is from 1 hours to 24 hours, and preferably is at least about 4 hours. A therapeutically effective temporary time of occlusion of a uterine artery to treat uterine fibroid tumors is from 1 day (24 hours) to 7 days (168 hours), and preferably is about 4 days (96 hours).
摘要翻译：子宫动脉的非永久性闭塞足以引起子宫肌瘤的消失，而不会不必要地将其他组织和解剖结构暴露于先前永久闭塞技术所伴随的缺氧。子宫动脉阻塞治疗子宫肌瘤的治疗有效瞬时时间为1小时至24小时，优选为至少约4小时。子宫动脉闭塞治疗子宫肌瘤的治疗有效临时时间是1天（24小时）至7天（168小时），优选约4天（96小时）。

26. 发明授权

US08718745B2 Tissue site markers for in vivo imaging 有权
标题翻译：用于体内成像的组织位点标记
公开(公告)号：US08718745B2
公开(公告)日：2014-05-06
申请号：US12787177
申请日：2010-05-25
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank R. Louw , Stephen A. DeSantis
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank R. Louw , Stephen A. DeSantis
IPC分类号： A61B6/00
CPC分类号： A61B19/54 , A61B6/12 , A61B8/0833 , A61B90/39 , A61B2090/08021 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987 , A61B2090/3991 , A61M37/0069
摘要： An intracorporeal site marker has high ultrasound reflectivity, presents a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The biopsy site marker may include features to fix the marker to the biopsy site so as to resist migration from the biopsy cavity.
摘要翻译：体内位点标记物具有高超声反射率，从小标记物提供了显着的声学特征，以避免在随后的成像研究中模糊诊断组织特征，并且可以容易地与生物学特征区别开来。活检部位标记可以包括将标记物固定到活检部位以防止从活检腔迁移的特征。

27. 发明申请

US20120277626A1 METHODS AND APPARATUS FOR SECURING MEDICAL INSTRUMENTS TO DESIRED LOCATIONS IN A PATIENT'S BODY 审中-公开
标题翻译：将医疗仪器安装在患者体内所需位置的方法和装置
公开(公告)号：US20120277626A1
公开(公告)日：2012-11-01
申请号：US13543309
申请日：2012-07-06
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick
IPC分类号： A61B10/02
CPC分类号： A61B10/04 , A61B10/02 , A61B10/0241 , A61B10/0266 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/12 , A61B18/14 , A61B18/1477 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B90/39 , A61B2017/320064 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00577 , A61B2018/00601 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/1475 , A61B2018/162 , A61B2019/5487 , A61B2019/5491 , A61B2090/3908 , A61B2090/3991
摘要： A medical device for localization of tissue at a target site in a patient's body includes a tube having a distal end, a proximal end, and a longitudinal axis. The medical device is configured for placement of the distal end at the target site. A fixation device is disposed on the distal end. The affixation device is configured to mechanically fix the distal end of the medical device to tissue at the target site.
摘要翻译：用于在患者体内的靶部位定位组织的医疗装置包括具有远端，近端和纵向轴线的管。医疗装置被配置为将远端放置在目标位置处。固定装置设置在远端。固定装置构造成将医疗装置的远端机械地固定在目标部位的组织。

28. 发明授权

US08219182B2 Cavity-filling biopsy site markers 有权
标题翻译：腔填充活检部位标记
公开(公告)号：US08219182B2
公开(公告)日：2012-07-10
申请号：US12852286
申请日：2010-08-06
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones
IPC分类号： A61B8/00 , A61B6/00 , A61B8/14
CPC分类号： A61B8/481 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/395 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61K49/222 , A61M37/0069
摘要： An ultrasound-detectable biopsy marker mass has a detectable in-vivo lifetime during which the marker mass remains readily detectable by ultrasound imaging. The ultrasound-detectable biopsy marker mass is formed of particles of a bio-resorbable material having bubble cavities and having a particle size between about 200 microns and about 500 microns.
摘要翻译：超声检测的活检标记物质具有可检测的体内寿命，在此期间，通过超声成像可以容易地检测出标记物质。可超声检测的活检标记物质由具有气泡腔并具有约200微米至约500微米的粒度的生物可吸收材料的颗粒形成。

29. 发明授权

US08152737B2 Tissue specimen encapsulation device and method thereof 有权
标题翻译：组织标本包封装置及其方法
公开(公告)号：US08152737B2
公开(公告)日：2012-04-10
申请号：US11811952
申请日：2007-06-12
申请人： Fred H. Burbank , Richard L. Quick , Jacob Frank Louw , Michael L. Jones , Paul Lubock
发明人： Fred H. Burbank , Richard L. Quick , Jacob Frank Louw , Michael L. Jones , Paul Lubock
IPC分类号： A61B10/00 , A61B18/18 , A61B17/32
CPC分类号： A61B10/0266 , A61B10/02 , A61B17/00234 , A61B17/221 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/1487 , A61B18/1492 , A61B90/37 , A61B2017/00287 , A61B2017/2212 , A61B2017/320064 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： A device for encapsulating tissue specimens includes a wand assembly, a sheath, and a guide assembly. The guide assembly pulls, draws, or otherwise moves the sheath about the tissue specimen. The wand assembly is disposed proximate to the tissue specimen, typically either adjacent or through the specimen. In an aspect of the encapsulating device, the guide assembly has sheath deployment members that are disposed about the tissue specimen. The sheath, which is attached to ends of the sheath deployment members and the wand assembly, is drawn over the tissue specimen as the sheath deployment members are pushed or pulled. The guide assembly is an arm or a housing that rotates about the tissue specimen. The sheath, which is secured at one end to the guide assembly and at another end to the wand assembly, is drawn over the tissue specimen as the guide assembly rotates.
摘要翻译：用于封装组织样本的装置包括棒组件，护套和引导组件。引导组件拉动，牵引或以其他方式使护套围绕组织标本移动。棒组件靠近组织标本设置，通常是相邻的或通过样本。在封装装置的一个方面中，引导组件具有围绕组织标本设置的护套展开部件。当护套展开构件被推动或拉动时，附接到鞘展开构件和杆组件的端部的护套被拉过组织标本。引导组件是围绕组织标本旋转的臂或壳体。当引导组件旋转时，在一端固定到引导组件并且另一端固定到杆组件的护套在组织样本上被拉伸。

30. 发明申请

US20110092815A1 MARKER OR FILLER FORMING FLUID 有权
标题翻译：标记或填充液形成流体
公开(公告)号：US20110092815A1
公开(公告)日：2011-04-21
申请号：US12967639
申请日：2010-12-14
申请人： Fred H. Burbank , Michael L. Jones , Frank Louw , Paul Lubock
发明人： Fred H. Burbank , Michael L. Jones , Frank Louw , Paul Lubock
IPC分类号： A61B6/00 , A61M5/31
CPC分类号： A61B90/39 , A61B2090/3908 , A61B2090/3925 , A61B2090/3933 , A61B2090/3987 , A61K49/226
摘要： A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is coupled in fluid communication with the chamber of the marker delivery device. The delivery tube has a distal end with a discharge port through which the marking substance is expelled. A releasable remotely detectable distal tip is coupled to the distal end of the delivery tube and is configured to be released to remain within the porous bioabsorbable body within the cavity upon the formation thereof.
摘要翻译：一种用于至少部分地填充和标记患者体内的部位的空腔的系统包括标记物输送装置，其具有被配置为容纳标记物质并具有被配置为排出标记物质的机构的室。标记物质的量被容纳在标记物输送装置的室内。标记物质构造成至少部分地填充空腔并在其中形成多孔生物可吸收体。输送管与标记物递送装置的腔室流体连通地联接。输送管具有远端，其具有排出口，排出标记物质。可释放的可远程检测的远侧末端联接到输送管的远端，并且构造成在其形成时被释放以保持在腔内的多孔生物可吸收体内。

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