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21. 发明申请

US20070190133A1 Dosage forms having a microreliefed surface and methods and apparatus for their production 审中-公开
标题翻译：具有微孔表面的剂量形式及其生产方法和装置
公开(公告)号：US20070190133A1
公开(公告)日：2007-08-16
申请号：US11235841
申请日：2005-09-27
申请人： Frank Bunick , Jen-Chi Chen
发明人： Frank Bunick , Jen-Chi Chen
IPC分类号： A61K9/20 , A61K9/24
CPC分类号： A61K9/2095 , A61J3/005 , A61J3/007 , A61K9/2072 , A61K9/2893
摘要： The present invention provides an edible dosage form that incorporates optical elements (e.g., printed patterns, microrelief gratings, and/or macrorelief gratings), capable of producing unique optical effects and images in order to enable a user to better identify and differentiate the dosage forms, as well as to improve the detection of counterfeit production thereof, wherein the edible dosage forms may be made in a variety of ways to incorporate the optical elements therein.
摘要翻译：本发明提供了一种可食用的剂型，其包含能够产生独特的光学效果和图像的光学元件（例如，印刷图案，微纤维格栅和/或宏观光栅），以使用户能够更好地识别和区分剂型，以及改进其假冒生产的检测，其中可食用剂型可以以各种方式制成以将光学元件并入其中。

22. 发明申请

US20060088587A1 Dosage forms having a microreliefed surface and methods and apparatus for their production 审中-公开
公开(公告)号：US20060088587A1
公开(公告)日：2006-04-27
申请号：US11236041
申请日：2005-09-27
申请人： Frank Bunick , Jen-Chi Chen
发明人： Frank Bunick , Jen-Chi Chen
IPC分类号： A61K9/48
CPC分类号： A61K9/2893 , A61J3/005 , A61J3/007 , A61K9/2072 , A61K9/2095
摘要： The present invention provides an edible dosage form that incorporates optical elements (e.g., printed patterns, microrelief gratings, and/or macrorelief gratings), capable of producing unique optical effects and images in order to enable a user to better identify and differentiate the dosage forms, as well as to improve the detection of counterfeit production thereof, wherein the edible dosage forms may be made in a variety of ways to incorporate the optical elements therein.

23. 发明申请

US20060087051A1 Dosage forms having a microreliefed surface and methods and apparatus for their production 审中-公开
公开(公告)号：US20060087051A1
公开(公告)日：2006-04-27
申请号：US11236446
申请日：2005-09-27
申请人： Frank Bunick , Jen-Chi Chen
发明人： Frank Bunick , Jen-Chi Chen
IPC分类号： B27N3/00
CPC分类号： A61J3/007 , A61J3/005 , A61K9/2072 , A61K9/2095 , A61K9/2893 , B29C33/565 , B29C45/2673 , B29C45/372 , B29K2105/0035 , B41F17/36
摘要： The present invention provides an edible dosage form that incorporates optical elements (e.g., printed patterns, microrelief gratings, and/or macrorelief gratings), capable of producing unique optical effects and images in order to enable a user to better identify and differentiate the dosage forms, as well as to improve the detection of counterfeit production thereof, wherein the edible dosage forms may be made in a variety of ways to incorporate the optical elements therein.

24. 发明授权

US06432442B1 Chewable product 失效
标题翻译：咀嚼产品
公开(公告)号：US06432442B1
公开(公告)日：2002-08-13
申请号：US09027629
申请日：1998-02-23
申请人： Gail K. Buehler , Frank Bunick
发明人： Gail K. Buehler , Frank Bunick
IPC分类号： A61K910
CPC分类号： A61K9/0056 , A61K9/2063
摘要： The present invention is directed to a gelatin matrix which contains a pharmaceutically active ingredient. In a preferred embodiment, a hydrocolloid is added to the gelatin matrix to improve the physical properties, taste and mouthfeel of the gelatin matrix. A method for making the gelatin matrix containing the hydrocolloid is also disclosed.
摘要翻译：本发明涉及含有药物活性成分的明胶基质。在优选的实施方案中，将水胶体加入到明胶基质中以改善明胶基质的物理性质，味道和口感。还公开了制备含有水胶体的明胶基质的方法。

25. 发明授权

US08211465B2 Immediate release and sustained release ibuprofen dosing regimen 有权
公开(公告)号：US08211465B2
公开(公告)日：2012-07-03
申请号：US13367504
申请日：2012-02-07
申请人： Der-Yang Lee , Frank Bunick , James Schwing
发明人： Der-Yang Lee , Frank Bunick , James Schwing
IPC分类号： A61K9/22 , A61K31/19
CPC分类号： A61K31/19 , A61K9/2086 , A61K9/209 , A61K9/2095 , A61K9/2866 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K31/192
摘要： A method of administering non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, is provided. The inventive dosage forms provide an initial release of the NSAID and a second sustained release of NSAID, preferably in a single dosing step.

26. 发明申请

US20080069880A1 ENROBED CORE 有权
公开(公告)号：US20080069880A1
公开(公告)日：2008-03-20
申请号：US11946967
申请日：2007-11-29
申请人： Frank Bunick
发明人： Frank Bunick
IPC分类号： A61K9/28 , B05D3/02
CPC分类号： A61K9/209 , A61J3/005 , A61K9/2072 , A61K9/2893 , B30B11/16 , B30B11/34 , Y10T428/13 , Y10T428/1352 , Y10T428/2933 , Y10T428/2935
摘要： An enrobed a core, such as a tablet core, that has a coating made of one or more patterned films each having portions that are visually distinct (e.g., differently colored) from one another and having a transition line segment between these visually distinct portions. At least a portion of an outer surface of the core is covered with the film or films, such that the transition line segments form a substantially continuous transition line on the coating and a film seam is formed which is different from the transition line. Where the patterned films are bi-colored, the resulting enrobed core can be bi-colored, or the resulting enrobed core can have a coating with at least four visually distinct portions alternately arranged thereon, thereby forming a “checkerboard” pattern on the coating. In either case, the film seam of the coating is different from the transition line of the coating.
摘要翻译：具有由一个或多个图案化膜构成的涂层的核心，例如片芯，其具有各自具有视觉上彼此不同（例如不同颜色）的部分，并且在这些视觉上不同的部分之间具有过渡线段。芯的外表面的至少一部分被膜或膜覆盖，使得过渡线段在涂层上形成基本上连续的过渡线，形成与过渡线不同的膜接缝。在图案化的膜是双色的情况下，所得到的被包裹的芯可以是双色的，或者所得到的被包埋的芯可以具有交替地布置在其上的至少四个视觉上不同部分的涂层，从而在涂层上形成“棋盘”图案。在任一种情况下，涂层的胶层不同于涂层的过渡线。

27. 发明申请

US20070098931A1 Enrobed core 审中-公开
公开(公告)号：US20070098931A1
公开(公告)日：2007-05-03
申请号：US11643058
申请日：2006-12-21
申请人： Frank Bunick
发明人： Frank Bunick
IPC分类号： B31B45/00
CPC分类号： A61K9/209 , A61J3/005 , A61K9/2072 , A61K9/2893 , B30B11/16 , B30B11/34 , Y10T428/13 , Y10T428/1352 , Y10T428/2933 , Y10T428/2935
摘要： An enrobed a core, such as a tablet core, that has a coating made of one or more patterned films each having portions that are visually distinct (e.g., differently colored) from one another and having a transition line segment between these visually distinct portions. At least a portion of an outer surface of the core is covered with the film or films, such that the transition line segments form a substantially continuous transition line on the coating and a film seam is formed which is different from the transition line. Where the patterned films are bi-colored, the resulting enrobed core can be bi-colored, or the resulting enrobed core can have a coating with at least four visually distinct portions alternately arranged thereon, thereby forming a “checkerboard” pattern on the coating. In either case, the film seam of the coating is different from the transition line of the coating.

28. 发明申请

US20060093560A1 Immediate release film coating 审中-公开
标题翻译：立即释放薄膜涂层
公开(公告)号：US20060093560A1
公开(公告)日：2006-05-04
申请号：US10977633
申请日：2004-10-29
申请人： Jen-Chi Chen , Frank Bunick
发明人： Jen-Chi Chen , Frank Bunick
IPC分类号： A61K9/68 , A61K9/24
CPC分类号： A61K9/286 , A61K9/2866 , A61K9/2893
摘要： The present invention is directed to a composition having a shell-forming component that contains a low-molecular weight water-soluble polymer and at least one gum capable of forming or contributing to the formation of thermoreversible gel, wherein the water-soluble polymer has a cloud point in an aqueous system within a temperature range of about 20° C. and about 90° C. The compositions are particularly suited for forming shell coatings on medicinal dosage forms.
摘要翻译：本发明涉及一种具有壳形成组分的组合物，其含有低分子量水溶性聚合物和至少一种能够形成或有助于形成热可逆凝胶的胶，其中所述水溶性聚合物具有在约20℃和约90℃的温度范围内的水系统中的浊点。该组合物特别适用于在药物剂型上形成壳涂层。

29. 发明申请

US20060088586A1 Dosage forms having a microreliefed surface and methods and apparatus for their production 审中-公开
公开(公告)号：US20060088586A1
公开(公告)日：2006-04-27
申请号：US11236040
申请日：2005-09-27
申请人： Frank Bunick , Jen-Chi Chen
发明人： Frank Bunick , Jen-Chi Chen
IPC分类号： A61K9/48
CPC分类号： A61K9/2893 , A61J3/005 , A61J3/007 , A61K9/2072 , A61K9/2095
摘要： The present invention provides an edible dosage form that incorporates optical elements (e.g., printed patterns, microrelief gratings, and/or macrorelief gratings), capable of producing unique optical effects and images in order to enable a user to better identify and differentiate the dosage forms, as well as to improve the detection of counterfeit production thereof, wherein the edible dosage forms may be made in a variety of ways to incorporate the optical elements therein.

30. 发明申请

US20060088585A1 Dosage forms having a microreliefed surface and methods and apparatus for their production 有权
公开(公告)号：US20060088585A1
公开(公告)日：2006-04-27
申请号：US11236038
申请日：2005-09-27
申请人： Frank Bunick , Jen-Chi Chen
发明人： Frank Bunick , Jen-Chi Chen
IPC分类号： A61K9/48
CPC分类号： A61K9/2893 , A61K9/2072 , A61K9/2095
摘要： The present invention provides an edible dosage form that incorporates optical elements (e.g., printed patterns, microrelief gratings, and/or macrorelief gratings), capable of producing unique optical effects and images in order to enable a user to better identify and differentiate the dosage forms, as well as to improve the detection of counterfeit production thereof, wherein the edible dosage forms may be made in a variety of ways to incorporate the optical elements therein.

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