专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20120246181A1 METHOD FOR CONSTRUCTION AND USE OF A PROBABILISTIC ATLAS FOR DIAGNOSIS AND PREDICTION OF A MEDICAL OUTCOME 审中-公开
标题翻译：建立和使用概念性ATLAS进行诊断和预测医疗成果的方法
公开(公告)号：US20120246181A1
公开(公告)日：2012-09-27
申请号：US13512322
申请日：2010-11-23
申请人： Wieslaw Lucjan Nowinski , Varsha Gupta
发明人： Wieslaw Lucjan Nowinski , Varsha Gupta
IPC分类号： G06F17/30
CPC分类号： G06T19/00 , G06F19/321 , G06T7/0012 , G06T2207/20128 , G06T2207/30096 , G06T2210/41 , G16H50/50 , G16H50/70
摘要： Medical scan data, such as brain scan data, from a plurality of patients suffering from a medical condition such as a stroke is used to construct a probabilistic atlas. A first portion of the atlas indicates, for each location, the corresponding likelihood of a medical abnormality (such as a lesion) associated with the medical condition being present at that location. A second portion of the atlas includes, for each location and each of one or more parameters, corresponding parameter data indicative of the values taken by the parameter for those patients suffering from the medical abnormality at the corresponding location. The probabilistic map can be used to extract outcome data from a scan obtained from a new subject, such as by locating a medical abnormality within the scan of the subject, and obtaining the outcome data using the corresponding locations in the probabilistic map.
摘要翻译：使用患有诸如中风等医疗状况的患者的医学扫描数据（例如脑扫描数据）构建概率图谱。地图集的第一部分针对每个位置指示与该位置处的医疗状况相关联的医疗异常（例如病变）的相应可能性。地图册的第二部分对于每个位置以及一个或多个参数中的每一个包括相应的参数数据，该参数表示在相应位置处于患有医疗异常的那些患者的参数所采取的值。概率图可以用于从从新受试者获得的扫描中提取结果数据，例如通过在受试者的扫描内定位医学异常，以及使用概率图中的相应位置获得结果数据。

22. 发明申请

US20120095016A1 THERAPEUTIC 5,6,5-TRICYCLIC ANALOGS 有权
标题翻译：治疗5,6,5-三聚体类似物
公开(公告)号：US20120095016A1
公开(公告)日：2012-04-19
申请号：US13270982
申请日：2011-10-11
申请人： Varsha Gupta , Joel Renick , Graeme Freestone , Alan P. Kaplan
发明人： Varsha Gupta , Joel Renick , Graeme Freestone , Alan P. Kaplan
IPC分类号： A61K31/496 , A61K31/437 , A61P25/22 , A61P25/24 , A61P25/18 , A61P25/28 , C07D471/14 , A61P25/00
CPC分类号： A61K31/437 , A61K31/496 , C07D471/14 , C07D487/14
摘要： The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and negatively modulating the α5 subtype of GABAA, and use of the compound of formula I in the manufacture of a medicament for the treatment of GABAA receptor associated disorders. The invention further provides a method of modulation of one or more GABAA subtypes in an animal comprising administering to the animal an effective amount of a compound of formula (I).
摘要翻译：本发明提供了一种新型的式I化学系列，以及其用于结合GABA A受体的苯并二氮杂位点和负调节GABAA的α5亚型的方法，以及式I化合物在制备用于治疗GABA A受体相关疾病的药物。本发明进一步提供一种调节动物中一种或多种GABA A亚型的方法，包括向动物施用有效量的式（I）化合物。

23. 发明申请

US20100040264A1 REGISTERING BRAIN IMAGES BY ALIGNING REFERENCE ELLIPSES 失效
标题翻译：通过参考ELLIPSES注册脑图像
公开(公告)号：US20100040264A1
公开(公告)日：2010-02-18
申请号：US12306842
申请日：2007-06-28
申请人： Ihar Volkau , Bhanu Prakash K.N. , Ting Ting Ng , Varsha Gupta , Wieslaw Lucjan Nowinski
发明人： Ihar Volkau , Bhanu Prakash K.N. , Ting Ting Ng , Varsha Gupta , Wieslaw Lucjan Nowinski
IPC分类号： G06K9/00
CPC分类号： G06K9/32 , A61B6/03 , A61B6/5235 , G06K2209/051 , G06T7/344 , G06T2207/10072 , G06T2207/30016
摘要： In a method of registering three-dimensional brain images, a reference slice for a midsagittal plane of each image is constructed. The reference slice comprises image points forming a cortical edge. Edge points are selected from these image points such that an ellipse fit to the edge points approximates the cortical edge. The reference ellipse in each image that fits the edge points is determined. The images are registered in a same coordinate system such that the reference ellipses in the images are aligned with one another.
摘要翻译：在一种用于记录三维脑图像的方法中，构建了每个图像的中间平面的参考切片。参考切片包括形成皮层边缘的图像点。从这些图像点选择边缘点，使得适合于边缘点的椭圆近似于皮层边缘。确定每个图像中适合边缘点的参考椭圆。图像被记录在相同的坐标系中，使得图像中的参考椭圆相互对准。

24. 发明授权

US08369598B2 Method for identifying a pathological region of a scan, such as an ischemic stroke region of an MRI scan 失效
标题翻译：用于识别扫描的病理区域的方法，例如MRI扫描的缺血性卒中区域
公开(公告)号：US08369598B2
公开(公告)日：2013-02-05
申请号：US12518119
申请日：2007-12-05
申请人： Varsha Gupta , Bhanu K N Prakash , Wieslaw L. Nowinski
发明人： Varsha Gupta , Bhanu K N Prakash , Wieslaw L. Nowinski
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/68 , G06T2207/10088 , G06T2207/30016
摘要： A method for identifying a pathological region of a scan (such as a stroke region within a MRI DWI volume scan) is proposed. A region of the scan which is likely to contain pathological tissue (e.g. infracted tissue) is identified by obtaining a parameter which, for a given slice, or portion of a slice, characterizes the distribution of the intensity of pixels, e.g. the relative proportion of high intensity pixels. In a first case, such a parameter is used to identify those slices of a volume scan which are likely to include infarction. In a second case, such a parameter (hemisphere parameter) is obtained for each of the left- and right-hemispheres of a brain, to estimate which hemisphere contains the stroke. In either case, the parameter may be calculated based on ranges, percentiles and functions of the percentiles of the intensity distribution. These ranges, percentiles and functions of the percentiles are not pre-defined but are selected to maximize sensitivity.
摘要翻译：提出了用于识别扫描的病理区域（例如MRI DWI体积扫描内的中风区域）的方法。通过获得对于给定的切片或切片的一部分来表征像素强度的分布的参数来识别可能含有病理组织（例如，损伤的组织）的扫描区域。高强度像素的相对比例。在第一种情况下，使用这样的参数来识别可能包括梗塞的体扫描的那些切片。在第二种情况下，对于大脑的左半球和右半球中的每一个获得这样的参数（半球参数），以估计哪个半球包含中风。在任一情况下，可以根据强度分布的百分位数的范围，百分位数和函数来计算参数。百分位数的这些范围，百分位数和函数不是预定义的，而是选择以最大化灵敏度。

25. 发明授权

US08343957B2 Therapeutic pyrazoloquinoline urea derivatives 有权
标题翻译：治疗吡唑并喹啉脲衍生物
公开(公告)号：US08343957B2
公开(公告)日：2013-01-01
申请号：US12955792
申请日：2010-11-29
申请人： Alan P. Kaplan , Varsha Gupta
发明人： Alan P. Kaplan , Varsha Gupta
IPC分类号： A61K31/55 , A61K31/535 , A61K31/497
CPC分类号： C07D471/04
摘要： The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and modulating GABAA, and use of the compound of formula I for the treatment of GABAA receptor associated disorders. The general structure of formula I is shown below: The invention further provides a method of modulation of one or more GABAA subtypes in an animal comprising administering to the animal an effective amount of a compound of formula (I).
摘要翻译：本发明提供了一种新颖的式I化学系列，以及其用于结合GABA A受体的苯并二氮杂位点和调节GABAA的方法，以及式I化合物用于治疗GABA A受体相关病症的用途。式I的一般结构如下所示：本发明还提供了一种调节动物中一种或多种GABAA亚型的方法，包括向动物施用有效量的式（I）化合物。

26. 发明授权

US08311359B2 Registering brain images by aligning reference ellipses 失效
标题翻译：通过对齐参考椭圆注册大脑图像
公开(公告)号：US08311359B2
公开(公告)日：2012-11-13
申请号：US12306842
申请日：2007-06-28
申请人： Ihar Volkau , Bhanu Prakash K. N. , Ting Ting Ng , Varsha Gupta , Wieslaw Lucjan Nowinski
发明人： Ihar Volkau , Bhanu Prakash K. N. , Ting Ting Ng , Varsha Gupta , Wieslaw Lucjan Nowinski
IPC分类号： G06K9/40
CPC分类号： G06K9/32 , A61B6/03 , A61B6/5235 , G06K2209/051 , G06T7/344 , G06T2207/10072 , G06T2207/30016
摘要： In a method of registering three-dimensional brain images, a reference slice for a midsagittal plane of each image is constructed. The reference slice comprises image points forming a cortical edge. Edge points are selected from these image points such that an ellipse fit to the edge points approximates the cortical edge. The reference ellipse in each image that fits the edge points is determined. The images are registered in a same coordinate system such that the reference ellipses in the images are aligned with one another.
摘要翻译：在一种用于记录三维脑图像的方法中，构建了每个图像的中间平面的参考切片。参考切片包括形成皮层边缘的图像点。从这些图像点选择边缘点，使得适合于边缘点的椭圆近似于皮层边缘。确定每个图像中适合边缘点的参考椭圆。图像被记录在相同的坐标系中，使得图像中的参考椭圆相互对准。

27. 发明申请

US20100231216A1 Segmenting infarct in diffusion-weighted imaging volume 失效
标题翻译：扩散加权成像体积分割梗死
公开(公告)号：US20100231216A1
公开(公告)日：2010-09-16
申请号：US12311484
申请日：2006-10-03
申请人： Bhanu Prakash K.N. , Varsha Gupta , Wieslaw Lucjan Nowinski
发明人： Bhanu Prakash K.N. , Varsha Gupta , Wieslaw Lucjan Nowinski
IPC分类号： G01R33/48
CPC分类号： G06T7/11 , G06T7/136 , G06T2207/10092 , G06T2207/20104 , G06T2207/30016 , G06T2207/30101
摘要： Methods (2900), apparatuses (3000), and computer program products for segmenting an infarct in a diffusion-weighted imaging (DWI) volume are disclosed. A Region of Interest in at least one slice of the DWI volume is selected (2912). The ROI comprises at least a portion of the slice. A threshold for a minimum size of an infarct region is selected (2916). An energy mask is convolved (2918) with that slice, and the resulting energy image is normalized (2920). The ROI in the convolved energy image is selected (2922). An initial threshold is determined (2924) using a histogram of the ROI of the slice without a background region, and an initial segmentation of the slice is performed (2926). Individual components of the initial segmentation of the slice are labeled (2930). A final threshold is determined (2932) using histograms of labeled components if the initial segmentation, and a final segmentation if the slice is performed (2934) using that threshold.
摘要翻译：公开了用于分割扩散加权成像（DWI）体积中的梗塞的方法（2900），装置（3000）和用于分割梗塞的计算机程序产品。选择DWI卷的至少一个片段中的感兴趣区域（2912）。 ROI包括切片的至少一部分。选择梗死区域的最小尺寸的阈值（2916）。能量掩模与该切片卷积（2918），并且所得能量图像被归一化（2920）。选择卷积能量图像中的ROI（2922）。使用没有背景区域的切片的ROI的直方图来确定初始阈值（2924），并且执行切片的初始分割（2926）。片段初始分割的各个成分被标记（2930）。如果初始分割，则使用标记分量的直方图来确定最终阈值（2932），以及如果使用该阈值执行切片的最终分割（2934）。

28. 发明申请

US20090005365A1 THERAPEUTIC PYRAZOLONAPHTHYRIDINE DERIVATIVES 有权
标题翻译：治疗性吡唑并噻吩衍生物
公开(公告)号：US20090005365A1
公开(公告)日：2009-01-01
申请号：US12135045
申请日：2008-06-06
申请人： Alan P. Kaplan , Varsha Gupta , Jan W.F. Wasley
发明人： Alan P. Kaplan , Varsha Gupta , Jan W.F. Wasley
IPC分类号： A61K31/496 , C07D401/14 , C07D413/14 , A61K31/5377 , A61K31/551 , A61P25/24 , A61P25/28 , A61P25/18 , A61P25/22 , A61K31/4375 , C07D471/14 , C07D243/08
CPC分类号： C07D471/14
摘要： The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and negatively modulating the α5 subtype of GABAA, and use of the compound of formula I for the treatment of GABAA receptor associated disorders. The general structure of formula I is shown below: The invention further provides a method of modulation of one or more GABAA subtypes in an animal comprising administering to the animal an effective amount of a compound of formula (I).
摘要翻译：本发明提供了一种新颖的式I化学系列，以及其用于结合GABA A受体的苯并二氮杂位点和负调节GABAA的α5亚型的方法，以及式I化合物用于治疗GABAA 受体相关疾病。式I的一般结构如下所示：本发明还提供了一种调节动物中一种或多种GABAA亚型的方法，包括向动物施用有效量的式（I）化合物。

29. 发明申请

US20080306049A1 THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES 有权
标题翻译：治疗性吡唑并喹啉衍生物
公开(公告)号：US20080306049A1
公开(公告)日：2008-12-11
申请号：US12135036
申请日：2008-06-06
申请人： Alan P. Kaplan , Varsha Gupta , Jan W.F. Wasley
发明人： Alan P. Kaplan , Varsha Gupta , Jan W.F. Wasley
IPC分类号： A61K31/496 , C07D401/10 , C07D413/10 , A61K31/551 , A61P25/22 , A61P25/18 , A61P25/24 , A61P25/00 , A61K31/5377 , C07D243/08
CPC分类号： C07D471/04
摘要： The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and modulating GABAA, and use of the compound of formula I for the treatment of GABAA receptor associated disorders. The general structure of formula I is shown below and can exist in tautomeric forms: The invention further provides a method of modulation of one or more GABAA subtypes in an animal comprising administering to the animal an effective amount of a compound of formula (I).
摘要翻译：本发明提供了一种新颖的式I化学系列，以及其用于结合GABA A受体的苯并二氮杂位点和调节GABAA的方法，以及式I化合物用于治疗GABA A受体相关病症的用途。式I的一般结构如下所示，可以以互变异构形式存在：本发明还提供调节动物中一种或多种GABA A亚型的方法，包括向动物施用有效量的式（I）化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式