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21. 发明授权

US6099122A Process for the functionalization of surfaces 失效
标题翻译：表面功能化的工艺
公开(公告)号：US6099122A
公开(公告)日：2000-08-08
申请号：US860130
申请日：1997-08-18
申请人： Peter Chabrecek , Dieter Lohmann
发明人： Peter Chabrecek , Dieter Lohmann
IPC分类号： G02C7/04 , B05D3/06 , C07C271/20 , C07C271/24 , C07C271/28 , C08F2/50 , C08F283/12 , C08F290/02 , C08F290/04 , C08G18/50 , C08G18/61 , C08G18/64 , C08G18/70 , C08G18/80 , C08G18/81 , C08G77/442 , C09D175/04 , G02B1/04 , G02B1/10 , G03F7/027 , G03F7/031 , G03F7/075
CPC分类号： G03F7/0757 , C07C271/20 , C07C271/24 , C07C271/28 , C08F2/50 , C08F283/124 , C08F290/02 , C08F290/042 , C08G18/5015 , C08G18/5024 , C08G18/61 , C08G18/6446 , C08G18/70 , C08G18/80 , C08G18/807 , C08G18/8166 , C08G18/8175 , C08G77/442 , G02B1/043 , G03F7/027 , G03F7/031 , C07C2101/14
摘要： The present invention describes a novel coating process that comprises the use of a functional photoinitiator, or a macroinitiator derived therefrom, in a cascade of process steps, wherein, on the one hand, a functional photoinitiator or a macroinitiator derived therefrom is covalently bonded to a carrier and, on the other hand, an oligomer or polymer forming a new surface layer is covalently bonded to the functional photoinitiator, or to the carrier modified by a functional photoinitiator, via functional groups that are co-reactive with isocyanate groups. The invention relates also to novel intermediates that are carriers to which functional photoinitiators that contain free isocyanate groups are bonded.
摘要翻译： PCT No.PCT / EP95 / 05013 Sec。 371日期：1997年8月18日 102（e）日期1997年8月18日PCT 1995年12月18日PCT PCT。 WO96 / 20796 PCT公开号日期1996年7月11日本发明描述了一种新颖的涂覆方法，其包括在级联的工艺步骤中使用功能性光引发剂或衍生自其的大分子引发剂，其中一方面由功能性光引发剂或衍生自其的大分子引发剂共价结合到载体上，另一方面，形成新表面层的低聚物或聚合物通过与异氰酸酯共反应的官能团共价键合到功能性光引发剂或由功能性光引发剂改性的载体上团体本发明还涉及作为包含游离异氰酸酯基团的功能性光引发剂键合的载体的新型中间体。

22. 发明授权

US5965631A Extended wear ophthalmic lens 失效
公开(公告)号：US5965631A
公开(公告)日：1999-10-12
申请号：US108714
申请日：1998-07-01
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号： G02C7/04 , A61F20060101 , A61F2/14 , A61L27/00 , A61L27/26 , A61L27/34 , B05D7/24 , B29C39/42 , B29C71/00 , B29D11/00 , C08F220/22 , C08F290/06 , C08F290/14 , C08F299/08 , C08G20060101 , C08G18/10 , C08G18/48 , C08G18/50 , C08G18/61 , C08G18/67 , C08G18/81 , C08G18/83 , C08G77/00 , C08G77/04 , C08G77/46 , C08J5/00 , C08K3/00 , C08L20060101 , C08L33/08 , C08L33/10 , C08L83/04 , G02B1/04 , G02C20060101
CPC分类号： G02C7/049 , A61L27/26 , A61L27/34 , B05D1/62 , B29C39/42 , B29D11/00076 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , A61L2430/16 , B29C71/00 , B29L2011/0041 , Y10S525/903 , Y10S525/936 , Y10S525/937
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

23. 发明授权

US5856416A Unsaturated carbohydrate derivatives polymers thereof and their use 失效
标题翻译：不饱和碳水化合物衍生物的聚合物及其用途
公开(公告)号：US5856416A
公开(公告)日：1999-01-05
申请号：US867747
申请日：1997-06-03
申请人： Frank Bachmann , Dieter Lohmann , Peter Chabrecek
发明人： Frank Bachmann , Dieter Lohmann , Peter Chabrecek
IPC分类号： G02C7/04 , A61L27/34 , C07H13/12 , C07H15/04 , C08B37/16 , C08F20/36 , C08F290/00 , C08F290/06 , G02B1/04 , C08F220/04
CPC分类号： C07H13/12 , A61L27/34 , C07H15/04 , C08B37/0012 , C08F20/36 , G02B1/043
摘要： The present invention relates to polymerizable derivatives of carbohydrates comprising a compound of formula (I)R.sup.1 --(COO--Alk).sub.m --(OCONH--R).sub.n --(NHCO).sub.p --Y--Z (I)whereinR.sup.1 is a radically polymerizable hydrocarbon group;m, n and p are 0 or 1;Alk is alkylene having up to 10 carbon atoms;R is a diradical, having up to 20 carbon atoms, of an organic diisocyanate;Z is a monovalent radical, minus a single hydroxy group, of a mono-, di- or tri-saccharide, of an oligosaccharide, of a cyclodextrin (CD) or of an anhydrosaccharide; andY is --O-- or --NH--;with the proviso that when p is zero, m and n are also zero and Y is --NH--; to homopolymers, copolymers, block copolymers, graft copolymers and polymeric networks thereof, to molded articles, for example contact lenses or biomedicinal articles, comprising the mentioned polymers, as well as to processes for the preparation of the mentioned polymers and articles.
摘要翻译：本发明涉及碳水化合物的可聚合衍生物，其包含式（I）化合物R1-（COO-Alk）m-（OCONH-R）n-（NHCO）p-Y-Z（I）的化合物，其中R1是可自由基聚合的烃基; m，n和p为0或1; Alk是具有至多10个碳原子的亚烷基; R是具有至多20个碳原子的双键，有机二异氰酸酯; Z是低聚糖，环糊精（CD）或非水解糖的单糖，二糖或三糖的单一基团，减去单个羟基; Y为-O-或-NH-; 条件是当p为0时，m和n也为零，Y为-NH-; 至均聚物，共聚物，嵌段共聚物，接枝共聚物和聚合物网络，包括所述聚合物的模塑制品，例如隐形眼镜或生物医学制品，以及制备所述聚合物和制品的方法。

24. 发明授权

US5760100A Extended wear ophthalmic lens 失效
公开(公告)号：US5760100A
公开(公告)日：1998-06-02
申请号：US569816
申请日：1995-12-08
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号： G02C7/04 , A61F20060101 , A61F2/14 , A61L27/00 , A61L27/26 , A61L27/34 , B05D7/24 , B29C39/42 , B29C71/00 , B29D11/00 , C08F220/22 , C08F290/06 , C08F290/14 , C08F299/08 , C08G20060101 , C08G18/10 , C08G18/48 , C08G18/50 , C08G18/61 , C08G18/67 , C08G18/81 , C08G18/83 , C08G77/00 , C08G77/04 , C08G77/46 , C08J5/00 , C08K3/00 , C08L20060101 , C08L33/08 , C08L33/10 , C08L83/04 , G02B1/04 , G02C20060101
CPC分类号： G02C7/049 , A61L27/26 , A61L27/34 , B05D1/62 , B29C39/42 , B29D11/00076 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , A61L2430/16 , B29C71/00 , B29L2011/0041 , Y10S525/903 , Y10S525/936 , Y10S525/937
摘要： An ophthalmic lens suited for extended-wear for periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

25. 发明申请

US20090046242A1 Extended Wear Ophthalmic Lens 审中-公开
标题翻译：延长佩戴眼科镜片
公开(公告)号：US20090046242A1
公开(公告)日：2009-02-19
申请号：US12252397
申请日：2008-10-16
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jurgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an opthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.
摘要翻译：一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。在一个实施方案中，眼用透镜是至少一种氧精，至少一种离子交换剂和交联剂的共聚产物。在一个实施方案中，透镜的拉伸模量小于约3.0MPa，而在另一个实施方案中，拉伸模量为约0.5至约1.5MPa。

26. 发明授权

US06835410B2 Bottle-brush type coatings with entangled hydrophilic polymer 有权
标题翻译：带有缠结亲水性聚合物的瓶刷型涂料
公开(公告)号：US06835410B2
公开(公告)日：2004-12-28
申请号：US10142300
申请日：2002-05-09
申请人： Peter Chabrecek , Jörg Leukel , Dieter Lohmann
发明人： Peter Chabrecek , Jörg Leukel , Dieter Lohmann
IPC分类号： A61L2700
CPC分类号： A61L27/34
摘要： The invention relates to a process for coating a material surface comprising the steps of: (a) providing an inorganic or organic bulk material having covalently bound to its surface initiator moieties for radical polymerization; (b) graft polymerizing a hydrophilic ethylenically unsaturated macromonomer from the bulk material surface in the presence of a biocompatible hydrophilic polymer being devoid of polymerizable ethylenically unsaturated groups and thereby entrapping said hydrophilic polymer within the polymer matrix formed by the polymerization of the macromonomer. Composite materials obtainable according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译：本发明涉及一种用于涂覆材料表面的方法，包括以下步骤：（a）提供与其表面引发剂部分共价结合的无机或有机本体材料用于自由基聚合;（b）将亲水烯属不饱和大分子单体从在生物相容性亲水性聚合物存在下，不存在可聚合的烯键式不饱和基团，从而将所述亲水性聚合物包埋在通过大分子单体聚合形成的聚合物基质中。根据本发明方法可获得的复合材料具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性，因此可用于制造诸如眼科装置的生物医学制品。

27. 发明授权

US06586038B1 Process for the modification of a material surface 失效
标题翻译：用于修饰材料表面的工艺
公开(公告)号：US06586038B1
公开(公告)日：2003-07-01
申请号：US09697859
申请日：2000-10-27
申请人： Peter Chabrecek , Dieter Lohmann
发明人： Peter Chabrecek , Dieter Lohmann
IPC分类号： G02B110
CPC分类号： G02B1/043 , C08J7/12 , C08J7/16
摘要： The invention relates to a process for coating a material surface. The process comprises the steps of: (a) covalently binding polymerization initiator radicals to the surface; (b) graft polymerizing a vinyl monomer carrying a reactive group onto the initiator-modified material surface and thereby providing a primary polymer coating comprising reactive groups; and (c) reacting the reactive groups of the primary polymer coating with a hydrophilic telomer having a functional group that is coreactive with the reactive groups of the primary polymer coating. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译：本发明涉及一种涂覆材料表面的方法。该方法包括以下步骤：（a）将聚合引发剂基团与表面共价结合; （b）将携带反应性基团的乙烯基单体接枝聚合到引发剂改性的材料表面上，从而提供包含反应性基团的初级聚合物涂层; 和（c）使主聚合物涂层的反应性基团与具有与主聚合物涂层的反应性基团相互作用的官能团的亲水性调聚物反应。通过本发明的方法可获得的涂覆制品具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性的所需特性，因此可用于制造生物医学制品如眼科装置。

28. 发明授权

US06521352B1 Process for the modification of a material surface 失效
标题翻译：用于修饰材料表面的工艺
公开(公告)号：US06521352B1
公开(公告)日：2003-02-18
申请号：US09698528
申请日：2000-10-27
申请人： Peter Chabrecek , Dieter Lohmann
发明人： Peter Chabrecek , Dieter Lohmann
IPC分类号： B32B2728
CPC分类号： G02B1/043 , A61L27/34 , Y10T428/31551 , Y10T428/31576 , Y10T428/31935
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) providing a hydrophilic telomer of formula (oligomer)-T (1), wherein the variables are as defined in the claims, and (b) covalently binding the hydrophilic telomer to the material surface. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译：本发明涉及一种用于涂覆材料表面的方法，包括以下步骤：（a）提供式（Ⅳ）的亲水性调聚物，其变量如权利要求中所定义，和（b）将亲水性调聚物共价结合到材料表面。通过本发明的方法可获得的涂层制品具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此可用于制造生物医学制品如眼科装置。

29. 发明授权

US06465056B1 Process for coating a material surface 失效
标题翻译：涂覆材料表面的工艺
公开(公告)号：US06465056B1
公开(公告)日：2002-10-15
申请号：US09698544
申请日：2000-10-27
申请人： Peter Chabrecek , Dieter Lohmann
发明人： Peter Chabrecek , Dieter Lohmann
IPC分类号： B05D306
CPC分类号： B82Y30/00 , A61L27/34 , B05D1/185 , B05D1/62 , B82Y40/00 , G02B1/043
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) providing the material surface with polymer brushes comprising polymerization initiator radicals; and (b) graft polymerizing one or more different ethylenically unsaturated hydrophilic monomers or macromonomers onto the polymerization initiator-modified polymer brushes. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译：本发明涉及一种用于涂覆材料表面的方法，包括以下步骤：（a）向材料表面提供包含聚合引发剂基团的聚合物刷; 和（b）将一种或多种不同的烯属不饱和亲水单体或大分子单体接枝聚合到聚合引发剂改性的聚合物刷上。通过本发明的方法可获得的涂覆制品具有关于对基材的粘附，耐久性，亲水性，润湿性，生物相容性和渗透性，因此可用于制造生物医学制品如眼科装置。

30. 发明授权

US5849811A Extended wear ophthalmic lens 失效
标题翻译：延长佩戴眼科镜片
公开(公告)号：US5849811A
公开(公告)日：1998-12-15
申请号：US682452
申请日：1996-07-17
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号： G02C7/04 , A61F20060101 , A61F2/14 , A61L27/00 , A61L27/26 , A61L27/34 , B05D7/24 , B29C39/42 , B29C71/00 , B29D11/00 , C08F220/22 , C08F290/06 , C08F290/14 , C08F299/08 , C08G20060101 , C08G18/10 , C08G18/48 , C08G18/50 , C08G18/61 , C08G18/67 , C08G18/81 , C08G18/83 , C08G77/00 , C08G77/04 , C08G77/46 , C08J5/00 , C08K3/00 , C08L20060101 , C08L33/08 , C08L33/10 , C08L83/04 , G02B1/04 , G02C20060101 , C08F230/08
CPC分类号： G02C7/049 , A61L27/26 , A61L27/34 , B05D1/62 , B29C39/42 , B29D11/00076 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , A61L2430/16 , B29C71/00 , B29L2011/0041 , Y10S525/903 , Y10S525/936 , Y10S525/937
摘要： An ophthalmic lens suited for extended-wear for periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
摘要翻译：适合在眼睛上延长穿戴至少一天的眼科镜片，而不会有临床显着量的角膜肿胀并且没有实质的佩戴者不适。透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。优选的透镜是含氧大分子单体和离子单体单体的共聚产物。本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。

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