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21. 发明授权

US4827011A Antihypertensive phosphate derivatives 失效
标题翻译：抗高血压磷酸盐衍生物
公开(公告)号：US4827011A
公开(公告)日：1989-05-02
申请号：US679790
申请日：1984-12-10
申请人： Allan Wissner , Robert E. Schaub
发明人： Allan Wissner , Robert E. Schaub
IPC分类号： C07F9/10 , A61K31/685
CPC分类号： C07F9/10
摘要： Antihypertensive phosphate derivatives having the following formula are described: ##STR1## wherein X is a C.sub.1 -C.sub.24 branched or straight chain alkyl group; R is selected from the group consisting of hydrogen and C.sub.1 -C.sub.4 alkyl, with the proviso that at least one R group is not hydrogen; T is selected from the group consisting of hydrogen and ##STR2## wherein R.sub.1 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.4 branched or straight chain alkyl, C.sub.1 -C.sub.4 branched or straight chain alkoxy and C.sub.1 -C.sub.4 branched or straight chain alkylamino; Q is a bivalent radical selected from the group consisting of --(CH.sub.2).sub.p -- and --(CHR.sup.1).sub.p --, wherein p is an integer from 2 to 12 and the moiety --(CHR.sup.1).sub.p -- represents an alkylene chain which is substituted by one or more C.sub.1 -C.sub.10 alkyl groups or phenyl groups; Z is selected from the group consisting of ##STR3## wherein R.sub.2 may be chain alkyl and q is an integer from 4 to 7; in either the racemic or in the optically active form.
摘要翻译：描述了具有下式的抗高血压磷酸酯衍生物：其中X是C 1 -C 24支链或直链烷基; R选自氢和C 1 -C 4烷基，条件是至少一个R基团不是氢; T选自氢和其中R 1选自氢，C 1 -C 4支链或直链烷基，C 1 -C 4支链或直链烷氧基和C 1 -C 4支链或直链烷基氨基 ; Q是选自 - （CH 2）p - 和（CHR 1）p - 的二价基团，其中p是2至12的整数，并且 - （CHR 1）p - 部分代表被取代的亚烷基链通过一个或多个C 1 -C 10烷基或苯基; Z选自，其中R 2可以是链烷基，q是4至7的整数; 以外消旋或旋光形式。

22. 发明授权

US07399865B2 Protein tyrosine kinase enzyme inhibitors 有权
标题翻译：蛋白酪氨酸激酶抑制剂
公开(公告)号：US07399865B2
公开(公告)日：2008-07-15
申请号：US10939007
申请日：2004-09-10
申请人： Allan Wissner , Sridhar Krishna Rabindran , Hwei-Ru Tsou
发明人： Allan Wissner , Sridhar Krishna Rabindran , Hwei-Ru Tsou
IPC分类号： C07D215/38
CPC分类号： C04B35/632 , C07D215/54 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification.
摘要翻译：本发明提供具有其中R 1，R 2，R 3，R 4，或S >和R 5在说明书中描述。

23. 发明申请

US20050059678A1 Protein tyrosine kinase enzyme inhibitors 有权
标题翻译：蛋白酪氨酸激酶酶抑制剂
公开(公告)号：US20050059678A1
公开(公告)日：2005-03-17
申请号：US10939007
申请日：2004-09-10
申请人： Allan Wissner , Sridhar Rabindran , Hwei-Ru Tsou
发明人： Allan Wissner , Sridhar Rabindran , Hwei-Ru Tsou
IPC分类号： C07D215/54 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/506 , A61K31/4709 , C07D417/02 , C07D43/02
CPC分类号： C04B35/632 , C07D215/54 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification.
摘要翻译：本发明提供式1化合物，其具有其中R1，R2，R3，R4和R5在本说明书中描述的结构。

24. 发明授权

US6002008A Substituted 3-cyano quinolines 失效
公开(公告)号：US6002008A
公开(公告)日：1999-12-14
申请号：US49718
申请日：1998-03-27
申请人： Allan Wissner , Bernard D. Johnson , Marvin F. Reich , Middleton B. Floyd, Jr. , Douglas B. Kitchen , Hwei-Ru Tsou
发明人： Allan Wissner , Bernard D. Johnson , Marvin F. Reich , Middleton B. Floyd, Jr. , Douglas B. Kitchen , Hwei-Ru Tsou
IPC分类号： C07D215/54 , C07D215/56 , C07D401/04 , C07D401/12 , C07D409/12 , A01N43/42 , C07D215/16 , C07D215/38
CPC分类号： C07D401/04 , C07D215/54 , C07D215/56 , C07D401/12 , C07D409/12
摘要： This invention provides compounds having the formula: ##STR1## wherein: X is cycloalkyl which may be optionally substituted; or is a pyridinyl, pyrimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally substituted;n is 0-1;Y is --NH--, --O--, --S--, or --NR--;R is alkyl of 1-6 carbon atoms;R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each, independently, hydrogen, halogen, alkyl, alkenyl, alkynyl, alkenyloxy, alkynyloxy, hydroxymethyl, halomethyl, alkanoyloxy, alkenoyloxy, alkynoyloxy, alkanoyloxymethyl, alkenoyloxymethyl, alkynoyloxymethyl, alkoxymethyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylsulfonamido, alkenylsulfonamido, alkynylsulfonamido, hydroxy, trifluoromethyl, cyano, nitro, carboxy, carboalkoxy, carboalkyl, phenoxy, phenyl, thiophenoxy, benzyl, amino, hydroxyamino, alkoxyamino, alkylamino, dialkylamino, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, phenylamino, benzylamino, ##STR2## R.sub.5 is alkyl which may be optionally substituted, or phenyl which may be optionally substituted;R.sub.6 is hydrogen, alkyl, or alkenyl;R.sub.7 is chloro or bromoR.sub.8 is hydrogen, alkyl, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, N-cycloalkylaminoalkyl, N-cycloalkyl-N-alkylaminoalkyl, N,N-dicycloalkylaminoalkyl, morpholino-N-alkyl, piperidino-N-alkyl, N-alkyl-piperidino-N-alkyl, azacycloalkyl-N-alkyl, hydroxyalkyl, alkoxyalkyl, carboxy, carboalkoxy, phenyl, carboalkyl+, chloro, fluoro, or bromo;Z is amino, hydroxy, alkoxy, alkylamino, dialkylamino, morpholino, piperazino, N-alkylpiperazino, or pyrrolidino;m=1-4,q=1-3, and p=0-3;any of the substituents R.sub.1, R.sub.2, R.sub.3, or R.sub.4 that are located on contiguous carbon atoms can together be the divalent radical --O--C(R.sub.8).sub.2 --O--;or a pharmaceutically acceptable salt thereof with the proviso that when Y is --NH--, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are hydrogen, and n is 0, X is not 2-methylphenyl, which are inhibitors of protein tyrosine kinase.

25. 发明授权

US5569762A Asymmetric synthesis of intermediates for retroviral protease inhibitor compounds 失效
标题翻译：逆转录病毒蛋白酶抑制剂化合物中间体的不对称合成
公开(公告)号：US5569762A
公开(公告)日：1996-10-29
申请号：US408362
申请日：1995-03-22
申请人： Allan Wissner , Michael P. Trova
发明人： Allan Wissner , Michael P. Trova
IPC分类号： C07D217/26 , C07D401/12 , C07D405/06 , C07D217/00
CPC分类号： C07D401/12 , C07D217/26 , C07D405/06
摘要： The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein R.sub.1, R.sub.50 and Z are described in the specification. The improved process includes either synthesis of diastereomeric iodolactones which are separated prior to conversion to compounds of Formula II or III or synthesis of an epoxide which is converted directly to compounds of Formula II and III.
摘要翻译：本公开描述了用于制备式II或III的光学活性化合物的改进方法，该化合物可用作制备作为逆转录病毒蛋白酶抑制剂有活性的化合物的中间体：其中R 1，R 50和Z 在说明书中描述。改进的方法包括合成在转化为式II或III化合物之前分离的非对映体碘内酯或合成直接转化为式II和III化合物的环氧化物。

26. 发明授权

US5432189A Bis-aryl amide and urea antagonists of platelet activating factor 失效
标题翻译：双芳基酰胺和尿素拮抗剂的血小板激活因子
公开(公告)号：US5432189A
公开(公告)日：1995-07-11
申请号：US247954
申请日：1994-05-24
申请人： Allan Wissner
发明人： Allan Wissner
IPC分类号： A61K31/415 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/47 , A61K31/472 , A61P7/02 , A61P9/00 , A61P9/02 , A61P11/00 , A61P11/08 , C07D213/20 , C07D213/38 , C07D213/40 , C07D215/10 , C07D217/04 , C07D217/12 , C07D233/61 , C07D277/22 , C07D277/28 , C07D471/04 , C07D521/00
CPC分类号： C07D213/20 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/22 , C07D277/28 , C07D471/04
摘要： Bis-aryl amide and urea compounds of the general formula: ##STR1## wherein X is a divalent amide or urea substituent and Y is a nitrogen containing heterocycle, which compounds are inhibitors of platelet activating factor. Pharmaceutical compositions containing the compounds and methods of treating platelet activating factor associated conditions are also included.
摘要翻译：双芳基酰胺和通式如下的脲化合物：其中X是二价酰胺或脲取代基，Y是含氮杂环，该化合物是血小板活化因子的抑制剂。还包括含有该化合物的药物组合物和治疗血小板活化因子相关病症的方法。

27. 发明授权

US5328901A Bis-arylphosphate ester antagonists of platelet activating factor 失效
标题翻译：血小板激活因子的双芳基磷酸酯拮抗剂
公开(公告)号：US5328901A
公开(公告)日：1994-07-12
申请号：US69638
申请日：1993-06-01
申请人： Allan Wissner , Kenneth Green , Robert E. Schaub
发明人： Allan Wissner , Kenneth Green , Robert E. Schaub
IPC分类号： A61K31/675 , A61P7/02 , A61P9/02 , A61P43/00 , C07F9/58 , C07F9/60 , C07F9/62 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/6539 , C07F9/6558
CPC分类号： C07F9/65061 , C07F9/581 , C07F9/60 , C07F9/62 , C07F9/650911 , C07F9/650958 , C07F9/65121 , C07F9/6539
摘要： The invention is novel compounds of the formula: ##STR1## which are antagonists of platelet activating factor.
摘要翻译：本发明是新颖的下式化合物：作为血小板活化因子的拮抗剂的“IMAGE”。

28. 发明授权

US5144045A Phosphocholine derivative inhibitors of phospholipase A.sub.2 失效
标题翻译：磷脂酶A2的磷酸胆碱衍生物抑制剂
公开(公告)号：US5144045A
公开(公告)日：1992-09-01
申请号：US612745
申请日：1990-11-13
申请人： Allan Wissner , Robert E. Schaub , Kenneth E. Green , Philip R. Hamann
发明人： Allan Wissner , Robert E. Schaub , Kenneth E. Green , Philip R. Hamann
IPC分类号： C07F9/10 , C07F9/568 , C07F9/655
CPC分类号： C07F9/568 , C07F9/10 , C07F9/65502
摘要： Phospocholine derivatives having the formula: ##STR1## in which W, Z, Q and R are described in the specification are disclosed as useful for inhibiting the enzyme phospholipase A.sub.2. Methods of making and using the compounds are also disclosed.
摘要翻译：公开了在说明书中描述的其中W，Z，Q和R所示的具有下式的其中的磷脂酰胆碱衍生物：其用于抑制磷脂酶A2。还公开了制备和使用化合物的方法。

29. 发明授权

US4310700A 1-Hydroxylmethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives 失效
标题翻译： 1-羟甲基-11-脱氧-16-羟基 - 前列腺-1-醇衍生物
公开(公告)号：US4310700A
公开(公告)日：1982-01-12
申请号：US137085
申请日：1980-04-03
申请人： Allan Wissner , Middleton B. Floyd, Jr.
发明人： Allan Wissner , Middleton B. Floyd, Jr.
IPC分类号： C07C45/59 , C07C59/245 , C07C405/00 , C07D307/42 , C07D307/46 , C07D317/16 , C07D317/24 , C07D317/34 , C07F7/18 , C07C49/597 , C07C35/06
CPC分类号： C07D307/42 , C07C405/0025 , C07C45/59 , C07C59/245 , C07D307/46 , C07D317/16 , C07D317/24 , C07D317/34 , C07F7/1856
摘要： Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.
摘要翻译：公开前列腺素类似物，其具有以基团-CH（OR'）OR“终止的α-链，其中R'和R”相同或不同，并且是氢，C 1至C 4烷酰基或任选取代的苯甲酰基，取代基选自C1至C4烷基，C1至C4烷氧基，卤素和三氟甲基。这些化合物可用作降压药，胃分泌和血小板聚集抑制剂和支气管扩张剂。

30. 发明授权

US4288633A 1-Hydroxymethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives 失效
标题翻译： 1-羟甲基-11-脱氧-16-羟基 - 前列腺-1-醇衍生物
公开(公告)号：US4288633A
公开(公告)日：1981-09-08
申请号：US137031
申请日：1980-04-03
申请人： Allan Wissner , Middleton B. Floyd, Jr.
发明人： Allan Wissner , Middleton B. Floyd, Jr.
IPC分类号： C07C45/59 , C07C49/707 , C07C51/09 , C07C405/00 , C07F7/18 , C07C35/06 , C07C49/597
CPC分类号： C07F7/1856 , C07C405/0016 , C07C405/0025 , C07C45/59 , C07C49/707 , C07C51/09
摘要： Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.
摘要翻译：公开前列腺素类似物，其具有以基团-CH（OR'）OR“终止的α-链，其中R'和R”相同或不同，并且是氢，C 1至C 4烷酰基或任选取代的苯甲酰基，取代基选自C1至C4烷基，C1至C4烷氧基，卤素和三氟甲基。这些化合物可用作降压药，胃分泌和血小板聚集抑制剂和支气管扩张剂。

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