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21. 发明申请

US20180015161A1 Checkpoint Inhibitor and Vaccine Combinations and Use of Same For Immunotherapy 审中-公开
公开(公告)号：US20180015161A1
公开(公告)日：2018-01-18
申请号：US15546740
申请日：2016-01-28
申请人： David WEINER , Karuppiah MUTHUMANI , Niranjan SARDESAI , The Trustees of the University of Pennsylvania , INOVIO PHARMACEUTICALS, INC.
发明人： David Weiner , Karuppiah Muthumani , Niranjan Sardesai
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： A61K39/395 , A61K39/0011 , A61K39/12 , A61K39/39558 , A61K2039/505 , A61K2039/53 , A61K2039/545 , A61K2039/585 , C07K16/2803 , C07K16/2818 , C07K16/2827 , C07K2317/76 , C12N2710/20034 , Y02A50/412 , A61K2300/00
摘要： Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.

22. 发明申请

US20160030536A1 Cancer Vaccines And Methods Of Treatment Using The Same 审中-公开
标题翻译：癌症疫苗及其治疗方法
公开(公告)号：US20160030536A1
公开(公告)日：2016-02-04
申请号：US14775047
申请日：2014-03-14
申请人： David WEINER , Karuppiah MUTHUMANI , Jewell WALTERS , Jian YAN
发明人： David Weiner , Jian Yan , Karuppiah Muthumani , Jewell Walters
IPC分类号： A61K39/00 , C12N9/02 , A61K39/395
CPC分类号： A61K39/0011 , A61K39/3955 , A61K2039/505 , A61K2039/53 , A61K2039/54 , A61K2039/55522 , A61K2039/55527 , A61K2039/575 , C12N9/0071 , C12N2710/20034 , C12N2730/10111 , C12N2770/24234 , C12Y114/18001
摘要： Disclosed herein are compositions and methods for treating cancer and in particular vaccines that treat and provide protection against tumor growth.
摘要翻译：本文公开了治疗癌症的组合物和方法，特别是治疗和提供针对肿瘤生长的保护的疫苗。

23. 发明申请

US20060140978A1 Genetic constructs and compositions comprising pre and cte and uses thereof 有权
标题翻译：遗传构建体和组合物，其包含前和后者及其用途
公开(公告)号：US20060140978A1
公开(公告)日：2006-06-29
申请号：US10535326
申请日：2003-11-19
申请人： David Weiner , Karuppiah Muthumani
发明人： David Weiner , Karuppiah Muthumani
IPC分类号： A61K48/00 , A61K39/21 , C12N15/867
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N2740/16122 , C12N2740/16134 , C12N2740/16322 , C12N2740/16334
摘要： Genetic constructs that comprise a coding sequence for HIV-1 Rev, and a coding sequence for a desired protein are disclosed. Compositions that comprise at least two nucleic acid molecules in which at least one nucleic acid molecule comprises a coding sequence for HIV-1 Rev, and at least one nucleic acid molecule comprises a coding sequence for a desired protein are disclosed. In such genetic constructs and compositions comprising nucleic acid molecules, the coding sequence for the desired protein comprises at least a portion of coding sequence for an HIV structural protein that includes an RRE and at least one CTE. Methods of inducing an immune response against an immunogen in an individual, methods of delivering proteins to an individual and methods of producing proteins are also disclosed.
摘要翻译：公开了包含HIV-1 Rev编码序列的遗传构建体和所需蛋白质的编码序列。包含至少两个核酸分子的组合物，其中至少一个核酸分子包含HIV-1 Rev的编码序列，并且至少一个核酸分子包含所需蛋白质的编码序列。在包含核酸分子的这种遗传构建体和组合物中，所需蛋白质的编码序列包含HIV结构蛋白的编码序列的至少一部分，其包括RRE和至少一种CTE。还公开了诱导针对个体免疫原的免疫应答的方法，将蛋白递送给个体的方法和生产蛋白质的方法。

24. 发明申请

US20050226849A1 Compositions and methods of using capsid protein from Flaviviruses and Pestiviruses 失效
标题翻译：使用来自黄病毒和瘟病毒的衣壳蛋白的组合物和方法
公开(公告)号：US20050226849A1
公开(公告)日：2005-10-13
申请号：US10966576
申请日：2004-10-14
申请人： David Weiner , Joo-Sung Yang , Karuppiah Muthumani
发明人： David Weiner , Joo-Sung Yang , Karuppiah Muthumani
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K38/16 , A61K38/22 , A61K38/43 , A61K39/00 , A61K39/12 , A61K48/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K14/16 , C07K14/18 , C12N15/67 , C12P21/02 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/569 , C12N15/86
CPC分类号： A61K38/162 , A61K48/00 , A61K2039/53 , C07K14/005 , C07K2319/02 , C12N2740/16222 , C12N2770/24122 , C12N2770/24322 , G01N33/56983 , G01N2469/20 , Y02A50/394
摘要： This invention provides methods of inducing cell death with Flavivirus or Pestivirus capsid protein, such as West Nile virus (WNV) capsid protein, and functional fragments thereof. The invention also provides methods of treating patients suffering from diseases characterized by hyperproliferating cells by administering pharmaceutical compositions comprising WNV or other virus including Flavivirus or Pestivirus capsid or other protein or a nucleic acid molecule encoding the same. Methods of identifying compounds which have anti-viral and/or anti-WNV and/or anti-Flavivirus and/or anti-Pestivirus capsid or other protein activity are disclosed. The invention also provides vaccine compositions comprising capsid or other proteins, or fragments thereof, or nucleic acids encoding same, from WNV or other virus including Flavivirus or Pestivirus and a pharmaceutically acceptable carrier. The invention also provides diagnostic methods and kits for identifying individuals exposed to WNV or other viruses including Flavivirus or Pestivirus.
摘要翻译：本发明提供了用黄病毒或瘟病毒衣壳蛋白（例如西尼罗河病毒（WNV）衣壳蛋白）及其功能片段诱导细胞死亡的方法。本发明还提供了通过施用包含WNV或其它病毒（包括黄病毒或瘟病毒衣壳或其他蛋白质）的药物组合物或其编码的核酸分子来治疗患有特征在于过度增殖细胞的疾病的患者的方法。公开了鉴定具有抗病毒和/或抗WNV和/或抗黄病毒和/或抗瘟病毒衣壳或其它蛋白质活性的化合物的方法。本发明还提供包含衣壳或其它蛋白质或其片段，或编码其的核酸的疫苗组合物，来自WNV或其它病毒，包括黄病毒或瘟病毒和药学上可接受的载体。本发明还提供用于鉴定暴露于WNV或其它病毒（包括黄病毒或瘟病毒）的个体的诊断方法和试剂盒。

25. 发明申请

US20050042202A1 Compositions for and methods of treating and preventing sirs/sepsis 审中-公开
标题翻译：治疗和预防先天/败血症的组合物和方法
公开(公告)号：US20050042202A1
公开(公告)日：2005-02-24
申请号：US10491800
申请日：2002-10-07
申请人： David Weiner , Karuppiah Muthumani
发明人： David Weiner , Karuppiah Muthumani
IPC分类号： A61K45/00 , A61K31/43 , A61K31/522 , A61K31/545 , A61K31/546 , A61K31/7036 , A61K35/76 , A61K38/00 , A61K38/16 , A61K45/06 , A61K48/00 , A61P1/00 , A61P7/00 , A61P9/00 , A61P9/04 , A61P9/14 , A61P11/00 , A61P13/12 , A61P25/00 , A61P29/00 , A61P31/04 , A61P37/00 , A61P39/00 , A61P43/00 , A61K38/17
CPC分类号： A61K45/06 , A61K31/43 , A61K31/522 , A61K31/545 , A61K31/546 , A61K31/7036 , A61K38/162 , A61K48/00 , A61K2300/00
摘要： The present invention relates to methods of inhibiting the immune response underlying sepsis, to methods of preventing sepsis, to methods of treating sepsis and to pharmaceutical compositions useful in such methods.
摘要翻译：本发明涉及抑制脓毒症下的免疫反应的方法，预防败血症的方法，治疗败血症的方法和用于这些方法的药物组合物。

26. 发明授权

US11925685B2 DNA antibody constructs encoding anti-ZIKV envelope antibodies 有权
公开(公告)号：US11925685B2
公开(公告)日：2024-03-12
申请号：US16334441
申请日：2017-09-19
申请人： David Weiner , Karuppiah Muthumani , Jian Yan
发明人： David Weiner , Karuppiah Muthumani , Jian Yan
IPC分类号： A61K39/12 , A61K31/7088 , A61K39/42 , A61P31/14 , C07K14/18 , C07K16/10 , C12N7/00 , A61K39/00
CPC分类号： A61K39/42 , A61K31/7088 , A61K39/12 , A61P31/14 , C07K14/18 , C07K16/10 , C07K16/1081 , C12N7/00 , A61K2039/505 , A61K2039/53 , C07K2317/56 , C12N2770/24134 , C12N2770/24171 , Y02A50/30 , A61K39/12 , A61K2300/00 , A61K39/42 , A61K2300/00
摘要： Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV-Envelope (anti-ZIKV E) Protein antibody.

27. 发明申请

US20160067334A1 Vaccines With Biomolecular Adjuvants 审中-公开
标题翻译：生物分子佐剂疫苗
公开(公告)号：US20160067334A1
公开(公告)日：2016-03-10
申请号：US14774428
申请日：2014-03-14
申请人： David WEINER , Karuppiah MUTHUMANI
发明人： David B. Weiner , Karuppiah Muthumani
IPC分类号： A61K39/39 , C07K14/52 , A61K41/00 , C07K14/47 , A61K39/21 , C12N7/00
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K41/0047 , A61K2039/53 , A61K2039/55516 , A61K2039/55522 , C07K14/4702 , C07K14/52 , C12N7/00 , C12N2740/16034 , C12N2740/16134 , C12N2740/16171 , C12N2740/16234 , C12N2740/16271 , Y02A50/412
摘要： Disclosed herein is a vaccine comprising an antigen and one or more bimolecular adjuvant. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
摘要翻译：本文公开了包含抗原和一种或多种双分子佐剂的疫苗。本文还公开了增加受试者的免疫应答的方法。所述方法可以包括向有需要的受试者施用疫苗。

28. 发明申请

US20060241150A1 P38 kinase inhibitor compositions and methods of using the same 审中-公开
标题翻译： P38激酶抑制剂组合物及其使用方法
公开(公告)号：US20060241150A1
公开(公告)日：2006-10-26
申请号：US10559227
申请日：2004-06-04
申请人： David Weiner , Karuppiah Muthumani
发明人： David Weiner , Karuppiah Muthumani
IPC分类号： A61K31/4439 , A61K31/551 , A61K31/522 , A61K31/513 , C12Q1/70
CPC分类号： A61K31/415 , A61K31/44 , C12Q1/18 , C12Q1/703 , G01N33/5023 , G01N33/56988 , G01N33/6872 , G01N2333/163 , C12Q2527/125
摘要： Methods of treating an individual who has been identified as having been infected with HIV are disclosed. Methods of treating an individual who is suspected of having been exposed to HIV are disclosed. Some methods disclosed comprise the step of administering to the individual an amount of a p38 inhibitor effective to inhibit FasL expression. Some methods disclosed comprise the step of administering to the individual an amount of a p38 inhibitor effective to inhibit HIV replication. Some methods disclosed comprise the step of administering to the individual an amount of a p38 inhibitor effective to inhibit HIV replication without inhibiting T cell activation. Some methods disclosed comprise administering to the individual one or more other anti-HIV compounds in combination with a p38 inhibitor. Methods of identifying compounds that inhibit Nef mediated upregulation of FasL expression are disclosed. Methods of identifying compounds that inhibit the p38 pathway are disclosed.
摘要翻译：公开了已经鉴定为感染了HIV的个体的治疗方法。披露了怀疑患有艾滋病毒的个体治疗方法。公开的一些方法包括向个体施用一定量的有效抑制FasL表达的p38抑制剂的步骤。公开的一些方法包括向个体施用一定量的有效抑制HIV复制的p38抑制剂的步骤。公开的一些方法包括向个体施用一定量的有效抑制HIV复制而不抑制T细胞活化的量的p38抑制剂的步骤。所公开的一些方法包括给予个体一种或多种其它抗HIV化合物与p38抑制剂的组合。公开了鉴定抑制Nef介导的FasL表达上调的化合物的方法。公开了鉴定抑制p38途径的化合物的方法。

29. 发明申请

US20050054104A1 Targeted particles and methods of using the same 有权
标题翻译：目标粒子及其使用方法
公开(公告)号：US20050054104A1
公开(公告)日：2005-03-10
申请号：US10478896
申请日：2002-05-28
申请人： David Weiner , Karuppiah Muthumani , Donghui Zhang , Mathura Ramanthan
发明人： David Weiner , Karuppiah Muthumani , Donghui Zhang , Mathura Ramanthan
IPC分类号： A61K39/00 , C07K14/16 , C07K14/475 , C12N15/867 , C12N15/861
CPC分类号： C12N15/86 , A61K39/00 , A61K39/0011 , A61K2039/505 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55522 , A61K2039/55555 , A61K2039/6031 , C07K14/005 , C07K14/475 , C07K14/70596 , C07K2319/00 , C07K2319/33 , C12N2740/16043 , C12N2740/16045 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2810/855
摘要： Drug delivery compositions and methods of delivering compounds to are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
摘要翻译：药物递送组合物和递送化合物的方法被公开。公开了免疫个体的疫苗和方法。公开了用于药物递送的组合物，包括基因治疗和使用这些组合物治疗个体的方法。

30. 发明申请

US20050026138A1 Hiv-1 vpr interactions with mitochondrial apoptosis inducing factor and methods of using the same 失效
标题翻译： Hiv-1 vpr与线粒体凋亡诱导因子的相互作用及其使用方法
公开(公告)号：US20050026138A1
公开(公告)日：2005-02-03
申请号：US10478742
申请日：2002-05-28
申请人： David Weiner , Karuppiah Muthumani
发明人： David Weiner , Karuppiah Muthumani
IPC分类号： G01N33/50 , C12Q1/68 , C12Q1/70 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/569
CPC分类号： G01N33/56988 , G01N2333/163 , G01N2500/02
摘要： Assays to identify Vpr/AIF interaction and translocation inhibitors are disclosed.
摘要翻译：公开了鉴定Vpr / AIF相互作用和易位抑制剂的试验。

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