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21. 发明授权

US5190960A Medicinal oxazolopyridine compounds 失效
标题翻译：药用恶唑啉吡啶化合物
公开(公告)号：US5190960A
公开(公告)日：1993-03-02
申请号：US791261
申请日：1991-11-12
申请人： Gerald Guillaumet , Christine Flouzat , Daniel H. Caignard , Pierre Renard , Michelle Devissaguet , Beatrice Guardiola
发明人： Gerald Guillaumet , Christine Flouzat , Daniel H. Caignard , Pierre Renard , Michelle Devissaguet , Beatrice Guardiola
IPC分类号： C07D213/74 , C07D498/04
CPC分类号： C07D213/74
摘要： Compounds of general formula (I): ##STR1## in which: R.sub.1 and R.sub.2 each represent a hydrogen atom or, with the nitrogen and oxygen which bear them, form an --O--CO--N link,W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as trifluoromethyl, and m being between 0 and 3,A is a linear or branched alkyl radical comprising from 1 to 6 carbon atoms,R.sub.3 and R.sub.4 are defined in the description.
摘要翻译：通式（I）的化合物：其中：R 1和R 2各自表示氢原子，或者与含有它们的氮和氧形成-O-CO-N键，W表示卤素原子或任选被一个或多个卤素原子取代的低级烷基或烷氧基，例如三氟甲基，m在0和3之间，A是包含1至6个碳原子的直链或支链烷基，R3和R4被定义在说明中。

22. 发明授权

US5155116A Medicinal oxazolopyridine compounds 失效
标题翻译：药用氧杂环丁烯化合物
公开(公告)号：US5155116A
公开(公告)日：1992-10-13
申请号：US711297
申请日：1991-06-06
申请人： Gerald Guillaumet , Christine Flouzat , Daniel H. Caignard , Pierre Renard , Michelle Devissaguet , Beatrice Guardiola
发明人： Gerald Guillaumet , Christine Flouzat , Daniel H. Caignard , Pierre Renard , Michelle Devissaguet , Beatrice Guardiola
IPC分类号： A61K31/44 , A61P9/00 , A61P25/04 , A61P25/28 , C07D213/74 , C07D498/04
CPC分类号： C07D213/74
摘要： Compounds of general formula (I): ##STR1## in which: R.sub.1 and R.sub.2 each represent a hydrogen atom or, with the nitrogen and oxygen which bear them, form an --O--CO--N link,W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as trifluoromethyl, and m being between 0 and 3,A is a linear or branched alkyl radical comprising from 1 to 6 carbon atoms,R.sub.3 and R.sub.4 are defined in the description have medicinal properties.
摘要翻译：通式（I）的化合物：其中：R 1和R 2各自表示氢原子，或者与含有它们的氮和氧形成-O-CO-N键，W表示卤素原子或任选被一个或多个卤素原子取代的低级烷基或烷氧基，例如三氟甲基，m在0和3之间，A是包含1至6个碳原子的直链或支链烷基，R3和R4被定义在说明书中具有药用性质。

23. 发明授权

US5147883A Acylbenzoxazolinones compounds 失效
标题翻译：氨基苯甲酸酯化合物
公开(公告)号：US5147883A
公开(公告)日：1992-09-15
申请号：US708515
申请日：1991-05-31
申请人： Hocine Aichaioui , Daniel Lesieur , Charles Lespagnol , Michelle Devissaguet , Beatrice Guardiola
发明人： Hocine Aichaioui , Daniel Lesieur , Charles Lespagnol , Michelle Devissaguet , Beatrice Guardiola
IPC分类号： A61K31/42 , A61K31/423 , A61K31/44 , A61K31/455 , A61K31/47 , A61P7/02 , A61P9/08 , A61P9/10 , C07D263/52 , C07D263/58 , C07D263/60 , C07D263/62 , C07D413/06
CPC分类号： C07D263/52 , C07D263/58 , C07D263/60 , C07D413/06
摘要： Compounds of general formula (I): ##STR1## in which: R.sub.1 represents a hydrogen atom or a lower alkyl group,A represents a hydrogen atom, and in this case B represents a group CO-G, G being:either a heteroaryl group selected from furan, indole, pyrrole, pyridine, quinoline, isoquinoline and benzofuran, optionally substituted with one or more lower alkyl or lower alkoxy groups or a halogen atoms,or a linear or branched lower alkyl group substituted with a carboxyl group,or a linear or branched lower alkenyl group substituted with a carboxyl group,or a phenyl or naphthyl group substituted with a carboxyl group,or alternatively A forms with B a group CO(CH.sub.2).sub.n CH(CH.sub.3) with n being a integer equal to 1, 2, 3 or 4, the CO group being attached to the aromatic ring of the benzoxazolinone at the 5- or 6-position,as well as, where appropriate, their isomers and, when the compound of formula (I) possesses a carboxylic acid group, their addition salts with a pharmaceutically acceptable base, and, when the compound of formula (I) contains a basic group, their addition salts with a pharmaceutically acceptable acid, it being understood that lower alkyl and lower alkenyl mean linear or branched groups comprising from 1 to 6 carbon atoms.Medicinal products.
摘要翻译：通式（I）的化合物：其中：R1表示氢原子或低级烷基，A表示氢原子，在这种情况下，B表示CO-G基团，G表示：选自呋喃，吲哚，吡咯，吡啶，喹啉，异喹啉和苯并呋喃的杂芳基，任选被一个或多个低级烷基或低级烷氧基或卤素原子取代，或被羧基取代的直链或支链低级烷基，或被羧基取代的直链或支链的低级链烯基或被羧基取代的苯基或萘基，或者与B a基团CO（CH 2）n CH（CH 3）形成A，其中n为等于1的整数，2,3或4，所述CO基团在5-或6-位连接于苯并恶唑啉酮的芳环，并且在适当的情况下连接其异构体，并且当式（I）化合物具有羧酸酸基，它们与药学上可接受的碱的加成盐并且当式（I）化合物含有碱性基团时，其与药学上可接受的酸的加成盐，应理解为低级烷基和低级烯基表示包含1至6个碳原子的直链或支链基团。药用产品。

24. 发明授权

US5519023A New aminoalkylchromones, processes for the preparation thereof 失效
标题翻译：新氨基烷基色酮，其制备方法
公开(公告)号：US5519023A
公开(公告)日：1996-05-21
申请号：US94564
申请日：1993-07-02
申请人： Marc Payard , Genevieve Baziard-Mouysset , Gilbert De Saqui-Sannes , Beatrice Guardiola , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
发明人： Marc Payard , Genevieve Baziard-Mouysset , Gilbert De Saqui-Sannes , Beatrice Guardiola , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
IPC分类号： A61K31/35 , A61K31/352 , A61K31/357 , A61K31/40 , A61K31/435 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/495 , A61K31/505 , A61K31/535 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D311/22 , C07D317/58 , C07D405/06 , C07D405/12 , C07D407/12 , C07D521/00 , C07D405/14
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D311/22 , C07D405/06 , C07D405/12 , C07D407/12
摘要： The invention relates to compounds of the general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and Z are as defined in the description, their optical isomers and their addition salts with a pharmaceutically-acceptable acid or base and medicaments containing the same, useful in the treatment and prevention of stress, anxiety, and related ailments.
摘要翻译：本发明涉及通式（I）的化合物：其中R 1，R 2，R 3，R 4，R 5，R 6和Z如说明书中所定义，其光学异构体及其加成盐与药学上可接受的酸或碱和含有它们的药物，可用于治疗和预防压力，焦虑和相关疾病。

25. 发明授权

US5432173A 1-amidooctahydropyrido[2,1,-C][1,4]oxazine compounds 失效
标题翻译： 1-氨基八氢吡啶并[2,1，-C] [1,4]恶嗪化合物
公开(公告)号：US5432173A
公开(公告)日：1995-07-11
申请号：US135807
申请日：1993-10-13
申请人： Henri P. Husson , Jean C. Quirion , Martine Bonin , Beatrice Guardiola , Gerard Adam , Pierre Renard
发明人： Henri P. Husson , Jean C. Quirion , Martine Bonin , Beatrice Guardiola , Gerard Adam , Pierre Renard
IPC分类号： A61K31/535 , A61P25/00 , A61P25/18 , C07D498/04
CPC分类号： C07D498/04
摘要： The invention relates to the compounds of general formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and A are as defined in the description.their isomers, diastereoisomers, and enantiomers as well as their addition salts with a pharmaceutically acceptable inorganic or organic acid, andmedicinal products containing the same which are usable for the treatment of psycho-behavioral disorders.
摘要翻译：本发明涉及通式（I）的化合物：其中R 1，R 2，R 3，R 4，R 5和A如说明书中所定义。它们的异构体，非对映异构体和对映异构体以及它们与药学上可接受的无机或有机酸的加成盐，以及含有它们的可用于治疗精神行为障碍的药物。

26. 发明授权

US5397783A 3-aminochroman spiro compounds 失效
公开(公告)号：US5397783A
公开(公告)日：1995-03-14
申请号：US174205
申请日：1993-12-27
申请人： Gerald Guillaumet , Tchao Podona , Gerard Adam , Beatrice Guardiola , Pierre Renard
发明人： Gerald Guillaumet , Tchao Podona , Gerard Adam , Beatrice Guardiola , Pierre Renard
IPC分类号： A61K31/40 , A61K31/445 , A61P9/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D491/10 , C07D491/107 , C07D519/00 , C07D471/10 , A61K31/44
CPC分类号： C07D491/10
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, A and m are as defined in the description.Medicinal product which is useful for treating depression and anxiety.

27. 发明授权

US5310739A 1-amidooctahydropyrido[2,1-c][1,4]oxazine compounds 失效
标题翻译： 1-氨基八氢吡啶并[2,1-c] [1,4]恶嗪化合物
公开(公告)号：US5310739A
公开(公告)日：1994-05-10
申请号：US882273
申请日：1992-05-13
申请人： Henri P. Husson , Jean C. Quirion , Martine Bonin , Beatrice Guardiola , Gerard Adam , Pierre Renard
发明人： Henri P. Husson , Jean C. Quirion , Martine Bonin , Beatrice Guardiola , Gerard Adam , Pierre Renard
IPC分类号： A61K31/535 , A61P25/00 , A61P25/18 , C07D498/04
CPC分类号： C07D498/04
摘要： The invention relates to the compounds of general formula ##STR1## in which R.sub.1, R.sub.2, R.sub.4, R.sub.5 and A are as defined in the description.their isomers, diastereoisomers, and enantiomers as well as their addition salts with a pharmaceutically acceptable inorganic or organic acid, andmedicinal products containing the same which are usable for the treatment of psycho-behavioral disorders.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1，R 2，R 4，R 5和A如说明书中所定义。它们的异构体，非对映异构体和对映异构体以及它们与药学上可接受的无机或有机酸的加成盐，以及含有它们的可用于治疗精神行为障碍的药物。

28. 发明授权

US5420150A 3-aminochroman spiro compounds 失效
标题翻译： 3-氨基苯并二氢吡喃化合物
公开(公告)号：US5420150A
公开(公告)日：1995-05-30
申请号：US174187
申请日：1993-12-27
申请人： Gerald Guillaumet , Tchao Podona , Gerard Adam , Beatrice Guardiola , Pierre Renard
发明人： Gerald Guillaumet , Tchao Podona , Gerard Adam , Beatrice Guardiola , Pierre Renard
IPC分类号： A61K31/40 , A61K31/445 , A61P9/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D491/10 , C07D491/107 , C07D519/00
CPC分类号： C07D491/10
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, A and m are as defined in the description.Medicinal product which is useful for treating depression and anxiety.
摘要翻译：本发明涉及一种选自式（I）的化合物：其中R 1，R 2，R 3，A和m如说明书中所定义。用于治疗抑郁和焦虑的药用产品。

29. 发明授权

US5376661A 3-aminochroman spiro compounds 失效
标题翻译： 3-氨基苯并二氢吡喃化合物
公开(公告)号：US5376661A
公开(公告)日：1994-12-27
申请号：US36329
申请日：1993-03-24
申请人： Gerald Guillaumet , Tchao Podona , Gerard Adam , Beatrice Guardiola , Pierre Renard
发明人： Gerald Guillaumet , Tchao Podona , Gerard Adam , Beatrice Guardiola , Pierre Renard
IPC分类号： A61K31/40 , A61K31/445 , A61P9/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D491/10 , C07D491/107 , C07D519/00 , C07D471/20 , A61K31/44
CPC分类号： C07D491/10
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, A and m are as defined in the description.Medicinal product which is useful for treating depression and anxiety.
摘要翻译：本发明涉及一种选自式（I）的化合物：其中R 1，R 2，R 3，A和m如说明书中所定义。用于治疗抑郁和焦虑的药用产品。

30. 发明授权

US5849781A Tricyclic amides 失效
公开(公告)号：US5849781A
公开(公告)日：1998-12-15
申请号：US942177
申请日：1997-10-01
申请人： Michel Langlois , Monique Mathe-Allainmat , Philippe Delagrange , Pierre Renard , Beatrice Guardiola
发明人： Michel Langlois , Monique Mathe-Allainmat , Philippe Delagrange , Pierre Renard , Beatrice Guardiola
IPC分类号： A61K31/16 , A61K31/165 , A61K31/17 , A61K31/38 , A61K31/381 , A61P1/00 , A61P3/04 , A61P9/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07C231/12 , C07C231/14 , C07C233/06 , C07C233/23 , C07C233/25 , C07C233/32 , C07C233/54 , C07C233/58 , C07C233/60 , C07C273/18 , C07C275/26 , C07C327/42 , C07D209/90 , C07D307/92 , C07D333/74 , A61K31/34 , A61K31/40 , C07D209/56 , C07D307/77
CPC分类号： C07D307/92 , C07C233/06 , C07C233/23 , C07C233/58 , C07C233/60 , C07D209/90 , C07D333/74 , C07C2101/02 , C07C2101/04 , C07C2103/24 , C07C2103/26 , C07C2103/28
摘要： The invention relates to a compound selected from these of formula (I): ##STR1## in which R.sub.7, R.sub.8, Y, n and A are as defined in the description, and medicinal product containing the same useful for treating a disorder of the melatoninergic system.

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