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21. 发明申请

US20100029711A1 NOVEL CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 失效
标题翻译：新颖的2-酮衍生物及其作为单胺神经递质抑制剂的用途
公开(公告)号：US20100029711A1
公开(公告)日：2010-02-04
申请号：US12520236
申请日：2007-12-18
申请人： Dan Peter , John Paul Redrobe , Gunnar M. Olsen , Elsebet Østergaard Nielsen
发明人： Dan Peter , John Paul Redrobe , Gunnar M. Olsen , Elsebet Østergaard Nielsen
IPC分类号： A61K31/439 , C07D451/00
CPC分类号： C07D451/06
摘要： This invention relates to novel chromen-2-one derivatives of Formula (I) useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作单胺神经递质再摄取抑制剂的式（I）的新型色烯-2-酮衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

22. 发明申请

US20110028490A1 4-PHENYL-PIPERAZIN-1-YL-ALKYL-BENZOIMIDAZOL-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE IN-HIBITORS 审中-公开
标题翻译： 4-苯基 - 哌嗪-1-基-L-烷基苯并咪唑-2-酮衍生物及其作为单胺神经递质重新获得抑制剂的用途
公开(公告)号：US20110028490A1
公开(公告)日：2011-02-03
申请号：US12812272
申请日：2009-01-21
申请人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
发明人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
IPC分类号： A61K31/496 , C07D403/06 , C07D403/08 , A61P25/00 , A61P25/28 , A61P25/16 , A61P29/00 , A61P25/30 , A61P13/00 , A61P15/12 , A61P15/10
CPC分类号： C07D235/26
摘要： This invention relates to novel 4-phenyl-piperazin-1-yl-alkyl-benzoimidazol-2-one derivatives of structure (I) useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作单胺神经递质再摄取抑制剂的结构（I）的新型4-苯基 - 哌嗪-1-基 - 烷基 - 苯并咪唑-2-酮衍生物。在其他方面，本发明涉及这些化合物在治疗方法中的用途，以及包含本发明化合物的药物组合物。

23. 发明申请

US20100311699A1 NOVEL CARBOXYLIC ACID 4-PHENYLAZO-PHENYL ESTER DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 失效
标题翻译：新型羧酸4-苯甲酰苯酯衍生物及其作为单胺神经递质抑制剂的用途
公开(公告)号：US20100311699A1
公开(公告)日：2010-12-09
申请号：US12745530
申请日：2008-11-27
申请人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
发明人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
IPC分类号： A61K31/655 , C07D471/08 , A61P25/24 , A61P25/22 , A61P25/16 , A61P25/28 , A61P25/06
CPC分类号： C07D487/08 , C07D243/08 , C07D295/205 , C07D471/08
摘要： This invention relates to novel carboxylic acid 4-phenylazo-phenyl ester derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作单胺神经递质再摄取抑制剂的新型羧酸4-苯基偶氮苯基酯衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

24. 发明申请

US20100286195A1 NOVEL BENZOOXAZOL-AND BENZOOXATHIOL-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开
标题翻译：新型苯并恶唑和苯并恶唑-2-酮衍生物及其作为单胺神经递质抑制剂的用途
公开(公告)号：US20100286195A1
公开(公告)日：2010-11-11
申请号：US12677077
申请日：2008-09-08
申请人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
发明人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
IPC分类号： A61K31/439 , C07D453/02 , A61P25/24 , A61P25/16 , A61P25/28 , A61P25/36 , A61P25/32 , A61P35/00 , A61P1/00 , A61P19/02 , A61P3/04 , A61P25/14
CPC分类号： C07D411/12 , C07D413/12
摘要： This invention relates to novel benzooxazol- and benzooxathiol-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作单胺神经递质再摄取抑制剂的新型苯并恶唑和苯甲酰硫醇-2-酮衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

25. 发明申请

US20110053984A1 NOVEL 4-BENZHYDRYLOXY-TETRAALKYL-PIPERIDINE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开
标题翻译：新型4-苄氧基 - 四氢吡啶衍生物及其作为单胺神经递质抑制剂的用途
公开(公告)号：US20110053984A1
公开(公告)日：2011-03-03
申请号：US12921030
申请日：2009-02-27
申请人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
发明人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
IPC分类号： A61K31/445 , C07D211/46 , A61P25/00 , A61P29/00 , A61P13/00 , A61P15/00
CPC分类号： C07D211/46
摘要： This invention relates to novel 4-benzhydryloxy-tetraalkyl-piperidine derivatives of Formula (I), any of its stereoisomers or any mixture of its stereoisomers, or an N-oxide thereof, or a pharmaceutically acceptable salt thereof, wherein Ra represents hydrogen or C1-6-alkyl; Rb and Rc independent of each other represent a phenyl group, which phenyl group is optionally substituted with one or more substituents independently selected from the group consisting of halo, trifluoromethyl, trifluoromethoxy, cyano, C1-6-alkoxy and methylenedioxo; R′, R″, R′″ and R″″ independent of each other represent C1-6-alkyl; and with the proviso that the compound is not 4-benzhydryloxy-1,2,2,6,6-pentamethyl-piperidine, useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及式（I）的新型4-二苯甲氧基 - 四烷基 - 哌啶衍生物，其任何立体异构体或其立体异构体的任何混合物或其N-氧化物或其药学上可接受的盐，其中R a表示氢或C 1 -6-烷基; Rb和Rc彼此独立地表示苯基，该苯基任选被一个或多个独立地选自卤素，三氟甲基，三氟甲氧基，氰基，C 1-6 - 烷氧基和亚甲基二氧基的取代基取代; R'，R“，R”“和R”“彼此独立地表示C 1-6 - 烷基; 并且条件是该化合物不是4-二苯甲基氧基-1,2,2,6,6-五甲基哌啶，其可用作单胺神经递质再摄取抑制剂。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

26. 发明申请

US20100298380A1 N-ARYL-N-PIPERIDIN-4-YLMETHYL-AMIDE DERIVATIVES AND THIER USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开
标题翻译： N-ARYL-N-哌啶-4-甲酰胺衍生物，并用作单胺神经递质抑制剂
公开(公告)号：US20100298380A1
公开(公告)日：2010-11-25
申请号：US12671592
申请日：2008-07-31
申请人： Dan Peters , John Paul Redrobe , Gordon Munro , Elsebet Østergaard Nielsen
发明人： Dan Peters , John Paul Redrobe , Gordon Munro , Elsebet Østergaard Nielsen
IPC分类号： A61K31/454 , C07D401/06 , A61P29/00 , A61P25/28 , A61P25/22 , A61P25/00 , A61P25/24 , A61P25/30 , A61P19/02 , A61P1/00 , A61P15/00 , A61P43/00 , A61P25/32 , A61P25/34
CPC分类号： C07D401/06
摘要： This invention relates to novel N-aryl-N-piperidin-4-ylmethyl amide derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作单胺神经递质再摄取抑制剂的新型N-芳基-N-哌啶-4-基甲基酰胺衍生物。在其他方面，本发明涉及这些化合物在治疗方法中的用途，以及包含本发明化合物的药物组合物。

27. 发明申请

US20100227883A1 NOVEL CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 失效
标题翻译：新颖的2-酮衍生物及其作为单胺神经递质抑制剂的用途
公开(公告)号：US20100227883A1
公开(公告)日：2010-09-09
申请号：US12160403
申请日：2007-02-13
申请人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
发明人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
IPC分类号： A61K31/46 , C07D451/12 , C07D451/06 , A61P25/00 , A61P29/00 , A61P15/10 , A61P13/00
CPC分类号： C07D451/06
摘要： This invention relates to novel chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作单胺神经递质再摄取抑制剂的新型色烯-2-酮衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

28. 发明申请

US20100160333A1 NOVEL 3,9-DIAZABICYCLO[3.3.1]NONANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 失效
标题翻译：新的3,9-二氮杂双环[3.3.1]非衍生物及其作为单胺神经递质抑制剂的用途
公开(公告)号：US20100160333A1
公开(公告)日：2010-06-24
申请号：US12716111
申请日：2010-03-02
申请人： Dan PETERS , John Paul Redrobe , Elsebet Østergaard Nielsen
发明人： Dan PETERS , John Paul Redrobe , Elsebet Østergaard Nielsen
IPC分类号： A61K31/4985 , C07D471/04 , A61P25/00 , A61P25/24 , A61P25/22
CPC分类号： C07D471/08
摘要： 3,9-diazabicyclo[3.3.1]nonane derivatives, useful as monoamine neurotransmitter re-uptake inhibitors. Also, use of these compounds in a method for therapy and in pharmaceutical compositions comprising the compounds. The 3,9-diazabicyclo[3.3.1]nonane derivatives have the formula wherein Ra and Rb are as described in the application. Also disclosed are stereoisomers and pharmaceutically acceptable salts of the compounds.
摘要翻译： 3,9-二氮杂双环[3.3.1]壬烷衍生物，可用作单胺神经递质再摄取抑制剂。此外，在治疗方法中使用这些化合物和包含该化合物的药物组合物。 3,9-二氮杂双环[3.3.1]壬烷衍生物具有下式其中Ra和Rb如申请中所述。还公开了化合物的立体异构体和药学上可接受的盐。

29. 发明申请

US20110136854A1 NOVEL 9-AZA-BICYCLO[3.3.1]NON-3-YLOXY CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开
标题翻译：新型9-氮杂双环[3.3.1]非3-氯乙烯-2-酮衍生物及其作为单胺神经递质抑制剂的用途
公开(公告)号：US20110136854A1
公开(公告)日：2011-06-09
申请号：US12866093
申请日：2009-02-04
申请人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
发明人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
IPC分类号： A61K31/439 , C07D451/14 , A61P25/00 , A61P25/24 , A61P29/00 , A61P25/16 , A61P25/28 , A61P25/22 , A61P25/30
CPC分类号： C07D451/14
摘要： This invention relates to novel 9-aza-bicyclo[3.3.1]non-3-yloxy chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作单胺神经递质再摄取抑制剂的新型9-氮杂 - 双环[3.3.1]壬-3-基氧基色烯-2-酮衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

30. 发明授权

US07700596B2 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效
标题翻译： 3,9-二氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途
公开(公告)号：US07700596B2
公开(公告)日：2010-04-20
申请号：US12161905
申请日：2007-02-09
申请人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
发明人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
IPC分类号： A61K31/495
CPC分类号： C07D471/08
摘要： 3,9-diazabicyclo[3.3.1]nonane derivatives, useful as monoamine neurotransmitter re-uptake inhibitors. Also, use of these compounds in a method for therapy and in pharmaceutical compositions comprising the compounds. The 3,9-diazabicyclo[3.3.1]nonane derivatives have the formula wherein Ra and Rb are as described in the application. Also disclosed are stereoisomers and pharmaceutically acceptable salts of the compounds.
摘要翻译： 3,9-二氮杂双环[3.3.1]壬烷衍生物，可用作单胺神经递质再摄取抑制剂。此外，在治疗方法中使用这些化合物和包含该化合物的药物组合物。 3,9-二氮杂双环[3.3.1]壬烷衍生物具有下式其中Ra和Rb如申请中所述。还公开了化合物的立体异构体和药学上可接受的盐。

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