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21. 发明授权

US09588230B2 Systems and methods for calibrating a silicon photomultiplier-based positron emission tomography system 有权
标题翻译：用于校准基于硅光电倍增管的正电子发射断层扫描系统的系统和方法
公开(公告)号：US09588230B2
公开(公告)日：2017-03-07
申请号：US12560054
申请日：2009-09-15
申请人： Ronald Grazioso , Debora Henseler , Nan Zhang
发明人： Ronald Grazioso , Debora Henseler , Nan Zhang
IPC分类号： G01D18/00 , G12B13/00 , G01T1/164 , A61B6/03
CPC分类号： G01T1/1644 , A61B6/037 , G01T1/1648
摘要： A representative positron emission tomography (PET) system includes a positron emission tomography detector having one or more silicon photomultipliers that output silicon photomultipliers signals. The PET system further includes a calibration system that is electrically coupled to the silicon photomultipliers. The calibration system determines a single photoelectron response of the silicon photomultipliers signals and adjusts a gain of the silicon photomultipliers based on the single photoelectron response.
摘要翻译：代表性的正电子发射断层摄影（PET）系统包括正电子发射断层摄影检测器，其具有输出硅光电倍增管信号的一个或多个硅光电倍增管。 PET系统还包括电耦合到硅光电倍增管的校准系统。校准系统确定硅光电倍增管信号的单个光电子响应，并且基于单个光电子响应调整硅光电倍增管的增益。

22. 发明授权

US09244975B2 Just-in-time analytics on large file systems 有权
标题翻译：大型文件系统的即时分析
公开(公告)号：US09244975B2
公开(公告)日：2016-01-26
申请号：US13328810
申请日：2011-12-16
申请人： Gautam Das , Hao H. Huang , Sandor Szalay , Nan Zhang
发明人： Gautam Das , Hao H. Huang , Sandor Szalay , Nan Zhang
IPC分类号： G06F17/30
CPC分类号： G06F17/30442
摘要： As file systems reach the petabytes scale, users and administrators are increasingly interested in acquiring high-level analytical information for file management and analysis. Two particularly important tasks are the processing of aggregate and top-k queries which, unfortunately, cannot be quickly answered by hierarchical file systems such as ext3 and NTFS. Existing pre-processing based solutions, e.g., file system crawling and index building, consume a significant amount of time and space (for generating and maintaining the indexes) which in many cases cannot be justified by the infrequent usage of such solutions. User interests can often be sufficiently satisfied by approximate (i.e., statistically accurate) answers. A just-in-time sampling-based system can, after consuming a small number of disk accesses, produce extremely accurate answers for a broad class of aggregate and top-k queries over a file system without the requirement of any prior knowledge. The system is efficient, accurate and scalable.
摘要翻译：随着文件系统达到PB级，用户和管理员越来越有兴趣获取用于文件管理和分析的高级分析信息。两个特别重要的任务是处理聚合和top-k查询，不幸的是不能通过分层文件系统（如ext3和NTFS）快速回答。现有的基于预处理的解决方案，例如文件系统爬行和索引构建，消耗了大量的时间和空间（用于生成和维护索引），这在许多情况下不能被这种解决方案的频繁使用所证明。用户兴趣通常可以通过近似（即统计准确的）答案来充分满足。基于时间抽样的系统可以在消耗少量磁盘访问后，通过文件系统为广泛的聚合和顶级查询提供非常准确的答案，而无需任何先前的知识。该系统是高效，准确和可扩展的。

23. 发明授权

US09086492B2 Concurrent DC-coupled anode and dynode readout scheme for PET block detectors 有权
标题翻译：并联DC耦合阳极和用于PET块检测器的倍增电极读出方案
公开(公告)号：US09086492B2
公开(公告)日：2015-07-21
申请号：US11753067
申请日：2007-05-24
申请人： Nan Zhang , Matthias J. Schmand , Niraj K. Doshi , Michael D. Loope
发明人： Nan Zhang , Matthias J. Schmand , Niraj K. Doshi , Michael D. Loope
IPC分类号： G01T1/00 , G01T1/164
CPC分类号： G01T1/1642 , G01T1/208
摘要： A scintillation detector including one or more photomultiplier tubes, a scintillation block optically attached to the photomultiplier tubes, and a DC-coupled bleeder circuit combining outputs of dynodes of the photomultipliers to provide a DC-coupled dynode output together with a DC-coupled anode output of the photomultiplier tubes. The DC-coupled bleeder circuit includes a RF transformer. A positive high voltage supply also can be used together with a DC-coupled bleeder circuit for the anode outputs.
摘要翻译：闪烁检测器，包括一个或多个光电倍增管，与光电倍增管光学连接的闪烁块，以及组合光电倍增管的倍增电极输出的DC耦合泄放电路，以提供DC耦合的倍增电极输出以及直流耦合的阳极输出的光电倍增管。直流耦合放电电路包括RF变压器。阳极高压电源也可以与阳极输出的直流耦合泄放电路一起使用。

24. 发明授权

US08884213B2 Energy correction for one-to-one coupled radiation detectors having non-linear sensors 有权
标题翻译：具有非线性传感器的一对一耦合辐射探测器的能量校正
公开(公告)号：US08884213B2
公开(公告)日：2014-11-11
申请号：US13539931
申请日：2012-07-02
申请人： Ronald Grazioso , Debora Henseler , Nan Zhang
发明人： Ronald Grazioso , Debora Henseler , Nan Zhang
IPC分类号： G01T1/202 , G01T1/24
CPC分类号： G01T1/248 , G01T1/202
摘要： Systems and methods for correcting output signals from non-linear photosensors, specifically silicon photomultipliers (SiPMs). SiPMs are used in a PET detector to readout light emissions from LSO scintillator crystals. The non-linear output of the SiPM can distort and compress the energy spectrum which is crucial in PET imaging. The non-linearity effect for inter-crystal scattered events can place an energy event outside of the PET detector energy window, resulting in a rejected event. Systems and methods to correct the SiPM non-linearity for inter-crystal scattered events, so as to be able to obtain the proper energy event and produce an accurate medical image, are disclosed.
摘要翻译：用于校正非线性光电传感器，特别是硅光电倍增管（SiPM）的输出信号的系统和方法。 SiPM用于PET检测器以读出LSO闪烁体晶体的光发射。 SiPM的非线性输出可以扭曲和压缩在PET成像中至关重要的能谱。晶体间散射事件的非线性效应可以将能量事件置于PET检测器能量窗口之外，导致被拒绝的事件。公开了用于校正晶间散射事件的SiPM非线性的系统和方法，以便能够获得适当的能量事件并产生精确的医学图像。

25. 发明授权

US08859565B2 Compound for inhibiting type 5 phosphodiesterase and preparation method thereof 有权
标题翻译：抑制5型磷酸二酯酶的化合物及其制备方法
公开(公告)号：US08859565B2
公开(公告)日：2014-10-14
申请号：US13512524
申请日：2010-07-30
申请人： Nan Zhang , Rong Zhong
发明人： Nan Zhang , Rong Zhong
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04 , C07C59/265
CPC分类号： C07D487/04 , A61K31/519 , C07C59/265
摘要： The present invention discloses a compound of formula (I) and citrate thereof as type 5 phosphodiesterase inhibitor, a preparation method thereof, and a pharmaceutical composition including the compound of formula (I) and citrate thereof. The experimental results of the present invention prove that the compound of formula (I) and citrate thereof can inhibit activity of type 5 phosphodiesterase, and can be used for treating erectile dysfunction, inhibiting platelet aggregation and treating thrombosis, decreasing pulmonary hypertension and treating cardiovascular diseases, treating asthma and treating diabetes gastroparesis.
摘要翻译：本发明公开了式（I）化合物及其柠檬酸盐作为5型磷酸二酯酶抑制剂及其制备方法，以及含有式（I）化合物及其柠檬酸盐的药物组合物。本发明的实验结果证明，式（I）化合物及其柠檬酸盐可抑制5型磷酸二酯酶的活性，可用于治疗勃起功能障碍，抑制血小板聚集和治疗血栓形成，降低肺动脉高压和治疗心血管疾病治疗哮喘和治疗糖尿病胃轻瘫。

26. 发明申请

US20130062525A1 Positron Emission Tomography Block Detector Interconnect 有权
标题翻译：正电子发射断层扫描检测器互连
公开(公告)号：US20130062525A1
公开(公告)日：2013-03-14
申请号：US13229797
申请日：2011-09-12
申请人： James Frank Caruba , Niraj K. Doshi , John W. Young , Nan Zhang
发明人： James Frank Caruba , Niraj K. Doshi , John W. Young , Nan Zhang
IPC分类号： G01T1/20 , G01T1/164
CPC分类号： G01T1/1648
摘要： Using standard or “off the shelf” cable to interconnect between the PET block detector and the detector circuit may save substantial costs given the number of PMTs in a PET system. Given space constraints, simple maintenance with reduced risk of disturbing cabling is desired, making ongoing use of standard cabling without adding further cabling desired. To implement digital gain control, a further communication is provided between the PET detector block and the detector circuit. Since the standard cable may not have additional wires for such communications and to reduce timing degradation, the PMT signals are combined, such as generating position and energy signals at the PET detector block. The four PMT signals are reduced to three signals without reduction in function, allowing a fourth twisted pair of wires in a CAT5 cable to be used for digital gain control.
摘要翻译：使用标准或现货电缆在PET块检测器和检测器电路之间进行互连可以节省大量成本，因为PET系统中PMT的数量。鉴于空间限制，需要简单的维护，减少干扰布线的风险，不断增加布线需求，不断使用标准布线。为了实现数字增益控制，在PET检测器块和检测器电路之间提供进一步的通信。由于标准电缆可能没有用于这种通信的附加电线并且减少定时劣化，所以组合PMT信号，例如在PET检测器块处产生位置和能量信号。四个PMT信号减少到三个信号，而不会降低功能，允许CAT5电缆中的第四根双绞线用于数字增益控制。

27. 发明申请

US20130004371A1 Analytical Cartridge with Fluid Flow Control 有权
标题翻译：具有流体流量控制的分析盒
公开(公告)号：US20130004371A1
公开(公告)日：2013-01-03
申请号：US13608408
申请日：2012-09-10
申请人： Zhiliang Wan , Nan Zhang
发明人： Zhiliang Wan , Nan Zhang
IPC分类号： G01N21/75
CPC分类号： G01N33/558 , B01L3/502746 , B01L3/502753 , B01L2200/04 , B01L2200/0631 , B01L2200/16 , B01L2300/0654 , B01L2300/069 , B01L2300/0819 , B01L2300/0883 , B01L2300/0887 , B01L2300/165 , B01L2400/0406 , Y10T137/0318
摘要： Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample.
摘要翻译：使用毛细管流分析样品的分析柱，系统和方法。垂直梯度样品过滤将滤液提供到孵育室，由孵育室出口处的流动调节器控制一段时间。流量调节器可以包括没有侧壁的蛇形毛细管流动路径。孵育的滤液可以在预定时间后从孵育室流出到检测通道。检测室可以在多孔基底中包括一个或多个分析区域，用于从相同的样品检测相同盒上的两种或更多种分析物。

28. 发明申请

US20120112083A1 High Density, Proportional-Mode, APD Arrays for Individual Scintillator Readout in PET Applications 有权
标题翻译：高密度，比例模式，APD阵列用于PET应用中的单个闪烁读出
公开(公告)号：US20120112083A1
公开(公告)日：2012-05-10
申请号：US12943164
申请日：2010-11-10
申请人： Nan Zhang , Ronald Grazioso , Debora Henseler , Matthias J. Schmand
发明人： Nan Zhang , Ronald Grazioso , Debora Henseler , Matthias J. Schmand
IPC分类号： G01T1/20
CPC分类号： G01T1/1642 , A61B6/037
摘要： The present invention is a photodetector including improved photosensors configured of an array of small (sub-millimeter) high-density avalanche photodiode cells utilized to readout a single scintillator. Each photosensor comprises a plurality of avalanche photodiodes cells arranged in an (n×n) array of avalanche photodiode cells (where, n>1) that are coupled to a single scintillation crystal. The overall (n×n) array area as the photosensor is the same as the area of a face of the scintillator and each avalanche photodiode cell has a surface area that is not greater than one square millimeter. The photosensor is also configured to facilitate reading the output of each avalanche photodiode cell in the array. By reading out each small avalanche photodiode cell independently, the noise and capacitance are minimized and thereby provide a more accurate determination of energy and timing.
摘要翻译：本发明是一种光电检测器，其包括由用于读出单个闪烁体的小（亚毫米）高密度雪崩光电二极管阵列的阵列构成的改进的光电传感器。每个光传感器包括以与单个闪烁晶体耦合的雪崩光电二极管单元（其中，n> 1）的（n×n）阵列排列的多个雪崩光电二极管单元。作为光传感器的整体（n×n）阵列区域与闪烁体的面的面积相同，并且每个雪崩光电二极管单元的表面积不大于1平方毫米。光传感器还被配置为便于读取阵列中每个雪崩光电二极管单元的输出。通过独立地读出每个小雪崩光电二极管单元，噪声和电容被最小化，从而提供更准确的能量和时间的确定。

29. 发明申请

US20110301385A1 CATALYST FOR OLEFIN POLYMERIZATION AND METHOD OF PREPARATION THEREOF 有权
标题翻译：烯烃聚合催化剂及其制备方法
公开(公告)号：US20110301385A1
公开(公告)日：2011-12-08
申请号：US13153997
申请日：2011-06-06
申请人： Licai Wang , Zhanxian Gao , Wei Li , Guotong Zheng , Qingxin Dong , Riping Liu , Xiaohuan Wang , Nan Zhang , Jingzhuang Wang , Shimian Cai
发明人： Licai Wang , Zhanxian Gao , Wei Li , Guotong Zheng , Qingxin Dong , Riping Liu , Xiaohuan Wang , Nan Zhang , Jingzhuang Wang , Shimian Cai
IPC分类号： C07C41/01
CPC分类号： C07C37/11 , C07C41/16 , C07C39/15 , C07C43/2055
摘要： A catalyst for olefin polymerization and method of preparing the same are disclosed.
摘要翻译：公开了一种用于烯烃聚合的催化剂及其制备方法。

30. 发明申请

US20100009430A1 Analytical cartridge with fluid flow control 有权
标题翻译：具有流体流量控制的分析筒
公开(公告)号：US20100009430A1
公开(公告)日：2010-01-14
申请号：US12456247
申请日：2009-06-12
申请人： Zhiliang Wan , Nan Zhang
发明人： Zhiliang Wan , Nan Zhang
IPC分类号： C12M1/00 , G01N33/53 , G01N21/01 , F17D1/00
CPC分类号： G01N33/558 , B01L3/502746 , B01L3/502753 , B01L2200/04 , B01L2200/0631 , B01L2200/16 , B01L2300/0654 , B01L2300/069 , B01L2300/0819 , B01L2300/0883 , B01L2300/0887 , B01L2300/165 , B01L2400/0406 , Y10T137/0318
摘要： Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample.
摘要翻译：使用毛细管流分析样品的分析柱，系统和方法。垂直梯度样品过滤将滤液提供到孵育室，由孵育室出口处的流动调节器控制一段时间。流量调节器可以包括没有侧壁的蛇形毛细管流动路径。孵育的滤液可以在预定时间后从孵育室流出到检测通道。检测室可以在多孔基底中包括一个或多个分析区域，用于从相同的样品检测相同盒上的两种或更多种分析物。

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