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    • 21. 发明授权
    • Antibodies that specifically bind to neurokinin B
    • 特异性结合神经激肽B的抗体
    • US07514079B2
    • 2009-04-07
    • US10981692
    • 2004-11-05
    • Craig A. RosenSteven M. Ruben
    • Craig A. RosenSteven M. Ruben
    • A61K39/395G01N33/53C07K16/26
    • C07K16/18A61K2039/505C07K2317/21C07K2317/622Y10S424/80Y10S424/804Y10S424/806Y10S424/809Y10S435/975
    • The present invention relates to antibodies and related molecules that specifically bind to neurokinin B. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including pre-eclampsia, hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain. The invention also relates to nucleic acid molecules encoding anti-neurokinin B antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially pre-eclampsia, as well as hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to neurokinin B.
    • 本发明涉及与神经激肽B特异性结合的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症以及免疫系统疾病和病症,包括先兆子痫,高血压,炎症,哮喘, 胃肠道疾病,焦虑症,抑郁症,成瘾症或疼痛。 本发明还涉及编码抗神经激肽B抗体的核酸分子,含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防,检测,诊断,治疗或改善疾病或病症,特别是先兆子痫以及高血压,炎症,哮喘,胃肠道疾病,焦虑,抑郁,成瘾或疼痛的方法和组合物,其包括 向动物,优选人施用有效量的一种或多种特异性结合神经激肽B的抗体或其片段或变体或相关分子。
    • 25. 发明授权
    • Antibodies that specifically bind to chemokine beta-4
    • 特异性结合趋化因子β-4的抗体
    • US07375192B2
    • 2008-05-20
    • US10513705
    • 2003-04-30
    • Craig A. RosenSteven M. Ruben
    • Craig A. RosenSteven M. Ruben
    • C07K16/00
    • C07K16/24A61K2039/505C07K2317/21C07K2317/565C07K2317/622C07K2317/76C07K2317/92
    • The present invention relates to antibodies and related molecules that specifically bind to CK-B4. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including cancers, as well as immune system diseases and disorders including autoimmune diseases, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease. The invention also relates to nucleic acid molecules encoding anti-CK-B4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to CK-B4.
    • 本发明涉及特异性结合CK-B4的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症以及包括癌症在内的免疫系统疾病和病症,以及免疫系统疾病和病症,包括自身免疫性疾病,炎症性疾病,免疫缺陷,感染,HIV,关节炎,过敏 ,牛皮癣,皮炎和炎性肠病。 本发明还涉及编码抗CK-B4抗体的核酸分子,含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防,检测,诊断,治疗或改善疾病或病症,特别是癌症以及免疫系统疾病和病症的方法和组合物,包括自身免疫性疾病,炎症性疾病,免疫缺陷,感染,HIV,关节炎,过敏 牛皮癣,皮炎和炎性肠病,包括向动物,优选人类施用有效量的与CK-B4特异性结合的一种或多种抗体或其片段或变体或相关分子。
    • 26. 发明授权
    • Peptidoglycan recognition proteins
    • 肽聚糖识别蛋白
    • US07368244B2
    • 2008-05-06
    • US11214796
    • 2005-08-31
    • Paul E. YoungSteven M. RubenCraig A. RosenHenrik S. Olsen
    • Paul E. YoungSteven M. RubenCraig A. RosenHenrik S. Olsen
    • C07H21/00
    • C07K14/47A61K38/00
    • The present invention related to three novel peptidoglican recognition binding protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
    • 本发明涉及由角质形成细胞,伤口愈合组织和软骨肉瘤组织表达的三种新型肽基识别结合蛋白。 更具体地,提供分离的核酸分子,其编码人胶原聚糖识别蛋白相关蛋白(本文称为PGRP-K(角质形成细胞),PGRP-W(伤口愈合)和PGRP-C(软骨肉瘤))。 图1A-B, 图2A-C, 3,分别与人肽聚糖识别蛋白(PGRP)以及鼠Tag-7都具有同源性。 还提供了PGRP-K,PGRP-W和PGRP-C多肽。 进一步提供载体,宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K,PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K,PGRP-W和PGRP-C基因表达的诊断方法。
    • 30. 发明授权
    • Peptidoglycan recognition proteins
    • 肽聚糖识别蛋白
    • US07041802B2
    • 2006-05-09
    • US10180454
    • 2002-06-27
    • Paul E. YoungSteven M. RubenCraig A. RosenHenrik S. Olsen
    • Paul E. YoungSteven M. RubenCraig A. RosenHenrik S. Olsen
    • C07K16/00C12P21/08C12N5/06G01N33/53
    • C07K14/47A61K38/00
    • The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A–B, FIGS. 2A–C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
    • 本发明涉及由角质形成细胞,伤口愈合组织和软骨肉瘤组织表达的三种新的肽聚糖识别结合蛋白。 更具体地,提供分离的核酸分子,其编码人胶原聚糖识别蛋白相关蛋白(本文称为PGRP-K(角质形成细胞),PGRP-W(伤口愈合)和PGRP-C(软骨肉瘤))。 图1A-B, 图2A-C, 3,分别与人肽聚糖识别蛋白(PGRP)以及鼠Tag-7都具有同源性。 还提供了PGRP-K,PGRP-W和PGRP-C多肽。 进一步提供载体,宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K,PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K,PGRP-W和PGRP-C基因表达的诊断方法。