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21. 发明申请

US20110181702A1 METHOD AND SYSTEM FOR GENERATING A REPRESENTATION OF AN OCT DATA SET 审中-公开
标题翻译：用于产生OCT数据集的表示的方法和系统
公开(公告)号：US20110181702A1
公开(公告)日：2011-07-28
申请号：US12844696
申请日：2010-07-27
申请人： Christoph Hauger , Martin Hacker
发明人： Christoph Hauger , Martin Hacker
IPC分类号： H04N13/02 , G06K9/00 , H04N15/00
CPC分类号： G01B9/02087 , A61B3/102 , A61B3/1225 , G01B9/0203 , G01B9/02091
摘要： A method of generating a representation of an OCT data set includes obtaining the OCT data set, representing a plurality of tuples, each of which comprises values of three spatial coordinates and a value of a scattering intensity, obtaining a color image data set representing a plurality of tuples, each of which comprises values of two spatial coordinates and a color value, and generating an image data set, representing a plurality of tuples, each of which comprises values of three spatial coordinates and a color value. Generating the image data set is performed depending on an analysis of the OCT data set and an analysis of the color image data set.
摘要翻译：一种产生OCT数据集的表示的方法包括获得表示多个元组的OCT数据集，每个元组包括三个空间坐标值和散射强度的值，获得表示多个的彩色图像数据集每个元组包括两个空间坐标和颜色值的值，并且生成表示多个元组的图像数据集，每个元组包括三个空间坐标和颜色值的值。根据OCT数据集的分析和彩色图像数据集的分析来执行图像数据集的生成。

22. 发明授权

US08740380B2 Article for use in an OCT-method and intraocular lens 有权
标题翻译：用于OCT方法和眼内镜的文章
公开(公告)号：US08740380B2
公开(公告)日：2014-06-03
申请号：US12858216
申请日：2010-08-17
申请人： Marco Wilzbach , Martin Hacker , Christoph Hauger
发明人： Marco Wilzbach , Martin Hacker , Christoph Hauger
IPC分类号： A61B3/00 , A61B3/14 , A61F2/16
CPC分类号： A61B3/102 , A61B5/0066 , A61B17/30 , A61B90/30 , A61F2/16 , A61F2/1613 , A61F2250/0096 , B29D11/023 , B82Y20/00 , G01B9/02091 , G02B5/08 , G02B5/22
摘要： An article for use in an OCT method, the article comprising a solid substrate and nanoparticles dispersed in or on the substrate in at least one light transmissive portion of the article such that the nanoparticles result in an increased extinction of the light transmissive portion along a transmission direction of the light transmissive portion compared to the substrate being free of nanoparticles. The extinction of the light transmissive portion along the transmission direction is less than 6, wherein the extinction is defined as a negative decadic logarithm of a ratio of an intensity of light which is transmitted through the light transmissive portion to an intensity of light which is incident on the light transmissive portion, wherein the light is in at least one of a visible and a near infrared wavelength range.
摘要翻译：一种用于OCT方法的制品，所述制品包含固体基质和纳米颗粒，其分散在所述制品的至少一个透光部分中或所述基底中或基底上，使得所述纳米颗粒导致所述透光部分沿着透射的消光增加光透射部分的方向与衬底相比没有纳米颗粒。沿透射方向的光透射部分的消光小于6，其中消光被定义为通过透光部分透射的光的强度与入射光的强度之比的负十进制对数在所述光透射部分上，其中所述光处于可见光和近红外波长范围中的至少一个。

23. 发明申请

US20110199577A1 ARTICLE FOR USE IN AN OCT-METHOD AND INTRAOCULAR LENS 有权
标题翻译：用于OCT方法和内镜镜片的文章
公开(公告)号：US20110199577A1
公开(公告)日：2011-08-18
申请号：US12858216
申请日：2010-08-17
申请人： Marco Wilzbach , Martin Hacker , Christoph Hauger
发明人： Marco Wilzbach , Martin Hacker , Christoph Hauger
IPC分类号： A61B3/14 , G02B5/22 , G02B5/08 , G01B9/02 , A61F2/16 , B82Y20/00
CPC分类号： A61B3/102 , A61B5/0066 , A61B17/30 , A61B90/30 , A61F2/16 , A61F2/1613 , A61F2250/0096 , B29D11/023 , B82Y20/00 , G01B9/02091 , G02B5/08 , G02B5/22
摘要： An article for use in an OCT method, the article comprising a solid substrate and nanoparticles dispersed in or on the substrate in at least one light transmissive portion of the article such that the nanoparticles result in an increased extinction of the light transmissive portion along a transmission direction of the light transmissive portion compared to the substrate being free of nanoparticles. The extinction of the light transmissive portion along the transmission direction is less than 6, wherein the extinction is defined as a negative decadic logarithm of a ratio of an intensity of light which is transmitted through the light transmissive portion to an intensity of light which is incident on the light transmissive portion, wherein the light is in at least one of a visible and a near infrared wavelength range.
摘要翻译：一种用于OCT方法的制品，所述制品包含固体基质和纳米颗粒，其分散在所述制品的至少一个透光部分中或所述基底中或基底上，使得所述纳米颗粒导致所述透光部分沿着透射的消光增加光透射部分的方向与衬底相比没有纳米颗粒。沿透射方向的光透射部分的消光小于6，其中消光被定义为通过透光部分透射的光的强度与入射光的强度之比的负十进制对数在所述光透射部分上，其中所述光处于可见光和近红外波长范围中的至少一个。

24. 发明授权

US08230866B2 Systems and methods for treating glaucoma and systems and methods for imaging a portion of an eye 有权
标题翻译：用于治疗青光眼的系统和方法以及用于对眼睛的一部分进行成像的系统和方法
公开(公告)号：US08230866B2
公开(公告)日：2012-07-31
申请号：US12000477
申请日：2007-12-13
申请人： Christoph Hauger , Peter Andrews , Werner Nahm , Ralf Kuschnereit , Martin Hacker , Gabor Scharioth
发明人： Christoph Hauger , Peter Andrews , Werner Nahm , Ralf Kuschnereit , Martin Hacker , Gabor Scharioth
IPC分类号： A61B19/00
CPC分类号： A61B3/13 , A61B3/102 , A61B3/14 , A61F9/008 , A61F2009/00868
摘要： Systems and methods are described for imaging an eye portion or for treating glaucoma in an eye of a patient. In a first step an optical microscopic image of a portion of the eye is acquired. In the optical microscopic image a distinguishable anatomical structure is identified to predict a location of a volume portion to be imaged three-dimensionally. Three-dimensional imaging of the located volume portion is performed by acquiring an optical coherence tomography image of the located volume portion. The volume portion is treated by either directing a laser beam to the volume portion or inserting an implant based on the OCT-image.
摘要翻译：描述了用于对眼部进行成像或用于治疗患者眼睛中的青光眼的系统和方法。在第一步骤中，获取眼睛的一部分的光学显微镜图像。在光学显微镜图像中，识别出可区分的解剖结构以预测待三维成像的体积部分的位置。通过获取定位体积部分的光学相干断层摄影图像来执行定位体积部分的三维成像。通过将激光束引导到体积部分或基于OCT图像插入植入物来处理体积部分。

25. 发明授权

US08810907B2 Surgical microscope system and method 有权
标题翻译：手术显微镜系统及方法
公开(公告)号：US08810907B2
公开(公告)日：2014-08-19
申请号：US13193759
申请日：2011-07-29
申请人： Michael Haisch , Christoph Hauger , Hartmut Wolf , Joachim Hug , Schwarz Brigitta , Gerhard Gaida , Andreas Raabe
发明人： Michael Haisch , Christoph Hauger , Hartmut Wolf , Joachim Hug , Schwarz Brigitta , Gerhard Gaida , Andreas Raabe
IPC分类号： G02B21/06
CPC分类号： G02B27/0172 , A61B5/0066 , A61B5/0071 , A61B5/0086 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/1782 , G01N2021/6421 , G02B7/002 , G02B21/16 , G02B21/18 , G02B21/22 , G02B21/361 , G02B21/365 , G02B21/367 , G02B21/368 , G02B2027/0134 , G02B2027/0138 , G02B2027/014
摘要： A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.
摘要翻译：显微镜系统和方法允许观察积聚在组织中的荧光物质。可以在可见光和荧光的同时观察组织。可以观察到与可见光图像重叠的一系列先前记录的荧光图像。可以自动确定一系列图像的结束。可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。此外，可以分析荧光图像以识别其相干荧光部分。可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。

26. 发明授权

US08804236B2 Microscopy system 有权
标题翻译：显微镜系统
公开(公告)号：US08804236B2
公开(公告)日：2014-08-12
申请号：US13253852
申请日：2011-10-05
申请人： Fritz Strahle , Christoph Hauger
发明人： Fritz Strahle , Christoph Hauger
IPC分类号： G02B21/00 , G02B15/14 , G02B21/02 , G02B21/22
CPC分类号： G02B21/025 , G02B15/14 , G02B17/026 , G02B21/0028 , G02B21/22
摘要： A microscope system for imaging of an object that can be placed in an object plane of a microscope system includes an imaging system for providing at least one pair of optical imaging paths that include a stereoscopic angle in the object plane. The imaging system includes a first subsystem comprising a first plurality of optical lenses that are commonly traversed by both optical imaging paths of the at least one pair of optical imaging paths. The imaging system also includes a second subsystem comprising a second plurality of optical lenses that are traversed by only one optical imaging path. At least two optical lenses of the first plurality of optical lenses and at least two optical lenses of the second plurality of optical lenses are displaceable relative to one another along a common optical imaging path to respectively vary a magnification of the representation of the object.
摘要翻译：可以放置在显微镜系统的物体平面中的物体成像的显微镜系统包括用于提供至少一对光学成像路径的成像系统，该成像系统在物平面中包括立体角。该成像系统包括第一子系统，该第一子系统包括由至少一对光学成像路径的两个光学成像路径共同穿过的第一多个光学透镜。该成像系统还包括第二子系统，该第二子系统包括仅由一个光学成像路径穿过的第二多个光学透镜。第一多个光学透镜中的至少两个光学透镜和第二多个光学透镜中的至少两个光学透镜可以沿着公共光学成像路径相对于彼此移位，以分别改变对象的表示的放大率。

27. 发明授权

US08306600B2 Filter set for observing fluorescence radiation in biological tissue 有权
标题翻译：用于观察生物组织荧光辐射的滤光片
公开(公告)号：US08306600B2
公开(公告)日：2012-11-06
申请号：US12506016
申请日：2009-07-20
申请人： Joachim Steffen , Christoph Hauger
发明人： Joachim Steffen , Christoph Hauger
IPC分类号： A61B5/00
CPC分类号： G01N21/6458 , A61B5/0059 , G01J3/4406 , G01J2003/1213 , G01N21/6428 , G01N21/6486 , G01N2021/6419 , G01N2021/6421 , G01N2021/6471 , G02B5/20 , G02B5/208 , G02B21/16
摘要： A filter set for observing fluorescent radiation in biological tissue includes at least one illumination filter and at least one observation filter. The at least one illumination filter is arrangeable in an illumination system of an optical system. The at least one least one observation filter is arrangeable in an imaging system of the optical system.
摘要翻译：用于观察生物组织中的荧光辐射的滤光片组包括至少一个照明滤光片和至少一个观察滤光片。所述至少一个照明滤光器可布置在光学系统的照明系统中。所述至少一个至少一个观察滤波器可布置在所述光学系统的成像系统中。

28. 发明申请

US20120120486A1 MICROSCOPY SYSTEM 有权
标题翻译：微观系统
公开(公告)号：US20120120486A1
公开(公告)日：2012-05-17
申请号：US13253852
申请日：2011-10-05
申请人： Fritz Strähle , Christoph Hauger
发明人： Fritz Strähle , Christoph Hauger
IPC分类号： G02B21/04 , G02B21/02 , G02B21/22
CPC分类号： G02B21/025 , G02B15/14 , G02B17/026 , G02B21/0028 , G02B21/22
摘要： A microscope system for imaging of an object that can be placed in an object plane of a microscope system includes an imaging system for providing at least one pair of optical imaging paths that include a stereoscopic angle in the object plane. The imaging system includes a first subsystem comprising a first plurality of optical lenses that are commonly traversed by both optical imaging paths of the at least one pair of optical imaging paths. The imaging system also includes a second subsystem comprising a second plurality of optical lenses that are traversed by only one optical imaging path. At least two optical lenses of the first plurality of optical lenses and at least two optical lenses of the second plurality of optical lenses are displaceable relative to one another along a common optical imaging path to respectively vary a magnification of the representation of the object.
摘要翻译：可以放置在显微镜系统的物体平面中的物体成像的显微镜系统包括用于提供至少一对光学成像路径的成像系统，该成像系统在物平面中包括立体角。该成像系统包括第一子系统，该第一子系统包括由至少一对光学成像路径的两个光学成像路径共同穿过的第一多个光学透镜。成像系统还包括第二子系统，其包括仅由一个光学成像路径穿过的第二多个光学透镜。第一多个光学透镜中的至少两个光学透镜和第二多个光学透镜中的至少两个光学透镜可以沿着公共光学成像路径相对于彼此移位，以分别改变对象的表示的放大率。

29. 发明申请

US20110166420A1 IMAGING METHOD AND APPARATUS 审中-公开
标题翻译：成像方法和装置
公开(公告)号：US20110166420A1
公开(公告)日：2011-07-07
申请号：US12756692
申请日：2010-04-08
申请人： Hans-Joachim Miesner , Christoph Hauger , Werner Nahm , Frank Rudolph , Guido Hattendorf , Peter Maxwell Delaney , John D. Allen
发明人： Hans-Joachim Miesner , Christoph Hauger , Werner Nahm , Frank Rudolph , Guido Hattendorf , Peter Maxwell Delaney , John D. Allen
IPC分类号： A61B1/06
CPC分类号： A61B1/00078 , A61B1/00009 , A61B1/00041 , A61B1/00045 , A61B1/0005 , A61B1/0008 , A61B1/00172 , A61B1/042 , A61B1/06 , A61B1/227 , A61B1/233 , A61B1/267 , A61B1/313 , A61B5/0066 , A61B5/0068 , A61B5/0075 , A61B5/0084 , A61B5/064 , A61B5/065 , A61B5/6835 , A61B5/6852 , A61B5/6855 , A61B7/02 , A61B8/12 , A61B90/90 , A61B90/92 , A61B90/94 , G02B21/0028 , G02B23/2476
摘要： An imaging apparatus and method are provided. The probe for an imaging apparatus includes a manually manipulable proximal portion; a straight distal portion with a distal tip for locating at a site to define an observational field; and a curved portion between the proximal portion and the distal portion. The imaging method includes the steps of locating a distal tip of an imaging probe at a site to define an observational field; irradiating the observational field from the distal tip; and collecting a return signal at the distal tip; wherein the probe comprises a manually manipulable proximal portion. The apparatus and method provided herein are useful for various applications including but not limited to endomicroscopy and other microsurgical procedures performed under optical stereoscopic magnified visualization, such as neurosurgery, ENT/facial surgery and spinal surgery.
摘要翻译：提供了一种成像装置和方法。用于成像装置的探针包括手动可操纵的近端部分; 具有远端的直的远端部分，用于定位在现场以限定观察场; 以及在近端部分和远端部分之间的弯曲部分。该成像方法包括以下步骤：将成像探针的远侧末端定位在位置以限定观察场; 从远端照射观察场; 并在远端收集返回信号; 其中所述探针包括可手动操作的近端部分。本文提供的装置和方法可用于各种应用，包括但不限于在光学立体放大显微镜（例如神经外科手术，ENT /面部手术和脊柱手术）下执行的内窥镜和其他显微外科手术。

30. 发明申请

US20100097618A1 Microscopy system, microscopy method, and a method of treating an aneurysm 有权
标题翻译：显微镜系统，显微镜法和治疗动脉瘤的方法
公开(公告)号：US20100097618A1
公开(公告)日：2010-04-22
申请号：US12380286
申请日：2009-02-25
申请人： Michael Haisch , Christoph Hauger , Hartmut Wolf , Joachim Hug , Schwarz Brigitta , Gerhard Gaida , Andreas Raabe
发明人： Michael Haisch , Christoph Hauger , Hartmut Wolf , Joachim Hug , Schwarz Brigitta , Gerhard Gaida , Andreas Raabe
IPC分类号： G01B9/02 , G01B11/06 , H04N7/18
CPC分类号： G02B27/0172 , A61B5/0066 , A61B5/0071 , A61B5/0086 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/1782 , G01N2021/6421 , G02B7/002 , G02B21/16 , G02B21/18 , G02B21/22 , G02B21/361 , G02B21/365 , G02B21/367 , G02B21/368 , G02B2027/0134 , G02B2027/0138 , G02B2027/014
摘要： A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.
摘要翻译：显微镜系统和方法允许观察积聚在组织中的荧光物质。可以在可见光和荧光的同时观察组织。可以观察到与可见光图像重叠的一系列先前记录的荧光图像。可以自动确定一系列图像的结束。可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。此外，可以分析荧光图像以识别其相干荧光部分。可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。

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