专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US4946957A Anti-tumor DC-52 derivatives 失效
标题翻译：抗肿瘤DC-52衍生物
公开(公告)号：US4946957A
公开(公告)日：1990-08-07
申请号：US400883
申请日：1989-08-30
申请人： Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
发明人： Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
IPC分类号： A61K31/495 , A61P31/04 , C07D471/18 , C07D498/22
CPC分类号： C07D471/18 , C07D498/22
摘要： The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and Z represent --O-- in the form of --Y--Z--]. These compounds and pharmacologically acceptable salts thereof have high anti-tumor activity.

22. 发明授权

US4822882A DC-52 derivatives and their antitumor use 失效
标题翻译： DC-52衍生物及其抗肿瘤用途
公开(公告)号：US4822882A
公开(公告)日：1989-04-18
申请号：US102359
申请日：1987-09-29
申请人： Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
发明人： Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
IPC分类号： C07D471/18 , C07D498/22 , A61K31/495 , C07D487/18
CPC分类号： C07D471/18 , C07D498/22
摘要： Compounds represented by the following formula or by the corresponding hydroquinone type formula: ##STR1## in which R.sup.1 and R.sup.2 are independently hydrogen, lower alkoxy, azido, amino, lower alkylamino, di-lower alkylamino, cyclic amino, lower alkylthio or unsubstituted or substituted arylthio; and X represents hydroxyl and Y represents cyano or X and Y together represents --O-- in the form of --X--Y--, have an excellent antitumor activity.

23. 发明授权

US4879386A Anti-tumor DC-52 compounds 失效
标题翻译：抗肿瘤DC-52化合物
公开(公告)号：US4879386A
公开(公告)日：1989-11-07
申请号：US207639
申请日：1988-05-25
申请人： Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
发明人： Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
IPC分类号： A61K31/495 , A61P31/04 , C07D471/18 , C07D498/22
CPC分类号： C07D471/18 , C07D498/22
摘要： The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## ps [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and Z represent --O-- in the form of --Y--Z--]. These compounds and pharmacologically acceptable salts thereof have high anti-tumor activity.

24. 发明申请

US20070278049A1 Opposed piston type disc brake 审中-公开
标题翻译：反向活塞式盘式制动器
公开(公告)号：US20070278049A1
公开(公告)日：2007-12-06
申请号：US11806345
申请日：2007-05-31
申请人： Daisuke Kobayashi , Makoto Morimoto
发明人： Daisuke Kobayashi , Makoto Morimoto
IPC分类号： F16D65/38
CPC分类号： F16D65/095 , F16D55/228 , F16D65/0977 , F16D2055/0016
摘要： A coupling member configured to bridge outer and inner body portions 3c, 4c in a state of hampering the outer and inner body portions 3c, 4c from being displaced in directions of separating the outer and inner body portions 3c, 4c is constituted by a bridge portion 20a integral with a caliper 5c including the outer and inner body portions 3c, 4c. Further, a brake torque applied to the inner and outer pads 11a, 12a is supported by outer side coupling pins 13a, 13a configured to bridge two end portions of the outer and inner body portions 3c, 4c.
摘要翻译：一种联接构件，其构造成在妨碍外部主体部分3c和内部主体部分4c的状态下使外部主体部分3c和内部主体部分4c夹紧，从而在分离外部主体部分3c和内部主体部分4c的方向上移位由与包括外主体部分3c和内主体部分4c的卡钳5c成一体的桥部分20a构成。此外，施加到内垫片和外垫片11a，12a的制动扭矩由外侧联接销钉13aa，13a支撑，外侧联接销钉13aa，13aa构造成桥接外主体部分3c和内主体部分3c的两个端部。

25. 发明授权

US4999196A Compound DC-107 produced by Streptomyces sp. 失效
标题翻译：由Streptomyces sp。生产的复合DC-107
公开(公告)号：US4999196A
公开(公告)日：1991-03-12
申请号：US330990
申请日：1989-03-29
申请人： Hirofumi Nakano , Mitsunobu Hara , Isami Takahashi , Kozo Asano , Takao Iida , Makoto Morimoto
发明人： Hirofumi Nakano , Mitsunobu Hara , Isami Takahashi , Kozo Asano , Takao Iida , Makoto Morimoto
IPC分类号： A61K35/74 , A61K31/425 , A61P35/00 , C07D513/20 , C12P1/06 , C12P17/18 , C12R1/465
CPC分类号： C12P1/06 , Y10S435/886
摘要： A novel compound, DC-107, is produced by culturing a microorganism belonging to the genus Streptomyces. It is useful as a medicine because of its antibacterial and anti-tumor activity.

26. 发明授权

US4863935A Mitomycin compounds having useful anti-tumor activity 失效
标题翻译：丝裂霉素化合物具有有效的抗肿瘤活性
公开(公告)号：US4863935A
公开(公告)日：1989-09-05
申请号：US131619
申请日：1987-12-11
申请人： Yasushi Shida , Tokuyuki Kuroda , Ikuo Matsukuma , Makoto Morimoto , Tadashi Ashizawa
发明人： Yasushi Shida , Tokuyuki Kuroda , Ikuo Matsukuma , Makoto Morimoto , Tadashi Ashizawa
IPC分类号： C07D487/04 , A61K31/40 , A61P35/00 , C07D487/14
CPC分类号： C07D487/14
摘要： Mitomycin derivatives having potent anti-tumor activity against solid sarcoma 180 tumors and lymphocytic leukemia P-388 tumors.

27. 发明授权

US4795908A Infrared detector 失效
标题翻译：红外探测器
公开(公告)号：US4795908A
公开(公告)日：1989-01-03
申请号：US924758
申请日：1986-10-30
申请人： Makoto Morimoto , Mikio Kondo
发明人： Makoto Morimoto , Mikio Kondo
IPC分类号： G08B13/19 , G01J5/06
CPC分类号： G08B13/19 , Y10S250/01
摘要： An infrared detector is arranged so that a detection-input processing circuit part including an infrared sensor mounted on a circuit board is housed as isolated from ambient air in a chamber inhibiting any ambient air inflow, for sensing infrared rays emitted from a human body or the like object as condensed by a condenser irrespective of the ambient air conditions, the sensing ability of the infrared sensor the accuracy of which is likely to be easily deteriorated even with a very small change in the ambient temperature can be thereby stabilized, and a highly accurate infrared detection can be constantly achieved.
摘要翻译：红外线检测器被布置成使得包括安装在电路板上的红外线传感器的检测输入处理电路部分被容纳在与环境空气隔离的室中，该室禁止任何环境空气流入，用于感测从人体发射的红外线或像环境空气条件一样由冷凝器凝结的物体，即使环境温度的非常小的变化也可以容易地恶化其精度的红外传感器的感测能力，并且高度准确可以不断实现红外检测。

28. 发明授权

US4649199A Salt of DC-52 and a pharmaceutical composition containing the same 失效
标题翻译： DC-52的盐和含有它的药物组合物
公开(公告)号：US4649199A
公开(公告)日：1987-03-10
申请号：US697918
申请日：1985-02-04
申请人： Shinzo Ishii , Shigeo Katsumata , Yukou Arai , Kazuhisa Fujimoto , Makoto Morimoto
发明人： Shinzo Ishii , Shigeo Katsumata , Yukou Arai , Kazuhisa Fujimoto , Makoto Morimoto
IPC分类号： C07D498/22 , C12P17/18 , C12R1/465 , A61K31/495
CPC分类号： C07D498/22
摘要： A pharmacologically acceptable acid addition salt of DC-52 with 0.5-2.0 equivalent weight of inorganic acid, sulfonic acid, acidic amino acid, citric acid, transaconitic acid, .alpha.-ketoglutaric acid, itaconic acid, malonic acid or ascorbic acid on the basis of DC-52, having the same degree of antitumor activity as DC-52, is superior to DC-52 in stability at powdering or at preservation.
摘要翻译：磺酸，酸性氨基酸，柠檬酸，经官能度酸，α-酮戊二酸，衣康酸，丙二酸或抗坏血酸的基础上，加入0.5〜2.0当量的DC-52的药理学上可接受的酸加成盐与DC-52具有相同程度的抗肿瘤活性的DC-52在粉化或保存时的稳定性优于DC-52。

29. 发明授权

US4791113A Mitomycin derivatives as antileukemia agents 失效
标题翻译：丝裂霉素衍生物作为抗白血病剂
公开(公告)号：US4791113A
公开(公告)日：1988-12-13
申请号：US57889
申请日：1987-05-12
申请人： Tokuyuki Kuroda , Koji Hisamura , Tohru Sugaya , Yutaka Ohsawa , Hideo Ueno , Makoto Morimoto , Tadashi Ashizawa
发明人： Tokuyuki Kuroda , Koji Hisamura , Tohru Sugaya , Yutaka Ohsawa , Hideo Ueno , Makoto Morimoto , Tadashi Ashizawa
IPC分类号： C07D487/14 , A61K31/505 , A61K31/40 , C07D487/04
CPC分类号： C07D487/14
摘要： Mitomycin derivatives having potent antitumor activity having the formula: ##STR1## wherein A is ON--or R.sub.4 N.dbd.N--[wherein R.sub.4 is selected from ##STR2## and optionally substituted heterocyclic groups (wherein R.sub.5 and R.sub.8 are each independently selected from hydrogen, lower alkyl and lower cycloalkyl; R.sub.6 is selected from hydrogen, halogen, hydroxy, lower alkoxy, amino and nitro; R.sub.7 is selected from lower alkyl and lower cycloalkyl; and X is selected from oxygen, sulphur and imino)];R.sub.1 and R.sub.2 are each independently selected from hydrogen, lower alkyl, lower cycloalkyl, optionally substituted aralkyl, optionally substituted alkanoyl, optionally substituted arylcarbonyl, optionally substituted alkanesulfonyl, arylsulfonyl and aralkylsulfonyl;R.sub.3 is hydrogen or carbamoyl;Y is hydrogen or methyl;Z is selected from hydrogen, methyl and acetyl;and is an .alpha. or .beta. bond.
摘要翻译：丝裂霉素衍生物具有有效的抗肿瘤活性，具有下式：其中A为ON-或R 4 N = N- [其中R 4为选自下列任意取代的杂环基团（其中R5和R8 各自独立地选自氢，低级烷基和低级环烷基; R6选自氢，卤素，羟基，低级烷氧基，氨基和硝基; R7选自低级烷基和低级环烷基; X选自氧，硫和亚氨基）]; R 1和R 2各自独立地选自氢，低级烷基，低级环烷基，任选取代的芳烷基，任选取代的烷酰基，任选取代的芳基羰基，任选取代的烷基磺酰基，芳基磺酰基和芳烷基磺酰基; R3是氢或氨基甲酰基; Y是氢或甲基; Z选自氢，甲基和乙酰基; 并且是α或β键。

30. 发明授权

US4672206A Passive infrared detector 失效
标题翻译：被动红外探测器
公开(公告)号：US4672206A
公开(公告)日：1987-06-09
申请号：US758877
申请日：1985-07-25
申请人： Muneo Suzuki , Mikio Kondo , Makoto Morimoto , Kazuhito Kayanoki
发明人： Muneo Suzuki , Mikio Kondo , Makoto Morimoto , Kazuhito Kayanoki
IPC分类号： G08B13/193 , G01J5/08 , G01J5/02
CPC分类号： G08B13/193 , Y10S250/01
摘要： A passive infrared detector including an optical collector releasably attached to a base with a sensor on which incident infrared radiation directed through the optical collector is focused. The sensor is held by a joint member which is pivotally supported on the base and to which said optical collector is releasably attached, whereby the optical collector is rotatable together with the joint member relative to the base for adjustment of its angular position and the optical collector can be alone replaced as necessary without having to replace the base, the sensor and its associated electric circuitry.
摘要翻译：一种被动红外探测器，包括一个光学收集器，该光学收集器可释放地连接到一个传感器上，在该传感器上聚焦了通过光学收集器的入射红外辐射。传感器由可枢转地支撑在基座上的接头构件保持，并且所述光学收集器可释放地附接到该接合构件，由此该光学收集器可以与关节构件相对于基座一起旋转以调节其角位置，并且光学收集器可以根据需要单独更换，而无需更换基座，传感器及其相关的电路。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式