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21. 发明申请

US20080311212A1 CRYSTALLINE ISOXAZOLE DERIVATIVE AND PHARMACEUTICAL PREPARATION THEREOF 审中-公开
公开(公告)号：US20080311212A1
公开(公告)日：2008-12-18
申请号：US12195201
申请日：2008-08-20
申请人： Yasushi Ochiai , Kazuhiko Tomomura , Hiroyuki Nishii
发明人： Yasushi Ochiai , Kazuhiko Tomomura , Hiroyuki Nishii
IPC分类号： A61K9/14 , A61K31/5377 , C07D413/12
CPC分类号： C07D261/14 , A61K31/5377
摘要： Crystalline 3-[(1S)-1-(2-fluorobiphenyl-4-yl)ethyl]-5-{[amino(morpholin-4-yl)methylene]amino}-isoxazole that exhibits the following angle of diffraction (2θ) and relative intensity in a powder X-ray diffraction pattern, is very easy to handle and stable in a process of its formulation into a pharmaceutical preparation. 2θ (°)Relative intensity (%) 6.1100 14.155 16.074 18.536 20.043 25.439

22. 发明授权

US06994621B2 Ventilation member, vented housing using the same, pull-out prevention member for ventilation member and kit for forming ventilation structure 有权
公开(公告)号：US06994621B2
公开(公告)日：2006-02-07
申请号：US10437972
申请日：2003-05-15
申请人： Hiroaki Mashiko , Toshiki Yanagi , Hiroyuki Nishii , Yoshiki Ikeyama
发明人： Hiroaki Mashiko , Toshiki Yanagi , Hiroyuki Nishii , Yoshiki Ikeyama
IPC分类号： B01D19/00
CPC分类号： H05K5/0213 , F21S45/30 , F21V31/03 , H02K5/10 , H02K2205/09
摘要： A ventilation member having: a breathable film transmitting gas passing through an opening portion of a housing in a state in which the breathable film is fixed to the opening portion; and a support including a supporting portion for supporting the breathable film and an insertion portion to be inserted into the opening portion of the housing; wherein the insertion portion has a lock portion in an insertion-start-side end portion thereof, the lock portion having a tapered forward end, while the insertion portion is divided into a plurality of parts circumferentially at least on an insertion start side thereof.

23. 发明授权

US06696179B2 Fixing member, electroluminescent device using the member and backing substrate for the device 失效
标题翻译：固定构件，使用构件的电致发光装置和用于装置的背衬基板
公开(公告)号：US06696179B2
公开(公告)日：2004-02-24
申请号：US09813126
申请日：2001-03-21
申请人： Hiroaki Mashiko , Hiroyuki Nishii
发明人： Hiroaki Mashiko , Hiroyuki Nishii
IPC分类号： H05B3300
CPC分类号： H05B33/04 , H01L51/524 , H01L51/5259 , H05B33/02 , Y10S428/917 , Y10T428/239 , Y10T428/24777 , Y10T428/249982 , Y10T428/26 , Y10T428/28 , Y10T428/31544 , Y10T428/31855
摘要： Described are a fixing member formed of a sheet material equipped with a gas permeable portion covering a removing agent at a portion other than the peripheral portion of the sheet material, and an adhesion member disposed at the peripheral portion of the sheet material; an EL device using the fixing member; and a backing substrate of the EL device. Use of the fixing member contributes to a reduction in the manufacturing cost of an EL device.
摘要翻译：描述了一种固定部件，其由在片材周边部分以外的部分覆盖去除剂的气体可渗透部分和设置在片材周边部分的粘合部件构成的片材构成; 使用该固定部件的EL器件; 和EL器件的背衬衬底。使用固定部件有助于降低EL器件的制造成本。

24. 发明授权

US4773741A Electrochromic display device having auxiliary electrode 失效
标题翻译：具有辅助电极的电致变色显示装置
公开(公告)号：US4773741A
公开(公告)日：1988-09-27
申请号：US36893
申请日：1987-04-09
申请人： Hiroshi Inaba , Kiyoshi Nakase , Yukitoshi Yanagida , Hiroyuki Nishii
发明人： Hiroshi Inaba , Kiyoshi Nakase , Yukitoshi Yanagida , Hiroyuki Nishii
IPC分类号： G02F1/15 , G02F1/155 , G02F1/01
CPC分类号： G02F1/1523 , G02F1/155 , G02F2001/1517
摘要： The invention relates to an electrochromic (EC) display device having a transparent electrode layer coated with a first EC material which takes on color in its electrochemically oxidized state, such as Prussian blue, and an opposite transparent electrode layer coated with a second EC material which takes on color in its reduced state, such as WO.sub.3. For use in initial bleaching or coloration of one of the two EC layers, an auxiliary electrode is disposed in a marginal region of the space between the two opposite electrodes, and an electrolyte occupies the remaining space. An insulating covering permeable to ions intervenes between the electrolyte and the body of the auxiliary electrode, and an insulating layer substantially impermeable to ions intervenes between the auxiliary electrode body and each transparent electrode layer or the overlying EC layer to prevent leakage current. This manner of insulation of the auxiliary electrode is effective in shortening the length of time required for the initial bleaching or coloration treatment and extending memory time of the display device in actual operation.
摘要翻译：本发明涉及一种电致变色（EC）显示装置，其具有涂覆有第一EC材料的透明电极层，所述第一EC材料在其电化学氧化状态下呈现其颜色，例如普鲁士蓝，以及涂覆有第二EC材料的相对的透明电极层，呈现缩小状态的颜色，如WO3。为了用于两个EC层中的一个的初始漂白或着色，辅助电极设置在两个相对电极之间的空间的边缘区域中，并且电解质占据剩余空间。在电解质和辅助电极主体之间插入绝缘的绝缘覆盖层，并且绝缘层基本上不可渗透到介于辅助电极体和每个透明电极层或上覆的EC层之间以防止漏电流。辅助电极的这种绝缘方式在缩短初始漂白或着色处理所需的时间长度以及在实际操作中延长显示装置的存储时间方面是有效的。

25. 发明授权

US08778392B2 Oral disintegrating tablet 有权
标题翻译：口服崩解片
公开(公告)号：US08778392B2
公开(公告)日：2014-07-15
申请号：US12531150
申请日：2008-03-12
申请人： Makoto Matsuoka , Hiroyuki Nishii , Maki Kawamura
发明人： Makoto Matsuoka , Hiroyuki Nishii , Maki Kawamura
IPC分类号： A61K9/20 , A61K31/4422 , A61K9/12 , A61K31/519 , A61K31/47
CPC分类号： A61K9/2095 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/4422 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38
摘要： An oral disintegrating tablet containing (1) D-mannitol, (2) an active ingredient, (3) one or more disintegrating agents selected from the group consisting of crospovidone and carmellose, and (4) one or more lubricants selected from the group consisting of sodium stearyl fumarate and sucrose esters of fatty acids. The oral disintegrating tablet of the present invention has some excellent properties of (1) allowing easy production in a common facility without necessitating a specialized pharmaceutical technique, (2) having an appropriate strength that does not breakdown in the process of distribution, (3) having a fast disintegrating ability in the oral cavity, and (4) also having excellent ingestion feel such as greatly reduced bitterness or gritty feel; therefore, the tablet can be suitably used as a dosage form that is suitable for aged individuals, children, and seriously ill patients.
摘要翻译：一种含有（1）D-甘露糖醇，（2）活性成分，（3）一种或多种选自交聚维酮和羧甲纤维素的崩解剂的口腔崩解片，和（4）一种或多种选自以下的润滑剂：的硬脂酰富马酸钠和脂肪酸的蔗糖酯。本发明的口腔崩解片具有以下优点：（1）在普通设施中容易生产，不需要专门的药物技术，（2）具有在分配过程中不会破坏的适当强度，（3）口腔具有快速的分解能力，（4）也具有极佳的摄取感，如大大降低苦味或粗糙感; 因此，片剂可以适合用作适合老年人，儿童和严重疾病患者的剂型。

26. 发明申请

US20110027362A1 TABLET HAVING IMPROVED ELUTION PROPERTIES 有权
标题翻译：具有改进性能的片剂
公开(公告)号：US20110027362A1
公开(公告)日：2011-02-03
申请号：US12866999
申请日：2009-02-10
申请人： Makiko Yanagida , Hiroyuki Nishii , Masayuki Nakazono
发明人： Makiko Yanagida , Hiroyuki Nishii , Masayuki Nakazono
IPC分类号： A61K9/28 , A61K31/517 , A61P13/00
CPC分类号： A61K9/2054 , A61K9/2018 , A61K9/284 , A61K9/2866 , A61K31/517
摘要： The present invention provides a tablet having improved dissolution property, which comprises (+)-3-{1-[3-(trifluoromethoxy)benzyl]piperidin-4-yl}-4-phenyl-3,4-dihydro-2(1H)-quinazolinone or a pharmaceutically acceptable salt thereof as an active component, and a production method thereof.A film-coated tablet obtained by mixing granulated particles obtained by granulating a mixture containing (a) the aforementioned active component, (b) one or more kinds of fillers selected from lactose, D-mannitol, erythritol and crystalline cellulose, (c) a cellulose-based disintegrant and (d) a water-soluble binder with a later powder containing (e) one or more kinds of fillers selected from lactose, D-mannitol and crystalline cellulose and/or (f) a cellulose-based disintegrant, forming the mixture, and applying film coating. A production method of a film-coated tablet, including a step of producing the granulated particles, a step of producing a tablet by mixing with the later powder and forming the mixture, and a step of applying a film coating to the obtained tablet.
摘要翻译：本发明提供具有改善的溶解性的片剂，其包含（+） - 3- {1- [3-（三氟甲氧基）苄基]哌啶-4-基} -4-苯基-3,4-二氢-2（1H ） - 喹唑啉酮或其药学上可接受的盐作为活性成分，及其制备方法。（a）上述活性成分，（b）一种或多种选自乳糖，D-甘露糖醇，赤藓糖醇和结晶纤维素的填料的混合物混合制粒颗粒而得到的薄膜包衣片，（c）纤维素类崩解剂和（d）具有以下粉末的水溶性粘合剂，所述粉末含有（e）一种或多种选自乳糖，D-甘露糖醇和结晶纤维素的填料和/或（f）纤维素类崩解剂，形成混合物，并涂覆薄膜涂层。一种薄膜包衣片的制造方法，包括制造造粒颗粒的步骤，通过与后来的粉末混合制备片剂并形成混合物的步骤，以及将膜包衣涂布在所得片剂上的步骤。

27. 发明申请

US20090209707A1 IMPACT RESISTANCE IMPROVER, THERMOPLASTIC RESIN COMPOSITION, SHAPED ARTICLE AND METHOD FOR PRODUCING GRAFT COPOLYMER 有权
标题翻译：耐冲击改性剂，热塑性树脂组合物，成型制品和生产聚酯共聚物的方法
公开(公告)号：US20090209707A1
公开(公告)日：2009-08-20
申请号：US12439089
申请日：2007-08-29
申请人： Osamu Okunaka , Hiroyuki Nishii , Takashi Shouji , Keiji Nakamura , Tae Uk Kim , Byung Choon Lee
发明人： Osamu Okunaka , Hiroyuki Nishii , Takashi Shouji , Keiji Nakamura , Tae Uk Kim , Byung Choon Lee
IPC分类号： C08F279/00
CPC分类号： C08L51/003 , C08F257/02 , C08F279/02 , C08F291/00 , C08L51/04 , C08L55/02 , C08L2666/02 , C08L2666/14
摘要： Disclosed is a thermoplastic resin composition having excellent impact resistance at a low temperature, while maintaining high transparency; this thermoplastic resin composition is obtained by compounding an impact resistance improver into a thermoplastic resin, the impact resistance improver being composed of a graft copolymer which is obtained by polymerizing a vinyl monomer component in the presence of a polymer mixture containing a polymer having butadiene units as an essential component and a polymer having styrene units as an essential component, the polymer mixture containing 45 to 65% by mass of the butadiene units and 35 to 55% by mass of the styrene units.
摘要翻译：公开了一种在保持高透明度的同时在低温下具有优异的耐冲击性的热塑性树脂组合物; 这种热塑性树脂组合物是通过将耐冲击性改进剂混合到热塑性树脂中获得的，该耐冲击性改进剂由接枝共聚物组成，该接枝共聚物是通过在含有具有丁二烯单元的聚合物的聚合物混合物存在下聚合乙烯基单体组分必需成分和具有苯乙烯单元作为必要成分的聚合物，该聚合物混合物含有45〜65质量％的丁二烯单元和35〜55质量％的苯乙烯单元。

28. 发明授权

US5498447A Coating method 失效
标题翻译：涂布方法
公开(公告)号：US5498447A
公开(公告)日：1996-03-12
申请号：US331482
申请日：1994-11-04
申请人： Hiroyuki Nishii , Masaru Kobayashi , Kazutoshi Toya , Nobuo Uchiyama
发明人： Hiroyuki Nishii , Masaru Kobayashi , Kazutoshi Toya , Nobuo Uchiyama
IPC分类号： A61J3/06 , A61J3/00 , A61K9/50 , B01J2/00 , B01J2/16 , B05D1/02 , B05D7/24 , B05D7/00
CPC分类号： A61K9/5089 , A61J3/005 , B01J2/003 , B01J2/16 , A61K9/5078
摘要： A coating method which is characterized in that, when the surfaces of solid particles kept flowing are spray-coated with a thermally melted wax, a two-fluid nozzle adapted to mix a thermally melted wax with a heating gas in and eject the resultant mixture from one flow passage and eject a heating gas from the other flow passage is used, the two-fluid nozzle having spray ports of a diameter of 1.5 to 5.8 mm, and the two-fluid nozzle having no needle valve. According to this method, the use of an organic solvent for melting wax is omitted, and complicated operations for pulverizing a wax and for thermally melting the wax powder after it has been deposed on solid particles are not required. This method can also prevents clogging of the nozzle, powdering of the melted wax and forming of agglomerated solid, and permits simple and easy production of sustained release preparations and preparations for masking materials of unpleasant and bitter tastes.
摘要翻译： PCT No.PCT / JP93 / 00543 Sec。 371日期：1994年11月4日 102（e）1994年11月4日PCT PCT 1993年4月27日PCT公布。 No.W093 / 21893 PCT出版物日期：11月11日，1993。一种涂布方法，其特征在于，当保持流动的固体颗粒的表面被热熔融蜡喷涂时，适于将热熔融蜡与加热气体混合的双流体喷嘴并且从一个流动通道喷出所得到的混合物，并且使用来自另一个流动通道的喷射加热气体，双流体喷嘴具有直径为1.5至5.8mm的喷射口，并且没有针阀的双流体喷嘴。根据该方法，省略了使用有机溶剂来熔融蜡，并且不需要用于粉碎蜡并且在将蜡粉放置在固体颗粒上之后将其熔化的复杂操作。这种方法还可以防止喷嘴的堵塞，熔融蜡的粉化和聚集的固体的形成，并且允许简单和容易地生产用于掩蔽不愉快和苦味的材料的缓释制剂和制剂。

29. 发明授权

US4900630A Glass plate with reflective multilayer coatings to give golden appearance 失效
标题翻译：玻璃板与反光多层涂层呈现金色外观
公开(公告)号：US4900630A
公开(公告)日：1990-02-13
申请号：US199178
申请日：1988-05-26
申请人： Junichi Suzuki , Masato Nakamura , Nobuyuki Takeuchi , Yasunobu Iida , Hiroyuki Nishii
发明人： Junichi Suzuki , Masato Nakamura , Nobuyuki Takeuchi , Yasunobu Iida , Hiroyuki Nishii
IPC分类号： C03C17/36 , G02B1/10
CPC分类号： C03C17/3607 , C03C17/36 , C03C17/3613 , C03C17/3618 , C03C17/3626 , C03C17/3649 , C03C17/3681 , C03C17/3684 , G02B1/10 , C03C2217/78
摘要： A multilayer coating film is provided on one side of a transparent or semitransparent glass plate to afford a golden appearance to the coated glass plate at least when viewed from the uncoated side. Essentially the multilayer coating film is made up of a TiN layer adjacent to the glass plate surface and either a Ti layer or a Cr layer which overlies the TiN layer, and the coating film is formed such that the transmittance of the coated glass plate for visible light becomes not more than 40%. Optionally, the Ti or Cr layer is overlaid with either a TiO.sub.2 film or a Cr.sub.2 O.sub.3 film. Also optionally, either a TiO.sub.2 film or a Cr.sub.2 O.sub.3 film is interposed between the TiN layer and the glass plate surface. Each layer of the multilayer coating film can be formed by sputter deposition using a relatively simple method, an the multilayer coating has good durability.
摘要翻译：至少在从未涂覆的一侧观察时，在透明玻璃板或半透明玻璃板的一面上设置多层涂膜，以给镀膜玻璃板提供金色外观。本质上，多层涂膜由与玻璃板表面相邻的TiN层和覆盖在TiN层上的Ti层或Cr层构成，并且涂膜被形成为使得可涂覆的玻璃板的透射率光线不超过40％。任选地，Ti或Cr层用TiO 2膜或Cr 2 O 3膜覆盖。也可以在TiN层和玻璃板表面之间插入TiO 2膜或Cr 2 O 3膜。通过使用相对简单的方法通过溅射沉积可以形成多层涂膜的各层，多层涂层具有良好的耐久性。

30. 发明授权

US09980915B2 Oral disintegrating tablet 有权
公开(公告)号：US09980915B2
公开(公告)日：2018-05-29
申请号：US14295646
申请日：2014-06-04
申请人： Makoto Matsuoka , Hiroyuki Nishii , Maki Sasaki
发明人： Makoto Matsuoka , Hiroyuki Nishii , Maki Sasaki
IPC分类号： A61K9/20 , A61K31/4422 , A61K9/00 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38
CPC分类号： A61K9/2095 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/4422 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38
摘要： An oral disintegrating tablet containing (1) D-mannitol, (2) an active ingredient, (3) one or more disintegrating agents selected from the group consisting of crospovidone and carmellose, and (4) one or more lubricants selected from the group consisting of sodium stearyl fumarate and sucrose esters of fatty acids. The oral disintegrating tablet of the present invention has some excellent properties of (1) allowing easy production in a common facility without necessitating a specialized pharmaceutical technique, (2) having an appropriate strength that does not breakdown in the process of distribution, (3) having a fast disintegrating ability in the oral cavity, and (4) also having excellent ingestion feel such as greatly reduced bitterness or gritty feel; therefore, the tablet can be suitably used as a dosage form that is suitable for aged individuals, children, and seriously ill patients.

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