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21. 发明申请

US20080248079A1 TISSUE AUGMENTATION DEVICES AND METHODS 有权
标题翻译：组织补充装置及方法
公开(公告)号：US20080248079A1
公开(公告)日：2008-10-09
申请号：US12114456
申请日：2008-05-02
申请人： Ryan Dempsey , Jeffrey Miller , Steve Chen , Umesh H. Patel , F. Joseph Obermiller , Bhavin Shah , Chad E. Johnson
发明人： Ryan Dempsey , Jeffrey Miller , Steve Chen , Umesh H. Patel , F. Joseph Obermiller , Bhavin Shah , Chad E. Johnson
IPC分类号： A61F2/00 , A61M31/00
CPC分类号： A61F2/0059 , A61B17/06004 , A61B2017/06052 , A61F2/02 , A61L27/24 , A61M5/32 , A61M25/0662 , A61M2025/018 , Y10S623/915
摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.
摘要翻译：公开了组织增加装置，以及制造和使用它们的方法。在某些实施例中，组织增强装置包括细长的组织穿透构件和一定量的可重塑材料，其中细长构件的至少一部分被插管，并且至少部分材料量被容纳在至少一部分内的细长构件的插管部分。细长组织穿透构件可以提供至少一个变形，其被构造成收缩在细长构件内容纳的可重塑材料的量的部分。在替代实施例中，可植入生物材料上的柔性覆盖物提供保护并且允许将生物材料更容易地递送到组织道。

22. 发明授权

US09271817B2 Tissue augmentation devices and methods 有权
公开(公告)号：US09271817B2
公开(公告)日：2016-03-01
申请号：US12114456
申请日：2008-05-02
申请人： Ryan Dempsey , Jeffrey Miller , Steve Chen , Umesh H. Patel , F. Joseph Obermiller , Bhavin Shah , Chad E. Johnson
发明人： Ryan Dempsey , Jeffrey Miller , Steve Chen , Umesh H. Patel , F. Joseph Obermiller , Bhavin Shah , Chad E. Johnson
IPC分类号： A61F2/00 , A61M25/01 , A61L27/24 , A61F2/02 , A61B17/06 , A61M25/06 , A61M5/32
CPC分类号： A61F2/0059 , A61B17/06004 , A61B2017/06052 , A61F2/02 , A61L27/24 , A61M5/32 , A61M25/0662 , A61M2025/018 , Y10S623/915
摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.

23. 发明授权

US08470022B2 Implantable valve 有权
标题翻译：植入式阀门
公开(公告)号：US08470022B2
公开(公告)日：2013-06-25
申请号：US11513881
申请日：2006-08-31
申请人： Chad E. Johnson
发明人： Chad E. Johnson
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2415
摘要： Described are implantable prosthetic valve devices comprising isolated granulation tissue. Also described are methods of treatment that include implanting at least one of these valves within a body passageway of a patient, for example, within a vein to treat venous insufficiency.
摘要翻译：描述了包括分离的肉芽组织的可植入假体瓣膜装置。还描述了治疗方法，其包括将这些瓣膜中的至少一个植入患者的身体通道内，例如在静脉内以治疗静脉功能不全。

24. 发明授权

US08455008B2 Processed ECM materials with enhanced component profiles 有权
标题翻译：加工的ECM材料具有增强的组件配置文件
公开(公告)号：US08455008B2
公开(公告)日：2013-06-04
申请号：US13488519
申请日：2012-06-05
申请人： Chad E. Johnson
发明人： Chad E. Johnson
IPC分类号： A61F2/00 , A61K35/37
CPC分类号： A61L27/3633 , A61L27/3604 , A61L27/3695
摘要： Described are medical graft materials and devices having improved properties relating to their component profiles.
摘要翻译：描述了具有改进的与其组分轮廓相关的性质的医用移植材料和装置。

25. 发明申请

US20130079811A1 DEVICES AND METHODS FOR TREATING FISTULAE AND OTHER BODILY OPENINGS AND PASSAGEWAYS 有权
标题翻译：用于处理假肢和其他身体开放和穿刺的装置和方法
公开(公告)号：US20130079811A1
公开(公告)日：2013-03-28
申请号：US13247156
申请日：2011-09-28
申请人： Charles W. Agnew , Mark Duncan , Chad E. Johnson
发明人： Charles W. Agnew , Mark Duncan , Chad E. Johnson
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/12099 , A61B17/12159 , A61B17/12181 , A61B17/1219 , A61B2017/00004 , A61B2017/00579 , A61B2017/00601 , A61B2017/00628 , A61B2017/00641 , A61B2017/0065 , A61B2017/00884
摘要： Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.
摘要翻译：本发明的一些方面涉及用于治疗瘘管和身体其它通道和开口的独特产品和方法。在一些优选形式中，本发明的构造将包括结合有多个片状或片状片段的细长移植体。在一些布置中，多个片状或片状片段将沿着插塞体的长度沿大致纵向的方向堆叠，并且可选地，片段将被接收在一个或多个细长元件上。这种细长的元件可以采取各种形式，包括缝合线，丝线，细丝或其他相对细长的细长构件，尽管在某些形式中，细长元件将是或包括一些较高的结构，例如可生物降解的或不可生物降解的可生物降解的三维体。

26. 发明授权

US08329219B2 Methods for producing ECM-based biomaterials 有权
标题翻译：生产基于ECM的生物材料的方法
公开(公告)号：US08329219B2
公开(公告)日：2012-12-11
申请号：US12644607
申请日：2009-12-22
申请人： Laura-Lee Farrell , Chad E. Johnson
发明人： Laura-Lee Farrell , Chad E. Johnson
IPC分类号： A61K9/14 , B29C41/04 , A61P17/02
CPC分类号： A61K9/0087 , A61K38/39 , A61L27/3633 , A61L31/005 , B29C39/08 , B29C67/20
摘要： A method for forming an extracellular matrix material (ECM) material includes providing at least an ECM composition containing ECM particles varying in their capacity for migration through a fluid medium, including at least one population of expanded ECM particles. The ECM composition is combined in a fluid medium to form a flowable ECM composition. The flowable ECM composition is subjected to a centrifugal force in a mold for a period of time sufficient to distribute the ECM particles according to differences in their physical characteristics. The ECM composition is dried to form a dried ECM material having a density gradient extending from a less dense region to a more dense region. The dried ECM material may formed as a porous, substantially acellular ECM material expandable in an aqueous fluid environment by at least 100% in volume.
摘要翻译：用于形成细胞外基质材料（ECM）材料的方法包括提供至少一种含有ECM颗粒的ECM组合物，其中ECM颗粒的能力通过流体介质（包括至少一个扩展的ECM颗粒群体）迁移。 ECM组合物在流体介质中组合以形成可流动的ECM组合物。可流动的ECM组合物在模具中经受足够的离心力足以根据其物理特性的差异分布ECM颗粒。将ECM组合物干燥以形成具有从较不密集区域延伸至更致密区域的密度梯度的干燥的ECM材料。干燥的ECM材料可以形成为在水性流体环境中可膨胀至少100体积的多孔，基本上无细胞的ECM材料。

27. 发明授权

US08192763B2 Processed ECM materials with enhanced component profiles 有权
标题翻译：加工的ECM材料具有增强的组件配置文件
公开(公告)号：US08192763B2
公开(公告)日：2012-06-05
申请号：US12178321
申请日：2008-07-23
申请人： Chad E. Johnson
发明人： Chad E. Johnson
IPC分类号： A61K35/12 , A61K35/38 , A61K38/39
CPC分类号： A61L27/3633 , A61L27/3604 , A61L27/3695
摘要： Described are medical graft materials and devices having improved properties relating to their component profiles.
摘要翻译：描述了具有改进的与其组分轮廓相关的性质的医用移植材料和装置。

28. 发明授权

US07846199B2 Remodelable prosthetic valve 有权
标题翻译：可重塑假体瓣膜
公开(公告)号：US07846199B2
公开(公告)日：2010-12-07
申请号：US12273284
申请日：2008-11-18
申请人： Ram H. Paul, Jr. , Sean D. Chambers , Chad E. Johnson
发明人： Ram H. Paul, Jr. , Sean D. Chambers , Chad E. Johnson
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2230/0026 , A61F2230/0095 , A61F2250/0031
摘要： Prosthetic medical devices with delayed valve function and in situ remodeling of a portion thereof are provided, as well as methods of manufacturing the medical devices and methods of treatment using the medical devices. The medical devices may be adapted to initially maintain a remodelable material within a body vessel in a first configuration suitable to contact the remodelable material with a body fluid contacting the remodelable material for a first time period or a second configuration adapted to regulate the flow of body fluid contacting the remodelable material. The medical devices may include a releasable holding member configured to retain the remodelable material in the first configuration.
摘要翻译：提供具有延迟阀功能和其一部分的原位重塑的假体医疗装置，以及制造医疗装置的方法和使用医疗装置的治疗方法。医疗装置可以适于以适于使可重塑材料接触第一时间段接触可重塑材料的体液或适于调节身体流动的第二构型的第一构型在体体容器内最初维持可重塑材料液体接触可重塑材料。医疗装置可以包括被配置为将可重塑材料保持在第一构造中的可释放保持构件。

29. 发明申请

US20090318934A1 COMPRESSIBLE/EXPANDABLE MEDICAL GRAFT PRODUCTS, AND METHODS FOR APPLYING HEMOSTASIS 审中-公开
标题翻译：可压缩/可扩展的医用产品，以及应用HEMOSTASIS的方法
公开(公告)号：US20090318934A1
公开(公告)日：2009-12-24
申请号：US12488974
申请日：2009-06-22
申请人： Chad E. Johnson , David M.J. Ernst , Amy Overby
发明人： Chad E. Johnson , David M.J. Ernst , Amy Overby
IPC分类号： A61B17/28 , A61K9/00 , A61K38/18
摘要： Described are expanded collagenous materials useful in hemostatic applications. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, recovering the expanded material, processing the expanded material to provide a foam, and chemically crosslinking the foam. Expanded materials can exhibit beneficial resilience, persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.
摘要翻译：描述了可用于止血应用的扩张胶原材料。某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下处理具有碱性物质的第一胶原材料，回收膨胀的材料，加工膨胀的材料以提供泡沫和化学交联泡沫来制备。膨胀的材料可以在植入时显示出有益的弹性，持续性和组织生成特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

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